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August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

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Healthy People 2010 Immunization and Infectious Disease Objectives Infectious Disease objectives 14-2Chronic Hepatitis B virus infections in infants and young children 14-3Hepatitis B infections 14-4Bacterial meningitis in young children 14-5 Invasive pneumococcal infections 14-6Hepatitis A 14-7Meningococcal disease 14-8Lyme disease 14-9Hepatitis C 14-10Chronic Hepatitis C infection identified by state and local health departments 14-15International travelers who receive preventive services 14-16Invasive early onset group B strep disease 14-17Hospitalizations caused by peptic ulcer disease 14-18Course of antibiotics for ear infections for young children 14-19Courses of antibiotics prescribed for sole diagnosis of common cold 14-20Hospital-acquired infections in intensive care unit patients 14-21Anti-microbial use among intensive care unit patients 14-28Hepatitis B vaccine coverage among high-risk groups

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Page 1: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

August 20, 2003

Focus Area 14:Immunization and

Infectious Diseases Progress Review

Page 2: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

Healthy People 2010 Immunization and Infectious

Disease ObjectivesImmunization objectives14-1 Cases of vaccine-preventable diseases.14-22 Vaccination coverage levels for universally recommended vaccines

among young children.14-23 Vaccination coverage levels for children in licensed day care

facilities and children in kindergarten through first grade.14-24 Proportion of young children who receive all vaccines that have

been recommended for universal administration for at least 5 years.

14-25 Proportion of providers who have measured the vaccination coverage level among children in their practice population within the past 2 years.

14-26 Proportion of children who participate in fully operational population-based registries.

14-27 Routine vaccination coverage levels of adolescents.14-29 Proportion vaccinated against influenza and pneumococcal disease14-30 Vaccine-associated adverse events14-31 Persons under surveillance for vaccine safety

Page 3: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

Healthy People 2010 Immunization and Infectious

Disease ObjectivesInfectious Disease objectives14-2 Chronic Hepatitis B virus infections in infants and young children14-3 Hepatitis B infections14-4 Bacterial meningitis in young children14-5 Invasive pneumococcal infections14-6 Hepatitis A14-7 Meningococcal disease14-8 Lyme disease14-9 Hepatitis C14-10 Chronic Hepatitis C infection identified by state and local health departments14-15 International travelers who receive preventive services14-16 Invasive early onset group B strep disease14-17 Hospitalizations caused by peptic ulcer disease14-18 Course of antibiotics for ear infections for young children14-19 Courses of antibiotics prescribed for sole diagnosis of common cold14-20 Hospital-acquired infections in intensive care unit patients14-21 Anti-microbial use among intensive care unit patients14-28 Hepatitis B vaccine coverage among high-risk groups

Page 4: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

Healthy People 2010 Immunization and Infectious

Disease ObjectivesTuberculosis objectives

14-11 Rates of Tuberculosis.14-12 Proportion of tuberculosis

patients completing curative therapy.14-13 Proportion of contacts and

other high-risk persons with latent tuberculosis infection completing curative therapy.

14-14 Average time for a laboratory to confirm and report tuberculosis cases.

Page 5: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

20th CenturyAverage Annual Morbidity 2002†

2010 Target

Diphtheria

Measles

Mumps

Pertussis

Polio (paralytic)

Rubella

Congenital Rubella Syndrome

Tetanus

H. influenzae, type b and unknown (<5 yrs)

175,885

503,282

152,209

147,271

16,316

47,745

823

1,314

20,000‡

1

37

238

8,296

0

14

3

22

167

0

0

0

2,000

0

0

0

0

0

Source: CDC. MMWR 1999. 48: 242-264.

† Data are preliminary. ‡ Data are estimated.

Disease

Comparison of 20th Century Average Annual Morbidity and

2002 Morbidity, Vaccine-Preventable Diseases

Numbers in red indicate record lows in 2002

Page 6: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0

20

40

60

80

100

1967 1970 1973 1976 1979 1982 1985 1988 1991 1994 1997 2000

DTP(3+)†

MMR(1+) Polio (3+)

Hib (3+)

Hep B (3+)

Varicella (1+)

† DTP(3+) is not a Healthy People 2010 objective. DTP(4) is used to assess Healthy People 2010 objectives.Note: Children in the USIS and NHIS were 24-35 months of age. Children in the NIS were 19-35 months of age.Source: USIS (1967-1985), NHIS (1991-1993) CDC, NCHS, and NIS (1994-December 2002), CDC, NIP and NCHS; No data

from 1986-1990 due to cancellation of USIS because of budget reductions

2010 Target

14-22. Vaccine-specific coverage rates among pre-

school aged childrenPercent

Page 7: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0102030405060708090

100

1998 1999 2000 2001 2002

DTP

MMRPolio

Hib

Hep B

Varicella

Source: National Immunization Survey (NIS), CDC, NIP and NCHS.

2010 Target

14-22. Achieve and maintain effective vaccination coverage levels for

universally recommended vaccines

Percent of children 19-35 months

PCV

Page 8: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0

20

40

60

80

100

WhiteBlack

Measles vaccination coverage Measles vaccination coverage among among

preschool-aged children, by preschool-aged children, by racerace

Other

Note: Children in the USIS and NHIS were 24-35 months of age. Children in the NIS were 19-35 months of age.Source: 1970-1983 United States Immunological Survey (USIS), CDC, Division of Immunization, 1992-1993 National Health Interview Survey (NHIS), CDC, NCHS; 1994-2001 National Immunization Survey (NIS), CDC, EPO.

Percent

19831970 1976 1992 1994 2001

Page 9: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

White, Not Hispanic

Black, Not Hispanic

Hispanic**

American Indian / Alaskan Native*

405060708090

100

Varicella (1+)

405060708090

100

MMR (1+)

405060708090

100

HepB (3+)

Asian*

I 95% Confidence interval. § Data are statistically unreliable.*Includes persons of Hispanic and non-Hispanic origin ** Can be of any race Source: National Immunization Survey (NIS), CDC, NIP and NCHS.

Percent Percent

Percent Percent

2010 Target

405060708090

100

Hib (3+)

Native Hawaiian/ Other Pacific Islander* Multiple Race*

Obj. 14-22

§

§§

14-22. Universally recommended vaccination coverage among children 19-35 months, by race and ethnicity,

2002

Page 10: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

White, Not Hispanic

Black, Not Hispanic

Hispanic**

American Indian / Alaskan Native*

405060708090

100

405060708090

100

405060708090

100

Asian*

† DTP (3) is not a Healthy People 2010 objective. ‡ Developmental objective. Target has not been determined. * Includes persons of Hispanic and non-Hispanic origin ** Can be of any race I 95% Confidence interval.Source: National Immunization Survey (NIS), CDC, NIP and NCHS.

14-22. Universally recommended vaccination coverage among children 19-35 months, by race and ethnicity,

2002

020406080

100

DTP (4+) DTP (3+)

Percent Percent

Percent

4:3:1:3:3 Series

2010 Target

PCV(3+)‡

Percent

Native Hawaiian/ Other Pacific Islander* Multiple Race*

§

§

§

§ § §

Page 11: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

70

75

80

85

90

95

1002010 target ‡

14-23. Vaccination coverage of children in daycare, kindergarten,

and first grade, 2002†

† Developmental Healthy People 2010 objective. ‡ Proposed Healthy People 2010 target.^ Kindergarten and first grade percentage based on data from 40 states and the District of Columbia. All states require 3 doses of HepB, however the District of Columbia requires 2 doses. ^ ^ Kindergarten and first grade percentage based on data from 24 states and the District of Columbia. Source: National Immunization Survey (NIS), CDC, NIP and NCHS; School Entry Immunization Assessment Report, CDC, NIP.

Kindergarten and first grade

DaycarePercent

Hepatitis B^ Varicella^^

Page 12: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

HepB (3+) MMR (1+) DTaP (4)

14-27. Universally recommended vaccination coverage among children 13-

15 years, 2001

Source: National Health Interview Survey (NHIS), CDC, NCHS.

55%

74%

76%

93%

34

92%

55%

76%

34%

Shot-record data onlyShot record and recall data

2010 Target

Page 13: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0

20

40

60

80

100

1997 1998 1999 2000 2001

14-27a. 3 or more doses of Hepatitis B vaccination among adolescents 13-15

years

Source: National Health Interview Survey (NHIS), CDC, NCHS.

2010 Target

Shot record data only

Shot record and recall data

Percent

Page 14: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0

20

40

60

80

100

1997 1998 1999 2000 2001

14-27b. 1 or more doses of MMR vaccination among adolescents 13-15

years

Source: National Health Interview Survey (NHIS), CDC, NCHS.

2010 Target

Shot record data only

Shot record and recall data

Percent

Page 15: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0

20

40

60

80

100

1997 1998 1999 2000 2001

14-27c. 1 or more doses of Td vaccination among adolescents 13-15 years

Source: National Health Interview Survey (NHIS), CDC, NCHS.

2010 Target

Shot record data only

Shot record and recall data

Percent

Page 16: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

80-89%70-79%60-69%

† 4+DTP, 3+Polio, 1MCV, 3+Hib, 3+HepB

79 76

82

75

80

77

72

76

78

78

75

68

63

69

67

65

7676

73

81VT 81

75

73

79

70

69

75

80

82

79

7277

79

69

77

73

78

78

80

71

67

65

68

NJCT

MANH

RI

DC

DEMD

8477858276798670

National Coverage = 75%

Source: National Immunization Survey (NIS), CDC, NIP and NCHS.

14-24a. Vaccination coverage with the 4:3:1:3:3† series, among children 19-35

months, 2002

Page 17: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0102030405060708090

Note: Percent receiving vaccine is estimated per Influenza season, using the January-June interviews only. Source: National Health Interview Survey (NHIS), CDC, NCHS.

2010 target

14-29a. Influenza vaccination coverage during the past 12 months,

among adults 65 years and olderPercent

1988 1990 1992 1994 1996 1998 2000 2002

Page 18: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0102030405060708090

1002010 target

* Can be of any race.

Source: National Health Interview Survey (NHIS), CDC, NCHS.

White, Not Hispanic

Hispanic *

Black, Not Hispanic

14-29a. Influenza vaccination coverage during the last 12 months

of adults 65 years and older, by race/ethnicity

Percent

1989 1991 1993 1995 19991997 2001

Page 19: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0102030405060708090

100

1998 1999 2000 2001 2002† Data are preliminary.* Includes persons of Hispanic and non-Hispanic origin. ** Can be any race.Source: National Health Interview Survey (NHIS), CDC, NCHS.

White

African American

Hispanic**

2010 Target

Asian*

Total

14-29b. Pneumococcal vaccination coverage ever received among adults 65 years and

older, by race/ethnicityPercent

Page 20: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0

10

20

30

40

50

60

1997 1998 1999 2000 2001

† High risk persons include respondents with one or more of the following conditions: heart disease, diabetes, asthma, chronic bronchitis, kidney disease, and cancer (excluding skin cancer).Source: National Health Interview Survey (NHIS), CDC, NCHS.

2010 Target

14-29c. Influenza vaccination in past 12 months among adults with high risk

conditions†, ages 18-64Percent

50-64 years of age

18-49 years of age

Page 21: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0

10

20

30

40

50

60

† High risk persons include respondents with one or more of the following conditions: heart disease, diabetes, asthma, chronic bronchitis, kidney disease, and cancer (excluding skin cancer).* Includes persons of Hispanic and non-Hispanic origin. ** Can be of any race. I 95% Confidence interval.Source: National Health Interview Survey (NHIS), CDC, NCHS.

2010 Target

14-29c. Influenza vaccine coverageamong adults with high risk conditions†,

ages 18-64, by race/ethnicity1998 2001

TOTAL White, Not Hispanic

Black, Not Hispanic

Hispanic ** Asian* American Indian or

Alaska Native*

Percent

Page 22: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0

10

20

30

40

50

60

1997 1998 1999 2000 2001† High risk persons include respondents with one or more of the following conditions: heart disease, diabetes, asthma, chronic bronchitis, kidney disease, and cancer (excluding skin cancer).Source: National Health Interview Survey (NHIS), CDC, NCHS.

2010 Target

14-29d. Pneumococcal vaccination ever received, among adults with high risk conditions†, ages 18-64

years

50-64 years old

18-49 years old

Percent

Page 23: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0

10

20

30

40

50

60

** Can be of any race.† High risk persons include respondents with one or more of the following conditions: heart disease, diabetes, asthma, chronic bronchitis, kidney disease, and cancer (excluding skin cancer).Source: National Health Interview Survey (NHIS), CDC, NCHS.

HP 2010 Target

14-29d. Pneumococcal vaccine ever received among adults with high risk

conditions†, 18- 64 years, by race/ethnicity

Percent 1998 2001

TOTAL White, Not Hispanic

Black, Not Hispanic

Hispanic**

Page 24: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

14-6. Reduce Hepatitis A

0

2

4

6

8

10

12

1997 1998 1999 2000 2001 2002

Hepatitis A

2010 Target

Cases per 100,000

Source: National Notifiable Disease Surveillance System (NNDSS), CDC, EPO.

Page 25: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

Hepatitis A Incidence

0

4

8

12

16

1999 ACIP recommendations

1996 ACIP recommendations1995 vaccine licensure

† Data are preliminary.Source: National Notifiable Disease Surveillance System (NNDSS), CDC, EPO.

Cases per 100,000

1980 1985 1990 1995 2000 2002†

2010 Target

Page 26: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

14-6. Reduce Hepatitis A, by race and ethnicity

0

5

10

15

20

25

1997 1998 1999 2000 2001 2002

2010 Target

Cases per 100,000

* Not Hispanic ** Can be of any race AI/AN = American Indian Alaska Native A/PI= Asian or Pacific IslanderSource: National Notifiable Disease Surveillance System (NNDSS), CDC, EPO.

Hispanic**

AI/ AN

A/PI

Black*White*

Page 27: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

Hepatitis A Incidence, by age

02468

101214161820

Incidence per 100,000

† Data are preliminary.Source: National Notifiable Disease Surveillance System (NNDSS), CDC, EPO.

19 years and older

Less than 19 years old

1990 1992 1994 1996 1998 2000 2002†

Page 28: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

Hepatitis B Incidence

05

101520253035404550

† The number of hepatitis B cases reported to NNDSS by year of age is multiplied by age-specific ratios of infections to reported cases and by the age-specific proportions of infections which are symptomatic. Source: National Notifiable Diseases Surveillance System (NNDSS), CDC, EPO.

Estimated† cases per 100,000

19-39 years

40 years and older

Less than19 years

Obj. 14-3

1990 200220001998199619941992

Page 29: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0

5

10

15

20

25

14-3. Hepatitis B Incidence, by race and ethnicity, 2001

American Indian/ Alaska Native*

I 95% Confidence interval.*Includes persons of Hispanic and non-Hispanic origin **Can be of any race.Source: National Notifiable Diseases Surveillance System (NNDSS), CDC, EPO.

Per 100,000 2010 target

19-24 years 25-39 years 40 years and older

Asian or Pacific Islander*

Hispanic**

White, Not Hispanic

Black, Not Hispanic

Page 30: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

14-11. Cases of Tuberculosis

10000120001400016000180002000022000240002600028000

83 85 87 89 91 93 95 97 99 20011982

1986 1990

1994

1998 2002†

† Data are preliminary

Number of Cases

Source: National TB Surveillance System, CDC, NCHSTP.

Page 31: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

05

10152025303540

2010 target

14-11. Rates of Tuberculosis, by race and ethnicity

* Includes persons of Hispanic and non-Hispanic origin **Can be of any raceNote: Data are age adjusted to the 2000 standard population. Data in parentheses represent the percent change in the rate between 1998 and 2001.Source: National TB Surveillance System, CDC, NCHSTP.

20011998

American Indian or

Alaska Native*

Asian or Pacific Islander*

Black, Not Hispanic

White, Not Hispanic

Hispanic**TOTAL

Per 100,000 population

-15%-11%

-12%

-13%-20%

-26%

Page 32: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0

20

40

60

80

100Percent 2010 target

14-12. Proportion of Tuberculosis Patients

Completing Curative Therapy

* Includes persons of Hispanic and non-Hispanic origin **Can be of any raceSource: National TB Surveillance System, CDC, NCHSTP.

19991996

American Indian or

Alaska Native*

Asian or Pacific Islander*

Black, Not Hispanic

White, Not Hispanic

Hispanic**TOTAL

Page 33: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0

20

40

60

80

100

1991 1994 2002

Percent

Percent of Tuberculosis labs using recommended procedures

Source: Tuberculosis Elimination and Laboratory Upgrade Cooperative Agreements. Unpublished CDC data.

Rapid Drugs

Liquid Media

FluorochromeRapid I. D.

Page 34: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

0

20

40

60

80

100

1991 1994 2002

Percent

Percent of Tuberculosis labs meeting turn-around time goal

Note: Data for laboratories using Liquid Media procedures was not available.Source: Tuberculosis Elimination and Laboratory Upgrade Cooperative Agreements. Unpublished CDC data.

FluorochromeRapid I. D.

Rapid Drugs

Page 35: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

Developmental Objectives

14-10. Increase the proportion of persons with chronic Hepatitis C infection identified by State and local health departments.(proposed source, National Electronic Telecommunications System for Surveillance)

14-15. Increase the proportion of international travelers who receive recommended preventive services when traveling in areas of risk for: hepatitis A, malaria, and typhoid.(proposed source, Travelers’ Health Survey)

14-22g. Achieve and maintain the levels of pneumococcal conjugate vaccination coverage among young children. (future source, National Immunization Survey)

Page 36: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

Developmental Objectives

14-23d, e. Maintain vaccination coverage levels for children in licensed day care facilities- Hepatitis B and Varicella.(proposed source, National Immunization Survey)

14-23i, j. Maintain vaccination coverage levels for children in kindergarten and first grade- Hepatitis B and Varicella.(proposed source, The School Entry Immunization Assessment Report)

14-24b. Increase the proportion of adolescents who receive all vaccines that have been recommended for universal administration for at least 5 years(proposed source, National Immunization Survey)

Page 37: August 20, 2003 Focus Area 14: Immunization and Infectious Diseases Progress Review

Progress Review data and slides can be found on the web at:

http://www.cdc.gov/nchs/hphome.htm