ASMS 2017

ASMS 2017 Press Conference

Contents

Pain Points

Introductions before ASMS 2017

• Intuvo 9000 GC/MS Systems

• InfinityLab LC/MSD

• 6495B iFunnel LC/TQ

• 6545XT AdvanceBio LC/Q-TOF

Introductions at ASMS 2017

• BioConfirm B.09

• 7250 GC/Q-TOF

• Ultivo LC/TQ

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Safe Harbor This presentation contains forward-looking statements (including, without limitation, information and future guidance on the company’s goals, priorities, revenues, operating profit and operating margin, growth opportunities, customer service and innovation plans, new product introductions, financial condition and considerations, earnings, share repurchases, dividends, ability to access capital markets, the continued strengths and expected growth of the markets the company sells into, operations, operating earnings, and tax rates) that involve risks and uncertainties that could cause results of Agilent to differ materially from management’s current expectations. The words “anticipate,” “plan,” “estimate,” “expect,” “intend,” “will,” “should” “forecast” “project” and similar expressions, as they relate to the company, are intended to identify forward-looking statements.

In addition, other risks that the company faces in running its operations include the ability to execute successfully through business cycles; the ability to successfully adapt its cost structures to continuing changes in business conditions; ongoing competitive, pricing and gross margin pressures; the risk that our strategic and cost-cutting initiatives will impair our ability to develop products and remain competitive and to operate effectively; the impact of geopolitical uncertainties on our markets and our ability to conduct business; the impact of currency exchange rates on our financial results; the ability to improve asset performance to adapt to changes in demand; the ability to successfully introduce new products at the right time, price and mix, and other risks detailed in the company's filings with the Securities and Exchange Commission, including our annual report on Form 10-Q for the quarter ended January 31, 2017.

The company assumes no obligation to update the information in these presentations. These presentations and the Q&A that follows include non-GAAP measures. Non-GAAP measures exclude primarily the future impacts of acquisition and integration costs, pension curtailment gain, transformational initiatives, business exit costs and divestiture, and non-cash intangibles amortization. Also excluded are tax benefits that are not directly related to ongoing operations and which are either isolated or cannot be expected to occur again with any regularity or predictability. Most of these excluded amounts pertain to events that have not yet occurred and are not currently possible to estimate with a reasonable degree of accuracy. Accordingly, no reconciliation to GAAP amounts has been provided.

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ASMS 2017 Press Conference

Monty Benefiel

Vice President/General Manager

Mass Spectrometry Division

Jim Yano

Vice President/Marketing

Mass Spectrometry Division

ASMS 2017

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Agilent Results Q2’17

Deliver Above Market Growth

Expand Operating Margins

Agilent at ASMS 2017

Breakfast Sessions in Hospitality Suite, June 5–7

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AGILENT SATURDAY INNOVATION SYMPOSIUM Saturday, June 3 | 5:00–9:30 p.m. The Westin Indianapolis | 241 W Washington St. Indianapolis, IN 46204 Keynote: Enabling BioTherapeutic Discovery and Development Through Application of Advanced Mass Spectrometry Kevin Bateman, Ph.D., Pharmacokinetics, Pharmacodynamics, and Drug Metabolism Department Merck Research Labs

BIOLOGICAL RESEARCH PHARMA/BIOPHARMA FOOD/ENVIRONMENTAL

Agilent Customer Event Breakout Sessions

Date/Time Topic Speaker

Monday, June 5, 7:00–8:00 a.m.

Put the Pro in Protein Characterisation

Aaron Boice

Tuesday, June 6, 7:00–8:00 a.m.

Improve your outcomes with Agilent Triple Quadrupole LC/MS

Patrick Jeanville, Theresa Sosienski

Wednesday, June 7:00–8:00 a.m.

Think GC/MS couldn’t get any better? Think

Breaking traditions, not ions – new frontiers with GC/Q-TOF

Maggie Ostrowski Nathan Eno Becki Veeneman

ASMS 2017 Agilent Customer Event Breaking Tradition to Make a Difference Together!

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Conferees can cast their vote in the Hospitality Suite

Breast Cancer Research Foundation

Autism Speaks

Alzheimer’s Association

My Thoughts About Today’s MS Market

What Do I Hear From Our Customers?

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Pain Points

Make Them Go Away

Pain Points Confirm and Establish Priority

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Frost & Sullivan Survey Commissioned by Agilent Technologies

700 Managers

5 Markets Pharma and Biotech

Chemical, Energy and Mining

Food, Flavors and Fragrances

Environmental

Diagnostics and Clinical (Hospital)

First results: Highlights

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• Globally, 73% of respondents find ‘instrument maintenance/downtime’ to be their biggest challenge in managing their laboratories.

• Other key challenges (ranked in order from second to fifth), included: complexities around testing requirements (63%), time consumed on sample preparation (60%), keeping up with the changing regulations (52%) and need for better management of data (50%).

Instrument Maintenance/

Downtime

• 40% of respondents indicated that there is need to optimize workflow in their laboratory. Of those who indicated that this is the case, the main strategic changes that can be introduced to optimize workflow were listed as improving productivity and throughput (51%), followed by streamlining processes (26%) to manage growing workloads.

Workflow Optimization

• The majority of respondents (58%) indicated that their main business objective over the next 18 months is to ensure higher throughput/ productivity.

• Almost half (45%) of lab managers report that they face significant pressure to process more samples per week.

Throughput/ Productivity

• Approximately 20% of lab managers consider size/footprint to be a challenge affecting their laboratory performance. Of those, 75% believe space-saving designs of instruments can help overcome this challenge.

Size/ Footprint

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Horsepower

Performance Pain Point

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May not need more

horsepower

Performance Pain Point

of respondents list “complexity of test requirements” in their top 5 challenges

I really need better handling!

63%

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Downtime

Designed for supportability…

75% of respondents globally find “instrument maintenance /downtime” to be their biggest challenge in managing their laboratories

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DATA MANAGEMENT

The Newest Pain Point is

Just as Problematic…

50% 45%

of respondents list “better management of data” among their top 5 challenges

of respondents indicated that they face significant pressure to process more samples per week – in turn, increasing the challenges associated with data management

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Labs are crowded! Space is expensive!

The mass spec is on the bottom of

the cart

Bigger is NOT always better

~20%

of lab managers consider size/footprint to be a challenge directly affecting their lab performance

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Complete the Workflow

Image: Michael Paraskevas [CC BY-SA 3.0 (http://creativecommons.org/licenses/by-sa/3.0)], via Wikimedia Commons

40%

of respondents indicated that there is need to optimize workflow to improve productivity and throughput

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Finish Line Better Outcome

Innovation With Purpose

Professor Rick Yost, Univ of Florida “The number of mass spectrometrists at ASMS remains about 1000, but the

number of MS users has increased attendance to more than 6000”

Developed for Today’s Mass Spectrometrist and MS User

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What Has Happened in the

Last Year?

ASMS 2016 ASMS 2017

June

S M T W T F S

1 2 3 4 5 6 7 8 9 10

11 12 13 14 15 16 17 18 19 20 21 22 23 24

25 26 27 28 29 30

June

S M T W T F S

2 3 4 5 6 7 8 9 10 11

12 13 14 15 16 17 18 19 20 21 22 23 24 25

26 27 28 29 30

1

Mass Spec Introductions Since ASMS 2016

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• Intuvo 9000 GC/MS (SQ & TQ)

• InfinityLab LC/MSD (SQ)

• 6545XT AdvanceBio LC/Q-TOF

• 6495B iFunnel TQ

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Intuvo 9000 GC/MS

A completely re-imagined integrated system of GC consumables,

MS services & software

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Intuvo 9000 GC Innovations Disposable

guard chip

No-trim column

Direct heating

Modular Intuvo flow chips

Ferrule-free click-and-run connections

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Innovation With Purpose Disposable

guard chip

No-trim column

Direct heating

Modular Intuvo flow chips

Ferrule-free click-and-run connections

Save money

• Less space – Less power

Increase throughput

• Faster heating – Faster cooling

Avoid downtime

• Leak-free connections

• Consistent retention times

Simplify staff training

• Smart key self-aware

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Innovation With Purpose

62% of respondents had sustainability goals for reducing energy consumption

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InfinityLab Single Quad

LC/MSD

Stackable with 1260 or 1290 Infinity II LC

ESI, AJS, APCI, APPI & multimode ion sources

OpenLAB CDS ChemStation edition • Walkup, Mass-based

Purification, 2D-LC, CE, and more

OpenLAB CDS 2.0 • Pharma compliance • Next generation CDS

features

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6495B Triple Quadrupole MS iFunnel Sensitivity

Harmonize 6495 & 6470

• Mass Range, Scan Speed, Polarity Switching, MRM Dwell Time

Upgrade option from 6470 to 6495 iFunnel

No-vent maintenance

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BioPharma Workflows

Intact Proteins mAb Subunits Peptide Mapping PTMs • Disulfide Mapping • Glycan Characterization • Deamidation • Methionine Oxidation

ADCs

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6545XT AdvanceBio LC/Q-TOF

For Research Use Only. Not for use in diagnostic procedures.

For large biomolecules

• SWARM autotune

• Mass range to 30k m/z

• 50K resolution

• Quick-start protein method

No-vent maintenance

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What Will Excite ASMS Conferees?

Better HRAM Data

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Intact Protein Raw Spectral Quality

Analytical Sensitivity and Dynamic Range of Glycosylated Intact mAb

Linear Range: > 3.2 orders (0.0316->50ng)

Intact Protein Deconvolved Mass Accuracy and Isoform Detection

10’s of Samples? 100’s of Samples? 1,000’s of Samples? OK!

For Research Use Only. Not for use in diagnostic procedures.

Exceptional Data

Robust Operation 98%

of respondents list instrument reliability among the top 3 factors in an instrument purchase

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Kevin Bateman, PhD Distinguished Scientist Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM) Merck

Plenary Address: Enabling BioTherapeutic Discovery and Development Through Application of Advanced Mass Spectrometry

“I have been impressed with the data quality from the new 6545XT Q-TOF and expect the instrument to have a significant impact on our growing LC-MS based protein quantitation workflows.”

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CrossLab Service

AssayMap Bravo Sample Preparation 6545XT AdvanceBio

LC/Q-TOF

1290 Infinity II UHPLC

AdvanceBio Columns

MassHunter Walkup

BioConfirm ADC-DAR

Calculator

Productive Workflow is More Than an MS

40%

ASMS 2017 Introductions

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BioPharma Workflow: BioConfirm Software

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BioConfirm BioPharma Workflows

MS expertise NOT required!

Press the green button

Answer five questions about your sample

BioConfirm will tell you how well the protein was confirmed, along with reports and results

Tell BioConfirm how you prepared

the sample; then collect the report!

• Quantitation of glycoforms

• Quantitation of other PTMs

• Identification of released glycans

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BioConfirm B.09 Responding to Our Customers

High Resolution Accurate Mass: Q-TOF for GC/MS

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Horsepower

7250 GC/Q-TOF Defined by Agilent Collaborators

Collaborators Wanted MORE!

June 5, 2017 ASMS 2017 39

Industry collaborator

Industry collaborator

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7250 GC/Q-TOF

Improved Performance

• Higher resolution

• Better mass accuracy

• Wider dynamic range

Reproducible EI Spectra

• NIST searchable

SureMass Spectral Processing

• Deconvoution for HR-AM data

High Sensitivity EI Source

• Sensitive Low Energy EI with less fragment ions

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7250 GC/Q-TOF Exceed method requirements even in very complex matrices

Achieved by combining:

• Higher mass resolution

• Higher ion count from High Efficiency Source (HES)

7250 GC/Q-TOF

0.8 ppm (0.15 mDa) R=24645

7200B GC/Q-TOF

Not Detected

Analyte level: 5 ppb 2X below 10 ppb MRL

Low Energy EI Compound Identification in Complex Matrix

June 5, 2017 ASMS 2017 42

70 eV matrix: gas oil

15 eV matrix: gas oil

10 eV matrix: gas oil

3,5-dimethylbenzothiophene

M+

Low eV selectivity

CI-like spectra

M+ precursor for MS/MS

HES (High Efficiency Source)

sensitivity

Unbelievably Powerful and Remarkably Small LC/MS

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Approximately 20% of lab managers consider size/footprint to be a challenge affecting their laboratory performance Of those, 75% believe space-saving designs of instruments can help overcome this challenge

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Ultivo

Triple Quad

Infinity II

HPLC Stack

79 cm

31.1 in 39 cm

15.4 in

32 cm

12.6 in

Ultivo Triple Quadrupole LC/MS The Ultimate Evolution in Quadrupole LC/MS/MS

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Ultivo Triple Quadrupole LC/MS The Ultimate Evolution in Quadrupole LC/MS/MS

Ultivo

Triple Quad

Infinity II

HPLC Stack

15.4 inches

46

5 feet

6460 LC/MS System

Ultivo Innovation Goals: Space-saving, Sensitive, Robust & Serviceable

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Cyclone Ion Optics (Dual Twisted Hexapoles)

Vortex Collision Cell (Twisted Hexapole)

During the week of ASMS, Innovation Minute videos will be released to describe the

Cyclone Ion Optics and Vortex Collision Cell

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Dual, Twisted Hexapoles

Cyclone Ion Guide

Ultivo Innovation Goals: Space-saving, Sensitive, Robust & Serviceable

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Virtual

DC Filters (Ultra Thin)

Hyperbolic

Quadrupoles (Proprietary Process)

During the week of ASMS, an Innovation Minute video will be released to describe the

Virtual DC Filters

93%

Ultivo Innovation Goals: Space-saving, Sensitive, Robust & Serviceable

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Agilent Jet

Stream Ion

Source

HED Detector (Accessible in Stack)

VacShield (No-vent Maintenance)

of respondents emphasized the importance of “ease of maintenance and repairs”

Ultivo Innovation Goals: Space-saving, Sensitive, Robust & Serviceable

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Agilent Jet

Stream Ion

Source

HED Detector (Accessible in Stack)

VacShield (No-vent Maintenance)

Vortex Collision Cell (Twisted Hexapole)

Cyclone Ion Optics (Dual Twisted Hexapoles)

Virtual

DC Filters (Ultra Thin)

Hyperbolic

Quadrupoles (Proprietary Process)

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Mycotoxins in Food

20X lower than MRL for most mycotoxins RSD <10% for all mycotoxin

• Most <5% 0

2

4

6

8

10

12

14

Corn Peanut Black Pepper

1/5 MRL 1/10 MRL 1/20 MRL

Matrix

# o

f M

yc

oto

xin

s

• 12 mycotoxins in corn and peanuts

• 5 mycotoxins in black pepper

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Polar Organics in Drinking Water

PPCPs, pesticides, etc. Meets MDL of regulatory methods Linearity: R2 > 0.99

• 0.5 - 200ng/L

19 TOrCs < 0.5 ng/L 10 TOrCs

0.5 - 5 ng/L

2 TOrCs 5 – 10 ng/L

Measured Detection Limit (10 ng/L)

ng/L = ppt

<0.5 ng/ L, 19 TOrCs 0.5 - 5 ng/ L, 10 TOrCs

>5 ng/ L, 2 TOrCs

a b

c

Quant-My-Way

• Administrator tailors feature set to each method

• All operators – even novices – experience faster, easier and error-free analysis, review and reporting

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Next Generation of LC/TQ: ”Fit for Purpose”

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ULTIVO LC/TQ

Reduced footprint Accurate measurements Robust 24/7 for months Fast, simple maintenance Novice-friendly operation Quickly achieve high ROI

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Innovation With Purpose

Developed for Today’s Mass Spectrometrist and MS User

Innovation With Purpose (December 2016–May 2017)

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Dec ‘16 Mar ‘17 May ‘17

#1 The Analytical Scientist Top Innovation Award

Agilent Intuvo 9000 GC System

The Analytical Scientist

Cheshire, UK

Best Webinar Series of the Year

Biopharmaceutical Webinar Series

2017 Scientists’ Choice Award/Pittcon

Chicago, IL

Best New Separation Product

Agilent 1260 Infinity II LC System

2017 Scientists’ Choice Award/Pittcon

Chicago, IL

Most Influential Foreign Manufacturer

Agilent Technologies

Annual Conference of China Scientific Instruments (ACCSI

Nanjing, China

Most Popular Scientific Instrument

Agilent 5977B GC/MS System

Annual Conference of China Scientific Instruments (ACCSI

Nanjing, China

Green Product of the Year

Agilent Intuvo 9000 GC System

Annual Conference of China Scientific Instruments (ACCSI

Nanjing, China