APROTININ AFTER MYOCARDIAL INFARCTION

It may reduce myocardial ischemia and necrosis Aprotinin is a serine esterase inhibitor capable of inactivating kallikrein. In 25 patients who had an acute myocardial infarction, aprotinin was given 30-60 min after the start of symptoms, and effects on electrocardiographic myocardial ischemic injury , the extent of myocardial necrosis and the development ofQ waves were studied . Aprotinin was given as 100,000 kallikrein inhibitor units (KIU) bolus, followed by a continuous infusion (4ml/ min) that contained I O,OOOKIU /kg in 240ml of dextrose/water solution. Another group of 25 similar patients who did not receive aprotinin served as a control group. The average sum ofS-T segment elevations (EST) decreased significantly from 40.5mv to 12.95mv in the aprotinin group, but only fell negligibly in controls (from 54.25mv to 51. 7mv). Deeper Q waves also occurred in the control group, as compared with the aprotinin group. Aprotinin recipients had a significantly smaller estimated infarct size (19CPK-g-Eq \'S 57 .4CPK-g-Eq), suggesting that aprotinin lessens myocardial damage caused by acute infarctions. Cccefia-Scldncr. F .. \ . and Villarreal. J.: Angiology ~ I: 4HX (Jul 1980)

16 INPHARMA 15 Nov 1980 0156-2703/80/1115-0016 $00.50/0 <!MDIS Press