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The e-newsletter of The University of Toledo College of Pharmacy and Pharmaceutical Sciences
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AUGUST 2014
GINKGO AND STROKE
The popular supplement is
showing promise in the field of
stroke recovery, as studied by
Dr. Zahoor Shah.
PG2
LEADERSHIP LESSONS
As Dr. Paul Erhardt
celebrates 20 years of leading
the CD3, he reflects on what
has made him successful.
PG3
PHARMACY CAMP
The annual event introduces
high school students to a
career path and a source of
inspiration.
PG4
INTERNATIONAL APPE
An alumnus shares his
experience of completing an
Advance Pharmacy Practice
Experience in China.
PG4
Having left the comforts of the United States
to explore graduate education abroad, Dr.
Amanda Bryant-Friedrich has firsthand
knowledge of the complex transition
awaiting graduate students who come to the
College of Pharmacy and Pharmaceutical
Sciences from around the
academically and see the
world, but these experiences were often
challenging; missing her home and
community at times compounded the
challenges. In her new role as Director of
International Pharmaceutical Sciences
globe. Completing her
doctorate in Heidelberg,
Germany and postdoctoral
training in Basel, Switzerland
allowed her to grow
The monthly
e-newsletter of the
nationally ranked
University of Toledo
College of Pharmacy
and Pharmaceutical
Sciences
i m m i g r a t i o n a n d
matriculation that originate
from a lack of knowledge
from the perspectives of both
the student and the
respective institution of
Graduate Student Recruitment and
Retention, Dr. Bryant-Friedrich is a valuable
resource to graduate students experiencing
the United States, often for the first time.
“Students who decide to pursue advanced
degrees outside their country of origin are
often faced with barriers of
higher learning,” Dr. Bryant-Friedrich said.
As the College engages new regions of the
world to attract graduate students, Dr.
Bryant-Friedrich plans to introduce
(Continued on page 4)
Refill x
Welcoming and retaining international graduate students
HOME AWAY FROM HOME : away from homeaway from homeaway from home
NEW INTERNATIONAL GRADUATE
STUDENTS IN THE COLLEGE
20 20 19 19
2011 2012 2013 2014
The Center for Drug Design and
Development celebrated 20 years under
the leadership of Distinguished
University Professor Paul W. Erhardt
with a research symposium that
welcomed prominent researchers,
professor emeriti, alumni and scholars.
The plenary lecture, by Dr. Gunda
Georg, explored “Drug Discovery in
Academia: Minnelide for Pancreatic
Cancer and Gamendazole for Male
Contraception.” Dr, Georg is head of
medicinal chemistry at University of
Minnesota and the director of the
Institute for Therapeutics Discovery &
Development.
The keynote speaker was Dr.
C h r i s t o p h e r A . L i p i n s k i , a
pha rmaceu tica l co ns ulta nt and
contractor who is best known for his
"Rule of Five," the most frequently cited
medicinal chemistry publication of the
last decade. Dr. Lipinski discussed the
direction of drug discovery.
The dinner lecture on “Fascinating
Excursions into Chiral Chemistry: An
Insider‟s Perspective” was presented by
Dr. Mukund Chorghade, Chief Scientific
Officer at THINQ Pharma. Dr.
Chorghade, an adjunct faculty member
at Cal Tech, Harvard, MIT and
Cambridge Universities, has published
hundreds of articles and has received
three “Scientist of the Year” awards.
STROKE IN AMERICA
Stroke is the fourth leading cause of
death and a major cause of long-term
disability, which inflicts substantial
economic and societal burdens. Drug
therapies aimed at post-stroke recovery
that can enhance a person‟s own ability
to replenish injured or dead brain cells
with new developing brain cells
(endogenous neurogenesis) may help
minimize the cost related to prolonged
hospital stays and rehabilitation. Ginkgo
biloba, a widely studied herbal product
for the treatment of neurological
d i s o r d e r s , o f f e r s e n d o g e n o u s
neurogenesis-enhancing properties that
hold the promise of providing recovery-
improving benefits to stroke patients.
EFFECTS OF GINKGO BILOBA
Led by Dr. Zahoor A. Shah, Dr. Shadia E.
Nada and graduate student Jatin
Tulsulkar, researchers in the College of
Pharmacy and Pharmaceutical Sciences
have discovered that mice treated with
Ginkgo biloba 4 hours after inducing an
experimental stroke, and then daily for
seven days, had improved recovery and
less brain damage than the control mice.
It was also observed that Ginkgo biloba-
t r e a t e d m i c e h a d e n h a n c e d
neurogenesis, partly due to the increased
protein expression of hemeoxygenase 1,
an antioxidant gene that also has a role
in neurogenesis. Pertinently, mice
lacking the hemeoxygenase 1 gene were
observed to have reduced neurogenesis
after stroke. An important finding was
that in Ginkgo biloba-treated mice the
majority of these new cells were found
in the proximity of the stroke injury site,
suggesting their role in repairing the
injured/dead neurons.
Besides prevention, improving recovery
following a stroke should become the
USING REWARDS TO TREAT SUBSTANCE ABUSE In 2008, the National Survey on Drug Use
and Health (NSDUH) estimated that 1.9
million Americans were current cocaine
users, with the majority falling between the
ages of 18 and 25.
Ginkgo bilobaGinkgo bilobaGinkgo biloba ENHANCES STROKE RECOVERY
“Research is formalized curiosity. It is poking
and prying with a purpose.”
Zora Neale Hurston
author and anthropologist
CD3 ANNIVERSARY SYMPOSIUM
C o c a i n e ‟ s p h y s i o l o g i c a l a n d
psychological effects include cardiac
disturbances, strokes and seizures, and
psychosis, making treatment for cocaine
addiction a serious public health
concern.
Dr. Caren Steinmiller, who earned her
B.S. in „93 and her M.S. in „95 from The
LEADERSHIP LESSONS
1
2
3
4
THE EFFECTS OF TIME
“Has it really been that long? Time flies when you‟re having fun.”
AFFETTUOSO
“I have an all-encompassing fascination for the science of medicinal chemistry, a science where the intriguing relationships between its beautiful chemical structures and their biological properties are oftentimes applicable toward potentially alleviating some health issue being experienced by people less fortunate than I.”
TEAMING UP
“Addressing technical problems in a teamwork fashion, CD3‟s constituencies have always been supportive and have rallied to get the job done. Our numbers of patents, papers and graduate thesis documents provide solid testimonials to that, and we can all be very proud for such accomplishments.”
FOR AND BY THE PEOPLE
“It has been, and will always be, CD3‟s people that make the CD3 so very special in its productivity and fun. The camaraderie established when tackling this complex field has brought us together like a close-knit family, vibrant with each generation of new student members arriving as our matured graduates depart.”
On the occasion of his twentieth
anniversary of leading the Center for
Drug Design and Development,
Distinguished University Professor Paul
W. Erhardt looks back.
ASSET LIABILITY AND RESTRUCTURING
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tincidunt ut laoreet dolore magna aliquam.
LOREM IPSUM EUSIMOND TINCIDUNT WISI
prime focus of current stroke research.
We now know that neurogenesis is not
only an ongoing process in adults, but
can also be induced by pathological
conditions like traumatic brain injury
and ischemic stroke, and strategies that
promote endogenous neurogenesis as
part of the repair and regeneration
process should be prioritized.
Neurogenesis in the adult brain involves
not only the proliferation and migration
of precursor cells known as stem cells/
neural progenitor cells (NSCs) but also
their functional integration into the
neural network. Though ischemia is
potent in inducing the proliferation and
migration of NSCs, it does not provide
an environment conducive to their
survival, differentiation and integration,
and creating an environment with
exogenous drugs is paramount to
improving the number of NSCs that can
result in improved brain repair and
regeneration.
The study, first reported in Molecular
Neurobiology (Vol. 49, 2014) and then
reviewed in Neural Regeneration Research
(Vol. 9, 2014), confirmed that Ginkgo
biloba, in addition to its antioxidant,
neuritogenic and angiogenic properties,
provides a conducive environment for
the survival and functional integration
of NSCs into neural system.
“Controversies and other ethical issues
related to stem cell therapies make drug
induced, enhanced neurogenesis a
promising treatment strategy,” stressed
senior author Zahoor A. Shah. “Besides
one docu me nte d c l in ical tr ia l
recommending the use of Ginkgo biloba
after ischemic stroke, further high
quality and large-scale randomized
controlled trials are warranted to test
its efficacy in stroke recovery” he said.
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LOREM DOLORE
SIT ALIQUAM
23%
9%
68%
University of Toledo College of
Pharmacy and Pharmaceutical Sciences,
co-authored a paper on cocaine
addiction management that appeared in
Drug and Alcohol Dependence, one of the
leading journals for substance abuse
research.
Dr. Steinmiller, a lecturer in the
Department of Pharmacology, studied
the effectiveness of contingency
management treatment, a way of
rewarding substance abusers, often
monetarily, for adhering to their
treatment plans. Read the study and
results online.
Ginkgo bilobaGinkgo bilobaGinkgo biloba ENHANCES STROKE RECOVERY
ABOUT GINKGO BILOBA
One of the world‟s oldest living species of trees, the ginkgo tree can grow up to 120 feet tall and live for up to 1,000 years. Ginkgo biloba has been used for medicinal purposes for thousands of years to treat a broad range of disorders, from memory loss to circulatory disorders. The research on Ginkgo biloba‟s use for the treatment of Alzheimer‟s disease and stroke is a budding area of excitement among researchers. People who take Ginkgo biloba supplements should take note of the potential drug interactions and safety recommendations.
C o c a i n e ‟ s p h y s i o l o g i c a l a n d
psychological effects include cardiac
disturbances, strokes and seizures, and
psychosis, making treatment for cocaine
addiction a serious public health
concern.
Dr. Caren Steinmiller, who earned her
B.S. in „93 and her M.S. in „95 from The
Each summer, the college welcomes two
cohorts of 40 rising high school seniors
to Pharmacy Camp, a four-day
experience sponsored by Walgreens,
that introduces prospective students to
pharmacy in a hands-on format.
Campers shadowed Toledo pharmacists,
visited the Toledo Zoo where they
learned about veterinary pharmacy from
alumnus Matt Buderer, and made some
great friendships with other campers.
Proudly sporting their “future Rocket
scientist” gear, many of this summer‟s
pharmacy campers hope to be part of
next fall‟s freshman class.
Galvanizing students to explore careers
as pharmacists and pharmaceutical
scientists is the primary goal of
Pharmacy Camp.
One camper said, “I can't thank The
University of Toledo enough for giving
me such an amazing opportunity and
experience of a lifetime. I've never been
more positive and sure about anything
like I now am about attending this
school and pursuing pharmacy as my
future career.”
HOME AWAY FROM HOME continued from page 1
members of the college community to
the educational systems, culture and
research enterprise in each region. Her
new role also requires a heightened
sense of awareness of the political and
economic conditions of the countries
from which international learners
originate to make sure that students
receive counseling and support to help
them maintain an exceptional level of
academic performance, even when
thoughts of home are a distraction.
A n o t h e r a s p e c t o f r e t a i n i n g
international students is ensuring their
sense of community upon their arrival.
“ I inte nd to ma inta in s tro ng
relationships with community-based
organizations that have ties and services
important to the needs of our
international students. This will include
working with the UT Center for
International Students and Programs as
w e l l a s T o le d o S is t e r C i t i e s
International and other organizations
with a common interest in international
relationships,” Dr. Bryant-Friedrich said.
The college is continually increasing the
population of graduate students who are
well prepared academically for
coursework and research. Dr. Bryant-
Friedrich sees this as an opportunity to
create recruitment pipelines from
prestigious institutions abroad.
Dr. Bryant-Friedrich, who has mentored
17 graduate students from 11 countries,
feels fortunate for the opportunity to
ease the transition for graduate students
in the College of Pharmacy and
Pharmaceutical Sciences.
“The global scientific community relies
on the establishment of productive
collaborations based on mutual trust
and understanding,” Dr. Bryant-
Friedrich said. “What better way to
improve the human condition than to
bring brilliant students from around the
world together to improve what really
matters.”
INTERNATIONAL APPE: A STUDENT’S JOURNEY
As a P4 student pharmacist, I began my
Advance Pharmacy Practice Experiences
(APPEs) in a unique way. My first APPE
INSPIRES FUTURE ROCKET SCIENTISTS
pharmacy camp
rotation was at the Affiliated Hospital of
North Sichuan Medical College located
in Nanchong, the second most
populated city of Sichuan Province,
China.
Over the course of a month, I worked
with my preceptors to learn about
traditional Chinese medicine (TCM),
including acupuncture and herbal
By CHUN WONG, PharmD ‘14
SMOOTH SAILING
THROUGH STRATEGIC
BUSINESS DECISIONS
AROUND THE WORLD AND BACK AGAIN
DR. AMANDA BRYANT-FRIEDRICH IN 1997 ON THE DAY
SHE COMPLETED HER DOCTORATE FROM RUPRECHT
KARLS UNIVERSITÄT IN HEIDELBERG, GERMANY
“I have been impressed with the urgency of doing. Knowing is not enough; we must apply.
Being willing is not enough; we must do.”
Leonardo da Vinci
artist, inventor, original Renaissance man
COMMUNITY EDUCATION
KUDOS:
STUDENT RESEARCH
AND AWARDS
1
2
P4 student Elias Bassil, an officer in the UT chapter of Student
National Pharmaceutical Association, spoke at the Career
Pathways Center of the Norman and Louise Jones Foundation to
educate young adults about the adverse effects of illegal drugs.
Because of the success of his presentation, the foundation‟s
executive director invited Elias begin a weekly series of
presentations to discuss topics in pharmacy, careers, and
education for young adults and their families.
WALMART SCHOLARS AT AACP
Pharmacy students Kimberly Zitko and Philip King were selected to participate in the 2014 Wal-Mart Scholars program with their respective faculty mentors, Dr. Michelle Serres and Dr. Michael Peeters. Their $1000 scholarships funded their attendance at the American Association of Colleges of Pharmacy (AACP) Annual Meeting and Teachers‟ Seminar.
GRADUATE RESEARCH AWARD
Kush Patel, a graduate student mentored by Pharmaceutics Associate Professor Dr. Jerry Nesamony, earned a Graduate Student Award from the College of Graduate Studies for the Graduate Student Association (GSA). The award of $1893 will fund his research on “An Insulin Oral Drug Delivery via Calcium Alginate Nanoparticles”.
Save the date: 09.06.14 at 10 a.m. ROCKETS V. MISSOURI TAILGATE Network with alumni, faculty, students and
friends of the College of Pharmacy and
Pharmaceutical Sciences at the Pillbox tailgate
tent, sponsored by Giant Eagle. Bring your
business cards!
ABRINDO AS PORTAS
OPENING OUR DOORS
This fall, the College of Pharmacy and
Pharmaceutical Sciences welcomes
eight learners from Brazil to take
bachelor‟s level pharmaceutical science
courses at The University of Toledo as
part of the Brazil Scientific Mobility
Program (BSMP).
The one-year, non-degree program
allows Brazilian students to study in
some of the world‟s most prominent
institutions. The students, who are
nominated and supported by their home
universities, will take courses and
conduct research in cosmetic science
and formulation, pharmaceutics,
medicinal chemistry and pharmacology.
The BSMP program is sponsored by the
Brazilian Ministry of Education and the
Brazilian Ministry of Science and
Technology.
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niam, quis nostrud exerci tation ullamcorp er
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medicine, and the role TCM can play in
improving patient health.
I was able to converse and exchange
ideas about pharmacy practice in
institutional and community settings
with local clinical pharmacists,
pharmacy faculty and pharmacy
students at North Sichuan Medical
College.
I experienced the rich Chinese culture,
including celebrating the annual Dragon
Boat Festival. Overall, this experience
w as u ndo u bte dly f ru it f u l a nd
unforgettable for me. It has certainly
given me insights on the important roles
pharmacists play in improving the
health and wellness of patients around
the world.
rotation was at the Affiliated Hospital of
North Sichuan Medical College located
in Nanchong, the second most
populated city of Sichuan Province,
China.
Over the course of a month, I worked
with my preceptors to learn about
traditional Chinese medicine (TCM),
including acupuncture and herbal
3 OFFICIAL RECOGNITION
UT‟s chapter of the Student Society of Health-system Pharmacists has been officially recognized by the national parent organization, the American Society of Health-System Pharmacists.
08.15.14 Beginning of smoke-free campuses at UT 08.22.14 Professional Advancement Ceremony, Nitschke Auditorium, 4pm 08.25.14 Fall 2014 classes begin. 09.04.14 Dean‟s Commission on Pharmacy Education, two-day semiannual meeting 09.06.14 Pill Box tailgate tent sponsored by Giant Eagle for Rockets v. Missouri, 10am. 09.10.14 Infectious Disease Update Registration due by 09.04.14 Download printable brochure
10.04.14 Annual Wal-Mart Student Leadership Retreat 10.24.14 Pre-gala reception in Student Union room 2592, class reunion, Homecoming Gala in the Student Union Auditorium, and post-Gala gathering in Student Union room 2592 10.25.14 Homecoming parade 10am, alumni tailgate 12pm, Rockets v. UMass at 2pm
11.12.2014 Pharmaceutical Sciences Board, two-day annual meeting
get the picture Click the links for photos of recent college events.
CD3 Symposium
Mid-Atlantic Graduate Student Symposium in Medicinal Chemistry
CALENDAR OF EVENTS TRADITION, ETHICS and the PROFESSIONAL
ADVANCEMENT CEREMONY
White Coat Ceremonies occur at
medical and pharmacy schools
across the nation, but what do
they really symbolize, and how is
our ceremony different from many
others?
The Professional Advancement
Ceremony held by the college each
year to welcome P1 students into the
professional division has its roots in
the tradition of White Coat
Cere mo nies , r i tua l “ robing”
ceremonies for physicians and other
health care professionals.
Traditionally, such ceremonies
include oaths of commitment to the
ethical and professional standards
for the profession. The white coat
symbolizes the honor bestowed by
society upon health care and
laboratory professionals, and the
ceremony welcomes initiates in
these professions to the early stages
of their professional development.
At The University of Toledo, the
P r o f e s s i o n a l A d v a n c e m e n t
Ceremony has evolved uniquely to
include the “robing” of both students
in the Doctor of Pharmacy program
a nd tho se in th e B .S . in
Pharmaceutical Sciences program‟s
cosmetic science and formulation
design, medicinal and biological
chemistry, pharmaceutics, and
pharmacology/toxicology majors.
Students who major in pharmacy
administration are honored with a
professional portfolio, symbolic of
their use of data and management in
pharmacy.
All students touch the lives of others,
either through patient care,
management or research, thus the
emphasis on standards of behavior
and professionalism benefits the new
P1 students. Their understanding of
the rewards and responsibilities of
their chosen careers is an essential
brick in the foundation of
professionalism.
www.utoledo.edu/pharmacy/alumni Jeff Barton, 419-530-5413 or [email protected]
Ashleigh Sonnenberg, 419-530-5359
Join The University of Toledo College of Pharmacy and Pharmaceutical Sciences as
we celebrate Homecoming and the 110th anniversary of the college.
Class Reunions Pre-Gala Reception Homecoming Gala Post-Gala Gathering Homecoming Parade Alumni Tailgate Rockets vs. UMass
Annual Edward C. Schmakel Homecoming Parade Bancroft Street
Pre-game tailgate Koester Alumni Pavilion
Rockets vs. UMass ($25) Glass Bowl Stadium
Pre-Gala Reception, reunion Student Union Room 2592 Cash bar, hors d'oeuvres
Gala banquet ($30) Pharmacy honoree is Jerry Wisler, ‘79. Student Union Auditorium
Post-Gala Gathering Student Union Room 2592
This year’s Homecoming theme is Blast from the Past. Do you remember when Rocky looked like this?
Homecoming 2014