ars.els-cdn.com · Web view2016-09-29 · Encoded protein is a member of the delta-2 protocadherin subclass of the cadherin superfamily. ... V-myc myelocytomatosis viral oncogene

Supplementary Table 8 – Selection criteria, associated cancers, and references for targeted genesSignificant gene death

Gene Full name Function Associated cancers

Reference

ACSL3 Acyl-CoA synthetase long-chain family member 3

Encodes an isozyme of the long-chain fatty-acid-coenzyme A ligase family

Converts free long-chain fatty acids into fatty acyl-CoA esters, thereby playing a key role in lipid biosynthesis and fatty acid degradation

Prostate http://cancer.sanger.ac.uk/census

ADARB1 Adenosine deaminase, RNA-specific, B1

Encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosine

ALL; Glioblastoma

multiforme

http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=104

http://www.ncbi.nlm.nih.gov/pubmed/17908822http://www.ncbi.nlm.nih.gov/pubmed/21680795

ANAPC1 Anaphase promoting complex subunit 1

Encodes a subunit of the anaphase-promoting complex

An E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins and targeting them for degradation

None http://www.ncbi.nlm.nih.gov/pubmed?LinkName=gene_pubmed&from_uid=64682

ATG10 ATG10 (autophagy related 10) is a protein-coding gene.

Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5

Required for autophagy

Breast; Colorectal

http://www.genecards.org/cgi-bin/carddisp.pl?gene=ATG10


CCDC144NL Coiled-coil domain containing 144 family, N-

Unknown None http://www.ncbi.nlm.nih.gov/gene/339184

terminal likeCDH10 Cadherin 10,

type 2 (T2-cadherin)

Encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion

Involved in synaptic adhesions, axon outgrowth, and guidance

Colorectal; Lung



DOCK1 Dedicator of cytokinesis 1

Encodes a member of the dedicator of cytokinesis protein family.

Regulates the small GTPase Rac, thereby influencing phagocytosis and cell migration

Ovarian; Glioblastoma; Lung; Breast; Adenoid cystic

carcinoma of the salivary gland

http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=1793http://www.ncbi.nlm.nih.gov/pubmed/22175896http://www.ncbi.nlm.nih.gov/pubmed/23728337http://www.ncbi.nlm.nih.gov/pubmed/25488183http://www.ncbi.nlm.nih.gov/pubmed/23592719http://www.ncbi.nlm.nih.gov/pubmed/21692051

GABRB1 Gamma-aminobutyric acid (GABA) A receptor, beta 1

Multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system.

None http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=2560

GLYATL2 Glycine N-acyltransferase-like 2

Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine

Prostate http://www.omim.org/entry/614762?search=GLYATL2&highlight=glyatl2

http://www.pubmed.com/pmc/articles/PMC3421956/

GREM2 Gremlin 2, DAN family BMP antagonist

Encodes a member of the bone morphogenic protein antagonist family

Antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins

May play a role in regulating organogenesis, body patterning,

Carcinoid tumors http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=64388

http://www.ncbi.nlm.nih.gov/pubmed/21636701

and tissue differentiationIGF1 Insulin-like

growth factor 1 (somatomedin C)

Similar to insulin in function and structure

Member of a family of proteins involved in mediating growth and development

Prostate; Breast; Ewing’s

sarcoma; Colorectal; Hepatocellular; Melanoma; Endometrial; Lung; Esophageal


http://www.ncbi.nlm.nih.gov/pubmed/25683512http://www.ncbi.nlm.nih.gov/pubmed/25619494http://www.ncbi.nlm.nih.gov/pubmed/25609059http://www.ncbi.nlm.nih.gov/pubmed/25592039http://www.ncbi.nlm.nih.gov/pubmed/25225571http://www.ncbi.nlm.nih.gov/pubmed/25202118http://www.ncbi.nlm.nih.gov/pubmed/24904527http://www.ncbi.nlm.nih.gov/pubmed/24615087

Potentially targetable:http://www.ncbi.nlm.nih.gov/pubmed/24769281

KB-1047C11.2 Unable to locate

Not found Not identified in OMIM, GATHER, NCBI, or PubMed

KSR1 Kinase suppressor of ras 1

Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex.

Thyroid (papillary);

Breast; Oral squamous

cell CA; Endometrial

http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=8844http://www.genecards.org/cgi-bin/carddisp.pl?gene=KSR1&search=fd86581c3d79cccd6345c02409f5ae54

http://www.ncbi.nlm.nih.gov/pubmed/25608512http://www.ncbi.nlm.nih.gov/pubmed/25287073http://www.ncbi.nlm.nih.gov/pubmed/23581412http://www.ncbi.nlm.nih.gov/pubmed/21435442

Potentially targetable:http://www.ncbi.nlm.nih.gov/pubmed/23581412

MAPK9(JNK2)

Mitogen-activated protein kinase 9

Member of the MAP kinase family

Acts as an integration point for multiple biochemical signals

Angiosarcoma; NSCLC; Laryngeal

squamous cell



Involved in a wide variety of cellular processes including proliferation, differentiation, transcription regulation and development

Mediates immediate-early gene expression in response to various cell stimuli

Kinase blocks the ubiquitination of tumor suppressor p53, thus increasing the stability of p53 in non-stressed cells.

CA; Colorectal

http://www.ncbi.nlm.nih.gov/pubmed/16705311http://www.ncbi.nlm.nih.gov/pubmed/23365645http://www.ncbi.nlm.nih.gov/pubmed/25205654

MYCBP2-AS1

MYCBP2 Antisense RNA

RNA gene; nonprotein coding None http://www.genecards.org/cgi-bin/carddisp.pl?gene=MYCBP2-AS1&search=14c6f5f4b59f669079e977f0d9c367b4

NPAS1 Neuronal PAS domain protein 1

Encodes a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors

Exact function is unclear, but it may play protective or modulatory roles during late embryogenesis and postnatal development

Breast http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=4861

http://www.pubmed.com/pubmed/18636146

OPHN1 Oligophrenin 1

Encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members

Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis.

Prostate; Gastric; Colorectal



OXR1 Oxidation resistance 1

Exact function unknown; may be involved in protection from oxidative damage


http://www.genecards.org/cgi-bin/carddisp.pl?gene=OXR1&search=6e1d1f6b0db17801739dd707a9da79f2

PCBP3 Poly(rC) binding protein 3

Encodes a member of the KH-domain protein subfamily

Protein plays an important role in post-transcriptional activities


PHOX2B Paired-like homeobox 2b

Member of the paired family of homeobox proteins localized to the nucleus

Functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype

Gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element.

Neuroblastoma; Colorectal

http://cancer.sanger.ac.uk/censushttp://www.ncbi.nlm.nih.gov/pubmed/23329364http://www.ncbi.nlm.nih.gov/pubmed/22552777

PYGO1 Pygopus family PHD finger 1

Involved in signal transduction through the Wnt pathway

Interacts with BCL9 via the PHD-type zinc finger motif, and thereby becomes part of the nuclear beta-catenin/TCF complex


http://www.genecards.org/cgi-bin/carddisp.pl?gene=PYGO1&search=ffc4e023343954fd9d99e3fb18a9dc01

RP11-125B21.2 Unable to locate


RP11-307P5.1 Unable to locate


RP11-343J18.2 Unable to locate


RP11-40H20.3 Unable to locate


SAMD4A Sterile alpha motif domain containing 4A

Part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element

None http://www.ncbi.nlm.nih.gov/gene/23034

SIPA1L3 Signal-induced proliferation-associated 1 like 3

Encodes a GTPase-activating protein (GAP), which interacts with small GTPases of the Rap family via its Rap-GAP-domain

Role in cell growth, differentiation and organization of the cytoskeleton in the human lens


http://www.pubmed.com/pubmed/?term=SIPA1L3

TMPRSS13 Transmembrane protease, serine 13

Encodes a member of the type II transmembrane serine protease family

Functions in development, homeostasis, infection, and tumorigenesis


XYLT1 Xylosyl-transferase I

Encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate.

This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains.


Significant genes in chemo

Gene Full name Function Associated cancers

Reference

AC007277.3

N/A RNA gene N/A http://www.genecards.org/cgi-bin/carddisp.pl?gene=AC007277.3

ACVR2A Activin A receptor, type IIA

Autocrine/paracrine regulator in the human placenta

Colorectal Gastric Multiple

myeloma

http://www.omim.org/entry/102581?search=ACVR2A&highlight=acvr2ahttp://journals.lww.com/ajsp/pages/articleviewer.aspx?year=9000&issue=00000&article=98456&type=abstracthttp://www.ncbi.nlm.nih.gov/pubmed/23237666http://www.ncbi.nlm.nih.gov/pubmed/19926132

ALDH2 Aldehyde dehydrogenase 2 familyBottom of form

Second enzyme of the major oxidative pathway of alcohol metabolism.

Increased exposure to acetaldehyde in individuals with the catalytically inactive form of ALDH2 may confer greater susceptibility to many types of cancer

Esophageal Head & neck Gastric

http://www.omim.org/entry/100650?search=ALDH2&highlight=aldh2http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=217http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334541/

APOBEC3A

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A

Plays a role in immunity by restricting transmission of foreign DNA

Breast Pancreatic

Bladder

http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=200315http://www.ncbi.nlm.nih.gov/pubmed/24728294http://www.ncbi.nlm.nih.gov/pubmed/25502777

Bladder:http://www.ncbi.nlm.nih.gov/pubmed/25281661

C9ORF93 Encoding chromosome 9 open reading frame 93

Unknown Ewing’s sarcoma

Lung (small cell)

Breast

http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&q=C9orf93http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&q=C9orf93

CTNNA2 Catenin (cadherin-associated protein), alpha

Tumor suppressor Laryngeal Endometrial Breast

http://www.ncbi.nlm.nih.gov/pubmed/24100690/http://www.ncbi.nlm.nih.gov/pubmed/25824743

2ERC1 ELKS/RAB6-

interacting/CAST family member 1

Protein encoded by this gene is a member of a family of RIM-binding proteins, which regulate neurotransmitter release.

Papillary thyroid


FBLN2 Fibulin 2 Encodes an extracellular matrix protein (belongs to the fibulin family) which binds various extracellular ligands and calcium.

May play a role during organ development (ie, heart, skeletal and neuronal structures)

Candidate tumor-suppressor

Naso-pharyngeal

http://www.ncbi.nlm.nih.gov/pubmed/21743496/

GNAS GNAS complex locus

Complex imprinted expression pattern

Gastric adenoCA of the fundic gland

Appendiceal Intraductal

papillary mucinous neoplasms

Myelodysplastic syndrome

Prostate Parosteal

osteosarcoma Intraductal

papillary neoplasms of the bile duct

Breast Colorectal

Bladder

http://www.ncbi.nlm.nih.gov/pubmed/25288233/http://www.ncbi.nlm.nih.gov/pubmed/24925222http://www.ncbi.nlm.nih.gov/pubmed/24898823http://www.ncbi.nlm.nih.gov/pubmed/24795070http://www.ncbi.nlm.nih.gov/pubmed/24741584http://www.ncbi.nlm.nih.gov/pubmed/24525511http://www.ncbi.nlm.nih.gov/pubmed/24061513http://www.ncbi.nlm.nih.gov/pubmed/25757876http://www.ncbi.nlm.nih.gov/pubmed/25683705


GOPC Golgi- Encodes a Golgi protein with a Lung adenoCA http://www.ncbi.nlm.nih.gov/pubmed/23052255

associated PDZ and coiled-coil motif containing

PDZ domain

HPSE2 Heparanase 2 Encoded protein degrades heparin sulfate proteoglycans located on the extracellular matrix and cell surface.

Protein may be involved in biological processes involving remodeling of the extracellular matrix, including angiogenesis and tumor progression

Gastric Colorectal Nasopharyngeal Prostate


IKZF1 Encoding IKAROS family zinc finger 1

Tumor suppressor Proteins expected to have

molecular functions, including DNA binding, metal ion binding, promoter binding, protein binding, protein hetero-dimerization activity, transcription factor activity, and zinc ion binding

Proposed to participate in mesoderm development, B cell differentiation, cell cycle, chromatin modification, hemopoiesis, multicellular organismal development, natural killer cell differentiation, negative regulation of gene-specific transcription from RNA polymerase II promoter, and positive regulation of neutrophil differentiation and NK T cell

B-cell ALL Hodgkin’s

lymphoma Non-Hodgkin’s

lymphoma

http://www.ncbi.nlm.nih.gov/IEB/Research/Acembly/av.cgi?db=human&term=IKZF1&submit=Gohttp://www.ncbi.nlm.nih.gov/pubmed/19796813http://www.ncbi.nlm.nih.gov/pubmed/18332232

differentiation.IL6ST Interleukin 6

signal transducer (AKA gp130)

Signal transducer shared by many cytokines (IL-6), ciliary neurotrophic factor, leukemia inhibitory factor (LIF), and oncostatin M (OSM).

Functions as a part of the cytokine receptor complex (mediates cancer progression)

Hepatocellular adenoma

Breast Gastric Multiple

myeloma

http://www.ncbi.nlm.nih.gov/pubmed/24213527/http://www.ncbi.nlm.nih.gov/pubmed/24656773http://www.ncbi.nlm.nih.gov/pubmed/19665497http://www.ncbi.nlm.nih.gov/pubmed/10350333

*Targetable: http://informahealthcare.com/doi/abs/10.1517/14728222.2013.830105http://www.ncbi.nlm.nih.gov/pubmed/21995459

IMMP2L IMP2 inner mitochondrial membrane peptidase-like

Encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria

Prostate Thyroid Ovarian

http://www.ncbi.nlm.nih.gov/pubmed/25625310http://www.ncbi.nlm.nih.gov/pubmed/23894154http://www.karger.com/Article/FullText/108309

ITK IL2-inducible T-cell kinase

Encodes an intracellular tyrosine kinase expressed in T-cells

Thought to play a role in T-cell proliferation and differentiation

Peripheral T-cell lymphoma; Cutaneous T-cell lymphoma;

Bladder

http://cancer.sanger.ac.uk/censushttp://www.ncbi.nlm.nih.gov/pubmed/25337257


Bladder:http://www.ncbi.nlm.nih.gov/pubmed/21906447(1 article – in Chinese)Targetable:http://www.ncbi.nlm.nih.gov/pubmed/25730880

KDM5D Lysine-specific demethylase

Encodes a protein containing zinc finger domains


MAPK9 Mitogen-activated protein kinase 9

Encodes a member of the MAP kinase family

Mediates immediate-early gene expression in response to various cell stimuli

Blocks the ubiquitination of tumor suppressor p53, and thus increases the stability of p53 in

NSCLC; Breast;

http://www.ncbi.nlm.nih.gov/pubmed/20871632/http://www.ncbi.nlm.nih.gov/pubmed/19913278/

non-stressed cellsMDM4 Mdm4 p53

binding protein homolog

Encodes a nuclear protein that binds the p53 tumor suppressor protein and inhibits its activity

by binding its transcriptional activation domain

Protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions

Glioblastoma; CLL; AML; Retinoblastom Breast; Ovarian; Papillary

thyroid; Squamous cell

CA of the head and neck;

Rhabdo-myosarcoma;

Retinoblastom Burkitt

lymphoma; Melanoma;

Bladder

http://cancer.sanger.ac.uk/censushttp://www.ncbi.nlm.nih.gov/pubmed/23994448/http://www.ncbi.nlm.nih.gov/pubmed/22937789http://www.ncbi.nlm.nih.gov/pubmed/17651783

http://www.ncbi.nlm.nih.gov/pubmed/19762336http://www.ncbi.nlm.nih.gov/pubmed/19497887http://www.ncbi.nlm.nih.gov/pubmed/18335186http://www.ncbi.nlm.nih.gov/pubmed/17651783http://www.ncbi.nlm.nih.gov/pubmed/24027430http://www.ncbi.nlm.nih.gov/pubmed/22916154http://www.ncbi.nlm.nih.gov/pubmed/22845047http://www.ncbi.nlm.nih.gov/pubmed/22820643


*Potential therapeutic target

MIR663B Micro-RNA 663B

Micro-RNA N/A http://www.ncbi.nlm.nih.gov/gene/?term=MIR663B[sym]

MLL Myeloid/lymphoid or

mixed-lineage leukemia

Encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis

Responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation

AML; ALL; Large B-Cell

Lymphoma;

Bladder

http://cancer.sanger.ac.uk/censushttp://www.ncbi.nlm.nih.gov/pubmed/25510485/http://www.ncbi.nlm.nih.gov/pubmed/24798483/http://www.ncbi.nlm.nih.gov/pubmed/23457195


PTCH2 Patched 2 Encodes a transmembrane Nevoid basal http://www.ncbi.nlm.nih.gov/gene?

receptor of the patched gene family

Encoded protein may function as a tumor suppressor in the hedgehog signaling pathway

cell carcinoma; Basal cell

carcinoma; Medullo-

blastoma

cmd=Retrieve&dopt=Graphics&list_uids=8643http://www.ncbi.nlm.nih.gov/pubmed/23479190/http://www.ncbi.nlm.nih.gov/pubmed/10029063/http://www.ncbi.nlm.nih.gov/pubmed/9931336

PTGIS Prostaglandin I2 (prostacyclin) synthase

Encodes a member of the cytochrome P450 superfamily of enzymes

Protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation

Squamous cell CA of the head & neck;

Colorectal; Lung; Mesothelioma Breast

http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=5740http://www.ncbi.nlm.nih.gov/pubmed/25256272/http://www.ncbi.nlm.nih.gov/pubmed/22109564/http://www.ncbi.nlm.nih.gov/pubmed/17374734http://www.ncbi.nlm.nih.gov/pubmed/25771974http://www.ncbi.nlm.nih.gov/pubmed/19276290

RARB Retinoic acid receptor, beta

Encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators.

Receptor binds retinoic acid, which mediates cellular signaling in embryonic morphogenesis, cell growth and differentiation

Functions as a tumor suppressor

Lung; Prostate; Cervical; Breast; Hepatocellular; Esophageal

squamous cell CA; Rectal;

Melanoma; Thyroid

Bladder


http://www.ncbi.nlm.nih.gov/pubmed/25110096/http://www.ncbi.nlm.nih.gov/pubmed/24492483/http://www.ncbi.nlm.nih.gov/pubmed/25826459http://www.ncbi.nlm.nih.gov/pubmed/25805039http://www.ncbi.nlm.nih.gov/pubmed/25685469http://www.ncbi.nlm.nih.gov/pubmed/25514805http://www.ncbi.nlm.nih.gov/pubmed/25052224http://www.ncbi.nlm.nih.gov/pubmed/23851445http://www.ncbi.nlm.nih.gov/pubmed/23639973

Bladder (NMIBC):http://www.ncbi.nlm.nih.gov/pubmed/24998186http://www.ncbi.nlm.nih.gov/pubmed/21227392

REPS2 RALBP1 associated Eps domain containing 2

Encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral.

Expression can negatively affect receptor internalization

Breast (+ = favorable prognosis);

Prostate; Esophageal

squamous cell CA



and inhibit growth factor signaling

Plays important roles in inhibiting cell proliferation, migration and in inducing apoptosis of cancer cells

TBX22 T-box 22 Encodes a transcription factor involved in the regulation of developmental processes

Colorectal http://www.ncbi.nlm.nih.gov/pubmed/20126641

ZNF124 Zinc finger protein 124

Encoded protein may function as a transcription factor

Lung http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=7678


Potentially targetable:http://www.ncbi.nlm.nih.gov/pubmed/?term=ZNF124+leukemiaExpression of gene is increased after vascular endothelial growth factor (VEGF) stimulation in human leukemia cell lines and results in inhibition of apoptotic cell death induced by irradiation or exposure to etoposide.


Protein coding None http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=57209

Significant genes in metastatic disease:Gene Full name Function Associated

cancersReference

ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1

Encodes a member of the superfamily of ATP-binding cassette (ABC) transporters

Functions as a cholesterol efflux pump in the cellular lipid removal pathway

Colorectal; Ovarian; Glioblastoma; Medullo-

blastoma; Colorectal; Pancreatic;



Prostate; Breast


AC110285.1 Unable to locate



Encodes a subunit of the anaphase-promoting complex

E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins, which targets them for degradation


CACNA1C-AS3

Cacna1c antisense RNA 3

RNA gene Affiliated with the non-coding

RNA class

None http://www.genecards.org/cgi-bin/carddisp.pl?gene=CACNA1C-AS3&search=13f3ebb6e1a66275d5948928a10acdb1

CLDN1 Claudin 1 Integral membrane protein and a component of tight junction strands (cell-to-cell adhesion)

Hepatocellular Hepato-

blastoma; Colorectal; Gastric; Lung adenoCA; RCC; Breast; Pancreatic; Oral squamous

cell CA; Melanoma; NSCLC;

Bladder


http://www.ncbi.nlm.nih.gov/pubmed/25939253http://www.ncbi.nlm.nih.gov/pubmed/25824783http://www.ncbi.nlm.nih.gov/pubmed/25755790http://www.ncbi.nlm.nih.gov/pubmed/25562426http://www.ncbi.nlm.nih.gov/pubmed/25560639http://www.ncbi.nlm.nih.gov/pubmed/25393310http://www.ncbi.nlm.nih.gov/pubmed/25152584http://www.ncbi.nlm.nih.gov/pubmed/25078758http://www.ncbi.nlm.nih.gov/pubmed/25046141http://www.ncbi.nlm.nih.gov/pubmed/24112161

Bladder:Szekelyhttp://www.ncbi.nlm.nih.gov/pubmed/21832144

Potentially targetable:

Dehghan Esmatabadihttp://www.ncbi.nlm.nih.gov/pubmed/25824783

DAB2IP DAB2 interacting protein

GTPase-activating protein (GAP) that acts as a tumor suppressor, inhibiting cell survival and proliferation and inducing cell apoptosis.

Prostate; Breast; Gastric; Hepatocellular; Lung; Pancreatic; Medullo-

blastoma;

Bladder


http://www.ncbi.nlm.nih.gov/pubmed/23838317http://www.ncbi.nlm.nih.gov/pubmed/15041729http://www.ncbi.nlm.nih.gov/pubmed/23246699http://www.ncbi.nlm.nih.gov/pubmed/22168621http://www.ncbi.nlm.nih.gov/pubmed/22046421http://www.ncbi.nlm.nih.gov/pubmed/23558076http://www.ncbi.nlm.nih.gov/pubmed/22696229

Bladder:Shen:http://www.ncbi.nlm.nih.gov/pubmed/24684735Kunze:http://www.ncbi.nlm.nih.gov/pubmed/16328005

DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11

Encodes a DEAD box protein; possesses both ATPase and DNA helicase activities

Implicated in translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly

May function to maintain chromosome transmission fidelity and genome stability

Melanoma http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=1663


DPP6 Dipeptidyl-peptidase 6

Encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases

Binds specific voltage-gated potassium channels and alters

AML http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=1804


their expression and biophysical properties

EML6 Echinoderm microtubule associated

protein like 6

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer and more dynamic

None http://www.genecards.org/cgi-bin/carddisp.pl?gene=EML6&search=d28934976c4bd02f816c8ba72a3bb8a7

ERP27 Endoplasmic reticulum protein 27

Non-catalytic member of the protein disulfide isomerase family of endoplasmic reticulum proteins


FBXW7 F-box and WD-40 domain protein 7

Protein product binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation.

Acts as a tumor suppressor, responsible for the degradation of several proto-oncogenes

When inactivated, may result in sustained NOTCH1 activation

Colorectal; Squamous cell

(head & neck) (lung);

Liver; T-cell ALL; Cholangio-

carcinoma; Ovarian Endometrial;

Breast; Melanoma; Gastric; Endometrial;

Uterine carcino-sarcoma;

Cervical; Glioblastoma

Bladder

http://www.ncbi.nlm.nih.gov/pubmed/24586741/http://www.ncbi.nlm.nih.gov/pubmed/25493453http://www.ncbi.nlm.nih.gov/pubmed/24838835/

Bladder:Davis:http://www.sciencedirect.com/science/article/pii/S1535610814003766

Potentially targetable (mTOR inhibitors):Jardim:http://www.ncbi.nlm.nih.gov/pubmed/24586741

FMN1 Formin 1 An actin-nucleating protein, implicated in actin assembly and intracellular signaling

Colorectal http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=342184


FOXM1 Forkhead box Transcriptional activator Colorectal; http://www.ncbi.nlm.nih.gov/gene?

M1 involved in cell proliferation The encoded protein is

phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1

Functions as an oncogene

Cholangiocarcinoma;

Gastric; Esophageal

adenoCA; Breast; Glioblastoma; Hepatocellular; Gastroenteropa

ncreatic neuroendocrine tumors;

ALL; NSCLC; Pancreatic; Thyroid; Mesothelioma; Ovarian; Cervical; Lymphoma; Leukemia;

Bladder

cmd=Retrieve&dopt=Graphics&list_uids=2305

http://www.ncbi.nlm.nih.gov/pubmed/25935853http://www.ncbi.nlm.nih.gov/pubmed/25071344http://www.ncbi.nlm.nih.gov/pubmed/25907137http://www.ncbi.nlm.nih.gov/pubmed/25889361http://www.ncbi.nlm.nih.gov/pubmed/25869208http://www.ncbi.nlm.nih.gov/pubmed/25832656http://www.ncbi.nlm.nih.gov/pubmed/25828473http://www.ncbi.nlm.nih.gov/pubmed/25797272http://www.ncbi.nlm.nih.gov/pubmed/25760224http://www.ncbi.nlm.nih.gov/pubmed/25700356http://www.apocpcontrol.org/paper_file/issue_abs/Volume16_No1/23-29%2010.8%20Xinsen%20Xu%20[Mini-Review].pdf

Bladder:Inoguchi:http://www.ncbi.nlm.nih.gov/pubmed/24999187Kim:http://www.ncbi.nlm.nih.gov/pubmed/24714775Liu:http://www.ncbi.nlm.nih.gov/pubmed/23325617

Potentially targetable:

Chano-On:http://www.ncbi.nlm.nih.gov/pubmed/25897210Wang:http://www.ncbi.nlm.nih.gov/pubmed/25760224Kong:http://www.ncbi.nlm.nih.gov/pubmed/25700356Xu:http://www.apocpcontrol.org/paper_file/issue_abs/Volume16_No1/23-29%2010.8%20Xinsen%20Xu%20[Mini-Review].pdf

HOOK3 Hook microtubule-tethering protein 3

Cytosolic coiled-coil protein that contains conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles

Glioma http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=84376


KLF6 Kruppel-like factor 6

Encodes a member of the Kruppel-like family of transcription factors

The zinc finger protein is a transcriptional activator


Breast; Melanoma; Osteosarcoma; Prostate; Colorectal; Glioma; NSCLC; Gastric; Head & neck

squamous cell CA;

Hepatocellular; Ovarian


http://www.ncbi.nlm.nih.gov/pubmed/24519062http://www.ncbi.nlm.nih.gov/pubmed/24366496http://www.ncbi.nlm.nih.gov/pubmed/23322324\

http://download-v2.springer.com/static/pdf/870/art%253A10.1007%252Fs13277-014-1678-6.pdf?token2=exp=1431361651~acl=%2Fstatic%2Fpdf%2F870%2Fart%25253A10.1007%25252Fs13277-014-1678-6.pdf*~hmac=3e7d84eacb6fca1c0a7dac31b201dd1a42b759da8c1dfa87c70200c5cc6b8f6e

KRASP1 Kirsten rat sarcoma viral oncogene homolog pseudogene

Pseudogene; no function None http://www.genecards.org/cgi-bin/carddisp.pl?gene=KRASP1&search=86395e1b11095cde1bed3cff4566ba7e

KTN1 Kinectin 1 (kinesin receptor)

Binds kinesin and may be involved in intracellular organelle motility

Protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex.

Papillary thyroid

http://cancer.sanger.ac.uk/census


LPA Lipoprotein, Lp(a)

Encodes a serine proteinase that inhibits the activity of tissue-type plasminogen activator I

Oral squamous cell CA;

Colon;


Promote thrombogenesis Ovarian; Prostate; Breast; Melanoma; Thyroid; Gastric; Multiple

myeloma;

Bladder


http://www.sciencedirect.com/science/article/pii/S0014482714005060

Bladder:Kataoka:http://www.ncbi.nlm.nih.gov/pubmed/25524242

LPHN2 Adhesion G protein-coupled receptor L2

Encodes a member of the latrophilin subfamily of G-protein coupled receptors

Participates in the regulation of exocytosis

Squamous cell lung CA;

Bladder



Bladder:Zhang:http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0091466

MAGI1(CNKSR3)

CNKSR family member 3

Involved in transepithelial sodium transport

Regulates aldosterone-induced and ENaC-mediated sodium transport possibly through regulation of the ERK pathway

Melanoma http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=154043http://www.genecards.org/cgi-bin/carddisp.pl?gene=CNKSR3&search=d9e43b3b25f4482516336268825b3fc6

http://www.ncbi.nlm.nih.gov/pubmed/23357503MEGF11 Multiple EGF-

like-domains 11

Function uncertain May regulate the mosaic

spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion

None http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=84465http://www.genecards.org/cgi-bin/carddisp.pl?gene=MEGF11&search=edfd347720b2c93642d5b777049f322c

MUC4 Mucin 4, cell surface

associated

Encodes an integral membrane glycoprotein found on the cell surface

Tumor suppressor role

Lung adenoCA; NSCLC; Pancreatic

ductal



adenocarcinoma Breast; Oral squamous

cell CA; Cervical

squamous cell CA;

Gastric; Ovarian; Prostate; Glioblastoma; Papillary

thyroid;

Bladder

http://www.ncbi.nlm.nih.gov/pubmed/23370366http://www.ncbi.nlm.nih.gov/pubmed/24047396http://www.ncbi.nlm.nih.gov/pubmed/23408941http://onlinelibrary.wiley.com/doi/10.1002/ijc.26187/pdfhttp://www.ncbi.nlm.nih.gov/pubmed/19188823http://www.ncbi.nlm.nih.gov/pubmed/18781152http://www.ncbi.nlm.nih.gov/pubmed/18665193http://www.ncbi.nlm.nih.gov/pubmed/16302265http://www.ncbi.nlm.nih.gov/pubmed/24582898http://www.ncbi.nlm.nih.gov/pubmed/21615302

Bladder:Kaur:http://www.ncbi.nlm.nih.gov/pubmed/24671186Stojnev:http://www.ncbi.nlm.nih.gov/pubmed/25197366

NAV2(HELAD1)

Neuron navigator 2

Encodes a member of the neuron navigator gene family, which may play a role in cellular growth and migration

Colon http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=89797http://www.ncbi.nlm.nih.gov/pubmed/12214280

NPM1P21 Nucleophosmin 1 (nucleolar phosphoprotein b23, numatrin) pseudogene 21

Pseudogene; no function None http://www.genecards.org/cgi-bin/carddisp.pl?gene=NPM1P21&search=0b1e82f8c2b9194d9a7109d2003bbc53

ONECUT3 One cut homeobox 3

Transcriptional activator Binds the consensus DNA

sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters

None http://www.ncbi.nlm.nih.gov/gene/390874http://www.genecards.org/cgi-bin/carddisp.pl?gene=ONECUT3

PCDH11X Protocadherin 11 X-linked

Belongs to the protocadherin gene family, a subfamily of the cadherin superfamily


Encoded protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system

PCDH19 Protocadherin 19

Encoded protein is a member of the delta-2 protocadherin subclass of the cadherin superfamily

Protein thought to be a calcium-dependent cell-adhesion protein that is primarily expressed in the brain


PDE4D Phosphodiesterase 4D, camp-specific

Encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP

Part of the EGFR/PI3K/AKT signaling pathway

Nasopharyngeal Prostate; Glioblastoma; Lung; Breast; Melanoma


http://www.ncbi.nlm.nih.gov/pubmed/25289091http://www.ncbi.nlm.nih.gov/pubmed/25149359http://www.ncbi.nlm.nih.gov/pubmed/24989033http://www.ncbi.nlm.nih.gov/pubmed/22525277http://www.ncbi.nlm.nih.gov/pubmed/22362584http://www.ncbi.nlm.nih.gov/pubmed/19915147

Potentially targetable:Powers:http://www.ncbi.nlm.nih.gov/pubmed/25149359Kang:http://www.ncbi.nlm.nih.gov/pubmed/24989033

PLXDC2 Plexin domain Implicated in endothelial cell angiogenesis and increased capillary permeability

None http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=84898http://www.ncbi.nlm.nih.gov/pubmed/21310492

PPHLN1 Periphilin 1 Encoded protein may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation


PTPRF Protein tyrosine phosphatase, receptor type, F

Encoded protein a member of the protein tyrosine phosphatase (PTP) family

PTPs function as signaling molecules, regulating cell growth, differentiation, mitotic cycle, and oncogenic transformation

Functions in the regulation of epithelial cell-cell contacts at adherens junctions and in the control of beta-catenin signaling

Tumor-suppressor candidate

Lung; Nasal-type

natural killer/T-cell lymphoma;

Primary intraocular lymphoma;

Hepatocellular; Colorectal; Gastric Breast;

Bladder


http://www.ncbi.nlm.nih.gov/pubmed/25638566http://www.ncbi.nlm.nih.gov/pubmed/25612622http://www.ncbi.nlm.nih.gov/pubmed/24612100http://www.ncbi.nlm.nih.gov/pubmed/24470239http://www.ncbi.nlm.nih.gov/pubmed/23418360

Bladder:Zhang:http://www.ncbi.nlm.nih.gov/pubmed/24622401

RBFOX1 Rna binding protein, fox-1 homolog (c. Elegans) 1

Regulates tissue-specific alternative splicing

Mesothelioma; Colorectal

http://www.pubmed.com/gene/54715

http://www.pubmed.com/pubmed/23830731http://www.pubmed.com/pubmed/23301059

RP11-597A11.1

Unable to locate


TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor,

Encoded protein is the largest subunit of the basal transcription factor

Participates in basal transcription, serves as a coactivator, functions in promoter recognition, and modifies general transcription factors to facilitate complex assembly and transcription initiation

Possesses acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme

T-cell ALL; Endometrial; Prostate



TTLL5 Tubulin Encodes a member of the Endometrial http://www.pubmed.com/gene/23093

tyrosine ligase-like family member 5

tubulin tyrosine ligase like protein family Protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression


http://www.pubmed.com/pubmed/23028188

WFS1 Wolfram syndrome 1 (wolframin)

Encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed



Encodes a protein belonging to the Krueppel C2H2-type zinc-finger protein family

A transcription factors implicated in a variety of cellular processes

Head & neck squamous cell CA;

Wilm’s



Significant genes in nodal diseaseGene Full name Function Associated

cancersReference


Encodes a subunit of the anaphase-promoting complex, an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins and targeting them for degradation

None (evaluated in

gastric)


APLF Aprataxin polynucleotide kinase/phosphatase-like factor

DNA-damage-specific histone chaperone

None http://www.ncbi.nlm.nih.gov/pubmed/23689425http://www.ncbi.nlm.nih.gov/pubmed/21211722

ATP9A Atpase, class II, type 9A

Protein coding None http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=10079

C3ORF26 (CMSS1)

Cms1 ribosomal small subunit homolog

Protein coding NSCLC http://www.ncbi.nlm.nih.gov/gene?term=(c3orf26[gene])%20AND%20(Homo%20sapiens[orgn])%20AND%20alive[prop]%20NOT%20newentry[gene]&sort=weight

http://www.ncbi.nlm.nih.gov/pubmed/19160420C7ORF10(ORF19; DERP13)

Succinyl-coa:glutarate-coa transferase

Encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family


CADM2 Cell adhesion molecule 2

Encodes a member of the synaptic cell adhesion molecule 1family, part of the immunoglobulin superfamily

Crosslinks spectrin and interacts with other cytoskeletal proteins


Hepatocellular; RCC; Prostate;

http://www.ncbi.nlm.nih.gov/gene?term=(cadm2[gene])%20AND%20(Homo%20sapiens[orgn])%20AND%20alive[prop]%20NOT%20newentry[gene]&sort=weight


CDKAL1 CDK5 regulatory subunit associated protein 1-like 1

Encodes a member of the methylthiotransferase family

Function unknown

Bladder http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=54901Bladder: http://www.ncbi.nlm.nih.gov/pubmed/24231253http://www.ncbi.nlm.nih.gov/pubmed/18037967

CELF4 CUGBP, Elav-like family member 4

Member of the CELF/BRUNOL protein family

Regulates pre-mRNA alternative splicing and may be involved in mRNA editing and translation


CHRNA7 Cholinergic receptor, nicotinic, alpha 7 (neuronal)

Member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses

Stimulates the synthesis and release of excitatory

Small cell lung; Mesothelioma; Breast; Gastric; Pancreatic ductal

adenoCA;

http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=1139http://www.ncbi.nlm.nih.gov/pubmed/22300035http://www.ncbi.nlm.nih.gov/pubmed/22300036http://www.ncbi.nlm.nih.gov/pubmed/22300032http://www.ncbi.nlm.nih.gov/pubmed/21969082

neurotransmitters (serotonin in SCLC, noradrenaline/adrenaline in most other cancers) that drive cell proliferation, migration, angiogenesis, neurogenesis and metastasis while inhibiting apoptosis

Colorectal http://www.ncbi.nlm.nih.gov/pubmed/21630219http://www.ncbi.nlm.nih.gov/pubmed/19474681http://www.ncbi.nlm.nih.gov/pubmed/25407004

Possibly targetable:http://www.ncbi.nlm.nih.gov/pubmed/21729110

CICP11 Capicua transcriptional repressor pseudogene 11

No function; pseudogene None http://www.ncbi.nlm.nih.gov/gene/100288904

DAB2IP DAB2 interacting protein

A Ras GTPase-activating protein (GAP) that acts as a tumor suppressor, inhibiting cell survival and proliferation and inducing cell apoptosis

Prostate; Breast; Gastric; Hepatocellular; Lung; Pancreatic; Medullo-

blastoma;

Bladder


http://www.ncbi.nlm.nih.gov/pubmed/23838317http://www.ncbi.nlm.nih.gov/pubmed/15041729http://www.ncbi.nlm.nih.gov/pubmed/23246699http://www.ncbi.nlm.nih.gov/pubmed/22168621http://www.ncbi.nlm.nih.gov/pubmed/22046421http://www.ncbi.nlm.nih.gov/pubmed/23558076http://www.ncbi.nlm.nih.gov/pubmed/22696229

Bladder: http://www.ncbi.nlm.nih.gov/pubmed/24684735http://www.ncbi.nlm.nih.gov/pubmed/16328005

DDX11L9 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 like 9

No function; pseudogene None http://www.ncbi.nlm.nih.gov/gene/?term=DDX11L9

DLG2 Discs, large homolog 2

Encodes a member of the membrane-associated guanylate kinase family

Interacts at postsynaptic sites to

Cervical; Thyroid; Osteosarcoma; Oropharyngeal



form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins

squamous cell http://www.ncbi.nlm.nih.gov/pubmed/24718460http://www.ncbi.nlm.nih.gov/pubmed/24703847http://www.ncbi.nlm.nih.gov/pubmed/24481768

FBXO17 F-box protein 17

Encodes a member of the F-box protein family, one of the four subunits of the ubiquitin protein ligase complex (SCF) which functions in phosphorylation-dependent ubiquitination


FLI1 Friend leukemia virus integration 1

Encodes a transcription factor containing an ETS DNA-binding domain

Ewing sarcoma; ALL; AML; Ovarian; Prostate; Melanoma; Large B-cell

lymphoma; Breast

http://cancer.sanger.ac.uk/censushttp://www.ncbi.nlm.nih.gov/pubmed/23178492

http://www.ncbi.nlm.nih.gov/pubmed/21917756/http://www.ncbi.nlm.nih.gov/pubmed/19349856

http://www.ncbi.nlm.nih.gov/pubmed/24923303/http://www.ncbi.nlm.nih.gov/pubmed/22081504/http://www.ncbi.nlm.nih.gov/pubmed/18785112http://www.ncbi.nlm.nih.gov/pubmed/23926301http://www.ncbi.nlm.nih.gov/pubmed/17727680

HMHA1 Histo-compatibility (minor) HA-1

Elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT

Induces cell recognition and lysis by CTL

Melanoma http://www.ncbi.nlm.nih.gov/gene/23526http://www.uniprot.org/uniprot/Q92619


KIAA1432 (RIC1)

RAB6A GEF complex partner 1

Partial sequence of CIP150 Involved in phosphorylation, localization of cell-cell contacts

Small cell lung; http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=57589http://www.omim.org/entry/610354?

(gap junction), and dye transfer activity of GJA1

search=RIC1&highlight=ric1


LCE3E Late cornified envelope 3E

Keratinization None http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=353145http://www.uniprot.org/uniprot/Q5T5B0#section_comments

LMO7 LIM domain 7 May be involved in protein-protein interactions

Encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain

Lung; Colorectal; Breast



LMX1A LIM homeobox transcription factor 1, alpha

Transcription factor that acts as a positive regulator of insulin gene transcription

Plays a role in the development of dopamine producing neurons during embryogenesis

Functions as a metastasis suppressor in cervical cancer cells

Cervical; Gastric; Pancreatic; Meningioma



MAP2K1P1

Mitogen-activated protein kinase kinase 1 pseudogene 1

No function; pseudogene None http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=29778

MN1 Meningioma (disrupted in balanced translocation) 1

Contains two sets of CAG repeats. Inactivation may contribute to meningioma pathogenesis

AML; Meningioma

http://cancer.sanger.ac.uk/censushttp://www.ncbi.nlm.nih.gov/pubmed/23394438/http://www.ncbi.nlm.nih.gov/pubmed/7731706

MYC V-myc Encodes a protein with roles in Burkitt http://cancer.sanger.ac.uk/census

myelocytomatosis viral oncogene homolog

cell cycle progression, apoptosis and cellular transformation.

Regulates transcription of specific target genes

lymphoma; Breast; Pancreatic; NSCLC; Gastric; Cervical; Medullo-

blastoma; Neuroblastoma; Prostate; Melanoma; Multiple

myeloma;

Bladder


http://www.ncbi.nlm.nih.gov/pubmed/25927147http://www.nature.com/ncomms/2015/150409/ncomms7744/pdf/ncomms7744.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/25806711http://www.ncbi.nlm.nih.gov/pubmed/25649416http://www.ncbi.nlm.nih.gov/pubmed/25563377http://www.ncbi.nlm.nih.gov/pubmed/25533335http://www.nature.com/onc/journal/v18/n19/full/1202746a.htmlBladder:http://www.ncbi.nlm.nih.gov/pubmed/15986448http://www.ncbi.nlm.nih.gov/pubmed/9079756http://www.ncbi.nlm.nih.gov/pubmed/9103211

NELL1 Neural epidermal growth factor-like 1

Encodes a cytoplasmic protein that contains epidermal growth factor-like repeats.

May be involved in cell growth regulation and differentiation

RCC; Colorectal; GIST; Esophageal

adenoCA; Neuroblastoma; Medullo-

blastoma



NT5DC1 5'-nucleotidase domain containing 1

Protein belongs to the 5'(3')-deoxyribonucleotidase family

Protein function unknown

None http://www.genecards.org/cgi-bin/carddisp.pl?gene=NT5DC1

PARD3B Partitioning defective 3 homolog B

Putative adapter protein involved in asymmetrical cell division and cell polarization processes

May play a role in the formation of epithelial tight junctions

None http://www.uniprot.org/uniprot/Q8TEW8

PDE7B Phosphodiesterase 7B

Encodes a cAMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family

Functions as a second messenger in a variety of signal transduction pathways

Catalyzes the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provides a mechanism to downregulate cAMP and cGMP signaling

Mantle cell lymphoma;

CLL



PLCH2 Phospholipase C, eta 2

Member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol


PLXDC2 Plexin domain containing 2

Implicated in endothelial cell angiogenesis and increased capillary permeability


PTPRF Protein tyrosine phosphatase, receptor type, F

Member of the protein tyrosine phosphatase (PTP) family

Regulates cell growth, differentiation, mitotic cycle, and oncogenic transformation

Functions in the regulation of epithelial cell-cell contacts at adherens junctions and in the

Lung; Nasal-type

natural killer/T-cell lymphoma;

Primary intraocular lymphoma;

Hepatocellular;



control of beta-catenin signaling Tumor-suppressor candidate

Colorectal; Gastric Breast;

Bladder


RBFOX3 RNA binding protein, fox-1 homolog (C. Elegans) 3

RNA-binding protein Regulates alternative splicing

events

None http://www.ncbi.nlm.nih.gov/gene/146713http://www.genecards.org/cgi-bin/carddisp.pl?gene=RBFOX3

RHEB Ras homolog enriched in brain

Member of the GTPase superfamily

Vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway

Breast; NSCLC; Head & neck

squamous cell CA;

Hepatocellular; Colorectal; Gastric; Prostate;

Bladder


http://www.ncbi.nlm.nih.gov/pubmed/23110024http://www.ncbi.nlm.nih.gov/pubmed/20554106http://cancerres.aacrjournals.org/content/70/8/3287.longhttp://www.ncbi.nlm.nih.gov/pubmed/20127734

Bladder:http://www.ncbi.nlm.nih.gov/pubmed/22457270http://cancerres.aacrjournals.org/content/70/8/3287.long

Potentially targetable: (positively regulates mTOR)http://www.ncbi.nlm.nih.gov/pubmed/23996484http://www.ncbi.nlm.nih.gov/pubmed/21561413

RP11-179A16.1

N/a RNA gene, affiliated with the lncRNA class

None http://www.genecards.org/index.php?path=/Search/keyword/RP11-179A16.1

RP11-346K17.4

Unable to locate


RP11-368M16.1

Unable to locate


RP11-597A11.1

Unable to locate


SMARCA4 SWI/SNF Members of this family have Small cell http://cancer.sanger.ac.uk/census

related; matrix associated; actin dependent regulator of chromatin; subfamily a; member 4 (AKA BRG1)

helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes

Protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, required for transcriptional activation of genes normally repressed by chromatin

carcinoma of the ovary;

Hepatocellular; NSCLC; Prostate; Melanoma; Medullo-

blastomas;

http://www.ncbi.nlm.nih.gov/pubmed/24658004/http://www.ncbi.nlm.nih.gov/pubmed/24556940/http://www.ncbi.nlm.nih.gov/pubmed/18386774http://www.ncbi.nlm.nih.gov/pubmed/21092585http://www.tandfonline.com/doi/pdf/10.1080/15592294.2014.1003746http://www.ncbi.nlm.nih.gov/pubmed/23222069

SMOC1 SPARC related modular calcium binding 1

Encodes a multi-domain secreted protein that may have a critical role in ocular and limb development

Gliomas; Glioblastomas



TGFBR2 Transforming growth factor, beta receptor II

Encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily

Transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation

May act as a tumor suppressor or tumor promoter depending on the cellular context

Oral squamous cell CA;

Nasopharyngeal; Breast; Prostate; Colon; NSCLC; Lung

adenocarcinoma; RCC; Multiple

myeloma; Thyroid

(follicular);

Bladder


http://www.ncbi.nlm.nih.gov/pubmed/24846200http://www.ncbi.nlm.nih.gov/pubmed/24606633http://www.ncbi.nlm.nih.gov/pubmed/24336330http://www.ncbi.nlm.nih.gov/pubmed/24141771http://www.ncbi.nlm.nih.gov/pubmed/22672900http://www.ncbi.nlm.nih.gov/pubmed/22399565http://www.ncbi.nlm.nih.gov/pubmed/21725601http://www.ncbi.nlm.nih.gov/pubmed/20073064http://www.ncbi.nlm.nih.gov/pubmed/19548309http://www.ncbi.nlm.nih.gov/pubmed/24973511


TMPRSS13 Trans-membrane

Encodes a member of the type II transmembrane serine protease


protease, serine 13

family Regulated by protease inhibitors Function in development,

homeostasis, infection, and tumorigenesis.

UBE2G2 Ubiquitin-conjugating enzyme E2G 2

Encodes a member of the E2 ubiquitin-conjugating enzyme family

Modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation

Leukemia http://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=Graphics&list_uids=7327


XYLT1 Xylosyl-transferase I

Encoded protein catalyzes the transfer of UDP-xylose to serine residues of an acceptor protein substrate

This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains



Directly represses Patched1 expression and likely functions to repress the hedgehog response in cells


Abbreviation list:adenoCA = adenocarcinomaALL = Acute lymphoblastic leukemiaAML = acute myeloid leukemiaCLL = chronic lymphocytic leukemiacoA = coenzyme A; CA = cancerN/A = not applicableNSCLC = non-small cell lung cancerRCC = renal cell carcinoma

Documents

ars.els-cdn.com · Web view2016-09-29 · Encoded protein is a member of the delta-2 protocadherin subclass of the cadherin superfamily. ... V-myc myelocytomatosis viral oncogene