Author: Coroiu Costel

Coordinators: Molnar Calin MD, PhD

Saracut Claudiu MD, PhD Student

Co-authors: Simion Ioachim-Iustinian,Ion Razvan-Marius, Macec Adelina, Goidescu Alina-Olimpia

Gallbladder disorders in colorectal cancer

Introduction colorectal cancer is a disease that affects

more and more people and is the second cause of death after lung cancer in male population and the third cause of death after breast cancer and cervical cancer in female population.

Over 700.000 deaths worldwide render the importance of clinicopathological studies.

The evolution of the methods of investigation, diagnosis and treatment in the last few years provides a better way to prevent and treat the colorectal cancer.

[1-colorectal cancer]

The main purpose of our study is to observe the incidence and characteristics of colorectal cancer among patients diagnosed in the Surgery Clinic 1 of Tirgu Mures County Emergency Hospital.

The subsidiary purposes are: to observe some aspects and differences between patients with colorectal cancer and patients with gallbladder disorders and colorectal cancer and to use the results as a ground base for future statistical studies.

Objective

You can not change:age, inherited conditions and

syndroms, personal history of inflammatory

bowel disease, colorectal cancer or family history

of colorectal cancer or adenomatous polyposis

Life-style related factors:diets with red meat,

obesity, smoking, alcohol abuse

Another risk factor is gallbladder disorders like

cholelithiasis or a cholecystectomy in the

pathological history of the patient.

Risk factors for colorectal cancer

2-FAP

3-red meat

This is a retrospective study undertaken between 2003 and 2013 on 1005 patients who were hospitalized in the Surgery Clinic 1 of Tirgu Mures County Emergency Hospital. From 1005 cases we selected the ones only with colorectal cancer and we excluded the patients with anal canal cancer.

Using their records and histopathological bulletins, we analysed cancer location, sex distribution, frequency by years, histologic and macroscopic forms and we observed some correlations between location and symptoms.

To complete the study, we used some statistical instruments, such as GraphPad and Microsoft Excel.

We focused our study on patients with colorectal cancer, 939 cases, from which 167 were having gallbladder disorders.

MATERIALS AND METHODS

RESULTS

4.65

3.7

13.3

32.6

16.9

18.5

5.3

Cecum cancerAscending colon cancerDescending colon cancerTransverse colon cancerRectum cancerRecto-sigmoidian cancerSigmoidian cancerSynchronous tumors

Transverse colon includes liver flexure and splenic flexure

Sex distribution

with a P<000.1

Gallbladder disorders Without gallbladder disorders0.00%

10.00%

20.00%

30.00%

40.00%

50.00%

60.00%

70.00%

80.00%

90.00%

100.00%

FemalesMales

Years distribution

2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 20130

20

40

60

80

100

120

FrequencyPercent

Macroscopic form distribution

0.00%

5.00%

10.00%

15.00%

20.00%

25.00%

30.00%

35.00%

40.00%

45.00%

Gallbladder disorders Without gallbladder problems

Histological form distribution

0.00%

10.00%

20.00%

30.00%

40.00%

50.00%

60.00%

70.00%

80.00%

90.00%

100.00%

Gallbladder disordersWithout gallbladder problems

The number of colorectal cancer cases increases year by year. The first role in defeating the rising number of colorectal cancer cases should be assumed by the medical staff through different informing, screening and diagnosing campaigns.

According to our study, from 939 patients, a percentage of 17.78, which means a number of 167 patients, had gallbladder disorders and this should raise questions over the correlation of gallbladder disorders and colorectal cancer, which means that more studies should be performed in this direction.

Discussions

Our collected data may be used as a data base for next studies. But the main obstacle of our study was the limited access to patients records and the fact that most of the records were incomplete.

Novelty and limitations

Clasification system

4-cancer classification 5-cancer stagies

1)http://flplahore.blogspot.ro/2012/10/www.distributorpakistan.com_5.html

2) http://www.colorectaltumor.com/p/familial-adenomatos.html 3)

http://www.seattleorganicrestaurants.com/vegan-whole-foods/red-meat/

4)http://www.hopkinscoloncancercenter.org/CMS/CMS_Page.aspx?CurrentUDV=59&CMS_Page_ID=EEA2CD91-3276-4123-BEEB-BAF1984D20C7

5)http://www.bowelcanceraustralia.org/bca/index.php?option=com_content&view=article&id=148&Itemid=301

Bibliography