Organised by Dr Jose Prieto Garcia UCL SCHOOL OF PHARMACY | 29-39 BRUNSWICK SQ , WC1N 1AX LONDON

Artificial Intelligence + In silico Methods + Chemical Libraries: the new equation to Drug Discovery from Natural Products

UCL-FRENCH EMBASSY COLLABORATIVE S&T WORKSHOPS (2018-19)

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Application Form Please complete the following sections: Lead applicant names (UCL and France)

Dr Jose M. Prieto, UCL School of Pharmacy, Course Director MSc in Medicinal Natural Products & Phytochemistry. Prof. Bruno David, Medical School of Toulouse & Research Director in R&D of Natural Substances at the Research institute Pierre Fabre.

Title of proposed workshop: Aims and objectives. Indicate benefits to Applicants’ research programmes at UCL and in France including potential for future collaborative activities. (minimum 500 words; maximum 1000 words)

AIMS: To establish a Franco-British research network for the discovery of new active natural products for infective diseases and neurodegeneration. Objectives: - To establish a Franco-British academic group to advance bilateral natural products

research. - To create a solid and diverse bilateral research network able to deliver innovative

approaches and build up competitive projects at international level. Background: Drug Discovery from natural sources during the 20th century provided Medicine with innovative drugs by exploiting the concept of Natural Products Libraries and High-Throughput Screening [1]. The 21st century started with a major shift towards in silico Methods (such as docking) of virtual libraries [2] as the Biodiversity conventions discouraged in many cases the use of natural products in pharmaceutical research. The output of this new approach has been much lower and expensive than expected [3] prompting a new fresh look at natural products as a most effective source of drug leads [4]. This particularly holds in fields such as Infective diseases (example: artemisinin) and Neurodegeneration (example: galanthamine). The 2014 Nobel Prize to was a timely reminder of the opportunities in this multidisciplinary endeavour called pharmacognosy [5].

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As we approach 2020, artificial intelligence has gained the necessary momentum to promise a new change in research and development [6]. At the same time, protection of biodiversity is better regulated and less of an obstacle [7]. USA approved a new class of Medicines (Botanical drugs) which is providing new therapeutic avenues for difficult conditions [8]. It is time to reformulate drug discovery from natural products as a valid and innovative source of new medicines in our countries too. Objective 1: A sustainable Franco-British Network for Natural Products Research Differently to UK academics, French researchers on Natural products have a recognisable professional body (Association Francophone pour l'Enseignement et la Recherche en Pharmacognosie -AFERP). As a result, all past Franco-British collaborations on Natural Products Discovery were dependent on wider European associations or they formed upon individual interactions. We here aim to create a visible Franco-British network on natural products to stimulate bilateral scholarly collaborations and provide an example to our colleagues for sustainable interactions. Given the current scenario this may be also perceived as a positive message for post-Brexit scientific collaborations across the Channel. Deliverable 1: A web page will be created highlighting our aims, expertise and inviting both French and British colleagues to join our network. Objective 2: Mapping of Research Opportunities to Exploit AI/Molecular Networks (target: novel Anti-infective and Neuroprotective natural products). Each participant in this application is at the forefront of all the above-mentioned R&D approaches to natural products: Prof David (Univ Toulouse/Pierre Fabre) holds enormous expertise in both Biodiversity issues and Natural Libraries (both private and open) and will discuss whether these are still valid avenues for any future research efforts [9]. Dr Prieto (UCL), Dr Genta-Jouve (Paris-Descartes) and Dr Ebel-Edrada (Strathclyde) have been developing Artificial Intelligence-platforms for the anticipation and prediction of bioactivities of complex natural products [10-12]. Prof Okello (Newcastle), Dr Rahman(LJMU)/Prof Gibbons(UCL) are experts on the discovery of natural products for Neurodegeneration [13] and Infective diseases [14], respectively. Dr Beniddir will provide leadership in the application of more streamlined methods exploiting Molecular Networks [15]. Finally, Dr. Olusola (Sola) Idowu will provide with the necessary know-how and industrial perspective to help establishing academia-private sector links with mutual interests in the development of Natural Products as medicines and other healthcare products [16]. Deliverable 2: A detailed conceptual map of the win-win opportunities for each group to collaborate with others in a way that maximises expertise and minimising technical overlapping. Deliverable 3: A report identifying immediate topics which could be put forward in collaborative applications in short term.

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References: (authorship of applicants highlighted in bold) [1] David et al. The pharmaceutical industry and natural products: historical status and new trends. Phytochem Rev (2015) 14:299. [2] Davies et al. Streamlining lead discovery by aligning in silico and high-throughput screening. Curr Opin Chem Biol. (2006) 10:343. [3] Shih, Zhang & Aronov. Drug discovery effectiveness from the standpoint of therapeutic mechanisms and indications. Nat Rev Drug Discov. 2018 Jan;17(1):19. [4] Harvey, Edrada-Ebel & Quinn. The re-emergence of natural products for drug discovery in the genomics era. Nat Rev Drug Discov. (2015) 14:111. [5] Craig Hopp. A Nobel for Natural Product Discoveries . NCCIH Research Blog October 07, 2015. URL: https://nccih.nih.gov/research/blog/natural-product-nobel [6] Gawehn, Hiss & Schneider. Deep Learning in Drug Discovery. Mol Inform. (2016) 35:3. [7] McCluskey et al. The U.S. Culture Collection Network Responding to the Requirements of the Nagoya Protocol on Access and Benefit Sharing. MBio. (2017) 8(4). pii: e00982-17. [8] Frampton. Crofelemer: a review of its use in the management of non-infectious diarrhoea in adult patients with HIV/AIDS on antiretroviral therapy. Drugs (2013) 73:1121. [9] David & Ausseil. High Throughput Screening of Vegetal Natural Substances. Encyclopedia of Analytical Chemistry, Online 2006–2014 John Wiley & Sons, Ltd. [10] Cortes-Cabrera, Daynac & Prieto. Metabolome and bioactivities: artificial neural networks for the prediction of the in vitro antioxidant and antimicrobial activities of essential oils. Planta Med. (2009) 75(9):897. [11] Beauxis & Genta-Jouve. Metwork: a web server for natural products anticipation. Bioinformatics. 2018 Oct 5. doi: 10.1093/bioinformatics/bty864. [12] Chagas-Paula Oliveira Zhang, Edrada-Ebel et al.Prediction of Anti-inflammatory Plants and Discovery of Their Biomarkers by Machine Learning Algorithms and Metabolomic Studies. Planta Med. (2015) 81(6):450. [13] Okello, Abadi & Abadi. Effects of green and black tea consumption on brain wave activities in healthy volunteers as measured by a simplified Electroencephalogram (EEG): A feasibility study. Nutritional Neuroscience (2015) 19(5):196. [14] Rahman & Gibbons Antibacterial constituents of Neohyptis paniculata, Fitoterapia (2015) 105:269. [15] Hoang et al. Metabolomics-Driven Discovery of Meroterpenoids from a Mussel-Derived Penicillium ubiquetum. J Nat Prod. 2018 Nov 26;81(11):2501. [16] Antibacterial Combination Therapy, WO/2009/013480, 2009

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Workshop programme structure:

Format of Workshop (5th and 6th March)

Day 1 (UCL School of Pharmacy) 12.00-1400 Welcoming the participants

Check in of attendants already arrived (Goodenough Club or similarly closer Hotel).

Lunch at the Refectory of the School of Pharmacy.

14.00-1600 Workshop activity (UCL School of Pharmacy Room M3)

16-18.00 Workshop activity (UCL School of Pharmacy Room 228)

(open to UCL Staff and Postgraduate students, max 25) Presentation Slots 20-25 min per presentation, with 5-10 min for questions. Informal setup with Small Break, Coffee/Tea/Water available in the room all time.

14.00 Welcome (Dr Jose M Prieto, UCL, UK) 14.05 Brief Presentation of the UCL SoP Drug Discovery Cluster

(Prof. Matt Todd/, UCL School of Pharmacy, UK) 14.20 “Open Innovation and Natural fragments Library”

(Dr Bruno David, Pierre Fabre-Univ of Toulouse, France) 15.45 “Artificial Intelligence for the prediction of Bioactivities of Complex

Natural Products” (Dr. Jose M Prieto-Garcia, UCL School of Pharmacy, UK)

15.10 “MetWork, a web server for natural products anticipation” (Grégory Genta-Jouve, Université of Paris Descartes, France)

15.35 Tea Break and We move to room 228 15.55 “Unveiling unexpected chemistries from plant metabolomes using

molecular networking”. (Mehdi Beniddir, BioCIS UMR CNRS, France).

16.20 “Drug Discovery and Natural Products at Newcastle University” (Dr Ed Okello, Newcastle University, UK)

16.45 “Natural Products Centre at LJMU: opportunities for collaboration” (Dr Mukhlesur Rahman, Liverpool John Moores University, UK)

17.10 Comfort Break 17.20 “AI techniques to facilitate the development of breakthrough products

in skincare”. ( Dr. Ewa Marciewicz, Hexis Lab) 17.45 “Metabolomics-coupled functional pharmacology” (Dr RuAngelie

Edrada-Ebel, University of Strathclyde, UK) 18.10 Concluding remarks and open discussion

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19.00 Participants leave for their hotels

20.00 Participants Reconvene for Dinner at Brunswick Square Day 2 (UCL School of Pharmacy Room B37) 09.00-13.00 Continuation of workshop

(Only Official Participants and/or selected UCL Academic Staff)

09.00 Open Discussion: opportunities for a sustainable Franco-British Network for Natural Products Research

1. Mapping Synergies between participants 2. Scientific societies relevant to our work (=finding forums to use

as regular meeting points for our network) 3. Mapping Gaps to be filled (i.e. Identifying strategic collaborators

beyond the core participant groups / institutions) 4. How will BREXIT impact our collaboration? Identifying

contingency plans.

10.00 Open Discussion: Mapping of Research Opportunities to Exploit AI/Molecular Networks

1. Opportunities on Anti-infectives 2. Opportunities on Neuroprotective natural products 3. Opportunities on other topics (Skin, Cancer,etc.) 1. Identifying Hot Topics likely to receive funding 2. Identifying current and upcoming Grant Schemes to apply “in

pack”.

11.30-13.00 Next actions, setting a Road Map, Concluding Remarks. 13.00 Group Picture Outside the School

13.00-14.00 Lunch (UCL School of Pharmacy Refectory or Brunswick Sq)

14.00 Depart (to enable same-day journey end)

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Brief biographies of individual participants from UCL and from France should be provided in separate sections below indicating name, position, departmental affiliation, core research interest, three key relevant publications. Note that explicit commitment from all [i.e. up to 16] potential participants is not required at the time of application. However, brief information should be provided on at least three participants from UCL and three from France. If an application is selected for funding, data on the remaining participants will be required before the date of the proposed workshop.

UCL team biographies, 1st Applicant etc (200 words max per biography)

Dr. Bruno David, D.Pharm. (Dijon) Ph.D. (Phytochemistry, CNRS ICSN Gif sur Yvette) Ph.D. Pharmacology (CNRS IPBS Toulouse). Member of the French National Academy of Pharmacy ABS expert for the French Ministry of Research and the European Commission. Positions 2007- Director of Natural Products, R&D Sourcing & Botany. 2000- Professor, School of Medicine, University of Toulouse, France. 1998 - 2007, Head of the Natural Products Drug Discovery joint team (Pierre Fabre Research Institute/CNRS/IRD). 1990 -1998 Head of Phytochemistry. Pierre Fabre Pharmaceutical Group. Before 1990 Lecturer (Paris XI -Sud University, University of Malaya). Publications Co-authored more than 60 publications, books and patents. (1) David, Wolfender, Diaz. The pharmaceutical industry and natural products: historical status and new trends. Phytochemical Reviews, 2015. 14: 299–315 (2) David, Ausseil. High-throughput screening of vegetal natural substances. Book chapter In Handbook of Chemical and Biological Plant Analytical Methods John Wiley Sons, Ltd. Chapter 44, 987-1010, 2014. (3) David. New regulations for accessing plant biodiversity samples, what is ABS? Phytochemical Reviews (2018) 17:1211-1223. (4) Jiang, Vaysse, Gilard, Balayssac, Déjean, Malet-Martino, David, Fiorini, Barbin. (2012). Quality Assessment of Commercial Magnoliae Officinalis Cortex by 1H-NMR-based Metabolomics and HPLC Methods. Phytochemical Analysis: PCA. 23. 387-95. (5) Christophe, Beck, Cantagrel, Marcourt, Vendier, David, Plisson, Derguini, Vandenberghe, Aussagues, Ausseil, Lavaud, Sautel, Massiot, Georges. (2011). Proteasome Inhibitors from Neoboutonia melleri. Journal of natural products. 75. 34-47.

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Jose M Prieto-Garcia, M.Pharm., Ph.D., MRSC, FLS, FHEA j.prieto@ucl.ac.uk Positions 2012 - Course Director MSc in Medicinal Natural Products and Phytochemistry, School of Pharmacy, University College London, London, United Kingdom 2006 -Lecturer in Pharmacognosy, School of Pharmacy, University College London, London, United Kingdom 2005 – 2006 , Postdoctoral Research Fellow European Commission FP6, Project COOP-CT-2004-512696. School of Pharmacy, University of London, London, UK 2001 – 2004, Postdoctoral Research Fellow, European Community's Improving Human Potential Programme, Project: HPRN-CT1999-0054. School of Pharmacy, University of Pisa, Pisa, Italy. Education School of Pharmacy, University of Valencia, Valencia, Spain Ph.D. in Pharmacology, 2001, “Excellent Cum Laude” M.Pharm. 1993, Honors: “Excellent”. Key Publications Book chapters (4); Full papers (54); Short papers (3); Communications to Congresses (44). (1) Prieto. “Artificial intelligence for the modelling and prediction of complex natural products bioactivities”, In “Artificial Intelligence: Advances in Research and Applications”, 2017, Pages 277-300. Ed. Luis Rabelo, Nova publishers, New York, ISBN: 9781536126785. (2) Hanafi, Afzan, Yaakob, Aziz, Sarmidi, Wolfender, Prieto. In Vitro Pro-apoptotic and Anti-migratory Effects of Ficus deltoidea L. Plant Extracts on the Human Prostate Cancer Cell Lines PC3. Frontiers in Pharmacology (2017) 8:895. (3) Al-Qathama, Gibbons, Prieto. Differential Modulation of Bax/Bcl-2 ratio and onset of Caspase 3/7 activation induced by derivatives of Justicidin B in human melanoma cells A375. Oncotarget (2017) 8:95999-96012. (4) Daynac, Cortes-Cabrera, Prieto. 2015. Application of Artificial Intelligence to the Prediction of the Antimicrobial Activity of Essential Oils. Evidence-Based Complementary and Alternative Medicine (2015) Article ID 561024, 9 pages,. (5) Cortes-Cabrera , Prieto. Application of artificial neural networks to the prediction of the antioxidant activity of food additives: the case of essential oils. Food Chemistry (2010) 118(1): 141-146.

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France team biographies, 2nd Applicant etc (200 words max per biography) FRENCH SECONDARY APPLICANTS: Mehdi Beniddir, Pharm.D, Ph.D. Associate professor of natural product chemistry Address: Université Paris-Saclay, Univ. Paris-Sud, BioCIS, 5 Rue J.–B. Clément, 92290 Châtenay-malabry Email: mehdi.beniddir@u-psud.fr Education 2009-2012 Ph. D. Chemistry of Natural Products, Paris-Sud University, ICSN-CNRS, France. 2007-2009 M.Sc: Synthesis, pharmaceutical chemistry and natural products R&D, Paris-Sud University, France. 2002-2007 Pharm. D. University of Algiers, Algeria. Professional Experience 2014 Associate Professor of Pharmacognosy, Paris-Saclay University. 2012-2014 Post Doctoral Researcher, Paris-Sud University (France) with Prof. Dr. Erwan Poupon. Publications list 1. Hoang, Roullier, Boumard, Robiou du Pont, Nazih, Gallard, Pouchus, Beniddir, Grovel. Metabolomics-driven discovery of meroterpenoids from a mussel-derived Penicillium ubiquetum. Journal of Natural Products, 2018, 81, 2501-2511. (IF = 3,281). 2. N’Nang, Bernadat, Mouray, Kumulungui, Grellier, Poupon, Champy, Beniddir*Theionbrunonines A and B: dimeric vobasine alkaloids tethered by a thioether bridge from Mostuea brunonis. Organic Letters, 2018, 20, 6596-6600. (IF = 6.492) 3. Duong, Le Pogam, Beniddir, Nguyen, Nguyen. Two new triterpenoids from the roots of Phyllanthus emblica. Fitoterapia 2018, 130, 140-144. (IF = 2.642) 4. Duong, Beniddir, Nguyen, Aree, Gallard, Mac, Nguyen, Bui, Boustie, Nguyen, Chavasiri, Le Pogam. Sulfonic acid-containing flavonoids from the roots of Phyllanthus acidus. Journal Natural Products 2018, 81, 2026-2031. (IF = 3,281). 5. Duchemin, Skiredj, Mansot, Leblanc, Vasseur, Beniddir, Evanno, Poupon, Smietana, Arseniyadis. DNA-Templated [2+ 2] photocycloaddition: a straightforward entry into the aplysinopsin family of natural products. Angewandte Chemie International Edition, 2018, 57, 11786-11791. (IF = 11,70).

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Grégory Genta-Jouve, Ph.D. Université of Paris Descartes. Laboratoire de Chimie-Toxicologie Analytique et Cellulaire (C-TAC), UMR CNRS 8638 COMETE 4 Avenue de l’observatoire, 75006 Paris Email: gregory.genta-jouve@parisdescartes.fr Education 2015 Habilitation (HDR), University Paris Descartes 2008–2011 Ph.D. Analytical Chemistry, Advisor: Prof. Olivier P. Thomas, University of Nice Sophia-Antipolis. Academic appointments 2018-2019 Visiting Associate professor, National Museum of Natural History, Paris (délégation CNRS). 2013–present Associate professor in Natural Products Chemistry and Metabolomics, University Paris Descartes. 2012–2013 Postdoctoral associate, Advisor: Prof. Mark Viant, University of Birmingham. 2011–2012 Postdoctoral associate, Advisor: Prof. Olivier P. Thomas, University of Nice Sophia-Antipolis. Peer-reviewed journal articles Number of publications: 67 (1) Fu, Houël, Amusant, Touboul, Genta-Jouve, Della-Negra, Fisher, Brunelle, Duplais. Biosynthetic investigation of g-lactones in Sextonia rubra wood using in situ TOF-SIMS MS/MS imaging to localize and characterize biosynthetic intermediates. Scientific Reports, 2019, [Epub ahead of print] (IF 4.259) (2) Vallet, Strittmatter, Murua, Lacoste, Dupont, Hubas, Genta-Jouve, Gachon, Kim, Prado. Chemically-Mediated Interactions Between Macroalgae, Their Fungal Endophytes, and Protistan Pathogens. Metabolomics-driven discovery of meroterpenoids from a mussel-derived Penicillium ubiquetum. Frontiers in Microbiology, 2018, 9:3161 (IF 4.019). (3) Silva, Oberhansli, Tribalat, Genta-Jouve, Teyssie, Dechraoui-Bottein, Gallard, Evanno, Poupon, Thomas. Insights into the Biosynthesis of Cyclic Guanidine Alkaloids from Crambeidae Marine Sponges. Angewandte Chemie International Edition, 2018, 58(2): 520 (IF 12.10) (4) Hong, Bolard, Giraud, Prévost, Genta-Jouve, Deregnaucourt, Häussler, Jeannot, Li. Azetidine-containing Alkaloids Produced by a Quorum-sensing Regulated Non-ribosomal Peptide Synthetase Pathway in Pseudomonas aeruginosa. Angewandte Chemie International Edition, 2018, [Epub ahead of print] (IF 12.10) (5) Beauxis and Genta-Jouve. MetWork a web server for natural products anticipation. Bioinformatics, 2018, [Epub ahead of print] (IF 5.481).

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BRITISH SECONDARY APPLICANTS Dr Edward Okello, BSc (Hons.), MSc., PhD Executive Director of the Medicinal Plant Research Group Email: edward.okello@ncl.ac.uk Address: Human Nutrition Research Centre, Institute of Cellular Medicine Leech Building, Medical School, Newcastle University, NE2 4HH Funding Norvatis, Rington’s Tea Company, Mental Health Foundation, Royal Society, DEFRA, KTP with Citrox Limited, Wellcome Trust Summer Studentship, BBSRC CASE Studentship,Wirz Herbs. Selected Publications (1) Neto, Okello. In vitro Fermentation Method as a Tool to Assess the Effects of

Secondary Metabolites on Rumen Fermentation—A Brief Review. Journal of Agricultural Science 2018, 10(6), 28-32.

(2) Okello, Howes. Essential oils and aromas that affect mood and cognition. In: Philip N. Murphy, ed. Routledge International Handbook of Psychobiology. London and New York: Routledge, 2018, pp.195-208.

(3) Zakaria, Okello, Howes, Birch-Machin, Bowman. In vitro protective effects of an aqueous extract of Clitoria ternatea L. flower against hydrogen peroxide-induced cytotoxicity and UV-induced mtDNA damage in human keratinocytes. Phytotherapy Research 2018, 32(6), 955-1144.

(4) Watson, Okello, Brooker, Lester, McDougall, Wesnes. The impact of blackcurrant juice on attention, mood and brain wave spectral activity in young healthy volunteers. Nutritional Neuroscience 2018, epub ahead of print.

(5) Okello & Abadi. Effects of green and black tea consumption on brain wave activities in healthy volunteers as measured by a simplified Electroencephalogram (EEG): A feasibility study. Nutritional Neuroscience 2015, 19(5):196.

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Dr Ruangelie Edrada-Ebel Senior Lecturer Head of the Natural Products Metabolomics Group (NPMG) Strathclyde Institute of Pharmacy and Biomedical Sciences email: ruangelie.edrada-ebel@strath.ac.uk Scholar output Over 100 publications and two patents on the topic marine natural products. Recent Publications: (1) Bafor E, Eze, Omoruyi, Elvis-Offiah , Viegelmann, Edrada-Ebel. Green tea inhibits

uterine contractility in ex vivo (non-pregnant) mice models. Tropical Journal of Natural Product Research 2: 254-261 (2018).

(2) Bafor E, Nwogu , Elvis-Offiah , Amaechina, Ofeimun, Ayinde, Omoruyi, Viegelmann, Edrada-Ebel. Modulation of ex-vivo uterine contraction by the methanol leaf extract of Alchornea laxiflora Benth. (Euphorbiaceae) and preliminary spectrometric identification of associated secondary metabolites Journal of Medicinal Plants For Economic Development. 2(1)a33 (2018). (3) Bafor , Rowan , Edrada-Ebel. Metabolomics-coupled functional pharmacology of chlorophyll compounds isolated from the leaves of Ficus Exasperata Vahl (Moraceae) provides novel pathways on myometrial activity Reproductive Sciences 25: 923-937 (2018). (4) Edrada-Ebel, Ævarsson, Polymenakou, Hentschel, Carettoni, Day, Green, Hreggviðsson , Harvey, McNeil. SeaBioTech : from seabed to test-bed: harvesting the potential of marine biodiversity for industrial biotechnology. Grand Challenges in Marine Biotechnology pp 451-504 (2018). (5) Tawfike , Abbott, Young, Edrada-Ebel. Metabolomic-guided isolation of bioactive natural products from Curvularia sp., an endophytic fungus of Terminalia laxiflora. Planta Medica 84: 182-190 (2018).

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Dr Mukhlesur Rahman 2019- Senior Lecturer, School of Pharmacy and Biomolecular Sciences, Faculty of Science, Liverpool John Moores University, UK 2014-2019 Senior Lecturer in Pharmaceutical Science and Programme Leader of Pharmaceutical Science, Medicine Research Group, Health, Sport and Bioscience, University East London Email: m.rahman@uel.ac.uk Education BPharm (Hons) and MPharm (postgraduate) , University of Dhaka, Bangladesh PhD in Pharmaceutical Sciences, University of Strathclyde, Glasgow, UK. Postdoc Research Fellow, School of Pharmacy, University of London, UK Scholarship Fellow of the Higher Education Academy (FHEA), Fellow of the Royal Society of Chemistry (FRSC), Royal Society of Biology (MRSB), American Society of Pharmacognosy, International Society of Ethnopharmacology, Phytochemical Society of Europe and Academy of Pharmaceutical Sciences of Great Britain. Publications (1) Amaning Danquah, Kakagianni, Khondkar, Maitra, Rahman, Evangelopoulos, McHugh, Stapleton, Malkinson, Bhakta, Gibbons. (2018). Analogues of Disulfides from Allium stipitatum Demonstrate Potent Anti-tubercular Activities through Drug Efflux Pump and Biofilm Inhibition. Scientific Reports. 8. 10.1038/s41598-017-18948-w (2) Rahman, Shiu, Gibbons, Malkinson. (2018) Total synthesis of acylphloroglucinols and their antibacterial activities against clinical isolates of multi-drug resistant (MDR) and methicillin-resistant strains of Staphylococcus aureus, European Journal of Medicinal Chemistry, 155: 255-262. (3) Rahman, Gibbons (2015) Antibacterial constituents of Neohyptis paniculate. Fitoterapia 105:269-272. (4) Xia, Sun, Lou, Rahman (2014) Conversion of Conversion of salvianolic acid B into salvianolic acid A in tissues of Radix Salviae Miltiorrhizae using high temperature, high pressure and high humidity. Phytomedicine 21(6):906-11. (5) Kamal, Shaheen Sharif, Rahman, Rahman (2018) Potential antimicrobial activity of Achyranthes bidentata methanol extract against both gram (+) ve and gram (-) ve bacteria. Pharmacologyonline, 3:30.

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Ewa Markiewicz Dermatology Research Consultant Hexis Lab Limited, UK The Core, Newcastle Helix, Bath Lane, Newcastle, NE4 5TF M: +44 (0) 775 380 1278 T: +44(0) 191 495 7311 E: ewa@hexislab.com; ewamarkiewicz6@gmail.com W: www.hexislab.com Profile I hold PhD in Biochemistry and my professional experience has been built in the area of molecular dermatology, cell technologies and premature ageing through independent and collaborative research. Throughout my work I secured substantial external basic and translational collaborative research income from national and international funding bodies, government and commercial organizations. I also published peer reviewed articles mostly as first, senior and corresponding author leading to novel areas of development. Presently I am involved in both academic research and building working relationships with innovative businesses in life sciences and healthcare sector. Human ageing is caused by not only chronological processes, but also extrinsic factors associated with stress. We have identified the biomarkers that define the sensitivity to genotoxic and biophysical stress; therefore, have the capacities to counteract external damage and premature ageing. Focusing on human skin and molecular approaches combined with tissue engineering, we characterize the mechanisms of interactions with stress-inducing environment in three specific, mutually inclusive areas: 1) Aged Dermis-Epidermis Interaction; 2) Subcutaneous Adipose Tissue; 3) Wound Healing Response. We apply the next generation databases and artificial intelligence modeling approach towards multiple bionetworks, screening and design of bio-active compounds for development of novel interventions in skin rejuvenation and personalized skincare. Key publications Markiewicz E. and Idowu O. 2018. Involvement of the nuclear structural proteins in aging-related responses of the skin to the environmental stress. Clin Cosmet Investig Dermatol. 11, 297-307 Markiewicz E. and Idowu O. 2018. Personalised skincare: from molecular basis to clinical and commercial applications. Clin Cosmet Investig Dermatol. 11, 161-171

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Dr. Olusola (Sola) Idowu, PhD (Will be represented by Dr Markiewicz) Email: sola@hexislab.com PhD Mathematics Newcastle University, Newcastle upon Tyne, UK, 1997 – 2000 -CEO of HexisLab Limited. -Postdoctoral Research Fellow at Stanford University, School of Engineering, California from 2000 to 2002, -Postdoctoral Research Fellow at Newcastle University, School of Computing Science from 2002 to 2005. During his research at Newcastle University and Stanford University, he developed mathematical models for assessing and estimating the structural significance of complex interacting components and methods for predicting hidden topological structures in complex systems. The knowledge gained in his previous research was applied at e-Therapeutics plc for identifying synergistic multiple points of intervention in integrated interactomes leading to clinically validated multi-target drugs with polypharmacology. Sola was involved in the scientific projects and research that led to the formation of e-Therapeutics plc a network pharmacology and drug discovery company listed in the London stock exchange. He was responsible for building the technical infrastructure for drug discovery research and development. He led the discovery of 7 repositioned candidates in 2 years documented in different patents. One candidate, Dexanabinol (derived from a natural product), is currently in advanced oncology clinical trials at different hospitals in the UK and USA. Patents and publications Controlled Release Treatment of Depression, WO/2010/004256, 2010 Antibacterial Combination Therapy, WO/2009/013480, 2009 Dexanabinol with Inhibitors of BRAF or MEK for the Treatment of Melanoma, WO/2009/047505, 2009 Treatment of Melanoma, WO/2009/007700, 2009 Compositions and Methods for the Treatment of Fibromyalgia, WO/2009/136176, 2009 Treatment of Depression, WO/2009/001040, 2009 Clotrimazol for Treating Staphylococcal Infections, WO/2008/059261, 2008 Imidazoles for Treating Multi-drug Resistant Bacterial Infections, WO/2008/059258, 2008 Other publications Publications - Google Scholar Reference http://scholar.google.com/citations?user=qkLfgyMAAAAJ&hl=en&oi=ao

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MAP AND CONTACT DETAILS

From Euston, King’s Cross or St Pancrass Stations to the School of Pharmacy (RED SIGNPOST) Traverse to opposite side of the Road (Yellow Avenue), walk to Judd Street, all straight to Brunswick Square. The President Hotel is right back Russel Sq Station (5 min from the School) almost ‘opposite’ to The British Museum. MOBILE PHONE (Dr Jose M Prieto) (+44)(0)7533048718 School of Pharmacy (+44)(0)20 7753 5800