8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 1/21

 

BASAL CELL CARCINOMA

 Yono Hadi Agusni

Dept ofDermatovenereology

Padjadjaran University

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 2/21

 

Basal cell carcinoma

• Sinonim :

•   - Basal cell epithelioma

•   - Basalioma

•   - Ulcus roden / Rodent ulcer

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 3/21

 

Basal cell carcinoma

• Malignant tumor of the skin that isbelieved to arise from the hairfollicle

•   ( David J. Leffell & David A. Fitzgerald)

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 4/21

 

EPIDEMIOLOGY 

• US : 1! per 1""#"""

• $ustralia : %&! per 1""#"""

• “Over the past decade, signifcantincreases the incidence oc BCC have

een oserved in E!rope, A!stra"iaand #nited States “

• 'ndonesia : (

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 5/21

 

• Age  : over " )ears

• Sex : male more than female

• Race  : rare in black / bro*nskinned 

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 6/21

 

Predisposing factors

• $gents

• Skin +esions

• S)ndromes

• Settings

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 7/21 

Predisposing agents

• Ultraviolet light

• 'oni,ing radiation

• hemical carcinogens

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 8/21 

Predisposing skin

lesions• .ermatobromas

• 0evus sebaceous

• Burns scars hronic ulcers

• +inear unilateral basal cell nevus

• Stanley J. Miller 2

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 9/21 

$redisposing s%ndromes 

• 3eroderma pigmentosum

• 0evoid basal cell carcinomas)ndrome

• Ba,e4 s)ndrome

• (Stanley J. Miller)

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 10/21

 

Predisposing settings

• 'mmunosuppression

• 5enetic tendenc)

• Stanley J. Miller 

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 11/21

 

Physical examination (!

• .istribution : 6sun-e4posed area7

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 12/21

 

$h%sica" e&amination ("!

• Skin lesions :

•   8apule or nodule

•   translucents or 6pearl)7

•   6rodent ulcer7

•   9!"cer 'ith a ro""ed order 2

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 13/21

 

Physical examination (#!

• Color : 8ink or red

•   Bro*n to Black

• Palpation : ard rm

•   )stic lesion ma) occur

• Shape : Round oval depressed centre

•   9umbilicated2

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 14/21

 

$ariants %

• 0oduloulcerative t)pe

• Sclerosing t)pe 96morphea-like7t)pe2

• Supercial 9multicentric2 t)pe

• 8igmented t)pe

• -William A. Caro

• - Thomas B. Fitzpatrick 

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 15/21

 

La&oratory 'ndings

•   0one

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 16/21

 

Pathology anatomy %

• Site   ;pidermis < dermis

• Process  8roliferating at)picalbasal cells 9large oval deep-bluestaining on <; but *ith a littleanaplasia and infre=uent mitoses2*ith variable amounts of stroma#

• Thomas B. Fitzpatrick 

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 17/21

 

Dierent diagnosis

• S=uamous cell carcinoma

• >eratoacanthoma

• 0evus pigmentosus

• hronic ulcer

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 18/21

 

)omplications %

• B have a little tendenc) tometastasi,e

• B invade and destro) underl)ingtissue

• 6 destruction of underl)ing tissuemakes B lookslike malignant 6

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 19/21

 

*reatments

• ;4cision

• r)osurger)

• urettage

• ;lectrosurger)• Radiotherap)

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 20/21

8/9/2019 Basal Cell Carcinoma.ppt

http://slidepdf.com/reader/full/basal-cell-carcinomappt 21/21

 

Prognosis

• 'n general : .good/