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April 4, 2019
The SYNTAX Trials:The take home message for the surgical team
Scott R. Martin, MD FACC FSACIDirector, Interventional CardiologyStamford HealthcareAssistant Clinical ProfessorValegos College of Physicians & SurgeonsColumbia University
Disclosure Statement of Financial Interest
❖ None pertinent to this presentation
PCI for Left Main and Triple Vessel CAD
❖ Since the beginning of the PCI experience, there has been a push to treat complex disease and replace bypass surgery
PCI for Left Main and Triple Vessel CAD
❖ Since the beginning of the PCI experience, there has been a push to treat complex disease and replace bypass surgery
❖ In early experience, PCI was limited by poor imaging, primitive equipment, high rate of acute closure
❖ With advancements in equipment and technique (stents, DES), marked improvement in short-term outcomes
PCI for Left Main and Triple Vessel CAD
❖ Advantages of PCI over CABG:
❖ Recovery
❖ Decrease in early complications (stroke, renal failure)
❖ Acceleration of native disease with CABG, particularly with saphenous vein grafts
POD #1: CABG vs PCI
PCI for Left Main and Triple Vessel CAD
❖ Advantages of PCI over CABG:
❖ Recovery
❖ Decrease in early complications (stroke, renal failure)
❖ Acceleration of native disease with CABG, particularly with saphenous vein grafts
PCI for Left Main and Triple Vessel CAD
❖ Advantages of PCI over CABG:
❖ Recovery
❖ Decrease in early complications (stroke, renal failure)
❖ Acceleration of native disease with CABG, particularly with saphenous vein grafts
So why not PCI for all?
So why not PCI for all?
❖ Multiple trials over the years have shown marked increase in need for repeat revascularization with multi-vessel PCI with bare-metal stents
❖ ARTS 1, MASS 2, ERACI-II, AWESOME
❖ Long-term trials also show late mortality benefit of bypass surgery
❖ SOS
So why not PCI for all?
❖ SYNTAX trial designed to compare contemporary (2005-2007) treatment with DES vs CABG in multi-vessel or left main coronary disease
SYNTAX Trial
SYNTAX Trial
So why not PCI for all?
SYNTAX Trial
❖ Pre-specified subgroups of left main disease and triple-vessel disease
SYNTAX Trial
❖ Clear interaction between extent of disease and incremental benefit of CABG over PCI
SYNTAX Trial
So why not PCI for all?
❖ Even with DES there is clearly a reduction in repeat procedures with CABG
❖ Still a long-term decrease in mortality with CABG
❖ Incremental benefit increases with triple-vessel disease, complexity, diabetes
❖ PCI with equivalent outcomes to CABG in less complex left main disease
SYNTAX II Study
❖ Major technical and procedural advances in PCI since SYNTAX trial that influence outcomes
❖ Physiology based revascularization decision using iFR/FFR
❖ Second generation DES (thin strut, biodegradable polymer, everolimus eluting Synergy DES)
❖ IVUS guided optimization of stent deployment
❖ Contemporary CTO revascularization technique
❖ Improved guideline directed medical therapy
SYNTAX II Study
❖ Multi-center, prospective, single-arm, open label trial of patients with de novo triple-vessel CAD
❖ Compared to predefined comparator groups in the CABG and PCI arms of the original SYNTAX trial
❖ Primary endpoint of composite MACCE at two years
SYNTAX II Study
❖ Compared to SYNTAX I, contemporary state-of-the-art PCI in SYNTAX II led to significantly fewer lesions treated with PCI, and significantly higher success rates in CTO revascularization
❖ At one year, outcomes in intermediate SYNTAX score patients were similar to those observed in low SYNTAX score patients
❖ One-year outcomes were significantly improved compared to the SYNTAX I PCI-arm, and comparable to the SYNTAX I CABG-arm
Where are we now?
❖ When is CABG favored?
❖ High anatomic complexity / SYNTAX score
❖ Unable to achieve complete revascularization with PCI
❖ Diabetics
❖ Technically difficult PCI (tortuosity, calcification)
❖ Unable to tolerate dual-antiplatelet therapy
❖ Recurrent in-stent restenosis
Where are we now?
❖ When is PCI favored?
❖ Isolated left main coronary disease
❖ Frailty
❖ Oxygen dependent
❖ Porcelain aorta
❖ Poor surgical targets
Where are we now?
❖ What to expect going forward
❖ Expectation for optimal PCI / CABG
❖ IVUS or OCT guided / multiple arterial grafts
❖ Less complex left main disease patients will be treated with stents
❖ SYNTAX III
❖ CTA guided decision making