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Kingdom of Saudi ArabiaMinistry of Higher Education Taibah
University
Aspirin
Faculty of Science Chemistry Department
Supervised by : Dr. Laila Shakir
& Asst. Heba Alshareef
Presented by: Zubaydah Abdullah
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Contents
- Some Background"- The Chemistry of Aspirin"- Physical
properties "- Synthesis"- Mechanism"- IR and NMR
Spectroscopy"-Biological activity"- Brand names"- Conclusion
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- 1897 In Germany, Bayer's Felix Hoffmann develops and patents a
process for synthesising acetyl salicylic acid or aspirin. First
clinical trials begin."
Some Background
[ 1 ][ 2 ]
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It would later be marketed as aspirin a for acetyl and spirin
for Spirea, the genus name of the source plant for salicylic acid,
the pain-relieving agent.
Some Background
[ 3 ]
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Contents
- Some Background"- The Chemistry of Aspirin"- Physical
properties "- Synthesis"- Mechanism"- IR and NMR Spectroscopy"-
Biological activity"- Brand names"- Conclusion
-
Aspirin
IUPAC Name: 2-acetyloxybenzoic acid"!
Molecular Formula: C9H8O4"Molecular Weight: 180.15742 g/mol"The
chemical structure of aspirin:
also known as acetylsalicylic acid"
The Chemistry of Aspirin [ 4 ]
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The Chemistry of Aspirin
Stability and Reactivity :"- Stability: Stable in dry air."
- Hazardous Decomposition Products: Decomposes to acetic acid
and salicylic acids in the presence of moist air. Carbon dioxide
and carbon monoxide may form when heated to decomposition."
- Conditions to Avoid: Moisture.[ 5 ]
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Contents
- Some Background"- The Chemistry of Aspirin"-Physical
properties "- Synthesis"- Mechanism"- IR and NMR Spectroscopy"-
Biological activity"- Brand names"- Conclusion
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Physical properties [ 6 ]
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Contents
- Some Background"- The Chemistry of Aspirin"-Physical
properties "- Synthesis"- Mechanism"- IR and NMR Spectroscopy"-
Biological activity"- Brand names"- Conclusion
-
According to the above reaction, Salicylic acid is treated with
acetic anhydride causing the reaction that converts the hydroxyl
group on salicylic acid into and ester functionality."
The product of this reaction will be acetyl salicylic acid
(aspirin) and acetic acid. Sulphuric acid or phosphoric acid will
be used as a catalyst.
Reaction :
Synthesis
[ 7 ][ 8 ]
[ 9 ][ 10 ]
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The production of aspirin from raw materials can be divided into
four separate reactions. These are shown:
Synthesis
[ 11 ]
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Contents
- Some Background"- The Chemistry of Aspirin"-Physical
properties "- Synthesis"-Mechanism"- IR and NMR Spectroscopy"-
Biological activity"- Brand names"- Conclusion
-
Mechanism [ 12 ]
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Contents
- Some Background"- The Chemistry of Aspirin"-Physical
properties "- Synthesis"-Mechanism"- IR and NMR Spectroscopy"-
Biological activity"- Brand names"- Conclusion
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IR Spectroscopy [ 13 ]
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NMR Spectroscopy [ 14 ]
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Contents
- Some Background"- The Chemistry of Aspirin"-Physical
properties "- Synthesis"-Mechanism"- IR and NMR
Spectroscopy"-Biological activity"- Brand names"- Conclusion
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Aspirin works by reducing substances in the body that cause
pain, fever, and inflammation."
Aspirin is used to :"
- kill pain"
- reduce fever or inflammation"
- treat or prevent heart attacks, strokes."
Biological activity
[ 15 ]
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Contents
- Some Background"- The Chemistry of Aspirin"-Physical
properties "- Synthesis"-Mechanism"- IR and NMR Spectroscopy"-
Biological activity"- Brand names"- Conclusion
-
Brand names
-
Contents
- Some Background"- The Chemistry of Aspirin"-Physical
properties "- Synthesis"-Mechanism"- IR and NMR Spectroscopy"-
Biological activity"- Brand names"- Conclusion
-
Conclusion
- Aspirin is used for kill pain, reduce fever and prevent hearts
attack."
-Preparation of aspirin by esterfication of salicylic acid and
acetic anhydride"
-The structure of aspirin has been proved by Spectroscopic
instruments as IR and NMR ."
-The melting point = 135
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References1. aspirin-foundation.com/what/timeline.html"2.
inventors.about.com/library/inventors/blaspirin.htm"3.
mindhacks.com/2009/03/09/a-brief-history-of-aspirin"4.
aspirin-foundation.com/what/chemistry.html"5.
chem.uky.edu/courses/che554/0-SafetyIntro/AspirinMSDS.pdf"6.
chemglue4u.com/lab-helper/organic-chem-lab-helpers/synthesis-of-acetylsalicylic-acid-aspirin/"7.
The Organic Chemistry of Biological Pathways by John McMurry and
Tadhg Begley (Roberts
and Company, 2005)"8. Organic Chemistry of Enzyme-Catalyzed
Reactions by Richard Silverman (Academic Press,
2002)."9. K. L. Williamson, Macroscale and Microscale Organic
Experiments, 2nd Ed. 1994, Houghton
Miin, Boston. p379; revised 10/18/06"10. Palleros, Daniel R.
(2000). Experimental Organic Chemistry. New York: John Wiley &
Sons. p."11. aspirin-foundation.com/what/reactions.html"12.
Carstensen, J.T.; F Attarchi and XP Hou (1985). "Decomposition of
aspirin in the solid state in
the presence of limited amounts of moisture". Journal of
Pharmaceutical Sciences 77 "13. stonybrook.edu"14.
biosite.dk/leksikon/acetylsalicylsyre.htm"15.
drugs.com/aspirin.html
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Thank you for your attention
