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Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies

Humans are exposed daily to numerous naturally occurring and man-made chemicals, some of which may adversely affect health. Furthermore, each year, hundreds of new chemicals are synthesized and introduced into commercial use (https://www.epa.gov/tsca-inventory/about-tsca-chemical-substance-inventory). Currently, in the United States, more than 80,000 chemical compounds have been registered in commerce, with 15,000 used in large volume (NIEHS 2017). Toxicological profiles for most of these chemicals are inadequate or nonexistent (Dix et al. 2007). To meet the needs for rapid assessment of the potential toxicity of these chemicals, the Tox21 program, a multi-agency collaboration of the National Institutes of Health (NIH), the U.S. Environmental Protection Agency (EPA), and the Food and Drug Administration (FDA), has utilized a quantitative high-throughput screening (qHTS) approach to profile a library of ∼10,000 samples (∼8,300 unique structures), referred to as the Tox21 10K library, in a battery of biologically relevant cell-based assays (Kavlock et al. 2009; Shukla et al. 2010; Tice et al. 2013). Data sets generated from

these assays are being used to identify mechanisms of compound action (Attene-Ramos et al. 2015; Chen et al. 2015; Hsu et al. 2014; Huang et al. 2014), prioritize chemicals for more extensive toxicological evaluation, and develop predictive models of in vivo biological responses (Huang et al. 2016; Judson et al. 2015; Rotroff et al. 2014). Read more: https://ehp.niehs.nih.gov/ehp2589/

July 2018,

Issue 82

Army Industrial Hygiene News and Regulatory Summary

Hazardous Substances

Special Interest Articles: • PFAS • PPE Doffing • Impulse

Noise • Heat Stress • Letterkenny

Explosion

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Standardizing Industrial Hygiene Data Collection Forms Used By Workers’ Compensation Insurers

Workers’ compensation (WC) insurers collect large amounts of industrial hygiene (IH) data in the United States. The data collected is not easily accessible for research or surveillance purposes. Individual WC insurers are using computerized systems to standardize and store the IH data, leaving a gap in standardization among the different WC insurers. This study sought to standardize IH data collection among WC insurers and to determine the feasibility of pooling collected IH data. IH air and noise survey forms were collected from WC insurers. Data fields on the forms were evaluated for importance and a study list of core fields was developed. The core study list was presented to an IH review panel for review before finalization. The final core study list was compared to recommendations published by the American Conference of Governmental Industrial

Hygienists (ACGIH) and the American Industrial Hygiene Association (AIHA). Fifty-nine forms from 10 organizations were collected. Industrial hygienists from research organizations, state-based WC insurers, and private WC insurers participated in the data field evaluation and on the review panel. For both air and noise survey forms, more than half the data fields (55% and 54%, respectively) were ranked as “essential.” Three of the four fields in the worker and control observations category ranked “essential” were found less than half of the time on both types of survey forms. The study list of core data elements consisted of more than half of the data fields from both the air and noise survey forms. Three additional fields were added based on the comparison to the ACGIH-AIHA recommendations. Data fields essential to standardizing IH data collection were identified and verified. The “essential” data fields will be made available and have the potential to be incorporated into WC insurers electronic IH data management systems. Future research should focus on other IH survey forms, such as those used in ergonomic

Contents:

Hazardous

Substance..........1

Radiation............5

Ventilation…......6

PPE………….......7

Noise…………....8

Preventive

Medicine…..……8

Environmental

Health...............11

Ergonomics......13

Safety................13

Emergency

Preparedness

& Response......17

Deployment

Health……..…...17

Nanotech……...19

Regulatory

Research

& IH News ......20

Training…….....23

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assessments and specific chemical exposures, and methods to transfer data fields to electronic platforms.

Read more: Journal of Occupational and Environmental Hygiene, Accepted author version posted online: 09 Jul 2018 (Available with AIHA membership)

Database Analysis More Reliable than Animal Testing for Toxic

Chemicals

A study led by scientists at Johns Hopkins Bloomberg School of Public Health suggests that advanced algorithms working from large chemical databases can predict a new chemical's toxicity better than standard animal tests. The computer-based approach could replace many animal tests commonly used during consumer product testing. It could also evaluate more chemicals than animal testing, a change that could lead to wider safety assessments.

For the study, which appears online today in the journal Toxicological Sciences, the researchers mined a large database of known chemicals they developed to map the relationships between chemical structures and toxic properties. They then showed that one can use the map to

automatically predict the toxic properties of any chemical compound more accurately than a single animal test would do. Read more: https://hub.jhu.edu/2018/07/11/animal-testing-alternative-chemical-database/

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Parental Occupational Pesticide Exposure and Nonsyndromic Orofacial Clefts

Nonsyndromic orofacial clefts are common birth defects. Reported risks for orofacial clefts associated with parental occupational pesticide exposure are mixed. To examine the role of parental pesticide exposure in OFC development in offspring, this study compared population-based case-control data for parental occupational exposures to insecticides, herbicides, and fungicides, alone or in combinations, during maternal (one month before through three months after conception) and paternal (three months before through three months after conception) critical exposure periods between orofacial cleft cases and unaffected controls. Multivariable logistic regression was used to estimate odds ratios, adjusted for relevant covariables, and 95% confidence intervals for any (yes, no) and cumulative (none, low [<median exposure level in controls], high [≥median exposure level in controls]) occupational pesticide exposures and cleft lip ± cleft palate and cleft palate. Compared to controls, associations for cleft lip ± cleft palate tended to be near unity for maternal or paternal occupational pesticide

exposures, except for low paternal exposure to any pesticide, which produced a statistically significant inverse association with this subtype. Associations for cleft palate tended to be near unity for maternal exposures and mostly positive, but non-significant, for paternal exposures; a significant positive association was observed between paternal low exposure to insecticide+herbicide+fungicide and cleft palate. Combined parental exposure produced non-significant associations near or below unity for all orofacial cleft cases combined and cleft lip ± cleft palate and positive, but non-significant, associations for cleft palate. This study observed associations mostly near unity between maternal occupational pesticide exposure and orofacial clefts. Associations for paternal occupational pesticide exposures were mostly near or below unity for cleft lip ± cleft palate, and mostly positive for cleft palate. However, due to the limitations of this study, these subtype-specific results should be interpreted cautiously. Future research examining parental occupational pesticide exposure and orofacial clefts should attempt to improve exposure assessment and increase sample size to better facilitate risk estimation. Read more: Journal of Occupational and Environmental Hygiene, Accepted author version posted online: 11 Jul 2018 (Available with AIHA membership)

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ATSDR Publishes Toxicological Profile for Perfluoroalkyls

The federal Agency for Toxic Substances and Disease Registry has published a draft toxicological profile for perfluoroalkyls (PFAs), which are a group of man-made chemicals that are used to protect products such as carpet and fabric, as a coating for paper and cardboard packaging, and in some fire-fighting foams. Such profiles characterize the toxicology and adverse health effects information for toxic substances; they are peer-reviewed. ATSDR has also posted a two-page information sheet, the ToxFAQs™, that is helpful. Chemicals that are PFAs include:

• perfluorooctanoic acid (PFOA) • perfluorooctane sulfonic acid (PFOS) • perfluorononanoic acid (PFNA)

• perfluorohexane sulfonic acid (PFHxS)

• perfluordecanoic acid (PFDeA) Read more: https://ohsonline.com/articles/2018/06/22/atsdr-publishes-toxicological-profile-for-perfluoroalkyls.aspx?admgarea=ht.IndustrialHygiene

Evaluating the Use of a Field-Based Silica Monitoring Approach with Dust from Copper Mines

Monitoring worker exposure to respirable crystalline silica in dusty environments is an important part of a proactive health and safety program. This is the case for surface copper mines in Arizona and New Mexico. The spatial and temporal variability of respirable dust and crystalline silica concentrations in those mines, coupled with the time lapse in obtaining crystalline

silica analysis results from accredited laboratories, present a challenge for an effective exposure monitoring approach and the resulting intervention strategies. The National Institute for Occupational Safety and Health (NIOSH) is developing a novel approach to be used at a mine site for the quantification of crystalline silica in respirable dust samples collected with traditional sampling techniques. The non-destructive analysis is carried out using a portable Fourier transform infrared spectroscopy (FTIR) unit. In this study,

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respirable dust samples were collected over two visits to each of five copper mines, for a total of ten datasets. The silica in each respirable dust sample was estimated by analyzing the sample with the portable FTIR unit. The quality of the estimation was assessed using the results of the NIOSH 7500 method on the same samples. The confounding effect of other minerals present in the respirable dust in the mines was also assessed, and two quantification approaches were investigated to address it: a sector-specific and a mine-specific approach. The results showed that the sector-specific approach is not effective due to the high variability of relative composition of the minerals among mines. For this approach the combined average relative difference was -13% (-17.6%, -8.9% CI) When using the mine-specific

quantification approach, the average relative difference was as low as 2.8% (-3.7%, 9.3% CI); however, this approach was still affected by the variable relative composition of the minerals in the dust in each mine. The use of a multivariate approach on the analysis of each sample was proposed as the next step to achieve consistent low relative differences. This study demonstrates the potential of using a portable FTIR for estimation of crystalline silica in respirable dust samples for in-field exposure monitoring. Read more: Journal of Occupational and Environmental Hygiene, Accepted author version posted online: 09 Jul 2018 (Available with AIHA membership)

OSHA Releases Fact Sheet on Whistleblower Protections in Nuclear Industry

OSHA is informing certain nuclear industry employees of their whistleblower protections, in a recently issued fact sheet. The fact sheet includes information about the time limit for filing whistleblower complaints, which is “within 180 days after the alleged retaliatory action (that is, when the employee is notified of the action).” It also lists the groups of workers protected by the Energy Reorganization Act, or the Atomic Energy Act, as well as provides examples of retaliation for whistleblowing

Radiation

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and protected activities. Read more:

http://www.safetyandhealthmagazine.com/articles/17216-osha-releases-fact-sheet-on-whistleblower-protections-in-nuclear-industry

Simulations of Dust Dynamics around a Cone Hood in Updraft Conditions

A cone hood is an efficient device for capturing dust releases generated by a variety of process equipment. For stationary airflow conditions, a circular cone hood with a round flange is the most efficient design. The goal of this paper is to determine the effect that inflow velocity, suction velocity and terminal settling velocity of dust particles have on the aspiration coefficient in combination with hood length and inclination angle. No studies have yet addressed the efficiency of an exhaust hood facing an updraft flow of air with suspended dust particles. To simulate the moving fluid, we used the discrete vortices method accounting for flow separation at sharp edges of the cone hood. A custom test bench was built to validate the velocity field distribution around the exhaust hood. To evaluate capture efficiency, we determined the aspiration coefficient using plotted limiting trajectories of dust particles by solving equations of particle dynamics numerically in view of gravity and various streamlining

airflow patterns. In order to validate our estimate of the aspiration coefficient, we compared our findings with regularities identified by earlier researchers for a simpler problem of dust-air mixture approaching a circular exhaust opening. The following conditions were considered: the ratio of updraft velocity to the exhaust hood suction velocity varying between 0.01 and 0.5; the ratio of dust particle terminal velocity to the suction velocity varying between 0.000625 and 0.2; flange angle varying between 0° and 90° and the ratio of flange length to the exhaust opening radius varying between 1 and 4. Using regularities discovered by us, exhaust hood designs can be tailored to a variety of application conditions in terms of dust release capture efficiency. Read more: Journal of Occupational and Environmental Hygiene, Accepted author version posted online: 19 Jul 2018 (Available with AIHA membership)

Ventilation

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Researchers Detail Contamination Risk during PPE Doffing

Researchers who tested 10 different personal protective equipment (PPE) protocols for protecting healthcare workers from Ebola virus found a higher risk of self-contamination with doffing and fewer

problems with PPE sequences involving powered air-purifying respirators (PAPRs) and assisted doffing. A team from University of New South Wales in Australia reported their findings yesterday in the American Journal of Infection Control. Ten participants were randomly assigned to use three different PPE protocols. The 10 protocols tested were from the World Health Organization, the CDC, the European Centre for Disease Prevention and Control, Health Canada, North Carolina, New South Wales, and Doctors Without Borders. To simulate Ebola contamination, researchers applied fluorescent lotion and spray to the PPE surface. Then to assess self-contamination, they used ultraviolet light to count fluorescent patches on the skin. Read more: http://www.cidrap.umn.edu/news-perspective/2018/07/news-scan-jul-18-2018

PPE

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How Can We Measure Impulse Noise Properly?

Impulsive noise is typically generated by the rapid release of compressed gases (impulse) or the collision of solid objects (impact) and is defined as the instantaneous change in sound pressure over a short period of time. Considerable research has shown that

impulsive noise is more likely to cause noise-induced hearing loss (NIHL) than continuous noise of equal energy. Exposure to high-intensity impulses can cause acoustic trauma and instant mechanical damage to the inner ear. Exposure to impulsive noise is common among law enforcement and military personnel (e.g. firearms) and in construction (e.g. nail guns), manufacturing (e.g. forging, stamping), and mining sectors (e.g. roof bolting). Read more: https://blogs.cdc.gov/niosh-science-blog/2018/07/18/impulse-noise/

Trump Administration Rule Could Stop Public Reporting of Hospital Infections Despite Death Toll

Federal health regulators will have to stop releasing data on hospital infections — which affect one in 25 hospital patients every day — under a proposal set to take effect in November, according to an analysis by patient safety advocates. The Centers for Medicare and Medicaid Services' (CMS) plan, part of a complex 500-page proposed rule, could halt the public

Noise

Preventive Medicine

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Army Industrial Hygiene News and Regulatory Summary

disclosure of the "super bug" MRSA, post-operative sepsis and surgical site infections, as well as accidents and injuries ranging from bedsores to respiratory failure after surgery.

Read more: https://www.usatoday.com/story/news/politics/2018/06/19/feds-oppose-public-reporting-hospital-infections/710682002/

Long Work Hours Tied to Higher Diabetes Risk in Women

Women who work long hours may be at a heightened risk for diabetes, a new study found. Specifically, those who worked ≥45 hours in 1 week reported a significantly higher risk for developing incident diabetes compared with women who worked 35-40 hours each week (HR 1.63, 95% CI 1.04-

2.57), according to Mahée Gilbert-Ouimet, PhD candidate, of Centre de recherche FRQS in Quebec, and colleagues. However, this link was not seen in men who worked long hours (HR 0.81, 95% CI 0.59-1.11), they wrote in BMJ Open Diabetes Research & Care. Instead, men who worked more hours tended to have a slightly lower risk of incident diabetes, although this wasn't statistically significant. Read more: https://www.medpagetoday.com/endocrinology/diabetes/73818

Flight Attendants Have Higher Rates of Breast, Uterine, Other Cancers American flight attendants have a higher prevalence of several forms of cancer, including breast, uterine, gastrointestinal, thyroid, and cervical cancers, when compared with the general public, according to new research from the Harvard T.H. Chan School of Public Health. The analysis, one of the largest studies of cancer among cabin crew members to date, is the first to show that U.S. flight

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attendants also have an elevated rate of non-melanoma skin cancer. The findings are “striking given the low rates of overweight and smoking in our study population, which highlights the question of what can be done to minimize the adverse exposures and cancers common among cabin crew,” said Irina

Mordukhovich, a research fellow at Harvard Chan School and the corresponding author of the paper. Read more: https://news.harvard.edu/gazette/story/2018/06/harvard-study-finds-elevated-cancer-risk-among-u-s-flight-attendants/

NIOSH Confronts the Opioid Crisis

The effects of opioid use and misuse are not isolated to work or home environments, and the potential for addiction may be preceded by injuries that happen in the

workplace, with the consequences affecting both an individual’s working life as well as their home life. By using Total Worker Health principles, NIOSH is developing solutions to help workers and employers facing this epidemic in their communities. Learn more about the specific steps NIOSH is taking to approach this challenge. Read more: https://www.cdc.gov/niosh/topics/opioids/default.html

CPWR Offers Skin Cancer Prevention Tips For Outdoor Workers

Workers who spend all or part of their days outdoors have an increased risk of developing skin cancer, the Center for Construction Research and Training (also known as CPWR) cautions in a recently released hazard alert. The alert, published June 18, states that more than 90,000 people will be diagnosed

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with skin cancer this year and 9,000 will die because of melanoma – the deadliest form of skin cancer. CPWR recommends applying sunscreen, wearing protective clothing and staying in the shade, when possible, when working outside.

Read more: http://www.safetyandhealthmagazine.com/articles/17234-cpwr-offers-skin-cancer-prevention-tips-for-outdoor-workers

Global Warming Linked to Higher Suicide Rates across North America

Suicide rates and temperatures are both on the rise, but are these two occurrences connected? A new study suggests maybe so. The research revealed hotter-than-average months corresponded to more deaths by suicide—and the effect isn’t limited to the summer, even warmer winters show the trend. In the study, published in Nature Climate Change, the investigators looked at all of the suicides that occurred in the U.S. and Mexico over several decades (1968 to 2004 for the U.S. and 1990 to 2010 for Mexico),

comprising 851,088 and 611,366 deaths, respectively. They then observed how monthly temperature fluctuations over these periods in every county or municipality in both countries correlated to the suicide rates for that region. They discovered that for every 1-degree Celsius (1.8-degree Fahrenheit) rise in temperature, there was a 0.7 percent increase in suicide rates in the U.S. and a 2.1 percent increase in Mexico, averaging a 1.4 percent increment across both countries. That is, over the years, a given county would see more deaths by suicide in warmer-than-average months. Read more: https://www.scientificamerican.com/article/global-warming-linked-to-higher-suicide-rates-across-north-america/

Environmental Health

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EPA Forces Recall of Half-Million U.S. Trucks for Faulty Pollution

Controls An Indiana-based engine-maker is recalling a half-million trucks with faulty pollution controls, the Environmental Protection Agency said Tuesday. A defective part means pollution controls on the engines wear out more quickly than allowed, the agency said. The recall affects 2010-2015 medium- and heavy trucks with engines made by Cummins Inc. The trucks range from big pickups to utility trucks to big rigs. The EPA says emissions testing by the agency and by California discovered the problem.

Read more: https://www.bloomberg.com/news/articles/2018-07-31/polluting-parts-force-us-recall-of-half-million-trucks

Scientists Analyzing Smoke of Western Wildfires

A comprehensive effort to analyze smoke from western U.S. wildfires is getting under way. The Western Wildfire Experiment for Cloud Chemistry, Aerosol Absorption and Nitrogen, or WE-CAN, is supported by the

National Science Foundation (NSF) and will be the largest attempt to date. From late July through August, a four-engine cargo plane based in Boise, Idaho, and carrying scientists and sophisticated equipment will make 15-20 flights straight into hazy smoke from those wildfires. Read more: https://ohsonline.com/articles/2018/07/23/scientists-analyzing-smoke-of-western-wildfires.aspx?admgarea=news

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Take Matters into Your Own Hands: Understanding Hand Injuries in the Workplace

The hands are among a worker's most valuable tools, used for everything from threading delicate electrical wires to cutting through a thick steel pipe. Yet, despite how often the hands are used, hand safety and injury prevention can often be overlooked by both employers and employees. According to the U.S. Bureau of Labor Statistics (BLS), more than 1 million workers are sent to the emergency room each year because of serious hand injuries. From lacerations and cuts to burns and broken bones, these injuries can be costly for employers. In 2011, the National Safety Council estimated the cost of hand injuries, and the results may be surprising to some employers: The direct cost of a laceration can be $10,000, stitches are often $2,000, and a severed tendon can be more than $70,000.

Read more: https://ohsonline.com/articles/2018/08/01/take-matters-into-your-own-hands.aspx?admgarea=ht.HandProtection

OSHA to Employers: Consider Screening Workers for Heat Stress When Index Hits 85 Degrees

OSHA’s threshold for moderate occupational heat risks starts at a heat index of 91° F, but that “might not be

sufficiently protective,” according to an analysis by the agency.

Safety

Ergonomics

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Together with researchers from NIOSH, OSHA reviewed 25 cases of outdoor work-related heat illnesses (14 fatal and 11 nonfatal) that OSHA investigated between 2011 and 2016. In each case, researchers examined the worker’s personal risk

factors, heat acclimatization status, clothing and workload, along with environmental heat as measured by wet globe bulb temperature – which includes temperature, humidity, wind speed and sky conditions. The heat index was below 91° F in 12 of the cases, including six of the fatalities. OSHA does not enforce a permissible exposure limit for heat, but recommends “basic heat safety and planning” at heat indexes below 91° F. With heat indexes of 91° F and above, the agency recommends implementing precautions. Read more: http://www.safetyandhealthmagazine.com/articles/17296-osha-to-employers-consider-screening-workers-for-heat-stress-when-indexes-hit-85-degrees

USCG Researching LED Devices to Replace Distress Flares

The U.S. Coast Guard is researching the suitability of using light emitting diode (LED) devices as distress signals, rather than distress flares, according to a recent article written by Loretta Haring of the Office of Strategic Planning and Communication, Acquisition Directorate. She explained that USCG is conducting the research through its Research, Development, Test and Evaluation Program because pyrotechnic distress signals are old technology with significant drawbacks.

Read more: https://ohsonline.com/articles/2018/07/16/uscg-researching-led-devices-to-replace-distress-flares.aspx?admgarea=news

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Slope It. Shore It. Shield It. New Stickers Emphasize Trench Safety

When done safely, trenching operations can limit worker exposure to cave-ins, falling loads, hazardous atmospheres, and hazards from mobile equipment. The best way to prevent a trench collapse is to slope or bench trench walls, shore trench walls with supports, or shield trench walls with trench boxes. The new “Slope It, Shore It, Shield It” sticker can be affixed to equipment on a worksite. Read more: https://www.osha.gov/as/opa/quicktakes/qt071618.html (Scroll to the bottom of the page)

House Passes Bill Aimed At Boosting Maritime Vessel Safety

The House on June 27 unanimously passed a bipartisan bill that would require the U.S. Coast Guard to perform maritime vessel inspections that include ensuring crews and ships have necessary safety equipment and current weather forecast charts. Rep. Duncan Hunter (R-CA) introduced the Maritime Safety Act of 2018 (HR 6175) on June 21 in response to the October 2015 sinking of the U.S. cargo ship El Faro during Hurricane Joaquin. All 33 people on board were killed. The bill enacts the final action memorandum of the Coast Guard Commandant after the El Faro sinking. The legislation also would require the Coast Guard to ensure vessels are equipped with floating voyage data recorders that have

emergency position-locating beacons. Speaking June 27 during a full markup of the House Transportation and Infrastructure Committee, Hunter said the VDR aboard the El Faro sank at sea. Read more: hhttp://www.safetyandhealthmagazine.com/articles/17235-house-passes-bill-aimed-at-boosting-maritime-vessel-safety

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Workers Injured In Blast at Army Depot in Pennsylvania

A small explosion in a vehicle shop at an Army depot injured four workers, three of them seriously, officials said. The blast occurred at Letterkenny Army Depot in Chambersburg about 7:20 a.m., causing a small fire, said Col. Stephen Ledbetter, the depot commander. Depot officials quickly posted on social media the incident was contained, that

operations elsewhere on the base would not be affected and that there was no suspicion of terrorist activity. Officials later said all workers have been accounted for. Ledbetter said three victims were flown to Baltimore-area hospitals with what he described as serious injuries. Their conditions were not immediately known. Fire officials said they suffered burns. Ledbetter declined to discuss their injuries. The fourth victim was treated at a local hospital and released. A hospital spokeswoman said the person had minor injuries, but no burns. Read more: https://www.cbsnews.com/news/letterkenny-army-depot-explosion-today-2018-07-19-live-updates/

Temporary Worker Initiative This is the first in a series of guidance documents issued under the Occupational Safety and Health Administration’s (OSHA’s) Temporary Worker Initiative (TWI). This Initiative focuses on compliance with safety and health requirements when temporary workers are employed under the joint (or dual) employment of a staffing agency and a host employer.

Read more: https://www.osha.gov/temp_workers/OSHA_TWI_Bulletin.pdf

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In Wake of Volcanic Eruption, RDECOM C&B Advises First Responders

As emergency service personnel in Hawaii rescue evacuees and contain damage following the eruption of the volcano Kilauea, scientists at the U.S. Army Research, Development and Engineering Command Chemical & Biological Center are

providing their expertise to help safeguard the health of first responders. The volcano's continued eruption has cast ash and chemicals into the air, posing a health concern for first responders. For a century, scientists have developed equipment to protect warfighters for situations where they may be exposed to chemicals on the battlefield. Read more: https://www.army.mil/article/208128/in_wake_of_volcanic_eruption_rdecom_cb_advises_first_responders

Boston Small Business Develops Impact-Detecting Garments for Warfighters to Assist Combat Medics

A Massachusetts-based, woman-owned small business is leveraging an Air Force-supported technology accelerator to improve high-tech clothing designed to detect and treat wounds on its own. Boston-based Legionarius brought its impact-detecting garments to the Tech Warrior OPS, held in April at the National

Center for Medical Readiness, a Wright State Research Institute Laboratory in Fairborn, Ohio. The Tech Warrior Enterprise, sponsored by the Air Force Small Business Innovation Research/Small Business Technology Transfer Program, matches small business technology with warfighters and other first responders to use and evaluate.

Emergency Preparedness

Deployment Health

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The technology has the potential to help detect battle wounds, providing a significant benefit for the injured warfighter and the combat medics responsible for keeping them alive. The garment sends a distress signal and critical information – like wound type and location, as well as vital signs – to medics in the field. The garment also begins to apply compression to stop

hemorrhaging in the event of a gunshot or other wound that punctures the skin.

Read more: http://www.airforcemedicine.af.mil/News/Display/Article/1570484/boston-small-business-develops-impact-detecting-garments-for-warfighters-to-ass/

Army to Introduce New Fitness Test in 2020

Soldiers with the 10th Mountain Division will be the first to test the long-awaited exoskeleton that developers say can reduce injuries, carrying loads and help troops move around the battlefield with ease. The U.S. Army Natick Soldier Research, Development and Engineering Center partnered with the division in February to identify, evaluate and transition exoskeleton technology to the Army. NSRDEC has led exoskeleton efforts for the Army for a number of years. One of the more advanced products that will soon hit the division is made by Lockheed Martin. Army Times spoke recently with company officials about the ONYX device, which will

go through phases of testing, beginning as early as this fall. Read more: https://www.armytimes.com/news/your-army/2018/06/05/this-army-unit-will-be-first-to-test-an-exoskeleton-that-lightens-combat-load/

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A New 'Periodic Table' For Nanomaterials

A new approach could help materials scientists identify the appropriate molecules to use in order to synthesize target nanomaterials. The method was developed by Daniel Packwood of Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) and Taro Hitosugi of the Tokyo Institute of Technology. It

involves connecting the chemical properties of molecules with the nanostructures that form as a result of their interaction. A machine learning technique generates data that is then used to develop a diagram that categorizes different molecules according to the nano-sized shapes they form. Fabricating nanomaterials using a bottom-up approach requires finding precursor molecules that interact and align correctly with each other as they self-assemble. But it's been a major challenge knowing how precursor molecules will interact and what shapes they will form. Read more: https://phys.org/news/2018-07-periodic-table-nanomaterials.html#jCp

Nanotechnology

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Cal/OSHA Summit 2018: Prepare for the Workplace Violence Rule for

General Industry In 2017, California became the first state in the nation to implement a regulation requiring health care employers to take steps to prevent workplace violence. That rule took effect in April 2018. Now, the state’s Division of Occupational Safety and Health, better known as Cal/OSHA, is developing a similar standard for general industry. Read more: https://ehsdailyadvisor.blr.com/2018/07/cal-osha-summit-2018-prepare-workplace-violence-rule-general-industry/ Groups Petition OSHA to Issue Heat Stress Standard; Congresswoman

to Sponsor Bill More than 130 organizations and 90 individuals are petitioning OSHA to issue regulations aimed at protecting workers against heat stress. The petition, addressed to acting OSHA leader Loren Sweatt, is part of a national campaign led by advocacy groups Public

Citizen, United Farm Workers Foundation and Farmworker Justice. The organizations are asking OSHA to mandate rest breaks, access to water, heat acclimatization plans, worker training, and shaded or air-conditioned areas for approximately 130

Regulatory Research & Industrial Hygiene Professional News

OSHA

Legislation

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million affected workers. California, Minnesota, Washington and the U.S. military are the only entities with formal protections against occupational heat stress. Read more: http://www.safetyandhealthmagazine.com/articles/17257-osha-being-petitioned-to-issue-heat-standard-congresswoman-to-sponsor-bill

Effective July 6: Changes to OSHA’s Beryllium Standard for General Industry

OSHA’s “clarifying amendments” to its beryllium standard for general industry will go into effect July 6, the agency has announced. The changes address the application of the standard “to materials containing trace amounts of beryllium,” OSHA states in a July 2 press release. The agency issued a direct final rule May 7 and said it has received no significant adverse comments.

The direct final rule updates the definitions of the beryllium work area, emergency, skin contact and contamination. The agency states that the direct final rule also intends to clarify provisions for disposal and recycling and in instances of exposure to materials containing “at least 0.1 percent beryllium by weight.” Read more: http://www.safetyandhealthmagazine.com/articles/17231-effective-july-6-changes-to-oshas-beryllium-standard-for-general-industry

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New ATSDR Study, Released Amid Controversy, Calls Current EPA Recommendations into Question

The Agency for Toxic Substances and Disease Registry issued a draft report on June 20 on perfluoroalkyl compounds, suggesting that current advisory guidelines for exposure to such contaminants may be too high. The draft report is subject to public comment, but despite the current regulatory uncertainty, businesses should begin to examine their involvement with such substances and assess potential vulnerabilities to litigation and enforcement actions.

Read more: https://www.jdsupra.com/legalnews/new-atsdr-study-released-amid-16539/

e-Manifest Update: Receiving Facilities Have Extra Time to Submit

Paper Manifests

Many handlers of hazardous waste manifests have been struggling to get up to speed to be in compliance with the new requirements for e-manifests by its June 30th launch date. This has been especially true for receiving facilities, many of whom

have not yet completed the steps necessary to modify their software systems and to integrate them with the e-Manifest system so as to enable them to submit paper manifest electronically to the EPA. Knowing that to be the case, the EPA will give receiving facilities until September 30, 2018 to submit all paper manifests they receive between June 30, 2018 and September 1, 2018. Read more: https://ehsdailyadvisor.blr.com/2018/06/e-manifest-update-receiving-facilities-extra-time-submit-paper-manifests/

EPA

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Training

APHC

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Army Industrial Hygiene News and Regulatory Summary

This monthly summary is published by the Industrial

Hygiene Program Management Division for the Army Public Health Center.

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Articles appearing in this summary are a collection of articles taken verbatim from public sources and do not necessarily represent the opinions/views, policy, or guidance of the Department of the Army, Department of Defense, or the U. S. Government. The appearance of external hyperlinks does not constitute endorsement by the U.S. Army for the information, products or services contained therein. The U.S. Army does not exercise any editorial control over the information you may find at these locations. The use of trademarked names does not imply endorsement by the U.S. Army but is intended only to assist in identification of a specific product.