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BASIC analysis of ---Stress/overwork and cardiovascular disease data
Sino-Japanese cooperation project
---------by Mile Xiu
Background about this project
Experimental design
• We focus on the relationship between work stress and cardiovascular disease. Work stress is assessed by Job demand control scale. Cardiovascular risk factors and the ankle-brachial index(ABI) and Brachial–ankle pulse wave velocity (baPWV) is also collected
• Participants: 3,000 Chinese people and 100 Japanese people work in Shanghai rolled in our research
• Inclusion criteria: Cooperate with the investigation;≥18 years old; blood and urine sample left.
• Exclusion criteria: Do not finish our questionnaire ;<18 years old; blood or urine sample missed
Protocol
WWORK HOURS
DECISION LATITUDE
SOCIAL SUPPORT
JOB DEMAND
JOB STRENGTH
SPY
waist
SYSBP
PP
HR
LDL
HDL
UUA
HbA1c
PPWV Albumin
Ussmoking
Working condition
Cardiovascular risk
Organ damage
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Baseline
• Basic information: Name, gender, birthday, occupational type ,educational level, marital status, address, phone number.
• Anthropometric: height; body weight, abdominal circumference, blood pressure, heart rate.
• Family history: focus on cardiovascular-related family history• Personal history: smoke(no/post/yes), alcohol intake(yes/no),
Fatty liver(mild/moderate or heavier/no), exercise situation• Drug therapy: Antihypertensive drug, Antidiabetic drugs
Antilipemic drugs, Aspirin.
Blood and urine laboratory
• Total cholesterol(TC); Triglyceride(TG); High-density lipoprotein cholesterol (HDL-C); Low-density lipoprotein cholesterol (LDL-C)
• Fasting blood; Glycosylated Hemoglobin A_(1C)(HbA1c%).• Alanine aminotransferase (ALT);Aspartate aminotransferase
(AST);r-GTP• Uric acid, Urea nitrogen, Total protein, Albumin, Urinary
protein• Vascular screening: ABI and baPWV
Work stress scale
• Work time per week(<25h;25-34;35-44;45-54;>55);sleep time and clock in weekday; walk time everyday (none; in 1 hour;1-2 hours; >hours); diet type(Never eating too much from youth; can't eat too full due to the health concerns; Eating too much or eating too little; Eating full)
• Desicion latitude: The higher the score the greater the power• Social support: The higher the score the lower the support• Job demand: The higher the score the lower the required
degree.• Job strength: The higher the score the lower the work
strength.
Traditional CVD risk factors
• Blood pressure ≥ 140/90 mm Hg and/or hypertension history• Diabetes mellitus fasting glucose ≥ 7.0 mmol/L and/or
diabetes mellitus history (HbA1c ≥6.5%??)• Hyperlipidemia total cholesterol ≥ 5.72 mmol/L, and/or total
triglyceride ≥1.7 mmol/L, and/or low-density lipoprotein ≥ 3.64 mmol/L, and/or Hyperlipidemia history.
• Body mass index (BMI) normal(≤24), overweight (>24 and <28), and obesity (≥28)
• Smoke• Alchol intake
Data analysis
• Soft ware : SPSS version17.0
• chi-square test or t test
• Logistic regression
Description by gender
Characteristic All 2504Mean SD
Male 1582Mean SD
Female 922Mean SD
P value
Gender 2504 1579(63.2) 922(36.8) <0.001Age 46.1 47.5(11.4) 43.7(16.2) 0.005Education
Lower than senior high school; 259(10.5) 151 108
0.124Senior high school; 599(24.2) 366 233Bachelor 1455(58.9) 945 510Master OR higher 158(6.4) 101 57
Marital status Unmarried 169 74(4.7%) 95(10.5%)
<0.001 Married 2268 1475(94.7%) 793(87.7%) Divorced 8 4(0.3%) 4(0.4%) Widowed 17 5(0.3%) 12(1.3%)Height 167.4(7.98) 171.4(6.4) 160(5.3) <0.001Body weight 67.7(16.5) 72.7(10.6) 59.1(20.7) <0.001BMI 24.08(5.96) 24.77(4.25) 22.89(7.97) <0.001Abdominal circumference 85.02(11.16) 88.8(8.96) 77.38(11.28) <0.001SBP 126.1(17.6) 129.2(16.3) 120.9(18.6) <0.001DBP 78.0(11.7) 80.0(11.0) 73.3(11.2) <0.001PP 48.2(11.2) 48.4(10.6) 47.7(12.0) 0.127Heart rate 73.7(10.9) 73.3(10.7) 74.2(11.2) 0.063Smoke history Non-smoker 1638(65.7%) 740(47%) 898(97.9%)
<0.001 Post-smoker 126(5.1%) 123(7.8%) 3(0.3%) Smoker 729(29.2%) 713(45.2) 16(1.7)History of alcohol intake Non-drinker 1682(67.5%) 805(51.1%) 877(95.8%)
<0.001 Post-drinker 58(2.3%) 57(3.6%) 1(0.1%) Drinker 751(30.1%) 714(45.3%) 37(4.0%)Adiposis hepatica situation none 1612(64.8%) 863(53.5%) 749(81.4%)
<0.001 mild 665(26.7%) 541(34.5%) 124(13.5%) Moderate or heavier 212(8.5%) 165(10.5%) 47(5.1%)Active physical activity no 1552(62.6%) 878(56.1%) 674(73.7%)
<0.001 yes 928(37.4%) 687(43.9%) 241(26.3%)baPWV 1357(255.7) 1399.5(235.4) 1284.1(272.1) <0.001ABI 1.06(0.085) 1.07(0.85) 1.04(0.83) <0.001
Description by stress score Characteristic Low score
≤104Frequency/Percentage
High score>105Frequency/Percentage
P value
Gender
Male 688 799<0.001
Female 425 361
Education
Lower than high school; 101 88
0.002(wilcoxon)
Senior high school; 270 243
Bachelor 661 727
Master OR higher 63 93
Marital status
Unmarried 102 63
0.002 Married 985 1074
Divorced 3 4
Widowed 1 5
Smoker history
Non-smoker 768(69.4%) 706(60.9%)
<0.001 Post-smoker 123(3.5%) 56(4.8%)
Smoker 713(27.1%) 397(34.3%)
History of alcohol intake
Non-drinker 809(73.1%) 700(60.5%)
<0.001 Post-drinker 23(2.1%) 25(2.2%)
Drinker 275(24.8%) 432(37.3%)
Adiposis hepatica situation
None 736(66.5%) 727(63.1%)
0.002 Mild 303(27.4%) 307(26.6%)
Moderate or heavier 68(6.1%) 118(10.2%)
Exercise situation
No 685(62%) 716(62.2%)0.959
Yes 419(38%) 436(37.8%)
Antihypertensive drug situation
No 926(83.5%) 993(85.7%)0.151
Yes 183(16.5%) 166(14.3%)
Antidiabetic Drugs situation
No 1080(97.8%) 1130(97.7%)0.798
Yes 24(2.2%) 27(2.3%)
Antilipemic situation
No 1096(99.2%) 1146(99%)0.729
Yes 9(0.8) 11(1%)
Aspirin situation
No 1083(98.1%) 1134(97.9%)0.772
Yes 21(1.9%) 24(2.1%)
Characteristic Low score ≤104Mean SD
High score>105Mean SD
P value
BMI 23.74(3.34) 24.19(4.91) 0.011Age 44.7(11.4) 44.6(10.56) 0.789Abdominal circumference 84.2(10.55) 85.76(12.15) 0.005SBP 124.8(17.1) 125.6(16.4) 0.516PP 47.6(10.4) 46.9(9.99) 0.131Heart rate 73.9(11.2) 73.4(10.8) 0.301TC 4.75(0.85) 4.89(1.00) <0.001TG 1.53(1.28) 1.61(1.43) 0.181HDL-C 1.27(0.34) 1.3(0.46) 0.018LDL-C 2.78(0.7) 2.89(0.76) <0.001BG 4.86(1.03) 4.85(1.14) 0.848HbA1c(%) 5.31(0.842) 5.35(0.89) 0.847ALT 24.29(17.7) 27.25(23.29) <0.001AST 23.58(10.45) 23.87(15.8) 0.679r-GTP 30.8(34.74) 33.7(37.3) <0.001UA 321.8(95.4) 334.3(96.9) 0.002UN 5.23(3.51) 5.48(4.42) 0.147Total protein 73.1(5.67) 72.4(6.47) 0.002Albumin 46.5(3.2) 46.2(3.65) 0.066Urine protein 16.04(33.5)
(14.45-18.0)16.59(47.1)(13.85-19.33)
0.778
ABI 1.058(0.09) 1.059(0.081) 0.860baPWV 1340.6(261.8) 1338.8(219.7) 0.245Work hour/week
<25 66(6%) 36(3.2%)
<0.00125-34 43(3.9%) 43(3.8%)35-44 762(69.8%) 615(54.1%)45-54 169(15.5%) 296(26.1%)≥55 52(4.8%) 146(12.9%)
Sleep duration 7.14(0.975) 7.16(0.968) 0.666Diet type Never eating too much from youth 501(45.3%) 439(38.2)
<0.001 can't eat too full due to the health concerns 180(16.3%) 225(19.6%)
Eating too much or eating too little 186(16.8%) 161(14%) Eating full 239(21.6%) 325(28.3%)
Thanks !!!