AtosPharma-Intro.pdf

1Table of conTenTs

Table of conTenTs 1-3

aTos PHaRMa 4-5

1. oncoloGY

1.1. Viscum fraxini 2 6-7

2. caRDIoVascUlaR

2.1. cardioton 8-9

2.2. statosan 10-11

3. GasTRo-InTesTInal

3.1. carmipret 12-13

3.2. chamopect 14-15

3.3. Heparex 16-17

4. GYnaecoloGY

4.1. fiminosan 18-19

4.2. femicur 20-21

4.3. femivit 22-23

5. HePaTo-bIlIaRY

5.1. Heparsan 24-25

Table of contents

3Table of conTenTs

Table of contents

10. GenITo-URInaRY

10.1. Cystinol 54-55

10.2. Prostasan 56-57

11. MIneRals

11.1. bio-Mag 58-59

11.2. bioZinc 60-61

11.3. Ritchkal 62-63

alPHabeTIcal InDex 64-65

2 Table of conTenTs

6. IMMUnoloGY

6.1. Immulone 26-27

6.2. Mulone 28-29

6.3. Viscum fraxini 4 30-31

7. neURoPsYcHIaTRY

7.1. Kingosan 32-33

7.2. neuropatex 34-35

7.3. safamood 36-37

7.4. safamood forte 38-39

7.5. sedaneurin 40-41

8. ResPIRaToRY

8.1. Rosinol 42-43

8.2. Thymotal 44-45

8.3. Thymotal Plus 46-47

9. RHeUMaToloGY/oRTHoPeDIc

9.1. boswelia 48-49

9.2. Herpago 50-51

9.3. spondex 52-53

5aTos PHaRMa

capsules, liquid mixtures and drops are maintained by strict adherence to a comprehensive set of guidelines and rigorous quality control. To ensure the highest quality of all products from aTos Pharma, we adhere to:

stringent criteria which are applied dur-ing the selection of raw materials with the use of organic grown herbs, plants and natural ingredients.

The outstanding efficacy, tolerability, and therapeutic effects of the products which are maintained by strict adherence to a comprehensive set of guidelines and rigorous quality controls as well as the implementation of good laboratory practices (GLP) and good manufacturing practices (GMP).

The production process which complies with national and international regula-tions that conform ISO 9001 standards.

aTos also complies with Iso 17025, Iso 14000, oHsas 18001 and Demeter.

4 aTos PHaRMa

ATOS is a pioneer Phyto-Pharmaceutical company in Egypt which adopts the concept of natural healing by enhanc-ing the body’s own healing forces using natural remedies from herbal extracts, dietary supplements and orthomo-lecular medicine. In the process of all illnesses there are energetic and bio-chemical imbalances either in the form of deficiencies of vital substances or accumulation of harmful metabolites, which in turn disrupt the health state of the human being. ATOS products are basically aiming to heal the whole person rather than just suppressing the symptoms of diseases, in accordance with this principle ATOS is manufactur-ing its whole range of products to offer a more comprehensive natural method of treatment for a variety of diseases through regaining the balance of the human being as a whole.

This holistic approach is the keystone of the new uprising revolution in the field of medicine. In response to WHo declara-tions, ATOS Pharma was the first in Egypt

to support the concept of Holistic and Integrative Medicine that combines the benefits from conventional medicine as well as, well documented complemen-tary and Alternative Medicine (CAM) according to the regulations of World Health Organization on CAM. In coop-eration with European Universities and international scientific centers ATOS has conducted researches in the field of natural remedies as a part of holistic medicine therapies.

The products are developed to cover different fields: cancer management, cardiovascular, gastrointestinal, gynecol-ogy, hepato-biliary, immunology, neu-ropsychiatry, respiratory, genitourinary mineral and vitamin supplements.In order to ensure the highest quality of all products from aTos, stringent criteria are applied during the selection of raw materials and only organic grown herbs, plants and natural ingredients are used.

The outstanding efficacy, tolerability and therapeutic effects of the tablets,

Immunomodulator/cytotoxic

oncoloGY

Viscum fraxini 2

7

Each ampoule of 1 ml contains:

Mistletoe extract 15 mg(Equivalent to 10000 ng Lectins)

Pack size:

3 ampoules 1 ml of aqueous solution for injection.

Precautions/drug interactions:

Keep in cool dry place (8-16°C) in the lower part of the refrigerator. Keep out of reach of children.

6 oncoloGY

PROPERTIES AND ACTIONS:

Viscum fraxini 2, mistletoe extract, stimulates the T and B-cell components of the immune system, which leads to the expression and release of cytokines, proliferation and activation of immuno-competent cells; especially natural killer cells, T-cytotoxic cells and lymphokine activated killer cells. Treatment with Viscum fraxini 2 is as-sociated with an improvement of the quality of life of cancer patients. Viscum fraxini 2 stimulates the secretion of endogenous β-endorphins which leads to the control of pain. Viscum fraxini 2 contains lectins which enhance apoptosis and viscotoxins which exert direct cytotoxic effect on tumor cells.

INDICATIONS:

Pleurodesis in malignant pleural effusion. Supportive for inoperable hepatocellular carcinoma patients.complementary in breast cancer.

DOSAGE:

Dose in malignant pleural effusion: 5 ampoules of Viscum fraxini 2 mixed with 10 ml of glucose 5% intrapleural weekly till complete pleurodesis or up to six weeks.

Dose in inoperable hepatocellular carcinoma: Two ampoules subcutaneous per week are given till maximum response and/or 3 ampoules intralesional (sonar guided) weekly for 6 weeks, course can be repeated after 8 weeks, till maximum response.Dose in breast cancer: one ampoule subcutaneous weekly dur-ing the course of chemotherapy. For full mode of administration refer to Viscum product monograph.

CONTRAINDICATIONS:

In acute inflammatory conditions or if the temperature is above 38°C: treat-ment should be discontinued until the fever and the inflammation subside.Known hypersensitivity to Mistletoe preparations.studies on use for infants and young children are not available.Pregnancy use should be limited to spe-cial circumstances.

SIDE EFFECTS:

For full information about side effects refer to Viscum fraxini 2 product mono-graph.

cardiotonic

cardioton

caRDIoVascUlaR 9

Each tablet contains:

crataegus oxycantha extract 300 mg (Equivalent to 2.15 % flavonoids)

Pack size:

20 tablets in 2 blisters.

8 caRDIoVascUlaR


cardioton improves myocardial contrac-tility via inhibition of C-AMP phospho-diesterase enzymes. It also improves tissue perfusion through a vasodilator action mediated via activation of endo-thelial derived relaxing factors resulting in coronary vasodilatation of normal and atherosclerotic vessels with an increase of coronary blood flow. cardioton has peripheral arteriolar vasodilator effect with a reduction in peripheral resistance and mild reduction in blood pressure.

INDICATIONS:

Heart failure nYHa class I and II.Ischemic heart disease.Hypertension.senile cardiomyopathy.

DOSAGE:

Unless otherwise prescribed by the physi-cian; 1-2 tablets 3 times/day.

CONTRAINDICATIONS:

Pregnancy, lactation and children younger than 12 years old.

SIDE EFFECTS:

Very rare occurrence of gastro-intestinal disturbances, headache and dizziness.

PRECAUTIONS/DRUG INTERACTIONS:

cardioton has no recorded drug interactions.cardioton is safely administered with digitalis.

statosanFor healthy lipid profile

caRDIoVascUlaR 11

Each hard gelatin capsule contains:

Red Yeast Rice Powder 500 mg (Standardized to contain 10 mg/g Mevinolinic acid and related monacolins)

Pack size:

30 capsules in 3 blisters.

10 caRDIoVascUlaR


statosan is a natural source of at least 9 cholesterol-lowering compounds (natural statins) and is rich in Mevino-linic acid, a natural lipid-lowering agent. Mevinolinic acid, unlike other statins, is activated without the need of prior hydrolysis in the liver thus reducing the strain on the liver. statosan lowers plasma cholesterol levels by inhibiting 3-hydroxy, 3-meth-ylgluteryl-COA (HMG-COA) reductase enzymes. This reduces cholesterol synthesis by the liver and increases the number of lDl receptors on the cell sur-face, thereby increasing lDl-cholesterol uptake and catabolism and decreasing its overall serum levels. statosan is effective in mixed dyslip-idemia as it reduces triglycerides and increases HDl-cholesterol. Monascus pigment and other natural metabolites of Red Yeast Rice are also free radical scavengers that prevent the oxidation of lDl cholesterol and thereby reduce the risk of coronary artery diseases.

INDICATIONS:

Primary hypercholesterolemia and mixed dyslipidemia.elevated serum triglyceride level.

DOSAGE:

Unless otherwise prescribed by the physician; one capsule 2 times/day.

CONTRAINDICATIONS:

not recommended during pregnancy or lactation.not to be taken in case of advanced liver disease.

SIDE EFFECTS:

None reported within the therapeutic dose.


No special precautions or drug interac-tions reported.

carmipret Anti-spasmodic/anti-flatulent

GASTRO-INTESTINAL 13

Each enteric coated capsule contains:

Peppermint oil 90 mg caraway oil 50 mg

Pack size:


12 GASTRO-INTESTINAL


carmipret acts by causing smooth muscle relaxation and blocking the influx of cal-cium into muscle cells. This improves the rhythmic contraction of the intestine and relieves spasm.carmipret’s carminative effect; relieves abdominal distension and flatulence.carmipret’s choleretic effect; improves dyspeptic symptoms as well as intestinal symptoms.carmipret enteric coated capsules will not breakdown until it reaches the small intestine, so it doesn’t cause heartburn.

INDICATIONS:

Functional dyspepsia.Irritable bowel syndrome.

DOSAGE:

One capsule 3 times daily, 15-30 minutes before meals.

CONTRAINDICATIONS:

In cases of biliary obstruction.

SIDE EFFECTS:



carmipret and antacids should be taken with an interval around one hour to avoid premature dissolution of the capsule.

chamopect

Anti-diarrheal

Each 200 ml contains:

Pectin 6.4 g chamomile extract 5 g

Pack Size:

Bottle contains 200 ml.

15GASTRO-INTESTINAL


chamopect reduces duration of diarrhea. It contains Pectin which improves with its swelling ability, the passage of well formed stools, adsorbs toxins and muco-sal irritating substances in the intestinal lumen and forms a protective film on the intestinal mucosa.chamopect is used as a supportive treat-ment in bacterial diarrhea and improves the associated symptoms of diarrhea. chamopect contains chamomile extract which has spasmolytic, anti-inflammatory and ulceroprotective effects. chamopect has high acceptance and high tolerability.

DOSAGE (Unless otherwise prescribed by the physician) the recommended dose is:

INDICATIONS:

Gastroenteritis especially in infants and children.Supportive treatment in case of bacterial diarrhea.

CONTRAINDICATIONS:

none reported.

SIDE EFFECTS:



No specific precautions or drug interac-tions.

Age Starting Dose Maintenance After Resolution

Adults &School Children

Young Children

Infants

2 tablespoons

2 teaspoons (10 ml)

1 teaspoon (5 ml)

1 tablespoon/hr(min. 4-6 times/day)

1 teaspoon(5ml)/hr(min. 4-6 times/day)

½ teaspoon (2.5 ml)/hr(min. 4-6 times/day)

1 tablespoon(3 times/day)

1 teaspoon (5 ml)(3 times/day) ½ teaspoon (2.5 ml)(3 times/day)

14 GASTRO-INTESTINAL

HeparexDyspepsia with hepato-biliary disorders

17


cynara scolymus dried extract 320 mg(Equivalent to caffeoylquinoic acid 1.6 mg)

Pack size:


GASTRO-INTESTINAL16


Heparex has choleretic and cholekinetic effects, which stimulate the digestive process and improve fatty dyspepsia. Higher bile secretion increases the yield of bicarbonate in the duodenum that neutralizes excessive acidity, and improves dyspepsia. It also has anti-cholestatic activity that enhances biliary excretion and reduces symptoms of irritable bowel syndrome.Heparex has an antioxidative effect. Its’ active ingredients (luteolin, cynarin, chlorogenic acid and caffeic acid) protect the liver against toxins and reduce the free radicals' induced hepatocyte killing effect. Its caffeoylquinoic acid acts as a cell membrane stabilizer.

INDICATIONS:

Dyspepsia, indigestion and irritable bowel syndrome (distension, flatulence, fat indigestion), etc..Cholecystitis (especially calcular chole-cystitis, where it helps in stone dissolu-tion).Supportive therapy in chronic liver dis-eases (liver cirrhosis, fatty liver, etc.).

DOSAGE:

Unless otherwise prescribed by the physician; 1-2 capsules 3 times/day half an hour before meals.

CONTRAINDICATIONS:

Biliary obstruction, allergy to cynara or any of its components.

SIDE EFFECTS:



No special precautions or drug interac-tions known.

GASTRO-INTESTINAL

fiminosanMenopausal symptoms relief

GYnaecoloGY 19


cimicifuga racemosa dry extract 20 mg(Standardized to contain minimum 2.5% triterpeneglycosides.)

Pack size:


18 GYnaecoloGY


fiminosan is a hormone free alternative to estrogen replacement therapy to treat hot flushes, sweating, headache, nervous-ness, palpitation, sleep disturbances, and other symptoms of ovarian insufficiency that are especially common in perimeno-pausal and menopausal women. fiminosan exerts selective estrogen receptor modulatory activity on the hypothalamus and the anterior pituitary gland and thereby influences ovarian function and the neurotransmitters’ levels hence has an antidepressant effect and improves the psychic, vegetative and partially somatic disturbances that result from the changes to the hormonal levels during menopause.

INDICATIONS:

climacteric complaints.Post operative manifestations of ovarian insufficiency e.g. following bilateral oophorectomy. support for hormonal therapy.

DOSAGE:

Unless otherwise prescribed by the physi-cian; 1 tablet 2 times/day. No immediate effect of fiminosan is expected, but after approximately 4-6 weeks of treatment.

CONTRAINDICATIONS:

There are no restrictions on the use of fiminosan and it has an excellent toler-ance. none reported.

SIDE EFFECTS:

fiminosan has no carcinogenic effects. occasionally slight GIT discomfort may occur.


No specific precautions or drug interac-tions known.

femicurPre-menstrual symptoms relief

21

Each capsule contains:

Vitex agnus-castus extract 20 mg(Standardized to contain not less than 0.6% aucubin)

Pack size:


To be launched in 2011.

GYnaecoloGY20


femicur has an inhibitory effect on prolactin release through a dopaminer-gic principle of action mediated by D2 receptors (binding inhibition). Lowering the prolactin level cancels the disturbed secretion of gonadotrophins and normal-izes the physiological estrogen/proges-terone ratio which in turn abolishes the proliferative effect of prolactin on the mammary gland. Additional action in relieving pre-menstrual syndrome may be mediated by opioid receptors binding inhibition.

INDICATIONS:

Pre-menstrual syndrome.Mastalgia due to hormonal disturbances as hyper-prolactinemia.Menstrual disorders as menorrhagia, metrorrhagia, polymenorrhea and oligo-menorrhea.

DOSAGE:

one capsule in the morning, the treat-ment should be continued at least for three months without interruption.

CONTRAINDICATIONS:

none reported.

SIDE EFFECTS:

In rare cases, itching, urticarial rashes (ex-anthemas), headache, dizziness, and dry mouth may occur. In very rare cases con-fusion and agitation have been reported.


femicur capsules are not suited for the treatment of malignant diseases of the breast.

GYnaecoloGY

femivitfor females’ health & wellbeing

23

Each soft gelatin capsule contains:

borage oil 273 mg(Standardized to contain Gamma-linolenic acid 17-27% - Linoleic acid 30-41%)evening primrose oil 136.5 mg(Standardized to contain Gamma-linolenic acid 7-14% - Linoleic acid 65-85%)

Pack size:


* To be launched in 2011.

GYnaecoloGY22

INDICATIONS:

Maintenance of healthy skin and general wellbeing in females.

DOSAGE:

1-3 capsules three times daily.

CONTRAINDICATIONS:

Not used during pregnancy and lactation.

SIDE EFFECTS:

Mild gastrointestinal discomfort may occur.


No specific precautions or drug interac-tions were reported.


femivit contains borage and evening Primrose oils which are rich sources of the polyunsaturated fatty acid γ-linolenic acid (GLA). GLA is an important omega 6 nutrient which cannot be manufactured in the body but must be provided in the food. Omega 6 is an essential component of all membranes, conferring properties of fluidity and flexibility. By modulating membrane properties, omega 6 also modulates the behaviors of membrane associated proteins such as receptors, enzymes, ion channels and messenger systems. In addition to this structural role, with its functional consequences, omega 6 also acts as the precursor of a whole variety of short-term mediators, which regulate many aspects of cellular function. These mediators include several different prostaglandins, leukotrienes and thromboxanes, together with vari-ous other types of oxygenated essential fatty acids’ derivatives. One of these mediators is prostacyclin, formed from arachidonic acid (AA).femivit provides the polyunsaturated fatty acid GLA in the form most effec-tively absorbed and utilized by the body. Gla helps women to maintain hormonal harmony, healthy skin; and also helps joint mobility and general health and wellbeing.

GYnaecoloGY

Heparsanliver support/hepato-biliary disorders

HEPATO-BILIARY 25


Dry extract chelidonium majus 100 mgDry extract of curcuma xanthorrhizae 60 mgcurcuma xanthorrhizae oil 10 mg

Pack size:


24 HEPATO-BILIARY


Heparsan has an antioxidant activity as it contains curcumin which protects the liver against exogenous toxins. curcumin also proved, in studies, to suppress he-patic stellate cells and decrease fibrosis which may delay fibrosis in chronic liver diseases. Heparsan has an anti-inflammatory activity due to isoquinoline alkaloids in chelidonium; its curcumin content inhibits prostaglandins while the volatile oils suppress acute edema by inhibition of hyaluronidase enzyme. Heparsan has a choleretic effect, which stimulates production of bile and pan-creatic digestive enzymes that improves dyspepsia. It also has a cholecystokinetic effect. The alkaloids in chelidonium and cur-cumin in curcuma relieve the spasm and stimulate the under-active gallbladder, that help in biliary dyskinesia, cholecysti-tis, and gallstones.

INDICATIONS:

liver support in chronic liver diseases.Biliary dysfunction (gallstones, cholecystitis, biliary dyskinesia).Dyspepsia and indigestion (distention, flatulence, fat indigestion...).

DOSAGE:

One capsule 3 times daily.

CONTRAINDICATIONS:

During first trimester of pregnancy.Biliary obstruction. Acute hepatitis.

SIDE EFFECTS:

No side effects reported within the thera-peutic dose.



ImmuloneNon specific immune enhancer

IMMUnoloGY 27

Each lozenge contains:

echinacea purpurea extract 150 mgVitamin c 50 mg

Precautions/drug interactions:

The duration of continuous treatment should not exceed 8 weeks.No reported drug interactions.

Pack size:

20 lozenges in 2 blisters.

26 IMMUnoloGY


Caffeic acid derivatives (mainly chicoric acid), alkamides and polysaccharides are the main effective groups in Echinacea, the main active constituent of Immu-lone. Immulone contains also vitamin c which supports the integrity of mucous membranes. Immulone stimulates the immune response by enhancing phago-cytosis by macrophages and activation of natural killer cells. Immulone increases cytokine production, such as interferon which helps in controlling viral infection.Immulone has mild direct antibacterialactivity and direct anti-inflammatory activity. Immulone has anti-hyaluron-idase enzyme activity which prevents spreading of infection and accelerates re-covery. Immulone increases phagocytosis of candida by 45% and decreases the rate of recurrence of fungal infections. Through these actions, Immulone en-hances the resistance to viral, bacterial and fungal infections in healthy subjects and shortens the duration of illness and helps in rapid recovery.

INDICATIONS:

Prevention and treatment of common cold and influenza.Prophylactic therapy in cases of increased susceptibility to infections.Inflammatory skin diseases.Recurrent vaginal candidiasis.

CONTRAINDICATIONS:

Hypersensitivity to the active substance.In accordance with general principles, not to be used in patients with progressive systemic diseases such as tuberculosis, collagenoses, multiple sclerosis, HIV infec-tion and autoimmune diseases.

SIDE EFFECTS:

In rare cases hypersensitivity reactions, e.g. skin reactions, can occur.


Adults & Adolescents (> 14 yrs)Age

Dosage

Time

2 lozenges

3 times/day

1-2 lozenges

1 time/day

1 lozenge

3 times/day

Children (5-9 yrs) Adolescents (10-14 yrs)

MuloneNon specific immune enhancer

29


echinacea purpurea dry extract 3.75 g(Standardized to contain 3% chicoric acid)


Refrigerate after opening & use within 14 days.The duration of continuous treatment should not exceed 8 weeks.No reported drug interactions.

Pack size:

Bottle of 30 ml drops.Bottle of 60 ml syrup.

IMMUnoloGY28


Caffeic acid derivatives (mainly chicoric acid), alkamides and polysaccharides are the main active constituent in echinacea, the main of Mulone extract. Mulone stimulates the immune response by enhancing phagocytosis by macro-phages and activation of natural killer cells. Mulone increases cytokine produc-tion, such as interferon which helps in controlling viral infection. Mulone has mild direct antibacterial activity and direct anti-inflammatory activity. Mulone has anti-hyaluronidase enzyme activity which prevents spreading of infection and accelerates recovery. Mulone increases phagocytosis of candida by 45% and decreases the rate of recurrence of fungal infections. Through these actions; Mulone enhances the resistance to viral, bacterial and fungal infections in healthy subjects and shortens the duration of illness and helps in rapid recovery.

INDICATIONS:

Prevention and treatment of common cold and influenza.Prophylactic therapy in cases of increased susceptibility to infections.Inflammatory skin diseases.Recurrent vaginal candidiasis.

CONTRAINDICATIONS:

Hypersensitivity to the active substance.In accordance with general principles, not to be used in patients with progressive systemic diseases such as tuberculosis, collagenoses, multiple sclerosis, HIV infec-tion and autoimmune diseases.

SIDE EFFECTS:

In rare cases hypersensitivity reactions, e.g. skin reactions, can occur.


IMMUnoloGY

Adults & Adolescents (> 14 yrs)Age

Dosage

Time

10 ml (2 teaspoonful)

1-2 times/day

2.5 ml (½ a teaspoonful)

1-2 times/day

5 ml (1 teaspoonful)

1-2 times/day

Children (5-9 yrs) Adolescents (10-14 yrs)

Viscum fraxini 4Immunomodulator

31

Each ampoule of 1 ml contains:

Mistletoe extract 0.15 mg(Equivalent to 100 ng Lectins)

Pack size:

3 ampoules each 1 ml of aqueous solution for injection.

IMMUnoloGY30


Viscum fraxini 4, Mistletoe extract, stimulates the T-cell and B-cell compo-nents of the immune system, which leads to the expression and release of cyto-kines and proliferation and activation of immuno-competent cells. Viscum fraxini 4 is associated with improvement of patients' quality of life parameters, as it stimulates the secre-tion of endogenous β-endorphins with consequent control of pain, improvement of appetite and sleep quality. Treatment with Viscum fraxini 4 is associ-ated with increased level of endogenous interferon that protects cells from viral infection.

INDICATIONS:

Viral infections e.g. hepatitis virus, papil-loma virus.Immune enhancer in cases of immune deficiency e.g. post chemotherapy, convalescence, etc..

DOSAGE:

Unless otherwise prescribed by the physician; 1 ampoule subcutaneous Vis-cum fraxini 4, once/week. for full mode of administration refer to Viscum fraxini 4 product monograph.

CONTRAINDICATIONS:

In acute inflammatory conditions or if the temperature is above 38°C, treatment should be discontinued until the fever and the inflammation subside.Known hypersensitivity to Mistletoe preparations.studies on use for infants and young chil-dren are not available.In pregnancy the therapy should be lim-ited to special circumstances.

SIDE EFFECTS:

For full information about side effects refer to Viscum fraxini 4 product mono-graph.


Keep in cool dry place (8-16°C) on the refrigerator’s shelf. Keep out of reach of children.

IMMUnoloGY

KingosanImproves cerebrovascular circulation

neURoPsYcHIaTRY 33


Ginger extract 100 mg(Standardized to contain not less than 5% gingeroles)Ginkgo extract 60 mg(Standardized to contain 24.5% ginko flavon-glycosides) Pack size:



32 neURoPsYcHIaTRY


Kingosan improves the microcirculation and promotes the revascularization of ischemic tissues. Kingosan diminishes platelet activity and inactivates the platelet activating factor (PAF) through competitive interac-tion with the PAF membrane receptors. The antioxidant activity of Kingosan is mediated by the Ginkgo and Ginger content and greatly reduces oxidative metabolism in cerebral neurons by scavenging free radicals. both the free radicals scavenging activity and the PAF antagonism protect and improve cerebral blood flow. Kingosan acts as a memory-enhancer because it modifies the concentration of neurotransmitters and anti-motion sick-ness effect through central and peripher-al actions exerted by its Ginger content.

INDICATIONS:

Cerebrovascular insufficiency. Vertigo and motion sickness.Memory disorders and dementia associ-ated with aging.

DOSAGE:

Unless otherwise prescribed by the phy-sician; 1-2 capsules 1-2 times/day.

CONTRAINDICATIONS:

none reported.

SIDE EFFECTS:

None reported within the therapeutic dose.at higher doses mild GIT discomfort may occur.


Caution in patients on anticoagulants or anti-platelet medication.

neuropatexagainst neuropathies

35


alpha-lipoic acid 600 mg

Pack size:


neURoPsYcHIaTRY34


alpha-lipoic acid is a very unstable mol-ecule that has tendency to polymerize on exposure to heat, light, and moisture, turning into a sticky and ineffective product.neuropatex through its unique “self emulsifying Drug Delivery system” (SEDDS) ensures maximum stability, bio-availability and maximum effectiveness of alpha lipoic acid.neuropatex prevents the oxidative dam-age and reduces oxidative stress which is the main contributing factor in diabetic neuropathy through its potent antioxi-dant effect in both oxidized and reduced forms. neuropatex regenerates endogenous antioxidant’s activity of both vitamin C and e and enhances intracellular levels of glutathione and coenzyme Q-10 which are impaired and consumed in diabetic patients.neuropatex improves endoneurial perfusion through improvement of nitric oxide (NO) mediated vasodilatation, thus enhances the microcirculation and helps in peripheral nerve regeneration. neuropatex improves microcirculation so decreases the risk of vascular complica-tions especially retinopathy, nephropathy and cardiovascular complications and also has proven efficacy in treatment of different forms of autonomic neuropathy. neuropatex is effective in different

diseases associated with lowered anti-oxidant status and/or increased levels of oxidative stress as in neurodegenerative disorders.

INDICATIONS:

Diabetic neuropathy.Neuritis, polyneuritis and optic neuritis.Prophylaxis against long term vascular and neurological complications in diabetic patients.Helps in primary and secondary preven-tion of stroke in diabetic patients.

DOSAGE:

one capsule daily preferred on an empty stomach.

CONTRAINDICATIONS:

Hypersensitivity to alpha-lipoic acid.

SIDE EFFECTS:

Mild GIT upset with high dose have been reported in some cases.

neURoPsYcHIaTRY

Precautions/drug interations:

There are no adequate studies for its use in pregnancy and lactation.

safamoodPsychosomatic disorders

37


Hypericum perforatum dry extract 250 mg(Standardized to contain minimum 0.12% dianthrones calculated as Hypericine)Vitamin c 50 mg

Pack size:


neURoPsYcHIaTRY36


safamood regulates motility, sensitivity, and secretion of fluids of GIT.safamood inhibits synaptic reuptake of serotonin and to a lesser extent norepi-nephrine, resulting in increased levels of these neurotransmitters in the synapse and modulates the level of cytokines so it has an antidepressant effect and reduces the psychosomatic symptoms. safamood has a potential analgesic effect through activation of endogenous pain-inhibitory system in the brain. safamood exerts a mild anxiolytic action through the inhibition of Gamma Amino Butyric Acid (GABA) reuptake pump. safamood is well tolerated and causes no psychological or physical dependence, muscle relaxation, or cognitive impair-ment.

INDICATIONS:

Psychosomatic symptoms e.g. psycho-genic GIT disturbances, irritable bowel syndrome.

DOSAGE:

Unless otherwise prescribed by the physician; one tablet 2-3 times/daily.

CONTRAINDICATIONS:

Pregnancy and lactation.

SIDE EFFECTS:



Plasma level of Warfarin, Digoxin, The-ophylline, and Contraceptive pills may be reduced with safamood as it has enzyme inducing effects accelerating their metabolism.Concomitant use with Selective Sero-tonin Reuptake Inhibitors (SSRIs) may cause serotonin syndrome.

neURoPsYcHIaTRY6

safamood forteAnti-depressant

39

Each film coated tablet contains:

Hypericum perforatum extract 600 mg(Standardized to contain minimum 0.12% hypericin)Pack

Pack size:


neURoPsYcHIaTRY38


safamood forte is an active antide-pressant, because it inhibits synaptic reuptake of serotonin and to a lesser extent norepinephrine, resulting in in-creased levels in the synaptic gap. safamood forte suppresses interleukin- 6 (IL6), and thereby promotes the deacti-vation of the hyperactive hypothalamic-pituitary-adrenal axis (HPA). safamood forte indirectly inhibits the secretion of corticosteroids. safamood forte exerts a mild anxiolytic action through the inhibition of the Gamma Amino Butyric Acid (GABA) reup-take pumps.safamood forte is well tolerated and causes no physical dependence, muscle relaxation or cognitive impairment. There has never been a report of toxicity in humans.

INDICATIONS:

Mild and moderate depression.Obsessive compulsive disorders (OCD).Psychosomatic disorders.

CONTRAINDICATIONS:

not to be used during pregnancy and lactation.

SIDE EFFECTS:

GIT discomforts and headaches are slight and rare. Light sensitivity may occur.


Plasma levels of cyclosporine, Digoxin and Theophylline may be reduced and oral Contraceptive pills are less effective because their metabolism is accelerated.Concomitant administration with Mono-Amine Oxidase Inhibitors (MAOIs) and Selective Serotonin Reuptake Inhibitors (SSRIs) may increase their side effects.


Depression and OCD Psychosomatic disorders

Dosage

1-2 tablets/day

1 tablet/day

neURoPsYcHIaTRY

sedaneurin Anxiolytic, sedative

41


Valeriana officinalis dry extract 160 mg(Standardized to contain minimum 0.3% ses-quiterpinic acids expressed as valerenic acid)Hypericum perforatum dry extract 100 mg(Standardized to contain minimum 0.12% dianthrones calculated as Hypericine)

Pack size:


neURoPsYcHIaTRY40


sedaneurin is an anxiolytic drug with a dose-dependent sedative effect. It shows a potentiating effect in enhancement of GABA (Gamma Amino Butyric Acid) pathway, which is the main inhibitory neurotransmitter in the central nervous system, thus acts as sedative and sleep promoting agent. sedaneurin has an antidepressant effect due to inhibition of serotonin and to lesser extent the norepinephrine reup-take pump. sedaneurin restores normal sleep pattern through the increase of melatonin that plays a crucial role in the etiology of af-fective disorders and sleep.Moreover Hypericum increases its noc-turnal production. sedaneurin doesn’t cause substance dependence, habituation or hangover effect.

INDICATIONS:

Mild and moderate nervous tension and stress. Mixed anxiety and depressive disorders.occasional, transient or chronic insom-nia.Psychosomatic disorders.

CONTRAINDICATIONS:

Pregnancy and Lactation.

SIDE EFFECTS:

None reported within the therapeutic dose. With overdose mild symptoms such as blurred vision, headache, restlessness, GIT symptoms were noted.


If used with benzodiazepines the dose should be reduced.


Anxiolytic Insomnia

Dosage

1-2 tablets/day 2 tablets 1 hour before bedtime

neURoPsYcHIaTRY

Rosinolbronchodilator, expectorant

ResPIRaToRY 43


anise oil 100 mg

Pack size:


42 ResPIRaToRY


Rosinol contains up to 90% anethole. anethole is absorbed by the stomach, and mostly excreted via the lungs. Rosinol activates secretolytic and secre-tomotor activities of respiratory mucosa and improves ciliary movement. Rosinol contains the most effective dose of anise oil needed to liquefy the viscid bronchial secretions and enhances the mucociliary expectoration. Rosinol has antiseptic and spasmolytic ef-fects, which help to relieve symptoms of respiratory catarrh and bronchitis.

INDICATIONS:

Acute productive cough.Chronic bronchitis and tracheitis. bronchial asthma and spasmodic cough.

DOSAGE:

Unless otherwise prescribed by the phy-sician; 1-2 capsules 3 times/day.

CONTRAINDICATIONS:

first and second trimesters of pregnancy.

SIDE EFFECTS:



No special precautions or drug interac-tions.

ThymotalMucolytic, expectorant

45

Each 1 ml (15 drops) contains:

Thyme fluid extract 0.33 g(Standardized to contain not less than 0.03% total phenolic cempounds calculated as thymol)

Pack size:

Bottle of 100 ml syrup. Bottle of 30 ml drops.

ResPIRaToRY44


Thymotal increases hydration of the respiratory system by increasing water content of mucous to liquefy thick mucous, and stimulates the mucociliary apparatus. Thymol and carvacrol in Thymotal have a broad spectrum antibacterial activity by enhancing bacterial membrane perfora-tion. flavonoids in Thymotal inhibit calcium influx of the smooth muscles leading to smooth muscle relaxation.

INDICATIONS:

Acute and chronic bronchitis.Upper respiratory tract infections. Asthmatic bronchitis.

CONTRAINDICATIONS:

none reported.

SIDE EFFECTS:

None reported within the therapeutic dose. PRECAUTIONS/DRUG INTERACTIONS:



Children 2-12 years 12-18 years AdultsAge

Dosage

Time

0.5-1 ml

2 times/day

2.5 ml

3 times/day

5 ml

3 times/day

ResPIRaToRY

Thymotal PlusMucolytic, expectorant

47


Thyme (Thymus vulgaris fluid extract) 40 g(Standardized to contain minimum 10% Hederacoside C)Ivy (Hedera Helix extract) 0.7 g(Standardized to contain minimum 10%) Pack size:

Bottle of 100 ml syrup.


ResPIRaToRY46


Thymol and flavonoids in Thymotal Plus have secretolytic activity as they increase serous inter-ciliary fluid production to liquefy mucous. Thymotal Plus has an antibacterial effect against gram-positive and gram-negative bacteria and fungi, also an anti-viral activity through enhancing endog-enous interferon gamma production. flavonoids content of Thymotal Plus has anti-spasmodic activity leading to relaxation of smooth muscles of the airways. Thymus vulgaris has anti-oxidant properties. Thymotal Plus is alcohol free.

INDICATIONS:

Acute and chronic bronchitis.Upper respiratory tract infections. Asthmatic bronchitis.

CONTRAINDICATIONS:

not recommended during pregnancy.

SIDE EFFECTS:





Children AdultsAge

Dosage

Time

2.5 ml syrup

3 times/day

5 ml syrup

3 times/day

ResPIRaToRY

bosweliaAnti-inflammatory (anti-leukotriene)

49

Each capsule contains:

boswellia serrata extract 500 mg(Standardized to contain minimum 42% total organic acids calculated as β-Boswellic acid)

Pack size:



RHeUMaToloGY/oRTHoPeDIc48


Acetyl 11-Keto-β-boswellic acid (AKBA), a natural pentacyclic triterpene, is the major constituent of Boswellia serrata resin. boswelia is the first selective, direct, non-competitive, and non-redox type inhibitor of 5-lipoxygenase, which is the key enzyme for leukotriene biosynthesis. boswelia reduces the inflammatory process in diseases associated with increased Leukotriene production. boswelia reduces asthmatic attacks through restoration of the altered cellular activity, which usually accompanies the inflammatory process and contributes to the signs and symptoms of asthma. boswelia induces 80% remission in patients with ulcerative colitis grade II and III. boswelia reduces symptoms of rheuma-toid arthritis including reduction of swell-ing, pain and morning stiffness.

INDICATIONS:

Chronic inflammatory diseases: osteo-arthritis, ulcerative colitis, rheumatoid arthritis and bronchial asthma.

DOSAGE:

1-2 capsules 3 times/day.

CONTRAINDICATIONS:

Pregnancy and lactation.

SIDE EFFECTS:

None reported, within the therapeutic dose.



RHeUMaToloGY/oRTHoPeDIc

HerpagoAnti-inflammatory

51


Harpagophytum procumbens dried extract 400 mg (Standardized to contain minimum > 0.5% total Iridoid calculated as Harpagosid)

Pack size:



INDICATIONS:

Low back pain and sciatica.Inflammatory and degenerative forms of rheumatic pain: osteoarthritis, rheuma-toid arthritis, and ankylosing spondylitis.sport injuries and sprains, musculoskel-etal pains and tendenitis.

DOSAGE:

Unless otherwise prescribed by the physician: 1-2 capsules 3 times/day for 6-12 weeks.

CONTRAINDICATIONS:

During first trimester of pregnancy.

SIDE EFFECTS:



Herpago may affect the action of Warfa-rin, patients should be monitored regu-larly for adjustment of Warfarin dose.


Herpago has anti-inflammatory, mild analgesic and anti-exudative effects. Herpago reduces swelling, relieves pain and improves mobility of the joints. Herpago; iridoid glycosides and harpago-side contents are cyclooxygenase (COX) inhibitors mainly cox2 and to lesser extent cox1, reducing synthesis of the prostaglandins that play a major role in the causation of inflammation and pain. Herpago reduces the synthesis of TNF alpha and the release of cartilage metabolism regulating cytokine, inter-leukin-6, thus inhibits the acute phase reaction and production of pyrogens. The cytokines interleukin-1 and leuko-treine B4 are not affected. Unlike nsaIDs, Herpago does not cause gas-tritis, it has a choleretic effect resulting in increased production of bile, and thereby it increases the yield of bicar-bonate in the duodenum and neutralizes excessive acidity.


spondexChondro-protective

53


D-alpha tocopherol concentrate 400 mg

Pack size:

2, 3 or 5 blisters, 6 capsules/blister.



spondex restores the normal cartilage structure by stimulating the synthesis of proteoglycans and collagen as well as inhibiting collagenase type II. Due to its action as anti-oxidant, spondex prevents the damage caused by free radicals associated with specific disorders and life style patterns, including aging and rheumatic diseases. spondex reduces the damaging effect of nsaIDs on the gastro-duodenal mucosa as it normalizes the phospholipid con-tent of the endothelial cells. spondex is the most effective lipid soluble, chain breaking antioxidant that protects the cell membrane from per-oxidative damage. spondex combats free-radical-mediated pathology that develops over time in several degenerative diseases, as well as inflammatory processes. spondex aids the healing process of me-chanical tissue injuries and those due to cell rupture. natural D-alpha tocopherol is 40% more effective than the synthetic one, as it binds with higher affinity to the active sites on the cell membrane.

INDICATIONS:

Osteoarthritis.Rheumatoid arthritis. Ankylosing spondylitis.Traumatic injuries and muscle strains.

DOSAGE:

Unless otherwise prescribed by the physician; 1-2 capsules 3 times/day after meals, for 6-12 weeks.

CONTRAINDICATIONS:

bleeding tendency in advanced liver diseases.

SIDE EFFECTS:

None reported within the therapeutic dose. PRECAUTIONS/DRUG INTERACTIONS:

For patients on anticoagulant therapy, follow up of coagulation profile is ad-vised.


CystinolFor urolithiasis (and anti-inflammatory)

GENITO-URINARY 55


solidago virgaurea extract 425 mg(Standardized to contain not less than 1.5% total flavonoids calculated as Rutin)

Pack size:


54 GENITO-URINARY


Cystinol promotes the excretion of wa-ter more than electrolytes by increasing renal blood flow. This aquaretic effect facilitates the washout of bacteria from the urinary tract, prevents crystal for-mation and hence kidney stones. Cystinol inhibits the synthesis of prosta-glandinic acid metabolites and there-fore has an anti-inflammatory effect. The flavonoid content of Cystinol also has anti-inflammatory, anti-microbial and immunomodulatory properties. This anti-inflammatory effect supports urinary tract healing after passage of stones. Cystinol has an analgesic effect because it binds pain receptors. The mild spasmolytic effect of Cystinol relaxes contracted smooth muscles and thus relieves the pain associated with inflammation and stones. The saponin content of Cystinol pro-vides anti-infective properties through non specific immunostimulation while the ester-saponin exerts an anti-fungal effect against candida albicans and other candida species.

INDICATIONS:

Prophylaxis and treatment of crystallu-ria, and recurrent stone formation.Inflammatory diseases of the urinary tract.Adjuvant therapy to anti-microbials in urinary tract infection. Before and after operations and any invasive procedure to the urinary tract.

DOSAGE:

Unless otherwise prescribed by thephysician; 1 capsule 3-4 times/day (with a lot of fluids).

CONTRAINDICATIONS:

The safe use during pregnancy and lactation is not sufficiently well docu-mented.

SIDE EFFECTS:




ProstasanIn benign prostatic hyperplasia

GENITO-URINARY 57


Saw palmetto extract 160 mg Nettle root extract 120 mg

Pack size:

20 capsules in 2 blisters.60 capsules in 6 blisters.

* To be launched in 2011

56 GENITO-URINARY


Prostasan relieves most symptoms of prostatic enlargement. Increases the peak urinary flow rate, decreases residu-al urinary volume, decreases daytime and nocturnal urinary frequency and relieves painful micturation. Saw palmetto extract present in Prostasan exerts potent inhibitory actions on adrenoceptors and blocks calcium channels, thereby causing the spasmolytic effects and hence reliev-ing the dynamic obstruction present in cases of prostatic enlargement. It has also anti-androgenic effect since it inhib-its binding of DHT(dihydrotestosterone) to androgen receptors in prostatic cells, reduces 5 alpha reductase enzyme activity and has potent anti-estrogenic properties. The Nettle extract content of Prostasan has anti-inflammatory and an-ti-edematous effects because it inhibits the arachidonic acid cascade. Through this inhibition, Prostasan improves the congestion and non-infectious prostati-tis commonly associated with prostatic hyperplasia.

INDICATIONS:

Benign prostatic hyperplasia.Prostatic enlargement accompanied by symptoms of dysuria, frequency of urination, nocturia, and incomplete bladder emptying.adjuvant therapy in cases of acute and chronic prostatitis.

DOSAGE:

Unless otherwise prescribed by the phy-sician: 1 capsule 2 times/day with meals.The treatment must be maintained for at least 1 month.

CONTRAINDICATIONS:

none reported.

SIDE EFFECTS:

Mild GIT discomfort resolves when taken with meals.



bio-MagMagnesium aspartate

MIneRals 59

Each chewable tablet contains:

Magnesium hydrogen aspartate 1803 mg (Equivalent to 121.5 mg elemental magnesium)

Pack size:

20 chewable tablets in 2 blisters.

58 MIneRals


bio-Mag plays an important role in the regulation of vascular tone and de-creases the vascular resistance. since magnesium serves as a co-factor in the sodium-potassium pump, it prevents accumulation of sodium and calcium inside the cell, which is the cause of increased peripheral resistance and va-sospasm. bio-Mag reduces muscles’ ex-citability and cramps through reduction of neurotransmitters (catecholamines) release. also it relaxes irritable uterine muscles by stimulating β2-adrenergic receptors and cyclic AMP production. bio-Mag’s natural amino acid aspartate is the carrier molecule for the transport of magnesium in cells. In addition aspar-tate is involved in Dna synthesis and in carbohydrate and protein metabolism.Aspartic acid is a major excitatory trans-mitter in the brain.

INDICATIONS:

Magnesium deficiency diseases.Prevention and treatment of stress re-lated diseases (Hypertension, Diabetes). Prevention and treatment of cardiac ar-rhythmia and coronary spasm.Muscle cramps, GIT cramps and mi-graine.

spasm in pregnancy, pre-eclampsia and dysmenorrhea.For patients with or at risk for mag-nesium deficiency (eating processed food, malabsorption, pancreatitis, renal dysfunction, after the use of diuretics and alcoholism).non insulin dependent diabetes mel-litus.

DOSAGE:

Unless otherwise prescribed by the physician: 2-3 tablets/day.

CONTRAINDICATIONS:

Patients with renal impairment without the advice and direct supervision of the physician.

SIDE EFFECTS:



Diuretics, Aminoglycosides, Immuno-suppressants and Cytostatics induce an increase in renal magnesium loss.Indomethacin promotes the absorption of magnesium. It is so recommended to take magnesium and the above medica-tions separately.

bioZincZinc aspartate

MIneRals 61

Each film coated tablet contains:

Zinc Dl-hydrogen aspartate 50 mg (equivalent to 9.75 mg elemental zinc)

Pack size:


60 MIneRals


bioZinc is a vital constituent of metal-loenzymes like cytochrome oxidase, Rna polymerase, carbonic anhydrase and carboxypeptidase. bioZinc enhances the percentage of cD4 lymphocytes and improves cell mediated immunity, hence decreases the incidence of diarrhea and respiratory tract infections, espe-cially in elderly and diabetic patients. bioZinc can inhibit 5-alpha reductase (type I) which is required to produce dihydrotestosterone a potent hormone that is responsible for male-pattern hair loss. bioZinc blocks the formation of dihydrotestosterone within the scalp reducing its miniaturizing effects on the hair follicle, decreasing the injury it causes to the hair follicle and also the extent of the immune response targeted to the hair follicle. bioZinc is necessary for prepubertal growth, sexual matura-tion, semen quality and hence male fertility, and is essential for proper fetal growth. bioZinc is essential for normal epithelization of the skin and is required for hair and nail growth. bioZinc con-tains aspartic acid that acts as a carrier for zinc and thereby optimizes the effec-tive intestinal absorption, and utilization of zinc.

INDICATIONS:

Zinc deficiency 1ry and 2ry Pregnancy and lactationDelayed wound healing Sexual dysfunctionDermatitis and acne Growth retardation in childrenalopecia areata and hair loss Immune deficiencyReduced taste and smell sensation as adjuvant treatment in diabetes mel-litus

DOSAGE:

Unless otherwise prescribed by the phy-sician; 1 hour before meal, 1-2 tablets/day (adult), 1 tablet/day (children).

CONTRAINDICATIONS:

severe renal parenchymal damage.

SIDE EFFECTS:

Temporarily, a metallic taste, headache, nausea and diarrhea could occur, when overdosing.


No specific precautions or drug interac-tions reported.

Ritchkalcalcium supplement

MIneRals 63

Each chewable tablet contains:

Milk calcium 2000 mg (equivalent to 500 mg elemental calcium)

Pack size:

20 chewable tablets.

*To be launched in 2011

62 MIneRals


Ritchkal is 100% natural calcium and contains a range of other minerals, such as phosphorus and magnesium.Ritchkal contains Ca:P in a ratio of 2.2:1 which contributes to efficient calcium absorption.Ritchkal may be absorbed in the ab-sence of vitamin D. calcium is required for normal growth, development and maintenance of the bone and teeth.adequate calcium intake reduces the risk of several major chronic diseases including osteoporosis, hypertension, colon cancer, and possibly cardiovascu-lar disease and obesity.calcium is important for women’s health during pregnancy, lactation and post menopause.calcium is required for a number of basic regulatory functions including muscle contraction, blood coagulation, transmission of nerve impulses, activa-tion of enzyme reactions, stimulation of hormone secretions and integrity of intracellular cement substances.The inhibition of bone remodeling that generally occurs in response to a high calcium intake is less marked when cal-cium is supplied by milk products.

INDICATIONS:

Calcium deficiency.During pregnancy and lactation.Prophylaxis and treatment of osteoporosis.

DOSAGE:

The recommended daily dose is two tablets per day.

CONTRAINDICATIONS:

none reported.

SIDE EFFECTS:

none reported within the recommended dose.


Taken 2 hours apart from other medica-tions.

64 alPHabeTIcal InDex

ALPHABETICAL PRODUCT-INDEX

b

bio-Mag 58

bioZinc 60

boswelia 48

c

cardioton 8

carmipret 12

chamopect 14

Cystinol 54

f

femicur 20

femivit 22

fiminosan 18

H

Heparex 16

Heparsan 24

Herpago 50

I

Immulone 26

K

Kingosan 32

M

Mulone 28

n

neuropatex 34

P

Prostasan 56

R

Ritchkal 62

Rosinol 42

s

safamood 36

safamood forte 38

sedaneurin 40

spondex 52

statosan 10

T

Thymotal 44

Thymotal plus 46

V

Viscum fraxini 2 6

Viscum fraxini 4 30

Documents

AtosPharma-Intro.pdf