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The A.R. Smith Department of Chemistry Overview of Faculty Research Interests Fall 2017

ASU Chemistry Department Research Interests 10-26-17...and reactivity of lanthanide and transition metal complexes, as well as exploring ... Chemistry from Universidad Simon Bolivar

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  • TheA.R.SmithDepartmentofChemistry

    OverviewofFacultyResearchInterests

    Fall2017

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    [email protected]

    Dr. Babyak teaches Introductory, Analytical, andEnvironmentalChemistryclassesatAppalachianStateUniversity. SheholdsaPh.D. inAnalyticalChemistryfrom West Virginia University (WVU) under theguidance of Dr. Ronald B. Smart. Her researchinvolvedthedevelopmentofelectrochemicalmethodsfor the detectionmercury emitted from coal-burningpowerplants. Prior toherworkatWVU,Dr.Babyakwas an AmeriCorps member, and worked with coalmine drainage in southwestern Pennsylvania. Dr.Babyak received her Bachelor’s degree from Saint

    Vincent College, in Latrobe, PA,where shewasmentored by Dr. Caryle Fish. Dr.BabyakhasbeenatAppalachiansinceAugust,2004. Research in Dr. Babyak’s group centers around environmental analyticalchemistry and environmental monitoring. Students in Dr. Babyak’s group spendtime both in the lab developing analytical methods and in the field collectingsamples.Currentprojectsincludedevelopmentofananalyticalmethodtoquantifyenvironmental endocrine disruptors in water samples and investigation of theeffectsoftheTennesseeValleyAuthority(TVA)coalashspillonwaterqualityandaquatic life in the Emory River. Research ideas suggested by students are alsowelcomedandencouraged.Dr.JeffersonE.Bates [email protected]

    Dr. Jefferson Bates teaches general and physicalchemistry coursesatAppalachianStateUniversity.HereceivedhisPhDinChemicalandMaterialPhysicsfromtheUniversity of California Irvine under the guidanceofFilippFurchein2013.Hisgraduateworkfocusedonthe application of density functional theory to novellanthanide and transition metal chemistry. He alsodeveloped new quantum mechanical methods topredictabsorptionspectraandappliedthemtopredictthe spectra of seven never before seen divalentlanthanide oxidation states. Following his graduatework, he completed a postdoc at Northwestern

    University, followed by a second postdoc at Temple Universitywhere heworkedwith Adrienn Ruzsinszky and John Perdew. At Temple, Dr. Bates explored hisinterest for challenges in solid-state chemistry and physics and developed a newmethodforpredictingaccuratepressureinducedstructuralphasetransitions.

    Dr. Bates’ current research focus includes further exploring the propertiesand reactivity of lanthanide and transitionmetal complexes, as well as exploringchemical properties of technologically pertinent surfaces, such asmetals or silica,using computer simulations. New methods for predicting properties of magnetic

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    moleculesarealsounderdevelopment,andwilleventuallybeappliedtohelpguidethe synthesis of improved single-molecule magnets. Students working with Dr.Bates learn the basics of Linux, as well as the Python programing language andseveralmodellingsoftware,inordertocarryoutquantumchemicalsimulationsonpowerfulcomputers. [email protected]

    Dr.BennettteachesOrganicChemistryIandIIandFundamentalsofOrganicChemistry.AfterreceivingaB.S.inChemistryatUNC-ChapelHill,sheearnedaPh.D. in Organic Chemistry from the University ofWisconsin-Madisonin1996underthesupervisionof Edwin Vedejs. Dr. Bennett wrote her graduatethesisonProbingtheOriginsofStereoselectivity fortheWittig Reaction of Stabilized Ylides. Followinggraduate school, Dr. Bennett taught OrganicChemistryatHopeCollege inHolland,MI formanyyears. She happily left themid-west to become a

    professoratAppalachianintheFallof2002.Dr.BennettiscurrentlyservingasaProgramDirectoratNSFinWashington,DC.

    Dr. Bennett has three ongoing research projects that involve synthesis ofsmallmoleculesthatmayhaveimportantpharmacologicalproperties. Theyareasfollows:1)Totalsynthesisoftaxanediterpenesusingπ-allylpalladiumchemistry.2)Microwave-inducedpreparationofsubstitutedpyridinesand3)Formationofallylicethersusingtheinverseelectron-demandDiels-AlderReaction.Dr.ClaudiaCartaya-Marincartayacp@appstate.edu

    Dr. Claudia Cartaya-Marin is an organic syntheticchemistinterestedindevelopingsyntheticmethodsandin the total synthesis of natural products that possessanti-cancer properties. She obtained her B.S. inChemistry from Universidad Simon Bolivar in Caracas,Venezuela, and then came to the United States, whereshegotherMastersatNortheasternUniversity,workingonorgano-metallicchemistry.ShethenjoinedthelabofDr.BarrySnideratBrandeisUniversity,inWaltham,MA,where, forherPh.D.degree,sheaccomplishedthetotalsynthesisof(+)-nitramine,aproposedneurotoxin. She

    also studied Lewis acid-catalyzed reactions of aldehydes, and developed a novelcyclizationreaction.

    After completing her Ph.D., she accepted a post-doctoral position in theChemistry Department at Cornell University, where she worked on the totalsynthesisofbiosyntheticintermediatesoftheshikimicacidpathway.Sincearriving

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    atAppalachianStateUniversity in1986, shehasextendedherresearch to includetheonepotsynthesisof5,7-diphenyl-2,3-Dihydro-1H-pyrrolizine;thestudyofthereactions of sodium hydrogen selenide withα,β-unsaturated compounds and thesynthesisofenaminonesusingLewisacidsasactivators.

    Currently, Dr. Cartaya-Marin is studying the nucleophilic aromaticsubstitutionreactionof trihalogenatedbenzeneswithcyclicamines,aswellas theuseofmicrowavestoenhanceorganicreactions.She isalsocollaboratingwithDr.EceKaratanfromtheBiologyDepartmentonaprojectthatinvolvesthesynthesisofcyclic-diguanylicacidandusingthisacidtofindthecylic-diguanylicacid(c-di-GMP)regulatedsignaltransductionpathwaysinthebacteriumVibriocholerae.

    HerteachingresponsibilitieshaveincludedBiochemistry,AdvancedOrganicChemistry, Organic Synthesis, and Organic Chemistry I and II lectures andlaboratories.SheiscurrentlyteachingFundamentalsofOrganicChemistry.

    Students inher labobtainexperienceperforming literature searches; learnproper research notebook keeping and the use of modern synthetic techniques.TheyusechromatographictechniquestoseparateandpurifyproductsanduseNMRand IR spectroscopy and GC/MS to characterize the compounds that theysynthesize.

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    [email protected]

    Dr.ChristiangraduatedfromAppalachianStateUniversity in2005andreceivedherPh.D. inBiologicalChemistry in2010from the University of North Carolina at Chapel Hill. Hergraduatework in the research group of Dr. Linda Spremullifocused on mechanisms of translation initiation inmammalianmitochondria.Brookedidherpostdoctoralworkat Yale University as an NIH postdoctoral fellow in thelaboratory of Dr. Gerald Shadel where she studied thecontributionofmitochondrial reactiveoxygen species to theneurodegenerative disease Ataxia-Telangiectasia. Dr.Christian joined thedepartmentofchemistryatAppalachian

    StateUniversityin2015andteachesbiochemistryandbiochemistrylab.Currentresearchprojects in theChristian labare focusedonmitochondrial

    reactive oxygen species and the roles they play in assembly of oxidativephosphorylationcomplexesandinadipocytedifferentiation.TechniquesusedintheChristianlabincludetissueculture,westernblotting,qPCR,PAGE(denaturing/SDSandbluenative),shRNAknockdownofgenesofinterest,immunofluorescence,andsubcellularfractionation.

    [email protected]

    Dr. Culpepper received her Ph.D. in Analytical Chemistryin 2009 from the University of Kansas working in theresearch groups of Dr. Julian Limburg and Dr. Emily E.Scott. Her graduate work focused on determining thestructure and function of a prolyl 4-hydroxylase-likeprotein involved in collagen production. After graduateschool, Dr. Culpeppermoved toNorthwesternUniversitytothelaboratoryofDr.AmyC.Rosenzweigwhereshewasawarded an NIH postdoctoral fellowship studyingbiological methane oxidation by the membrane proteinparticulate methane monooxygenase. Dr. Culpepper

    joined the department of chemistry at Appalachian State University in 2014 andteachesclassesinAnalyticalandIntroductoryChemistry. Current research projects in the Culpepper lab utilize interdisciplinarytechniquesencompassingbiochemistry,molecularbiology,andanalyticalchemistry.Research projects investigate the protein structure and biochemical function ofenzymesinvolvedintheglobalsulfurcycle.Namely,anenzymeresponsibleforthedegradationofdimethylsulfide(DMS),themajorcontributingvolatileorganicsulfurcompound (VOSC) in our atmosphere implicated in climate regulation. Researchstudents learn protein expression and purification as well as biochemicalcharacterizationusinganalyticalinstrumentation

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    [email protected]

    Dr. Hambourger joined the faculty at Appalachian StateUniversity in 2009. He received his Ph.D. from ArizonaState University, under the tutelage of Dr. Thomas A.Moore; followedby a one-yearpostdoctoral appointmentin the same laboratory. Dr. Hambourger’s graduate andpost-doctoral work focused on photochemical charge-separation in organic/inorganic hybrid systems, proton-coupled electron transfers as related to photochemicalreactions,andcouplingbiologicalcatalystswithelectrodesfortechnologicalapplications.

    Dr. Hambourger teaches introductory chemistryandisestablishinganewresearchlaboratoryatAppalachianStateUniversitywhichis aimed at developing first-row transition metal catalysts suitable for wateroxidation,hydrogenproduction,and/orcarbondioxidereduction.Hislaboratoryisexploringlow-costmaterialsandprocessingtechniquesfortheelectrodepositionofsuitable catalysts, with the hope of identifying candidates for renewable energystorageatanappropriatescale.Further,Dr.Hambourgerisexploringtheinterfacebetween single electron photochemical events and multi-electron/multi-protoncatalyticreactions,inhopesofbetterunderstanding(andmimicking)theprocessofnaturalphotosynthesis.

    Students in the research laboratory are exposed to the fundamentals ofelectrochemistryandphotochemistry,aswellastoseveralspectroscopictechniquesused to characterize the materials produced. Students are encouraged to makesignificant contributions to laboratory research, while developing the skills, self-discipline,andconfidencenecessaryforasuccessfulscientificcareer.Dr.JenniferPerryCecilececilejp@appstate.edu

    Dr.PerryreceivedaPh.D.inChemistryin2003fromDukeUniversity working in the research group of Dr. JohnSimon. Her graduate research used fluorescencespectroscopy to characterizephotophysicalpropertiesofthe fungal metabolite ochratoxin a and to examine thebinding of various ligands to the blood protein humanserum albumin. After graduate school, Dr. PerrycompletedpostdoctoralresearchattheNationalInstituteof Environmental Health Sciences in the ResearchTriangle Park, NC. During that time, she studiedstructure/function interactions of negatively charged

    xenobioticsandafamilyofproteinsnamedtheorganicaniontransporters(OATs).She also became interested in the effects of genetic variability and regulation onOATproteinexpressionandfunction.

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    Dr.PerryjoinedthechemistrydepartmentatAppalachianStateUniversityin2007teachingintroductoryandphysicalchemistrycourses.Currently,herresearchinvolves techniques from biochemistry, biophysical chemistry and biology. Herresearch projects include implementing a nematode model system to studyxenobiotic transportbyOATs,buildingmodelsofOAT structure to analyzeaminoacids that contribute to OAT function, and observing functional consequences ofgenetic splice variants and single nucleotide polymorphisms on OAT proteinexpressionandregulation.Dr.LibbyPuckettpuckettlg@appstate.edu

    Dr. Puckett has been teaching Introductory,Analytical, and Forensic Chemistry classes atAppalachian State University since the fall of 2004.SheholdsaPh.D.inBioanalyticalChemistryfromtheUniversity of Kentucky under the guidance of Dr.Leonidas G. Bachas and Dr. Sylvia Daunert. Herresearch involved the development of sensingsystems forclinicalandpharmaceuticalapplications.Dr. Puckett received her Bachelor’s degree fromEastern Kentucky University in Forensic Science in1996.

    Although she is a bioanalytical chemist by training, her research looks atproblems from different perspectives. Her research crosses many disciplines,including forensic science, molecular biology, and electrical engineering, butultimately utilizes analytical chemistry as the unifying science. The currentresearch projects in her laboratory have two main concentrations – forensicanalysisandbiologicalapplications.Currently,therearethreedifferentinstrumentsbeing used to study forensic samples. The first project involves using capillaryelectrophoresis (CE) to separate compounds of forensic interest, including drugs,explosives,andinks/dyes.Thesecondprojectentailsthecomparisonofsolidphaseextractiontechniques(activatedcharcoalstrips(ACS),solidphasemicroextraction(SPME) “needles”, and the Gerstel Twister) for the analysis of arson accelerants.Comparisonswillbeperformedon thegaschromatograph(GC). The finalprojectutilizes the gas chromatograph-mass spectrometer (GC-MS) for the detection andquantificationofcocaineonU.S.andforeigncurrency.

    Therearecurrentlythreeprojectsfortheanalysisofbiologicalentities.Thefirst project involves using a custom-made capillary electrophoresis system inconjunction with chemiluminescence detection for the determination of enzymekinetics using a technique called enzyme mediated microanalysis (EMMA). Thesecond project is the creation of a homogeneous protein-based assay for thedetection of organophosphates by utilizing a fusion protein betweenorganophosphorus hydrolase (OPH) and enhanced green fluorescent protein(EGFP). This assay will allow us tomonitor the hydrolysis of organophosphatesfoundinpesticidesandchemicalwarfareagents.Thethirdprojectinvolvescreating

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    Functionalized HexaphenylbenzeneR = Active Site for Functionality

    awhole-cellsensor,containingafusionproteinbetweenβ-lactamaseandEGFP,tomonitor the rate atwhich β-lactamantibiotics (penicillins) cross cellmembranes.Thiswillaid indetermining thebioavailabilityofpossiblenewdrugcandidatesorinhibitorsofβ[email protected]

    Dr.Ramey teaches a variety of organic chemistryclassesatAppalachianStateUniversity.HeholdsaPh.D. in organic chemistry from theUniversity ofFlorida under the guidance of Dr. John Reynolds.His research involved the synthesis andcharacterization of water-soluble conjugatedpolymers for lightemission applications.Prior to hiswork at UF,Dr. Ramey attendedVirginiaPolytechnicand

    StateUniversitywhereheworkedwithDr. JudyRiffleonhigh temperature polymers. Following graduate studies,he worked as a researcher for the Air Force ResearchLaboratoriesatWright-PattersonAFB,Dayton,Ohio,untilhisappointmentatAppalachianinAugust2002. Currently,Dr.Ramey’sresearchcentersontheuseoforganicsynthetictechniquestoconstructmoleculesforthecontrolledreleaseoffragrancesandtheassemblyofchargedspeciesforionicconduction.Thematerialsunder development have potential in fuel cell/battery membranes and stimuliactivated scent release applications. Students are exposed to three principles ofresearch: self-discipline, in-depth synthetic knowledge / planning, followed byexperimentaldesignandexecution.Inputandnewideasfromstudentsarealwaysencouragedandexpected.

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    [email protected]

    Dr. Schwab received his Ph.D. in Polymer SciencefromTheUniversityofAkronandhisB.S.inMaterialsScience and Engineering from the University ofIllinois at Urbana-Champaign. His main researchinterests include the development of metallicnanoparticles as broadly applicable photocatalysts,computational studies of nanometer-scale self-assembly, and the development of novel rubbermaterials. When illuminated with laser radiation,metallic nanoparticles have the ability to enhance

    lightintensityatthesurfaceoftheparticle.Whentheseparticlesaredispersedinasystemof photochemical reagents, the light intensity enhancement can lead to anoverallincreaseinthereactionrate. Likeconventionalcatalysts,thenanoparticleswould not be consumed in the course of the resulting chemical reaction. Unlikeconventional catalysts, the nanoparticles can catalyze any photochemical reactionrather than reactions involving specific reactants. A student project in this areainvolves the synthesis of metal nanoparticles, characterization of particles withelectronmicroscopy,andquantificationofphotochemicalratesuponlaserexposure. Self-assembly, a process wherein molecules assemble into larger-scaleobjects is an important component of biological structure formation as well as avital tool in the burgeoning field of nanotechnology. In general, intermolecularattractive interactions drive molecular assembly and entropy counters assembly.One quickly realizes, however, that these thermodynamic counterparts are ratherlimitedintheirabilitytocontroltheoverallsizeofanygivenassembly.Toaddresstheseissuesofassemblysizecontrol,computationalstudieswillbeimplementedtodeterminethelimitsofthermodynamicsizecontrolandtodeviseassemblydesignstrategiesusingcomputationalevolutionalgorithms.Astudentprojectinthisareawill involve programming of Monte Carlo simulations and computer analyses ofsimulationresults. Rubber materials are typically composed of long chain molecules that arecovalently cross-linked to one another. These covalent cross-links impart thematerialwiththeabilitytoreversiblystretchtogreatlengths,butalsoremovethematerial’sabilitytoberecycled. Byalteringthechemicalnatureofthecross-linksbetweenthepolymerchainmolecules,thesematerialscanbemaderecyclable.Theunique cross-linking chemistry also offers several possibilities for developingrubbermaterialsthatactassensorstovariousstimuli.Astudentprojectinthisareawill includethesynthesisofnewpolymericmaterialsandtheirsubsequentopticalandmechanicalcharacterization.

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    [email protected]

    Dr.ShawjoinedthefacultyatAppalachianStatein2015.HereceivedhisB.A. inchemistryandmathematics fromSt. Olaf College in 2002. Upon completion of hisundergraduate degrees, he attended graduate school atClemson University, working in the laboratory ofmedicinal chemistry under the guidance of Dr. Dev P.Arya and received his Ph.D. 2010. His graduate workfocused on the development and synthesis of newaminoglycoside therapeutic agents. Following hisgraduatework, Dr. Shaw accepted a position as visitingassistant professor at The College of Wooster. From

    2011-2015,Dr. Shaw taught courses in introductory chemistry, organic chemistryandmedicinalchemistryandmentored17undergraduateresearchassistants.

    Currently, Dr. Shaw teaches courses in organic chemistry. The ShawResearch Group focuses on the development of new synthetic methodologies.Traditionally,syntheticorganicreactionsaredependentontheenergy,orientation,andvelocityofthereactants insolution. Thedifficultyassociatedwithcontrollingthese variables have historically resulted in increased reaction times, decreasedreaction yield, and decreased purity. Students in the ShawResearch Group haverecently developed new synthetic methodologies that circumvent traditionalsynthetic pitfalls and increase reaction yield andpuritywhile decreasing [email protected]

    Dr.Swarthoutisananalyticalenvironmentalchemist.Hisresearchappliesthetechniquesofanalyticalchemistrytostudyenvironmentalissuesoflocalandglobalconcern.HereceivedaPh.D.inEarthSystemsSciencefromtheUniversityofNewHampshirewherehisdoctoralresearchfocusedontheairqualityimpactsofhydraulicfracturingfornaturalgas.HealsoconductedpostdoctoralresearchatWoodsHoleOceanographicInstitutionstudyingtheenvironmentalimpactsofmajoroilspillsincludingtheDeepwaterHorizondisaster.HecurrentlyteachesIntroductory

    andCapstonecoursesinEnvironmentalChemistryandEnvironmentalScience.Dr.Swarthout’sresearchfocusesontheenvironmentalimpactsofnaturallyproducedorganiccompoundsandorganicpollutantsderivedfromfossilfuelproductiononairquality,waterquality,andclimate.OnecurrentresearchprojectinvolvesmeasuringvolatileorganiccompoundsandothertracegasesattheAppalachianAtmosphericInterdisciplinaryResearch(AppalAIR)atmosphericobservatoryinordertobetterunderstandthecomplexrelationshipbetween

    mailto:[email protected]

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    emissionsofvolatileorganiccompounds(VOCs)fromtreesandshrubsandclimate.ThethousandsofVOCsproducedbyplantscaninfluenceourclimatebecausetheycanformaerosolswhichreflectincomingsolarradiationandbecausetheycancompeteforreactionwithradicalspeciesthatcontrolthelifetimeofgreenhousegases.Anotherprojectinvolvesinvestigatingthechemicalweatheringofoilspills.Oilisacomplexmixtureofthousandsoforganiccompoundsandthecompositionofspilledoilchangesovertimeintheenvironment.Thegoalofthisresearchistounderstandhowthesechangesaffecttheenvironmentalfateandtoxicityoftheseweatheredoilresidues.

    Studentsworkingontheseprojectswillgainhands-onexperienceworkingwiththeanalyticalinstrumentationusedinatmosphericandenvironmentalchemistry.Theywillalsodevelopskillsinscientificcommunicationthroughthepresentationandpublicationoftheirfindings.Mostimportantlytheywillworktoprovidemuchneededinformationaboutpressingenvironmentalissuesthatwillhelpshapeongoingpolicydebates.Dr.BrettTaubman

    taubmanbf@appstate.eduDr.BrettTaubmanteachesanalyticalandenvironmentalchemistry as well as fermentation science andintroductorychemistrycourses. HereceivedhisPh.D.inChemistryfromtheUniversityofMarylandin2004underhis dissertation advisor Dr. Russell Dickerson. Hisgraduate work focused on the meteorological anddynamical impacts on regional air quality, specificallywith respect to aerosol optical properties, as measuredfroma lightaircraft. Followinghisgraduatestudies,Dr.Taubman worked as a Research Associate in ThePennsylvania State University Department of

    MeteorologywithhisresearchadvisorDr.AnneThompson.Therehedesignedandoperated a mobile atmospheric chemistry laboratory to investigate global airpollutiontransportandvalidatesatelliteretrievalsofatmosphericpollutants.

    As co-founder of the Appalachian Atmospheric Interdisciplinary Research(AppalAIR) facilityand throughon-goingcollaborationswithNASAandNOAA,hiscurrent research interests are focused on the relationships between aerosolchemical and optical properties and their impacts on the regional climate.Additionally,aspartofaninterdisciplinaryresearchteaminfermentationsciences,heperformsappliedresearchinbio-processingofagriculturalandindustrialwastestreams,water treatment, and environmental remediation aswell as in designinginnovative approaches for reducing resource utilization and improving operatingefficienciesinthecampusfermentationpilotplant.

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    [email protected]

    Dr.WeberteacheslecturesandlaboratoriesinOrganicChemistry at Appalachian State University. Afterreceiving his diploma in chemistry from HeidelbergUniversity, Germany in 2009, he earned his Ph.D. inOrganic Chemistry in 2012 under the supervision ofMichel R. Gagné. Dr.Weber returned to Germany forhispostdoctoralstudiesintheresearchgroupofAloisFürstnerattheMax-PlanckInstituteforCoalResearch.In 2015 he joined the chemistry department atAppalachian State University as a lecturer and waspromotedtoanAssistantProfessorin2017.Dr. Weber’s research focuses on sustainable organic

    synthesis guided by the principles of green chemistry. He currently has severalongoing research projects centered on microwave-assisted organic reactions, theapplication of biocatalysis in organic synthesis, the design ofcascading/tandem/one-potreactions,andonthedevelopmentofnewexperimentsfororganicteachinglaboratories.Dr.DaleWheelerwheelerde@appstate.edu

    Dr. Wheeler teaches introductory and inorganicchemistry classes atAppalachianStateUniversity.Heholds a Ph.D. in inorganic chemistry from theUniversity of Idaho under the guidance of Dr. LeszekCzuchajowski.Hisresearchinvolvedthesynthesisandcharacterization of organometallic salts as modelsystems for nonlinear optical materials. Prior to hiswork at UI, Dr. Wheeler attended Kansas StateUniversitywhere heworkedwithDr. EricMaatta onvanadium imido complexes. Following graduatestudies, he completed a postdoctoral fellowship at

    BereaCollegeasaHenryandCamilleDreyfusFellowandthenwasafacultymemberat theUniversityofWisconsin –Parksideuntil his appointmentatAppalachian inAugust1998. Currently,Dr.Wheeler’sresearchcentersaroundtheuseoforganicandair-sensitiveorganometallicsynthetictechniquestocreatemoleculesthatarepotentialnonlinear optical materials. The noncentrosymmetric crystallization of thesechromophores is an essential requirement for efficient second-order nonlinearoptical properties. The research has applications for optical and electro-opticaldevicesinthetelecommunicationsandopticaldata-processingindustries.Researchstudentslearnsynthesisandpurificationtechniques,characterizationmethods,andhowtoformulatedexperimentaldesign.