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A/Prof Kerrie McDonald
Cure Brain Cancer – Neuro-Oncology Group
Personalising treatment for
Glioblastoma patients
Glioblastoma
Never Stand Still Medicine Personalised treatment
Affects all ages
Affects both men and women
No preventative screening measures
No effective treatment strategy
Personalised Treatment
Never Stand Still Medicine Personalised treatment
Dynamic Biobanking
Never Stand Still Medicine Pipeline
Biobanking: Pre-clinical Models
Never Stand Still Medicine Case Study
Case Study 1
• Headaches and nausea for a week
• MRI revealed cystic mass in the temporal lobe
• Gross total resection April 2015
• Ki67 >30%
• Negative for amplification of EGFR, PDGFRA
• Negative for PTEN loss
• INI preserved
• IDH1 wildtype
• MGMT unmethylated
• Chromosomal CGH/ SNP Microarray
• Amplification 2p in 3 discrete sites including MYCN
• Copy Number gains of 1q and 7q
MP Rage before surgery
Whole Genome Sequencing
Never Stand Still Medicine Case Study
• TSC 1
• TP53
• CIC
T1 saggittal with gadolinium 3/9/15
at relapse
Treatment
Never Stand Still Medicine Case Study
Treatment
Never Stand Still Medicine Case Study
Treatment
Never Stand Still Medicine Case Study
• Treated with sirolimus
• Stable tumour response for 4-6 weeks
• Excellent quality of life
• Passed away after a 9 month battle
We need new treatments: Immunotherapy
Never Stand Still Medicine Case Study
(1) Tetanus-diphtheria vaccine
CMV
(2) CMV-PEPTIDE
CMV CMV Peptide + GM-CSF
Toxin released
Thank you!!
Never Stand Still Medicine Acknowledgements
Prof Charlie Teo Dr Mustafa Khasraw All of the patients and their families
Dr Jacob Fairhall Dr Raj Reddy
Dr Liz Hovey