MEETING ABSTRACT Open Access Association between Human T-Cell Lymphotropic Virus Type 1 and 2 (HTLV 1/2) infection and tuberculosis: systematic review and meta-analysis Sérgio Arruda 1,2* , Camila Loureiro 1 , Marcos Almeida 1 , Dayana Mendes 2 , Maria F R Grassi 1,2 , José R Lapa 3 , Afrânio Kritski 3 , Kristien Verdonck 4,5 , Eduardo Gotuzzo 4 , Bernardo Galvão-Castro 1,2* From 15th International Conference on Human Retroviruses: HTLV and Related Viruses Leuven and Gembloux, Belgium. 5-8 June 2011 Background HTLV-1 infection alters the immune function and increases the risk of several infectious diseases. In this meta-analysis, we assess the association between HTLV- 1/2 and active tuberculosis (TB). Methods Four databases were searched for relevant articles that describe the frequency of HTLV- 1/2 infection among TB patients and control groups of healthy individuals or patients without a history of TB. Data were analyzed using the EasyMA software. Results The search yielded two hundred and eight articles. Six met the inclusion criteria and were included in the meta-analysis. The estimated relative risk of HTLV- 1/2 infection in TB patients was 3.25 times higher than in the population based control groups. Conclusion Patients with active TB have a higher risk of HTLV- 1/2 infection. Prospective studies involving latent tuberculosis infection (LTBI) in HTLV-1-infected individuals are necessary to evaluate the potential benefit of TB chemoprophylaxis. Author details 1 Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil. 2 Laboratório Avançado de Saúde Pública, Centro de Pesquisas Gonçalo Moniz, Fiocruz, Salvador, Bahia, Brazil. 3 Universidade Federal do Rio de Janeiro,Faculdade de Medicina, RJ, Brazil. 4 Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru. 5 Institute of Tropical Medicine, Antwerp, Belgium. Published: 6 June 2011 doi:10.1186/1742-4690-8-S1-A80 Cite this article as: Arruda et al.: Association between Human T-Cell Lymphotropic Virus Type 1 and 2 (HTLV 1/2) infection and tuberculosis: systematic review and meta-analysis. Retrovirology 2011 8(Suppl 1):A80. Submit your next manuscript to BioMed Central and take full advantage of: • Convenient online submission • Thorough peer review • No space constraints or color ﬁgure charges • Immediate publication on acceptance • Inclusion in PubMed, CAS, Scopus and Google Scholar • Research which is freely available for redistribution Submit your manuscript at www.biomedcentral.com/submit * Correspondence: [email protected] 1 Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil Full list of author information is available at the end of the article Arruda et al. Retrovirology 2011, 8(Suppl 1):A80 http://www.retrovirology.com/content/8/S1/A80 © 2011 Arruda et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Association between Human T-Cell Lymphotropic Virus Type 1 and 2 (HTLV 1/2) infection and tuberculosis: systematic review and meta-analysis

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Page 1: Association between Human T-Cell Lymphotropic Virus Type 1 and 2 (HTLV 1/2) infection and tuberculosis: systematic review and meta-analysis

MEETING ABSTRACT Open Access

Association between Human T-Cell LymphotropicVirus Type 1 and 2 (HTLV 1/2) infection andtuberculosis: systematic review and meta-analysisSérgio Arruda1,2*, Camila Loureiro1, Marcos Almeida1, Dayana Mendes2, Maria F R Grassi1,2, José R Lapa3,Afrânio Kritski3, Kristien Verdonck4,5, Eduardo Gotuzzo4, Bernardo Galvão-Castro1,2*

From 15th International Conference on Human Retroviruses: HTLV and Related VirusesLeuven and Gembloux, Belgium. 5-8 June 2011

BackgroundHTLV-1 infection alters the immune function andincreases the risk of several infectious diseases. In thismeta-analysis, we assess the association between HTLV-1/2 and active tuberculosis (TB).

MethodsFour databases were searched for relevant articles thatdescribe the frequency of HTLV- 1/2 infection amongTB patients and control groups of healthy individuals orpatients without a history of TB. Data were analyzedusing the EasyMA software.

ResultsThe search yielded two hundred and eight articles. Sixmet the inclusion criteria and were included in themeta-analysis. The estimated relative risk of HTLV- 1/2infection in TB patients was 3.25 times higher than inthe population based control groups.

ConclusionPatients with active TB have a higher risk of HTLV- 1/2infection. Prospective studies involving latent tuberculo-sis infection (LTBI) in HTLV-1-infected individuals arenecessary to evaluate the potential benefit of TBchemoprophylaxis.

Author details1Escola Bahiana de Medicina e Saúde Pública, Salvador, Bahia, Brazil.2Laboratório Avançado de Saúde Pública, Centro de Pesquisas GonçaloMoniz, Fiocruz, Salvador, Bahia, Brazil. 3Universidade Federal do Rio de

Janeiro,Faculdade de Medicina, RJ, Brazil. 4Instituto de Medicina TropicalAlexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru.5Institute of Tropical Medicine, Antwerp, Belgium.

Published: 6 June 2011

doi:10.1186/1742-4690-8-S1-A80Cite this article as: Arruda et al.: Association between Human T-CellLymphotropic Virus Type 1 and 2 (HTLV 1/2) infection and tuberculosis:systematic review and meta-analysis. Retrovirology 2011 8(Suppl 1):A80.

Submit your next manuscript to BioMed Centraland take full advantage of:

• Convenient online submission

• Thorough peer review

• No space constraints or color figure charges

• Immediate publication on acceptance

• Inclusion in PubMed, CAS, Scopus and Google Scholar

• Research which is freely available for redistribution

Submit your manuscript at www.biomedcentral.com/submit

* Correspondence: [email protected] Bahiana de Medicina e Saúde Pública, Salvador, Bahia, BrazilFull list of author information is available at the end of the article

Arruda et al. Retrovirology 2011, 8(Suppl 1):A80http://www.retrovirology.com/content/8/S1/A80

© 2011 Arruda et al; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative CommonsAttribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction inany medium, provided the original work is properly cited.

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http://creativecommons.org/licenses/by/2.0