Automated Metered Dose InhalerAutomated Metered Dose InhalerPresentation #4 (03/22/04)Presentation #4 (03/22/04)

Presented By Group 11:Presented By Group 11:The “MDI Auto-Maniacs”The “MDI Auto-Maniacs”

Maria del Carmen CarrilloMaria del Carmen CarrilloJennifer B. StrubleJennifer B. StrubleLoyrirk TemiyakarnLoyrirk Temiyakarn

Problem DefinitionProblem Definition

Automatic Metered Dose Inhalant Automatic Metered Dose Inhalant (MDI) delivery device(MDI) delivery device: :

Electromechanical, in-hospital inhalant Electromechanical, in-hospital inhalant drug delivery systemdrug delivery system

Patients are mechanically ventilated and Patients are mechanically ventilated and sedatedsedated

Medication delivered Medication delivered automaticallyautomatically as as prescribed electronicallyprescribed electronically

Medication must be well shaken Medication must be well shaken (homogenized with propellant)(homogenized with propellant)

BackgroundBackground What is a Metered Dose What is a Metered Dose

Inhaler?Inhaler? pocket-sized handheld inhaler delivers standardized dose of

medication for bronchodilation

Who Uses Them?Who Uses Them? Patients with asthma or

chronic obstructive pulmonary disease (COPD)

Setting?Setting? Critical patients in hospitalsCritical patients in hospitals Prescriptions for outpatient or Prescriptions for outpatient or

in-home usein-home use

Existing MethodsExisting Methods Methods in-useMethods in-use

Manual administrationManual administration

Patent SearchPatent Search

Automatic Automatic methods are methods are NOT for NOT for mechanically mechanically ventilated ventilated patientspatients

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Design FactorsDesign Factors Integration with existing Integration with existing

endotracheal tubingendotracheal tubing Homogenization with Homogenization with

propellantpropellant Delivery of medication Delivery of medication

into ventilation systeminto ventilation system Tubing lengthTubing length Synchronization of Synchronization of

delivery with breathingdelivery with breathing Software/AutomationSoftware/Automation

User interfaceUser interface Prescription error Prescription error

checkingchecking

Project StatusProject Status

Preliminary Research Preliminary Research CompleteComplete Standard MDIStandard MDI

Completed ResearchCompleted Research Endotracheal TubingEndotracheal Tubing ConnectorsConnectors Ventilators (Siemens Ventilators (Siemens

Servo I)Servo I) Types of MedicationTypes of Medication

Continuing ResearchContinuing Research HomogenizerHomogenizer

Working Design: Working Design: Using Prefabricated CanistersUsing Prefabricated Canisters

Integrated with existing Integrated with existing tubingtubing In-line using In-line using

AeroChamberAeroChamber HomogenizeHomogenize

Pneumatic Actuator Pneumatic Actuator Laptop-based Laptop-based

prescription entryprescription entry Similar to error reduction Similar to error reduction

system, Guardrails® system, Guardrails® Safety Software, in Alaris Safety Software, in Alaris “Smart” IV Pump“Smart” IV Pump

Shaking = HomogenizationShaking = Homogenization

Key obstacle - Key obstacle - homogenizationhomogenization

Actuator - Actuator - homogenize and homogenize and administer Albuteroladminister Albuterol Pneumatic Pneumatic

Simple singular Simple singular directional motiondirectional motion

Control stroke lengthControl stroke length Detect positionDetect position

Experiment on HomogenizationExperiment on Homogenization

Overall - Difficult to quantify Overall - Difficult to quantify and so based on subjective and so based on subjective analysisanalysis

1.1. Soft vs. Vigorous Shakes - Soft Soft vs. Vigorous Shakes - Soft more effectivemore effective

2.2. Various Vigorous Shakes - One Various Vigorous Shakes - One worked better than twoworked better than two

3.3. Various Soft Shakes - Five Various Soft Shakes - Five better than three or tenbetter than three or ten

4.4. With the Spacer - ineffective, With the Spacer - ineffective, has to be inhaled to leave the has to be inhaled to leave the spacerspacer

TimelineTimeline Completed WorkCompleted Work

Preliminary research Preliminary research Clearly defined design Clearly defined design

factorsfactors Through Innovation Through Innovation

WorkbenchWorkbench Testing with AlbuterolTesting with Albuterol

Current WorkCurrent Work Discuss with Festo rep.Discuss with Festo rep. Order more components Order more components

to start building prototypeto start building prototype Actuator (pneumatic)Actuator (pneumatic)

Building Model ABuilding Model A

TimelineTimeline Order parts ~ immediateOrder parts ~ immediate Model A ~ End of MarchModel A ~ End of March Testing ~ End of MarchTesting ~ End of March Final prototype ~ AprilFinal prototype ~ April

Software includedSoftware included

ReferencesReferences

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Operation. 2003Operation. 2003