Embed Size (px)
Citation preview
APPENDIX 2
ACTIVITY PROFILES FORGENETIC AND RELATED EFFECTS
538 rARe MONOGRAHS VOLUME 49
APPENDIX 2
AeTIVTY PROFILES
FOR GENETIe AND RELATED EFFECTS
Methods
The x-axs uf the activity profile (Waters et al., 1987, 1988) represents the bioas-says in phylogenetic sequence by endpoint, and the values on the y-axs representthe logarithmically transformed lowest effective doses (LED) and highest ineffec-tive doses (HID) tested. The term 'dose', as used in this report, does not take intoconsideration length of treatment or exposure and may therefore be considered syn-onymous with concentration. ln practice, the concentrations used in all the in-vitrotests were converted to Jlg/ml, and those for in-vivo tests were expressed as mg/kgbw. Because dose units are plotted on a log scale, differences in molecular weightsof compounds do not, in most cases, greatly influence comparisons of their activityprofiles. Conventions for dose conversions are given below.
Profile-line height (the magnitude of each bar) is a function of the LED orHID, which is associated with the characteristics of each individual test system _such as population size, cell-cycle kinetics and metabolic competence. Thus, thedetection limit of each test system is different, and, across a given activity profile,responses wil vary substantially. No attempt is made to adjust or relate responsesin one test system to those of another.
Line heights are derived as follows: for negative test results, the highest dosetested without appreciable toxicity is defined as the HID. If there was evidence ofextreme toxicity, the next highest dose is used. A single dose tested with a negativeresult is considered to be equivalent to the HID. Similarly, for positive results, theLED is recorded. If the original data were analysed statistically by the author, thedose recorded is that at which the response was significant (p ~ 0.05). If the avail-able data were not analysed statistically, the dose required to produce an effect isestimated as follows: when a dose-related positive response is observed with twoor more doses, the lower of the doses is taken as the LED; a single dose resultingin a positive response is considered to be equivalent to the LED.
In order to accommodate both the wide range of doses encountered and posi-tive and negative responses on a continuous scale, doses are transformed logarith-
APPENDIX 2 539
micalIy, so that effective (LED) and ineffective (HID) doses are represented by pos-itive and negative numbers, respectively. The response, or logarithmic dose unit(LDUij), for a given test system i and chemicalj is reprcsented by the expressions
LDUij = -loglo (dose), for HID values; LDU -c0md (n!5LDUij = -loglo (dose x 10- ), for LED values; LDU ::0.
These simple relationships define a dose range of 0 to -510garithmic units forineffective doses (1-100 00 J!g/ml or mg/kg bw) and 0 to + 810garithmic units foreffective doses (100 00.001 J!g/ml or mg/kg bw). A scale ilustrating the LDUvalues is shown inFigure 1. Negative responses at doses less th an 1 J!g/ml (mg/kgbw) are set equal to 1. Effectively, an LED value ::100 00 or an HID value -c1produces an LDU = 0; no quantitative information is gained from such extremevalues. The dotted lines at the levels of log dose units 1 and -1 define a 'zone ofuncertainty' in which positive results are reported at such high doses (between1000 and 100 00 J!g/ml or mg/kg bw) or negative results are reported at such lowdose levels (1 to 10 J!g/ml or mg/kg bw) as to calI into question the adequacy of thetest.
Fig. 1. Scale of log dose units used on the y-axs of activity profiles
Positive(J.g/ml or mg/kg bw)
0.0010.010.11.0
10100
10010 00
100 00
...... .......... ..... ....... ......... .........
.... ......................... .............. .......
.. ............ ............. ........... ..........
...... .............. .......... ........ ..........
.. ............. ......... ... .......... ........
........................... .........
.... .......... .......... ............... .......
................. .......... ......... ... .....
. . . . . . . . . . . . . . . .. 1
. . . . . . . . . . . . . . .. 10
. . . . . . . . . . . . . .. 100
. . . . . . . . . . . . .. 100. . . . . . . . . .. 10 ()
. . . . . . . . . .. 100 00
Log doseunits
87654
321
o-1-2-3-4-5
Negative(J.g/ml or mg/kg bw)
LED and HID are expressed as J.g/ml or mg/kg bw.
540 lARe MONOGRAHS VOLUME 49
In practice, an activity profile is computer generated. A data entry programmeis used to store abstracted data from published reports. A sequential file (in ASCII)is created for each compound, and a record within that file consists of the nameand Chemical Abstracts Service number of the compound, a three-letter code forthe test system (see below), the qualitative test result (with and without an exoge-nous metabolic system), dose (LED or HID), citation number and addition alsource information. An abbreviated citation for each publication is stored in a seg-ment of a record accessing both the test data file and the citation file. During pro-cessing of the data file, an average of the logarithmic values of the data subset iscalculated, and the length of the profile line represents this average value. All dosevalues are plotted for each profile line, regardless of whether results are positiveor negative. Results obtained in the absence of an exogenous metabolic system areindicated bya bar (-), and results obtained in the presence of an exogenous meta-bolic system are indicated by an upward-directed arrow (t). When aIl results fora given assay are either positive or negative, the mean of the LDU values is plottedas a solid line; when conflicting data are reported for the same assay (i.e., both posi-tive and negative results), the majority data are shown by a solid line and the minor-ity data by a dashed line (drawn to the extreme conflicting response). In the fewcases in which the numbers of positive and negative results are equal, the solid lineis drawn in the positive direction and the maxmal negative response is indicatedwith a dashed line.
Profile lines are identified by three-letter code words representing the com-monly used tests. Code words for most of the test systems in CUTrent use in genetictoxicology were defined for the US Environmental Protection Agency's GENE-TOX Program (Waters, 1979; Waters & Auletta, 1981). For !ARC Monographs Sup-plement 6, Volume 44 and subsequent volumes, including this publication, codeswere redefined in a manner that should facilitate inclusion of additional tests. Ifa test system is not defined precisely, a general code is used that best defines thecategory of the test. Naming conventions are described below.
Data listings are presented with each activity profile and include end point andtest codes, a short test code definition, results .(either with (M) or without (NM) anexogenousactivation system), the associated LED or HID value and a short cita-tion. Test codes are organized phylogenetically and by endpoint from left to rightacross each activity profile and from top to bottom of the corresponding data list-ing. Endpoints are defined as follows: A, aneuploidy; C, chromosomal aberrations;D, DNA damage; E assays of body fluids; G, gene mutation; H, host-mediated as-says; l, inhibition of intercellular communication; M, micronuclei; E sperm mor-phology; R, mitotic recombination or gene conversion; S, sis ter chromatid ex-change; and 1: cell transformation.
APPENDIX 2 541
Dose conversions for activity profiles
Doses are converted to l1g/ml for in-vitro tests and to mg/kg bw per day forin-vivo expei;iments.
1. In-vitro test systems
(a) Weight/volume converts directly to l1g/ml.
(h) Molar (M) concentration x molecular weight = mg/ml = 1() l1g/ml; mMconcentration x molecular weight = l1g/ml.
(c) Soluble solids expressed as % concentration are assumed to be in unitsof mass per volume (i.e., 1% = 0.01 g/ml = 10 00 l1g/ml; also, 1 ppm= 1 l1g/ml).
(d) Liquids and gases expressed as % concentration are assumed to be givenin units of volume per volume. Liquids are converted to weight per volumeusing the density (D) of the solution (D = g/ml). Gases are convertedfrom volume to mass using the ideal gas lawj PV = nR1: For exposureat 20-37° C at standard atmospheric pressure, 1% (v/v) = 0.4 l1g/ml x mo-lecular weight of the gas. Also, 1 ppm (v/v) = 4 x 10-5 ltg/ml x molecularweight.
(e) ln microbial plate tests, it is usual for the doses to be reported as weight/plate, whereas concentrations are required to enter data on the activityprofile ch art. While remaining cognisant of the errors involved in the pro-cess, it is assumed that a 2-ml volume of top agar is delivered to each plateand that the test substance remains in solution within it; concentrationsare derived froID the reported weight/plate values by dividing by this arbi-trary volume. For spot tests, a 1-ml volume is used in the calculation.
(f Conversion of particulate concentrations given in l1g/cm2 are based on
the area (A) of the dish and the volume of medium per dish; i.e., for a100mm dish: A = 7TR2 = 7T x (5 cmf = 78.5 cm2. If the volume of me-dium is 10 ml, then 78.5 cm2 = 10 ml and 1 cm2 = 0.13 mL.
2. In-vitro systems using in-vivo activation
For the body fluid-urine (BF-) test, the concentration used is the dose (in mg/kg bw) of the compound administered to test animaIs or patients.
3. ln-vivo test systems
(a) Doses are converted to mg/kg bw per day of exposure, assuming 100%absorption. Standard values are used for each sex and species of rodent,inc1uding body weight and average intake per day, as reported by Goldet al. (1984). For example,in a test using male mi ce fed 50 ppm of the agent
542 lARe MONOGRAHS VOLUME 49
in the diet, the standard food intake per day is 12% of body weight, andthe conversion is dose = 50 ppm x 12% = 6 mg/kg bw per day.Standard values used for humans are: weight - males, 70 kg; females, 55 kg; sur-face area, 1.7 m2; inhalation rate, 20 l/min for light work, 30 l/min for mild exer-cise.
(b)When reported, the dose at the target site is used. For example, doses giv-en in studies of lymphocytes of hum ans exposed in vivo are the measuredblood concentrations in lLg/mL.
Codes for test systems
For specific nonmammalian test systems, the first two letters of the three-sym-bol code word define the test organism (e.g., SA- for Salmonella tyhimurium, EC-for Escherichia coli). If the species is not known, the convention used is -S-. Thethird symbol may be used to define the tester strain (e.g., SA8 for S. tyhimun'umTA1538, ECW for E. coli WP2uvrA). When strain designation is not indicated, thethird lettei is used to define the specific genetic endpoint under investigation (e.g.,-D for differential toxicity, -F for forward mutation, -G for gene conversion orgenetic crossing-over, -N for aneuploidy, --R for reverse mutation, -U for un-scheduled DNA synthesis). The third letter may also be used to define the generalendpoint under investigation when a more complete definition is not possible orrelevant (e.g., -M for mutation, -C for chromosomal aberration).
For mammalian test systems, the first letter of the three-Ietter code word de-fines the genetic end point under investigation: A-- for aneuploidy, B- for binding,C- for chromosomal aberration, D- for DNA strand breaks, G- for gene muta-tion, 1- for inhibition of intercellular communication, M- for micronucleus for-mation, R- for DNA repair, S- for sister chromatid exchange, T - for cell trans-formation and U- for unscheduled DNA synthesis.
For animal (Le., non-human) test systems in vitro, when the cell type is not spe-cified, the code letters -lA are used. For such assays in vivo, when the animal speciesis not specified, the code letters -VA are used. Commonly used animal species areidentified by the third letter (e.g., -C for Chinese hamster, -M for mouse, -R
. for rat, -S for Syrian hamster).For test systems using human cells in vitro, when the cell type is not specifie d,
the code letters -IH are used. For assays on humans in vivo, when the cell type isnot specified, the code letters - VH are used. Otherwise, the second letter specifiesthe cell type under investigation (e.g., -BR for bone marrow, -LH for lymphocytes).
Some other specific coding conventions used for mammalian systems are asfollows: BF- for body fluids, HM- for host-mediated, -L for leucocytes or lympho-cytes in vitro (-AL, animaIs; -HL, humans), -L- for leucocytes in vivo (-LA, ani-maIs; -LH, humans), -T for transformed cells.
APPENDIX 2 543
Note that the se are examples of major conventions used to define the assaycode words. The alphabetized listing of codes must be examined to confirm a specif-ic code word. As might be expected from the limitation to three symbols, somecodes do not fit the naming conventions precisely. ln a few cases, test systems aredefined by first-Ietter code words, for example: MS'l mouse spot test; SLp, mousespecific locus test, postspermatogonia; SLO, mouse specific locus test, other stages;DLM, dominant lethal test in mice; DLR, dominant lethal test in rats; MH'l mouseheritable translocation test.
The genetic activity profiles and listings that follow were prepared in collabo-ration with Environmental Health Research and Testing Inc. (EHRT) under con-tract to the US Environmental Protection Agency; EHRT also determined the dosesused. The references cited in each genetic activity profile listing can be found inthe list of references in the appropriate monograph.
References
Garrett, N.E., Stack, H.F., Gross, M.R. & Waters, M.D. (1984) An analysis of the spectraof genetic activity produced by known or suspected human carcinogens. Mutat. Res.,134, 89-111
Gold, L.S., Sawyer, C.B., Magaw, R., Backman, G.M., de Veciana, M., Levinson, R., Hoop-er, N.K., Havender, WR., Bernstein, L., Peto, R., Pike, M.C. &Ames, B.N. (1984) Acarcinogenic potency database of the standardized results of animal bioassays. Environ.Health Perspect., 58, 9-319
Waters, M.D. (1979) The GENE-TOX program. ln: Hsie, A.W., O'Neil, J.P. & McElheny,VK., eds, Mamalian Cel! Mutagenesis: The Maturation of Test Systems (Banbury Report2), Cold Sprig Harbr, NY, CHS Press, pp. 449-467
Waters, M.D. & Auletta, A. (1981) The GENE-TOX program: genetic activity evaluation.1 chem. lnt comput. Sci, 21,35-38
Watêrs, M.D., Stack, H.F., Brady, A.L., Lohman, P.H.M., Haroun, L. & Vainio, H. (1987)Appendix 1: Activity profiles for genetic and related tests. ln: lAC Monographs on theEvaluation of the Carcinogenic Risk of Chemicals to Human, Suppl. 6, Genetic and Re-lated Effects: An Update of Selected lARe Monographs from Volumes 1 to 42, Lyon,lARe, pp. 687-696
Waters, M.D., Stack, H.E, Brady, A.L., Lohman, P.H.M., Haroun, L. & Vainio, H. (1988)Use of computeried data listings and activity profies of genetic and related effectsin the review of 195 compounds. Mutat. Re., 205, 295-312
54lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
~ti~~~~H~euo!i~~
~ar.~
QH:i~ti ø:
80Q~ti~ ~
ti fê
~Fa8ti:.ti8ti~88 ~
ti Q
~ 0
8 U
§ ~
~ ~
.Q ,Q
i- i-i- i-
N O
' O' i- O
'00 N
00 N -- 00 --
O' 00 O
' i- l" 00 M O
'-- O' -- 00 00 O' 00 '-- '
-- O' O' -- O'' .
~, ~---- ,--~ ~~
~~
~~
~ ~
~ ~
~~
tt~~t~:~:&
it&i
'" ~~~~ ~HIH
::g~~
HC
1gC1': ':
~~~~o~U~iãg g
tltI~~
ÕQ
tIQii ii
0000000000000000000000000000000000000000000000000000000
00000000000+
+ IL
++
++
+f\.+..
~ ~ ~ ~
H H H H
:: :: :: ::
Ii Ii Ii IiH H H H
ooooootltItItIg::::::::::::~~~~HH
HH
HH
HFi~~t::
:: :: :: :: :: :: ri G G
G Ii
liIiIiIiIiIiOO
OO
HH
HH
HH
H:i:i:i:i
ti ti tI tI ti ti ei ei ei ei ~
~r.~~~~¡;¡;~¡;;:Ö
Ö Ö
Ö Ö
Ö 0- 0- 0- 0- tj
00000011111:i :i :i :i :i :i~~~~~~0-0-0-0-.... ""
nnnUU
~:E :E :E :? Po
"""oooo::~~~~~~~ee~~uuuuuuti ti ti ti ti ti
~~~~~~ëëëã~ti ti ti ti ti ti U
U U
U ,e
Ul
QI
W::Ul
o0. .X
.Q
I
H::wUo.lQI
WIlUl
QI
Ui:QI
wQI
IIQI
wWQI
.i.lo----IlHHHWUo.lQI
w::Ul
o0.xr...
Lnl---Z::WLnooLlo-l
8
6
4
2
o
-2
-4
CHROMIUM OCCUPATIDNAL EXPOSURE 7440-47-3 24-JUL-90
5 C AL L VH H H
------- - -------- - ------------- - - -- - - ---- - --- --- - --- --- ---- -- - -- - - - - - -- ---~--- - ----- - ---- - -- - ----- -- - - ------- -_.
. - - - --. - -- - - -- -- - - -- - - - -- - - - - - - -- - - - - - - - - - - - - - -- - - -- - - -- - - - - - - - - - - - - - - - - - - - - - -- - - - - - - - - - - - - - -- - - -- - - - - - - - - - - - --
Ä ÄÄ
PROKARYOTEs 1 LOVER EUKFlR. MAMMLs lN VITRO
5
L
H
HU HANS 1 F" /HI /'HHALslN VIVOlN VITRO
~"'ttZtj-~N
~VI
54I:~ï
1..t!
QH.. =tJ ø:
80Q~
fi~ lE
fi i
t!~fi=-fiE-
fi~~ ~
r. 0E
- U
~ ~2
lAR
e MO
NO
GR
AH
S V
OLU
ME
49
II~~ ~ ~ ~
~~ ~ ~ ~
~ ~~ ~ ~ ~
~ ~ II ~~ A ~ ~ ~
~ ~ .~ ~ .
...~ ~~~.. ~" ,.~,,. , "" ' ""
~..~
..~~
~~
~~
~ N
~~
~ ~
N~
~ ~
N~
~ N
~,~ ~~~.. ..~ ~~ ~~..~ø: ~~~ø: ~~~ø: ~~
... ,~~ ....S ~~ ~o ~~~S ~~~S ~~
i- 12....', , ~~
,~~
~~
~.. ~
~'H
.~., ,..ro.,~
,.~ro.,' 10.,~
i' roll 'E
-..; ; ;~o~
~.. ..r.1r.1Õ
:~ ;..~
,wÕ
:.. ; ;wÕ
:Õ:.. ; ;W
Õ: ;..
W~
~~
H~
~o~
~ i-~
HQ
~~
i-~Q
~~
~i-~
Q~
i-~~~t=..t ~ ~,~ tg: ~ ~~ ~~ ~~ ~~
ã t .. t t ~, t ~ t .... '~t _t ...., t t t" , ,t t t .., t; t-1 a a ~ ~ ~ ~ i ~ i ~ ~ ~ ~ ~ a 8 ~ ~ ~ ~ ~ a 0 ~ ~ ~ 8 ~g ~ ~ ~ 8
~ i ~ ~i; !aâl~ ii~;~~ ~ ;ä~; = ~l~;; ~ ~~~; ë ã
0000000000000000000000000000000000000 N
0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 000000000000000oo~oooo 0000 00 oooooo~oo 00 0000 00000 0 0000000000000 0 o~
o 0 oooo~o 0 oo~
~ 00 oo~
00. . . .. . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . . .~ ~o~o 0 0 0 000 O~ ~ ~o. .oo~" ..o~"~ ..o~"..
~N ~~,.o,.~,. ,.~~ o"~ ~ ~~,.~ "~,.~~"M
~"""M
"~ N
M M
"" ,. ~00010 1000000010000001000010000010001 1 1 1 1 + , , , , , , , 1 1 1 1 L , 1 L , , , 1 1 L , 1 L , L , , ,
~ ~ ~ ~
~ ~
~ ~
=- =
- =- ~
~ 12 12 Z
l2 l2 12 12 Z ~
~ ~
~ ~
~ ~
~ ~
~ ~
l , 1 1 E- E- E- E- H 0 0 0 0 0 0 0 0 HH H H H H H H H H H ~ Z Z ~
1 ¡lit t t g g g E ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~.~ ~ ~ ~ ~
m ~ m m 9 9 9 ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ l ~ ~:::: :::: ::: ~~ ~ ~
1 i il ~ ~ ~ 11111 ï 1111111 ~~ ~ ~ ~~ ~ ~ ~ ~ ~IIII""~llrororororo ,""" ,~~~~~~~CLCL~~
fIflflfl~ roro....HOOOOOONN,.,.,.,.,.,.,."",.,.,.""
ogog~ HHHHQoooooooo~~~~~~~~~~~~ClClCl
~~~~~ t t ~ ~~~~¡ a a ai i i a a i i i a a a i i i a ~ a a a~ ~~~~~ ~ ~ ~~~~ ~~~~ ~ ~~ ~~~~~ ~§§~ ~ ~§§~ § ~~ ~ ~ ~ ~ ~ ~.~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ i ~ ~ ~ ~ i i ~ ~ i
r.r.r.r. HHHH~~HHHHH~H~HHHHH~HHHHHHHH
~ ~ ~ ~ ~ ~ ~ ~ ~ ~ § ~ re re re re re æ re re re re re re re æ
æ re æ
æ æ
æ æ
re re~o ~ ~ ~ 8 8 8 fi fi fi fi ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~000 u
f re re re w w
w ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
0 ~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~ m m ~ ~ 9 ~ ~ ~ ~ ~ø: ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~
_ _ ~ ~ r. r. ~ ø: ø: ø: ø: fi fi fi
fi fi fi fi fi fi fi fi fi fi fi fi fi fi fi fi fi fi - fi
Q C CQ CQ Q CCQC C ~~~ ~~ ~ ~ ~~~ ~ ~ ~~ 0 ~ ~ ~~~~ ~ ~
ii~la~
t:H" :iiilJ i:80t:
~tJ
Hi:lJ
S~ ~
õlJ fi
U~
~
iSE-
lJ::lJE-
lJiiE-
fi ~ii 0E
- U
~ ~2
APPE
ND
IX 2
547
N N
Cl Cl
~I ~
I "' 0\ 0\Cl~~ClCl~~ ~
0\""''0\0\ ~ ~
Cl
~ClC
ll-l- " l-""~0\ 0\ l-....0 ~ """"0\0\l-0 ~ 0\0\ 0\ ~ ~ Cl Cl 0\ ~ 0\ ~ 1" Cl Cl Cl Cl ~I M Cl Cl ~ ~ Cl Cl N 0\ l-
'~l- "i:i:llinO\O\~O\~O\ ClMO\O\O\O\ClClO\O\O\O\O\O\Cl~~
. . ~ 0 0 C
l Cl ~
~ .- 0\ l- N
0\ Cl l- l- l- .- 0\ 0\ l- .- .- .- l- l- 0\ ~
,:i ~~:i t~~~, ~ ~ ,l-,~ l-~", ,l-l- "'" ,l- ~~~
t:i:it::~~ ~ ~~~:it: ~~-: ~ ~~~~~ ~ ~~~t:~~~ ~:i '~
1 t t 1 ~ ~
~ :i :i t t t ~
:i ~ ~
~ :i :i ~
~ t t :i :i t t ~
~ ~
t :i t ~ ~
~~ ~~~E-E- 2~t .-tE- tt ~ t~
i:i: ~~iiiitlH~ ~t ii~~H
H H
H ~~H
~~WSSW§~HH~~ÕW~~lJ ~~~lJHÕÕ~~ÕÕ~lJlJÕ~ ~a
~lala~
§~~
~ &
~la0G
HO
~~
HH
~~
~H
O~
~O
HH
~~
~S
~J~
~j~
re~~
~~
~~
~§~
ß~
~§~
~~
~~
~~
~§§~
~~
~~
00000000000000000000000000000000000~ oo~o 0 0 0 0 00 0 0 000 0 0 000 00 0 00 0 0 0 000 0 00N
00 1"00 000 0 0 0 00 0 0 00 0 ON
0 0 0 00 0 0 0 000 0 0000000 0 0 0 0 0 0 0 0 "' 0 0 0 0 C
l Cl ~
I 0 0 0000 0 0 000 "' ~I ~
.. . . ., .. . .. .. . . . . . . . .. . .. . .. .. .. . . . .. . . .. . . .. . .. .0000000000 0 ~
0001".-00\ 0\ 0 N 0 ~
I N N
1" 0 0 0000.. 0~
~.-~
l-1l ~I"" ~
I ~I~
I ininlllllll- ~I
l- .- 1" l-"' "'
0000000 + +
00000000000000000000000000+
11+1,.11+
+111111+
11+11' 1+
111++
++
++
11
~ 0
~e aaaaa ~
zzz~ ~~ HHHHH E-
222~ zz ~~~~~ ~~
~~~~~ HH
~~~~~ z~~~~~~~ ~~ ~~~aa~~~~aaa 0 H
~~wiiwi~ z(j(j~~~~~~~~~~~~~ ~~~~~~~à~
aaa ~z~2~~~zzzzzzzzzzzz ~ ~uq~
~~
~ ~
~ ~
~~
~ ~
~ ~
~~
~ ~
~ ~
~~
~ ~
~o 0 ~
~~
~~
~ ~
~ ~
~~~~~~~~OW
,,~(j(j(j(j(j(j(j(j(j(jtl(j~~à!!~~~~!ff,~
~~
~ w
U~
~~
wi:i:i:i:i:i:i:i:i:i:~
i:~~
uww
ww
wtl ~
Cl~
~~
lJW~
zzuwiiw
iiww
iiiiww
ww
zzi:~lJlJlJlJ~
_~ooo~ i:z ::::~E-E-E-E-E-E-E-E-E-E-E-E-HHW~~!i~~w 0
~;;;§~~~ '~~~~~~~~!~~~!!!àà~88ããã~lJ~
HHHHU '~~~~~iiiiwiiwwiiiiiiwwwuu """ ,0
§ § ~ ~ ~ i i ~ ~ ~ ~ ~ i i i i i i i i i i i i ~ ~ ~ ~ ~ ff ff ff ~ ~ ~lla
~~HH ~~~~~HHHHHHHHHHHH~~~~~~~~~~
rererere:::::: ~~~OÕ
ÕÕ
ÕddÕ
ÕÕ
dÕÕ
~~lJ ~~~ .~~~~ooo (j ~~~~~~~
U U
U U
~~~~~~~~~~~~~~~~~o eO o~ o~ 0e ~o ~o ~
. . . . . . . .. t:uuuuuuuuuuuuuuu w~ lJ lJ lJ ii w
w lJ lJ lJ lJ ~ lJ lJ lJ lJ lJ lJ lJ lJ lJ lJ lJ lJ lJ lJ lJ U
~ lJ lJ lJ la ~
1" ~ i: ~
~ ~
U U
U U
U U
U U
U uu U
~ ~
lJ U U
U U
U ~
~ lJ
~~
~~
u UU
UU
HH
HH
HH
H H
HH
HH
HH
HH
HH
HH
HH
HH
HU
lJ lJ lJ lJ ii w w
lJ lJ t: t: ~ lJ lJ lJ lJ lJ lJ lJ lJ lJ lJ lJ ~
lJ lJ lJ U U
U U
U U
U E
-
~ ~ ~ ~ ~ ~ ~ i: ~ t: Q t: lJ lJ lJ lJ lJ lJ lJ lJ lJ lJ ~ lJ lJ lJ lJ U
U U
U U
U U
E-
548lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
~..t!
~~
QH~ =
~ p;
80Q~
u§e
ui~ :E
ui ¡t!~~uiE
-uir.E
-fß ~
~ 8
~ ~
r. ~
\Ø0)01.-II
'.QO
)~M
II.-M ~~ !9~~
OIo)o)N
o)o) N N
OIO
I f.01
l~i~n~~~~l~Jll'~. H
~ t . H t t t t 0 ~ l: ti ui
~n~~~~i~~h~512~ iida lE
2 Øl 8 ui in E
~ ~ ~ ~ E- 8
0000000000000000oO
OO
OO
OO
ON
OO
OO
.OO
~000000001l000000000\Ø
00NO
OO
l"1I1l000" . l. . . . . . . . . . . . . .
o 0 II N 0 0 II N
0 0 .- 0 0) II \Ø \Ø
\Øl" M
IIM l".-.-
.- .-
0000000000000000+
11111111+1+
++
11
~ ~
~~ ~~~~~ 00
in in tJ ~ ~ E- E- E- E- E- ~ l)
~~~HH
~~~~~ ¡;~:i:i::~~ ~~~~~ ~~
::;: HHHHHQHH
:j :j :j tl tl ~ ~ ~ in in in ui in fí ~ ~
tltltl ~~~r.r.~r.5~~~
~UU
ii;ii~h~ßiiu.. -~
~~
n~~
~~
~h~
UIU
iuUU
1iUInU
iiiUH
hU:j:j:jl~lI' ,~~~~~~l~tl tJ tJ in in § ~
~ e e ~
e e ~ in in
tltltl==
..~~~~~~8=~~
E- E- E- S Sš m ff õ õ õ õ tJ ~ Ei E;
E- E
- E- Q
Q C
I in tJ U U
U U
U -i C
I CI
.'0§o~uCD
~'loi:o....¡Il~.¡i:QI
ui:ouQI
~.¡oi:,.¡i:mQI
r-QI
QI
.i.¡'lolni:o....¡Il~.¡i:QI
ui:oulnIli:QI
::...0-QI
~IllnQI
ln8..
8
6
4
Lnf-0-Z::wLnooLlo-i
2
o
CHROMIC CHLORIDE
S
A
S
5 5C C(j R
10025-73-7
cr
Il
01
C AH iL H
-2
J11111111111r11111rr111 1
---~------H------1 11 11 11
1T1~1111111111
- - - -- - --- - - - --- - --- ---_ _ _ _ _ __ _ J_ _ __1111
T11111111111l111111111111- - - - -- r --- -- - - -- --111
24-JUL-90
- ~ - -- - - - - - - - - - -- - - - -- - -- - - -- - - ---
~111
- - -r - -- - -- 4- -- - - -- - - - - -- - _ _ _ _ _ _ ___ ___1111.
-4L
p EH 5 !m o U !b 5 C T 0 5 0R im A fß 1 i Il i i c i H VB II o sm A A 015 5 L H L A
PROKARYOTES 1 LOI.ER EUKAR. 1 PLANTS iiN~trTI HAHMALS lN VITRO 1 HUHANS IF/HI l'HHALS lN ViVOlN VITRO
i111111111
-- - -- --- - - --------- ----- - - - - - -- - --
Ji jl 1\llni
~lotrZo~~N
~\0
550
f&~~u~~
i..~
QH::~
ø;
f& 0
tI8 Q~
tI~ :f
tI ~~t5E
-tI~tIE
-tIf&E
-
ti ~f&
0E
- U
~ ~
f& ~
lAR
e MO
NO
GR
AH
S V
OLU
ME
49
N N
CI CI
\D'" 0\ 0\
0( lU O
(.. tG .. ~ "
0\ ~CI O
\~~ ~~ CI C
I" 0( r- " 0( 0( 0( CI ~ ~ r- ,. 0\ 0\ 0 0\ 0 r-
0\ 0\ 0\ 0\ 0\ 0\ 0\ ~ ~ 0\ 0( r- r- CI r- 0( 0\
~ CI " " ~ .- .- .- .- p; ø; .- 0\ 0\ 0\ 0\ 0\ 0\ "
'0\' 00 .-.-"" .-"
M.. .... ~.... .. "H M .. ..
.c ..cU~..ftftftlI..rira."'-i.... .... .
E- : ~ ~ ~ E- ~ ~ ~ .~ ~ ~ ~ ~ f& f& ~ J J ~ J ~ li J ~ ~
~H O
\~ 0\0\0\0\ QQ
~~o~O\o~O
\~
tt" tt"".-.-tt~~
t a.-~"t
~ t ~ 1 i ~ 3 ~ i i i i ~ ~ 3 31 ~ ~ ~ ~ ~ ~ ~ ~ °1
~~
~ ~
ië~~
~~
~~
~Ë
Ë ~
gtl;a~;a
3~~ ~~~~~~~~~~~~ ~~§~~§~~
00000000000000000000000000000000000000000000000000000000000000000000000001'0000000 0 \D
0 0 0 \D \D
\D \D
0 0 0 0 0( 0 0 0 0 ~ 0 0 1' C
I. . '.. ... . . . . . . . . . . . . . . . .
o ~ ~
0 ,. ~ 0 0 ,. ,. ,. M
00 000 N ~
0 0 0 ~ 0 ~
0r-r-or- ,.r- ~~N
~"" .-~
.-.-
o 1 +00 100000000000000000000
1 ++
+ 111111111111 +
1111 ++
++
+
~ ~
~~ ~~~ .~~ ~~ 0
~~
~~
~~
~sss~
~~
Z~
~~
~ Ö
~~
~~
~~
~S
~~
00 HH
~~~~~~~~~~~~~~~~~ ~ ~~ ~~ ~
u~~
~~
~ f&
f&~
H ~
~ f&
f&0
H f&
f&f&
tItl~ ~
UU
~ti
~~X~f&f&f&f&tlltl ø;ø;~~~o~~~ NNE-f&
~H
&i&
i&i&
iØ; ø
;f& ~
o _HH
__H
n~U
~~
~~
_~I!~
w~
;~~
U~
U~
~"~
.. ~ ~
~ ~
~r-ci ø
;ø;1 ~
H~
~ f&
~tItl ..O
NN
NM
MM
~f&f&
f& f&
ø;ø; f&f&
..O
O~
HO
OO
O~
~~
o(§§ &i ~
Uf&
f&~
tItlö~ ~~ ~ ~ ~ ~ ~ ~ ~ ~ B
~ ~ i ~ ~ tl ~ ~ ~ ~ ~ ~ ~ !R 0 Q ~ ~ ~ ~ ~ § ~ ~ š š š ~ ~ ~ 0 ~ ~ ~ f& õ õ ~
z~ ~
HH
HH
HH
HH
HH
~::::::f&
f&U
~~
.. ~HHUtI~~~~~~~~~~NN~UUtItl ~~ ~
~ ~~~5i5i5i5i5i!f!f5i5i!f~~~ ~ ~~~¡¡f&f&if&
~~~~~~~~~~~~~~~~~~~~~8~~ ~
::::~~~~~~~~~~~~__~HHUUE:f~ ~
~~8t1~~~~~~~r.~~888~~ '~~oo ,000 ~~f&f&f&~~f&~
~ p: . . . . . . . .-. . . . . .. u U U
U~ ~ f& ~ ti ti ti ti ti ti tI ti ti ti f& f& f& ti ti ti ti
~~~~~~~~~~~~~~~~ô8~~~~~~~..~
~ f&
~ ti tI ti tI ti ti ti ti ti ti f&
f& f&
~ ~
ti ti ti U U
ti Õ
Q Q
Q Q
~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ti ti ti U U
ti U
.'Ú§o~UQ
I.t.l'Ioi:o-ri.ltUi..li:Q
Iui:ouC
I
:5.loi:~.li:mQ
I.-Q
I
QI
.t.l'Io1/i:o-ri.ltUi..li:Q
Iui:ou1/tUi:Q
I:.-ril:Q
Ii.tU1/Q
I1/
8
APPE
ND
IX 2
551
aDl1
..V
I 0::
z ;:-,
i :;
1
:: Z~
%-
ru0;;:;3V
I..~l%..~
..:: -'V
I 0Z
0:ut:: -'
~~::%3
~1
aM0
10:l-
U)
;:U
)3
a'- - '-
~V
I..
ut-z:ut _ '-
l1: el èS
il-Ui.ln3lnl-Za:..a.cia:~::i.W
0:1-
i.::a:
01-
..WU
.. L. Cl
a:lnL
.
lf 1 SI
l-U
0~ï:
.c~æ
ei0:
1a:
01
~0:
10
ff tQ 8
10:
:i1
a.U
CO QI ..
---~----l
coU
)~
rua
ru1
~1
SlINn 3500 ~OL
552~~u~B
irit!
Qi-~ =
wCI ~
8 Q~
CI
~ ~
CI ~
t!~foCI
~CI
foCI
wfof¡ ~W 0
fo U
~ ~2
lAR
e MO
NO
GR
AH
SVO
LU
ME
49
IIC
Il'
\0 0\ N'
CI Il" CI
A il
A II
0\ ~C
I O\~
~~
N' C
I" C
l1' ~ N'"C
I CIC
I Cl0\0 0\0 l'
O\O
\O\~
Nci 0\ N
~ N
~ N
O\O
\ O\l'ciN
I'ClN
O\
~CI""ø: CiO\~" ClI' Cl1' CI"" .-O\O\ciO\O\ci"
. 0\ 0 O\.-' 0\ 0\ 0\ 0\ 0\ .- " Ø
I .- .- 0\H
" ~~
.. .- .. ~.-.- .-.-.- ~
~ ~
" .- ~,e ..rsiu ..,c-cU
ftca ca .. ..... .... ..t ::;:;w
~ :~t:;~ : :~~ ::~ ::;:; :;~~ :~~ ::;¡ :; t t : ~ :; t ~ :; :; ~. ~ :; :; ~ :; t t ~ t ~ :;~. :; t g
t ~tt3 ~tt ~ ~tt1 ~t ~CIi!tt2tto~
~13~
i-~~
~ ~
~ ~
~~
O~
i- ~H
!~~S S~Õ SS~~SS~~S~SS~~CIÕ~CIÕ~ ~
3~; ~;~~~;;I~;;~~;~;;~~§~~§~~ ~
00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000 l' 0.. .. . t. .. . . . . . .. .. . . .. . . . . . . .. . . . . . . . . .
00\ CI N
' ~ .- 00 ~
0 .- 0 0 .-" 0 0 .- 0000 N' 000000" 0
N'.-\O
cil' ON
'Cl O
N' O
N' 0 .-~
~~
~~
~"
CI ~
~ .- ~
.- ~.- ~
.- " .- .- .-.- ".- .- N
.- .- "o 11000 11100 1000100 10000000000001 1 + + 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 + 1 1 1 1 1 1 1 1 1
~~~ ZZ ~
~~ ~ZZZZ~Z~~~~~~~ gg Z ~~~ß
1 1 foOO
OO
OO
HH
i-i-i-i-H~Z
~~ H Z
ZZ
fo~~ O~H~i-i-i-~~~~~~~ag~~ 00 i-HH~
~~~~~~~~~~~~~~~~~~~~~ àeee~~~~~~~~~~~~~~w
ww
ww
ww
~~ww
U~~~~~~C
I~
ii ~;iiiiii ~~ ~~~~ ~IIll~ ~¡¡¡llli:
~~tt:òòòò~~~~~~~~~ ~ ~~~~~ø:ø:lkWWWí-!E
o 0 ~ i- 0 0 0 0 0 0 ~ ~ ~ ~ ~ ~ ~ CI CI ~ ~ ~ z W W W CI CI CI
~~E ~~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~
~ ~ ~ ~ § § § § § § § § § § § § § § § § § ~ ~~ ~ ~ õ õ õ ~ ~
~ ~~~ ~ i ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~~ i i i àààà§W
W i- i- H
i- i- i- i- H H
H i- i- H
H H
i- i- i- ~ ~
i- i- i- ~ ~
~ ~
u~~~~rerererererererererererererererereriiõoõ.. i~
~8C
1~~
~~
~~
~~
~~
~~
~~
~~
~~
~ ~
~§§§§~
~ß...................~ ~~~£!£!eie¡
~ ~
W ~
CI C
I CI C
I CI C
I CI C
I CI C
I CI C
I CI C
I CI C
I CI ~
CI C
I CI C
I 0 0 0 0 !E
~ ~ ~~~~~~~~~~~~~~~~~~~ u ~ ~~~ ~ ~ ~..~~
~ W
~ C
I CI C
I CI C
I CI C
I CI C
I CI C
I CI C
I CI C
I CI C
I ~ Q
CI C
I CI U
U U
0 ~
Q Q Q Q ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ U Q CI CI CI U U U U ~
.'Ó§ioUG
l
:5\lo§-ri.¡IlI-.¡r:Gl
ur:ouGl
.i.¡.¡or:~.¡r:mG
l.-G
l
Gl
.i.¡\loCI
r:o.ri.¡IlI-.¡r:Gl
ur:ouCI
IIr:Gl
=-
.ri0'Gl
I-IICI
Gl
CI
8-
8
-4
6
CHROMIC NITRATE
fB
Æì
II
7789-02-8 24-JUL-90
-- -~- - --- - - - - - - -- - - -- -- -- -- - - - - - - - - - - - - - - - - - -- - - -- - - - - - - - - -- - - - - - - - -- - - -- - - - - - - - - - - - - - - - - - -- - - -- - - - - - - - - - - - - -_.
._- - ---~ ---- - - - -- -- -~- - - - - - - - - -- - - -- - - -- - - - - - -~ - - - - - -- - - - ~ - - -~ - - - - - - - - - - -- -- - - - - -- - - - - - - - - - -~ - - - - - - -- - - - - - - - - --
P
R
B
$ 5$fi RfI
æ 500
PROKARYOTES 1 LOWER EUKAR.
o
i
R
5 C1 1C C
MAHHALS lN VITRO
C
H
L
H
V
H
HUHANS 1 F /HI l'HHALS lN ViVOlN VITRO
~"itrZo-~N
VIVIv.
554
!CI
u1
l=
Q.... =ra8 ~Q~
CI
~ i:
~ fi
~~CI
fi~fi ~~ 8
å ~2
lAR
e MO
NO
GR
AH
S V
OLU
ME
49
ØI
~~ ~~~ ~ ~
~~
~~
~~
~~
~~
~ ~
ØI
~ ~ØI~ØI~~~ØI~~~~ ~~~~ ~
~ ~~ØI~~~~~ØI~~~ ~~~~
~ ØI ~ ~ ~ ~ ~ ØI~ØlØI~'
~ 0 ~, , , , , 'N ~ ~ ~ ~ ~
;~ ;~
J~J~
J~J~
J~~
'J' ;~g
: J: t t t t t t t t t t t J! tl: ~ ~
~t~~8~8~8~8~8~t.8~~~~i~i~~~~~~~~;§;j§~§i~l000000000000000000000000000000000000000000oooooooooO
OO
OO
OO
NO
OO
OoooooooooO
OO
OO
OO
N~O
~O. . . .. . . . . . . . . . . . . . . .. . .
oooooooooooooo~~o~o~~~
~~
~ ~
~ ~
~ ~
oN N~ ~ ~~ ~ "
0000101010101000000001 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 + + 1 1
~ ~ ~
~~l:zz~~~~~~ ~~~9
aageeii5iii~~ ~~~~
~~~II~~~~~~~~~~~l~~~~ggg.... .... ~~~~~~ ~ ~ ~~
11111~~~~~~li !iii Il I¡~~âii~~55aaG
Gleel~~ e
~~~aaaaaaaaaa~~~ ~~~~
~~
~§§§§§§§§§§~
~~
õBC
I~
~ ä l l l l l l l l l l l l ~ ~ ~ d d dd
~~~ ~~ ~~ ~ ~ ~ ~ ~ ~ ~ ~~~~ ~ ~~. ..c . . . . . . . . . . .(j(j(j~
~~
ß~
~ ~
CI C
I CI C
I CI C
I CI C
I CI C
I ra CI C
I CI ~
~ ~
õ
Q Q 9 g 0 ~ ~ ~ ~ ~ ~ ~ ~ ~ u u u u u CI ~
~ ~
¡ ~ ~
~ ~
~ ~
CI C
I ~ C
I ra ~ ~
~ tl tl tl Ö
Q Q Q ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ CI CI CI U U U U
.'0§luQ
I
:5\Ioi:o....lIIi-.li~oUQI
.i.l.loi:,.li:1.~QI
QI
.i.l\Ioeni:o....lIIi-.li:.ui:ouenIIi:QI
::...tJQI
i-IIenQI
en
B..
APPE
ND
IX 2
555
aDl1
-lln a
::z :;
-,~
:;1
:: z"f
:i _ru
a:;:;~ln..a::E:E~:i..t.Ul a
z Ila: !::E :;
::C
O:i 2!
1
tlLi1
aIl..
1-a
:;..
t:::tñ2!
a'- - '-
..ln..
ut _ '-l~1-UWln2!ln1-Za:..D
-
eia::w::wW
Il1-
w,a:
aL
...
-l::U1
lnw
III!1-
Ua)0
i:on a: C)
~0
:iaa:
II Bi B
tE:iu
colD
"fru
aru1
"f1
SlINn 3500 ~Ol
556
~ui!§Hui~uï
i..fi
QH.. ::w8 ~Q~
li~ :l
~ ~
!ui~ui~liw~ti ~~ 8
~ ~2
lAR
e MO
NO
GR
AH
S V
OLU
ME
49
Idco 1" 1" 1" l"
l' 1" 1" 1" 1" . N
~~ M ~ ~ ~ ~ ~ co
Id Id ~~ coA~ ~ ~ coldcoA~
~ ~ ~~ ~~~~~
co co~ ~" ~co" ,~co~co Ø\O~O
~:~
~ ~
~~
,~~
~ ~
,~,~
cñt;~t;~
Ø\ ~o~SS . S S S . . ~~~~~
..P".. co H
.. Hi .... ..
. .. . ,~ '.... II 4; ... id.. Id II .. II 4; . 4;' ,,-,~ J ~ ~ ~ ~ ~ ~ i t ~ ~ i ~ i i ~ i t ~ t ~ ~~ ~ ~ ~
t t t t ~ t ~ ~:3 t ~ ~ ~ ~ ~ ~ ~a t ~ t ~ i t i t
~ ~~~t ~~ ~ ~ ~ ~~~~ ~ ~ ~~I~ 1 ~ ~:~: ~
;~;s á &~~: B: ~;ë:: ~ ;i: i: ~ ~ ~ ~ ~
_~ _ c ~
c ~ ~
Q ~
Q ~
- ~Q
Q ~
- ~Q
~ Q
~ ~
~ ~
~0000000000000000000000000000000 0 0 0 0 0 0.0 0 0 0 0 0 0 000 0 0 0 0 0 0 0000000000000000000000000000o 0 0 0 0 0 0 0 co 0 0 0 co 0 co co 0 co M 0 M 0 0 0 0 0 0
. . . ll . . . . . . . . . . . . . . . . . . . . . . .~
1" ~ 0000 N
ON
0 NO
N 00 N
0 ~ 0 ~
0 ~ 0000
~~M MO~ . ~ ~ ~ O~~~
~ ~~ 0 ~"~~
~
0110001101010100100000000001 1 + 1 1 1 1 1 1 l .1 1 1 1 l l l 1 1 1 1 1 + 1 1 + +
~ ~
~ ~
~ ~
~ ~ i 3
~~tJtJ~~Ø
;Ci
~~~E-
tJtJ~1
~~ ~~~
~~ ~~~~~~~~~~~~~ ~~~
1 1 ~E
-HO
OO
OO
HH
HH
H~
~~
~~
~~~ OO~HHHHH~~~~~~~g~~~
~ ~
~ H
ft ~ ~
~ ~
~ ~
~ ~
l ~ ~
~ ~
~ ~
~ ~
Il ~ 11111111 ~~~~~i ii!!!
"1...... "" ,~~I"I"CO ø;ø;ø;
uill ....HO
OO
NN
MM
MM
M' - 'w
ww
ø;ø;ww
00 HH
QO
OO
OO
~~
~~
~cococo~
~~
ww
uiui~~t~~~aaaaaaaaaa~~~~~~ ~~~~
~ ~
a ~ y C
i !§ !§ !§ !§ !§ !§ !§ !§ !§ !§ !§ !§ !§ § !§!§ ~ ~
õ d
::~~ ~l~ ~ ~il ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ,.
~9!1ti~~:::i:i:::::i:i:i:i:::::::i:i:::: ,:i:i~~:i = - 5 5 Ci ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ui U U
~ ~
~ ~
~~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ci ci ~
~~ ~ w
~ ~ ~ li li ui ui ui li li li li ui ui li li li ui ui ~ lI li Õ 0
mme ~ Q ~~~~~~~~~~~~~~~ ~ ~ 8~~~ ~
~ ~
~ ~
~ ~
li li li ui ui uill ui ui ui li ui li li ui ui ~ li li U
U
Q Q Q Q Q Q C ~ cee cee cee ~ ~ C cc Q li li U U
.
1u~~oi:o'rl.lIdi..li:lIui:oulI:5.loi:,.li:1lIr-lIlI.i.l~ouii:o'rl.lIdi..li:QI
ui:ouuiIIi:QI
=-
'rl'"QI
i.IIuiQI
ui
8..
APPE
ND
IX 2
557
0Dl1
-.ln 0
::z :;
-,~
;:1
:: z"ì
:i _ru
0:;;::5ln..~~:i....ln 0Z
Il~~::
or:i~
1
001
0Ilor
1-"f
:;or
:50
'- - '-or
ln..en _ '-
~a:i:1-uWln~lnW
1-Z1-
a:a:
..0-L
L-.
0. -' =::
ci(J
a:::L
::w::
0:--(J
w=-
Ul
0a:
..l-DC
llnW
t: lE ~
1-U
t: lE Dl
0)-L
t: lE el
0:a:D
i-et
æe;s
0..exc:
10:
l1
0-U
! oceL ex CD
cotD
"fru
oru1
"fJ
511Nn 3500 ~OL
VIVI00
CHMIUM AL
-EN TEST TEST SYSTEM RESULTS DOSE 1 REFERCE
~POINT CODE NM M (LED OR BIO)
~G SAO S. TYPHIMUM TAlOO, REE MUATON - 0 712.0000 PETLL r. DE FLORA, 1978a 0
ZG SAO S. TYPHIMUM TAlOO, REE MUATION - 0 5.5000 DE FLORA, 1981a 0G SAO S. TYPHIMUIUM TAlOO, REE MUATION - - 340.0000 VEER ET AL., 1982 0G SAS S. TYPHlMUIUM TAl535, REE MUATION - 0 5 :5000 DE FLORA, 1981a
~G SAS S. TYPHlMUUM TAl535, REE MUATION - - 340.0000 VEIER ET AL., 1982G SA7 S. TYPHIMIUM TAl537, REE MUATION - 0 5.5000 DE FLORA, 1981aG SA8 S. TYPHlMUUM TAl538, REE MUATION - 0 5 . 5000 DE FLORA, 1981a =i
C"G SA8 S. TYl'HlMUUM TAl538, RERSE MUATION - - 340.0000 VEIER ET AL., 1982
dG SA9 S. TYPHlMUIUM TA98, REE MUATION - 0 5.5000 DE FLORA, 1981aG sA9 S. TYPHIM'UM TA98, REE MUATION - - 340.0000 VEER ET AL., 1982
8S SIC SCE, CHlNESE HATER CELL lN VITR 1 + 0 0.1800 VEER ET AL., 1982S SIC SCE, CHlNESE HATER CELL lN VITR - 0 27.0000 LES r. MA0NE, 1981 ~C CIC CHOM ABERR, CHlNESE HATE CELL lN VITR + 0 4.5000 LES r. MA0NE, 1981 tiC CIC CHOM ABER, CHlNESE HATER CELL lN VITR 1 + 0 0.1800 VEER ET AL., 1982 .;1.
1Doses are given as concentrations of the element, not the concentration of the compund.IContaminated wi th traces of Cr (VI)
APPE
ND
IX 2
559
0rn1
~ln 0
:Jz;:
--l :;
1
:: z'\
:z _ru
0;::;~ln..lf:z..lAln 0Z
0:~~:::z ~
01
rn1
rn1
0l
10:
1..
cot
:;r
co1
~l'
1..-..
1l'
1ln
1..
1
l----:--11
f1
..UWln~ln..Za:..iiciet:.::w0:W1:
,0:J
..~a:
ln1:
w
~laIS:
..::
0-
;)1:
0:~
en a: ."
et0
:.0a:
0::i
iiU
coln
q-ru
orul
'\1
SlINn 3500 ~OL
56lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
IlC
I"0\.-~
.-.-CI 00
i0\ 0\
.- .-
ii1l1l1l1l1l' ,.- .- .- .- .- f; f;
W 00 00 00 C
I 00ii
QO
\ClC
lO\O
\oot!
...-.-.-.-.-~~~~~~~~::
.'0
Ë .. ii ii ii .. § §
§
ø.~~~I!~~0u
UQ
00000000H
H00000000
QI
a.. =
00000000ii
t1 ~O
\D\D
\D\D
\DO
OO
. . . '. . . . .80
ON
NN
NN
"'O..
,.,
N0
WQ
\D
~~
i:0.of.l
CI
IIC
I~ :E
00000000i..l
U~
1
CI §
1 1 1 1 1
1 1 +
ut!
i:0u~
QI
?3~
ii
1
.lt2 t2 rš rš ~
~g
OO
HH
Ht2 ~
,
un~U3
.li:f;
1QI
.-r.r.r. t2tl
CI
nUIM
He
CI
.i.l
. . J ~ ~
..
!0
.. 'Il r- co
uiO
OM
MM
'ewi:
CI
ooinininCl CI
0lM
~~aa~a!B.of
CI
.lIlfi
?3 ?3 ?3 ?3 ?3?3 i5i..l
~i:
iiiiiilsQ
Iui:0
~~~~~~~:uuiII
. . . . . . tl ~
i:QI
CI CI CI CI CI CI CI
~.of'"fi f:
~~~~aa~öQ
I
~ 8i.IIui
i ~
QI
uiC
J CJ C
J CJ C
J CJ C
I uB
g..
APPE
ND
IX 2
561
am1
-.U
l a::
z ~
ix -
-,:i ~
1:: z
~:i _
rua~~~U
l-iix:i:i~:i"-liU
l az Ilix !::i ~::
~:i
~1
m('1a
MIll-
m:;
a~
~L- - '-
tDU
l-iixEix:il-uWU
l~U
ll-Zix-ia-
U-lfci
crix
CD
:i::wW
a:i-
w=-
cra
u.-i
-.::lfU
lw
tll~l-
ua~
-a:
L..a:e
ix0
:ia0:
a::i
a-U
cotD
~ru
aru1
~1
51INn 3500 ~OL
CHC OXIDE
EN TEST TEST SYSTE RESULTS DOSE 1 REFERCEPOINT CODEHM M (LED OR HID)
0 £R E. COLI RECi DIFFERIA TOXICITY - 0 3760.0000 YAGI , NISHIOKA, 1977G G9H MtATION, CH V79 CELL, HPRT + 0 10.0000 ELI ET AL. 1 1986S SIC SCE, ClINESE HATER CELL lN VITR + 0 34.0000 ELIA ET AL.i 1983S SIM SCE 1 MOUSE CELI lN VITRO - 0 104 :0000 ANEREN, 1983T TCL CELL TRSFORMTION 1 OT CELL LINES - 0 274.0000 HASEN , STE, 1985
lDoses are qiven as concentrations of the element, not the concentration of the compund.
~
-~~.oz8
~en
âE~tT~\0
APPE
ND
IX 2
563
0Dl1
:-l
,II
a::
,z
~,
~;;
--,
1,
::~
'\. ,
:i,
ru,,
a,
~,
:;111
~11
II11
..1
~~:i..L.
II az a:
ii ~:::i
~D
l1
en1"aa:
1..
CO
:;0
~1"~
II..ui_~
CJ _ x:
l.. GO::
~..Ui.II1
~11,,
II1
..1
Z,
a:,
..,
a..,1,1
ri,,
a:1
~,
::,
i.11
a:1
i.1
=-
W1
01
..0
11
X,1
01
Ul
i.1
..1
0U
1,.
i:1
~1
01
:i1
0a:
1a:
1.._C
I:i
la.
Ul, .
coil
'\ru
aru1
'\1
SlINn 3500 ~01
56lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
irat!
i:H- :i(¡ ~80i:~
~~1
CI
~ lE
CI i
t!~eE-
CI
~fi ~~ 8
~ ~2
IlCI
..0'.-,.
N C
IC
I 0'0'.-.-
.-.-N
CI C
I NCI 0' 0' CI
0' .- .- 0'
.- .-
,~ra Il ' Il Il Il Il.- ".-.-.-.- 'ww '
wco 'HOOCOOOCO 'zz .
i:Ø\~"-Ø
\Ø\Ø
\Ø\~oo~
.-"- .-.- .- .- .. ') ') .... 'tt", ,tiit~~ H
:i:i:i~ ....ësg¡~SSSSC
íClC
ICi
ø.;løi;;;;l§§l000000000000000000000000000000000000000000000'000'000\00000.-.-.-.-0'0'0
Ø\
0' Ø
\Ø\Ø
\"",.0.-,.,.1,1,
.-
00++
00000000+
++
+1 J J 1+
++
+.. ..
~ ~
........iziziz ~~
~~
~~
~ggi iziz
5555~~~5~~HH
~~~~fS:S:~~~~~iaw
wf tJtl
nnUlw
~~~~..JtltlU
.. .. .. "'10""
co0000,.1,1, ,~
~w
wo 00 0 in II II CI W W CI CI
aaaaaaaa~~~~§§§§§§§§:ã:ãõõ
iiiiiiiillàà:i:i:i:i:i:i:i:i:i:i ~ ~
ø.~ø.ø.ø.ø.ø.ø.uu
~ ~ ~ ~ ~ ~ ~ ~ titi~ ~
CI C
I CI C
I CI C
I CI C
I CI C
I 0 0
9oooini:c;OlU
UU
U...c............ H H H H
CI C
I CI C
I CI C
I CI C
I CI C
I U U
CI C
I CI C
I CI C
I CI C
I CI C
I U U
'0§§:oUQI
.i~\loc:o'r4~IIW~c:QI
Uc:oUQI
.i~~oc:,~¡QI
r-QI
QI
.i~\loII Hc: ::
o ~.r4 W
~ U
IIW \l
~ 0
c:QI II
U QI
c: U
o IIU W~
IIIl .i
~c: -r4
QI ~
:;.r4 '0t¡ QI
~Q
I Ilw
c:II .r4
eII IlQ
I ~II c:
88- ..
APPE
ND
IX 2
565
aDl1
-lln a
::z ;:
-,i: :;
1:J Z
~:r _
rua;::;~ln.J~~:r"-i.ln az a:
~ 3;
:J:r ~ru1..M
aa:1
l-C
O::
a~
M..ln.J
.. -'-l~l-UL
&ln~lnl-Za:.Jelcia:li:iL
&
a:L&
:aaW
.J0:a
lnL&
Wut lE
~l-a
r-~
ï:a:
uia:ca:
alia
0:a:
ln.
U
colD
~ru
aru1
~1
51INn 3500 :JOL
56lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
"\DCI
01M
.
i:4t
..ti
f;
l§
iii:
l~
()Q
0H
0G
I.. =
0.c
(i0
~8 fj
.N
..II
0Qt3
c:
~0."
1
~en
"~
:10
..~c:
~ Ii
GI
+g
u~
0()GI
~:5
~~8
l!,~
~c:1
tJ..G
I
1
GI
:5..
e0
,iln§
~:i
."en
~~
"f4
..en
~~
1
c:GI
()c:0()
~
ln"c:GI
en=
-."tJ
fi ~~
al
~ 8
..i:
"ln
å ~
GI
lni:
82
..
APPE
ND
IX 2
567
a(J11
..l
ln a::
1Z ~
1
l ~
-il
11
:: zl
~1
:: _ru
11.a
1~
1~
113
111ln
l..
l
l111
~11.1
:r1
"-1
..1111
ln al1
Z 0:
1~
~1l
::C
Ol
:i ~1
1l1
CO
11..
11
1a
M1
0:1
t-L
n1
~1
a11
~ru
1..
11ln
1..
1
~111
~111
CI _ co
111t-
1U
1W
1ln
1~
111ln
lt-
1Z
1C
I1
..ciriCI
:i::w
W0:W
l-,
ï:a..
0et:iln
UWt-a
U~0:
-C
Iet
:iaa.
0:::
ciU
colO
~ru
aru1
~1
51INn 3500 ~OL
568
i..r;
QI-~
:iWfi ~80
1
Qt3
fi~ lE
I-Qfi i
!3r;
I-fi~
~fofi~fifofi~ti i:W 0
fo U
å ~2
lAR
e MO
NO
GR
AH
S V
OLU
ME
49
.QMcoCI
.-\0cor-, 0 0 0 0 0
clco r-~r- co co~ co~ co~ co~ co~.- CI co ~ r- r- .- .- M CI co M CI co CI co M CI co M CI co
.- CI C
I 0 CI C
I co co co N .- C
I co N .- C
I ~ .- C
I co N .- C
I ~ co N
.- CI
, co.- fo .- .- CI CI CI co .- .Q ~ CI co .- r- .- CI co ~ r- CI co ~ ~
. 'CI I- o.-.- .- CI' CI co .- CI' CI' .- CI' CI.- CI' CI
:;:Z.- 'w
, 'co .- . 'co CI .-. ,..- . , .-. '.- .-..co
~I- ,~
!2rá~~
~: :: ,:;~
~.- : ,:;~
,~~
: ,:;~ ,: ,:;~
~fj ~
~2~
':;o~~
o.fo '''~~
fo ~f4 :;~
fo ~:;~
fo 'f4fj :i.-fj' co f4wfj.:i f4r&fjf4r&t flr&tf4 f4r&t.
~~
tl;~~
~fj~
ttt~ :;~
tfj~ t~
fjfj~ fjfjfj~
~fi ff ff ~ ~ 0 ~ fj t3 ~~ 8 ff i i fj:z 8 ff i i 0 i i8 ff i i ~ 8 ff i i t
~ ~ i ~ ~ ~ ~ ~~ ¡ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ i ~ ~ ~ i ~ ~ ~ ~ i ~ ~ ~
00000000000000000 \0 0 0000000000000000000000000000000000000000000000000000000000 00000 o~o~o 0 0 00 0 0 0 0 00 0 0 0 o~o~ 0~ .- 0 0 0 0 0 0 000 0 ~ r- 0 r- co 0 0 000 M 0 0 co 0 0 0 M co r- 0 r- ~
. . . " . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .M
ON
\0 0 ~ \0 \0 \0 0 .- 0 ~ .- 0 .- NO
r- r- 0 r- .- 0 r- .- r- 0 r- .- .- .- 0 .- M.- r- C
I co N \0 N
\0 \0\0 .- N N
r-.-
0+ +
0000000000 +0 +
000 10 100 10 10 100 10+0
++
++
++
++
++
++
++
1 ++
+ l' 1 1 +
, 1 + 1 l' +
++
1 ++
~~~~ ~
~~
~~
~~
~~
~~
:z:z:zz:zz~~
~~
~~
~~
~~
~~
I-, L , 1 ~
fo fo fo fo fo I- 0 0 0 0 0 0 I- I- I- I- I- I- I- I- I- I- I- I- :z z z :z ~~
~ ~
~ ~
~ ~
~ ~
~ ~
I- I- I- I- I- I- ~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
2 2 2 2 ~
~ ~ ~ ~ ~~ ~ ~ ~ ~ ~ ~ 111111:::::::::::: 1 i Il :
; i ; i l: l l IL l 1111111 ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ 1111 l
""~~......r.r... ",;., ,~~~~~r-r-cococococo 1
fi fi
fi fi ~..r.r.r.I-OOOOONMMMMMMMMMMMM""
o 0 0 0 I- I- i- i- i- Q 0 0 0 0 0 0 ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ co co co co
~~~~ ~~~~~~~aaaaaaaaaaaaaEEEaa~~~a-
~ ~
~ ~
~ Q
Ir; r; r; ~ §!3 § § § !3!3 § § § ~
!3!3 ~ ~
!3!3 §!3!3!3 ~!3 §
~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ i i ~ ~ ~ i i ~ ~ i ~ ~ ~~ ~
W W
W W
, I- i- i- i- i- -i i- i- i- i- ¡s I- i- i- i- i- I- I- I- i- i- i- I- i- i- ¡s ~ !i !i~ ~ ~ ~ ~ ~ ~ § § § § ~ re re re re re re re re re re re re re re re re re ~ re re re re re~
~ ~
~ B
B fi fi fi fi fi ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~liiili.......f4...................... .~ ~ ~ ~ W
W ~ ~ ~ ø ø ~ fi fi fi fi fi fi fi fi fi fi fi fi fi fi fi fi fi fi fi fi fi fi fi
m m mm ~ ~ ~~ ~ ~ ~ ~ ~ ~ ~ ~ ~ a a a a a a a a a a a ~ a ~ ~ ~ ~ ~
~~
~~
~ ~
~~
~~
~ ~
~~
~~
~ ~
~~
~~
~
ir.~
QH.. :ifi ~80
~
Qtl
~li~ :E
H0li ~
!i~
Hli~
~lii.liE-
lifiE-
~ ~
~ 8
~ ~
fi 2
APPENDIX 2 569
'0 '0
co co
CI CI
.- .-
, ,N N
~ ~
~ ï ~
~ ~ ~~ ~ ~
~ M H
HC
I .- .-co 'co 0 ~ ~.-C
I !' CI coco Q
Q 'l" N
.- :;.- CI l' 10 '0 l' 10 '0 :: ::' .- M . l' M 0 l' .- CI co M l'
a 1'.- CI co l' co co l' . co co ~ CI co ~ co co l' CI co co
,~ fi ' co .- 10 CI CI CI 10 CI CI o. .Q o. ,. CI CI .. .- CI CI CI CI .- CI CI
l co H :i CI ' co .-.- .- co .- .- '0 CI .. .- .- .-.- .- .- .- .-
CIfi 8.- . 'C
I CI C
ON
CO
N E
- ,:i .,.-. ~ 10 ~ '10 ~ ~ .-. =-: =- .- i: ~ ~ ~ a t : : fi ~ : ~ : : : ~ : :
~ :!E
~li~
~t : ~
~~
: ~:i..~
'~H
:i:ig :io:i:i:i :i:i~:i o. ~ 2 ~ ~ t ~ i ; t; ~ 5; t i~ ~ ~ ~ t t 2 t t : t t t t t t
; t ~ ~
o. t ~ Ill 10 t .- o. H
o. t .- o. Ä t ~
t ~ ~
tl H ~
~ z z Z
Z 9 ~
H H
~ ~ §§ ~ a.§ .. ~~. ~..~ ~.~. ~ ~ ~ ~ ~ ~ ~ ~ m ~ ~ r. ~ ~ 8 8 ~ ~ ~ ~
~ ~
~. ~
~ ~
~ ~
li ~ 2 ~
~ li ~
ß g i ~
ß ~
e ~~
~ ~
~ ~
~ ~
~ ~
~00000000000000000000000000000000000o 0 0 0 0 00 0 0.0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0
0000000000000000000.000000010 M ~
~ ~
co 0 0 '0000 010 10 0 0 00 0 0 ~
0 0 0 0 ~N
ON
0 0 00 M .-0 0 0 0 .- 0 l' N
. . . 1. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
o ~ l' 10 0 M
10 0 '0 g 0.-0 0 ~ O
.- 0 l' '0 10 0 ~ 0 N
.- 0 0 0 00 O.- 00
NI'N N.-'D N.-OO N.- 0 ~inNin .-
'0 .- .- .- N 0 .- .-.-.-
000000000 +0000000000000000000000000
++
++
++
++
++
++
+ 1 +
++
++
++
++
+ 1 +
++
++
++
++
+
~ ~ ~ ~
~ ~
~ ~
~ ~ Z
H H
0
~~~ ËË ~~~~
~~~~~.~ Z ~~ 3333
11fi~~~ 2 zzzz tl~ ~~~~ß
I~~~~zz~~~~ 2222 ~~ ~I~~~ E-888~8~
00 ~~OO~HHH ~~~~ 00 po~~~~ ~~
~ ~fiII: 1: ~ ~ : III ~ ~ ~ ~ ~ ft ~ ~ ~ ~ ~ ~ ~ ~ m ~ ~ ~ ~ ~ ~ ~
~~
~ iiI888iH
Ifififi~§11. g; '" '~
~333~
~33
~~I fifi ~I~~g;fjfj~~~~~~ ~~~~~~~
l?l? Il ~~~ § § :~lIlI~HHHH ~
l2 Z '" &i fi fi 00 1. ,. ~ ~ ~.;:: CI CI CI CI CI.
CI CI
HH
O~
~~
..~~
~ur.. . ~
'~ III 1 ~
~t;~
~i;i;i;t;
~§r.g~~ ~~~~iB~i~i i~e~~~~~~~~~~o~~~,.,.~~
x ~ ~N N N ~~~ ~ H ~ ~ H ~ H eH ~ ~ ~ õ õ 0 õ õ d õ Õ
fi fi .- ~ ~
~ ~
~ li li li li li li li li g 8 8. ~
: : : H H H H H : ¡ ~ ~ ~ Hi i ¡ ¡ i 1. ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~
~,.~~~~~~~æ~~~ ææ~ ~~~~~~~~HHHHHHHH
88BB888B8~~~2uu~~2 ~~~~~~~~~~~~~~~~
~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ci ci dll li li ~ g ~ ~ ~ ~ ~ ~ ~ ~
l' l' tj iS iS iS tj 0 fj 8 8'8 g l' fj fj fj ~ f: ~ ~ a1 ~ ~ ~ ~ ~ 8 ~ g; g; ~ ~ g; g;fi fi fi fi fi fi fi fi fi li li li li li li li li ~ li ~ ~ ~ 0 0 0 0 ~ ~ ~ 0 0 ~ l? ~ ~
~ ~
~ 0 ~
~ ~
0 ~ ~
~ ~
~ 0 ~
~ ~
~ ~
~ ~
~ 0 000 a ~
~ l? ~
ø l? ~
e
570
~..fi
QH.. :itl ø;
80
1
Q~
CI~ lE
HQCI fi
§fi
HCI
~
l5E-
CI
~CI
E-
CI
r.E-
&; ~
~ 8
~ ~2
lAR
e MO
NO
GR
AH
S V
OLU
ME
49
1"GO
Ø\n Ø\~ 1" .
.l" ..inN .. Ø\I"GO
¡GO
nMM
Ø\O
Ø\G
OG
OG
O M
.Ø\ ~
OØ
\Ø\""~
nl"GO
inØ\N NN~GOGOI"GOI"Ø\Ø\Ø\MGO MGOI"NGOGOI"I"Ø\GO Ø\Ø\ GO
~GO
GO
GO
Ø\Ø
\Ø\O
\Ø\Ø
\n~~GO
O\ G
OØ
\Ø\G
OØ
\O\. O
\Ø\~Ø
\I" '~~""Ø\
Ø\N
Ø\Ø
\~~n~~~ Ø\~ O
\~~Ø\~nn~ ~I"l ..~
--..co.... " ...... .... .. 0\ ....0\
!~ ~~¡¡I~ll~l~ ~ ~ ¡~~¡~I¡I~l~~ li~ ~ ~ ileH W t t t ~ H ~ ~ H ~ H 8 H t H a t~ ~ t ~ H ~ 3 ~ ~ ~ ~ ~ ä ~ ~
III lI! Ii ~l il 1 ~l! i Iii iii ~! 1 ~ Ii i ~ ill
0000000000000000000000000000000000000000000000000000000000 0 o~
o o~oooo
000000000000 n. 0 0000000000 GO
" O. M
in 0.0NO 0 GO ~ ~ ~ n O~ 0 ~ 0 0 0 ~ ~ ~ ~ 0 " ~ ~ 0 ~ ~ 0 .. 0 0 ~ ~ 0 ~
. . .. . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . .in ~
~ 0 0 0 0 0 ~
0000 0 ~ 0 0 0 0 N
0 0000000000000
0000000000000000000000000000000000+
++
++
++
++
++
++
++
++
++
++
++
++
++
++
++
1 ++
~~ss~~ 0
~~~~~~ ~~~ ~~
ZZ
ZZ
ZZ
E-H
.i;.H
HH
HH
H Z
HP~C
ICI
~~~~~~S~~~~~ 0 0 H~~~~~
ZC
I~~~~~HH
HH
H~~ e:~~~~~~~ ~H
tl~~~
B ~
~~
~~
~~
~~
~~
~tltltltltltl~
~ ~
NZ
Z~ ~ s ~~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ e e e e e e: E tl ~ ~ ~~ ~
. . ~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ 0 ~
~ ~
~ ~
~ ~
~ H
~ e Q
~ a ~
~~ ~ ~ tl tl tl tl tl tl tl tl ~ ~ tl tl ~ ~ ~ ~ tl ~ ~ ~ ~ ~ ~ ~~ ~ m
~ 0 ~ CI
r.r.~ø;ø;ø;ø;~ø;ø;ø;ø;~~ø; r.wwwr.r.u~ o~...
u ur. w r. r. r. r. r. W W w r. w w Z Z Z Z ø; CI CI CI CI CI CI r. z.. ~ Z Z Zo
U E
- E- E
- E- E
- E- E
- E- E
- E- E
- E- H
H H
H W
~ ~
~ ~
~ ~
wu .i C
I _ 00
~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ß ! ~ ~ B B ~ ~ ~ ~ ~ ~ ~jj j
:i:iinr.wr.r.r.r.r.r.r.r.r.wtltluu .......... '000
U U ~ CI CI CI CI
en CI CI CI CI CI CI CI ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ $ ~ .. .. ..
~ ~
~ ~
~ ~
~ ~
~ ~
~~
~ ~
~ tl tl tl tl H
r. w w
r. r. r. w r. r. ~
r. ~ ~
~B
B B
~ ~
~ ~
B ~
~ ~
~~
~ ~
~ ~
~ ~
~~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
e:E-E-E- ClJ:~~~~~~J:~~~
~ ~ ~ ~~~~~~~~~~~~~~~~~~ ~ ~ g g g~ g g g g ~ ~ ~~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ CI ~ ~~ 0 0 0 0 0000000 tl tl tl
:i 0 E- U
U U
U U
U U
U U
U U
u J: J: J: J: CI u u u u u u J: ø
; CI E
- ~ ~
CI C
I0\ 0\ in H
H H
H H
H H
H H
H H
H H
H H
H H
H H
H H
H H
H H
H H
HO
U U
e e e CI C
I CI C
I CI C
I CI C
I CI en C
I CI C
I CI C
I CI C
I U U
U U
U U
U U
U U
U E
- E- E
-
e e e CI C
I CI C
I CI C
I CI C
I CI C
I CI C
I CI C
I CI C
I CI U
U U
U U
U U
U U
U U
E- E
- E-
POASSIUM DI CHOMATE
END TEST TEST SYSTEM RESULTS OOSE i REFERCEPOINT CODE NM M (LED OR HID)
T TCL CELL TRSFORMTION, OTER CELL LlNES + 0 0.0150 RAFET ET AL., 1977T TCL CELL TRSFORMTION, OT CELL LINES + 0 1.8000 BIACHI ET AL., 1983T TCL CELL TRSFORMTION, OTER CELL LlNES + 0 2 :6000 HASEN & STER, 1985T TCL CELL TRSFORMTION, OTER CELL LlNES + 0 5.2000 LARACHI ET AL., 1988D DIH STR BRE/X-LINK, HU CELL lN VITRO + 0 0.1200 SNYER, 1988D DIH STR BRE/X-LINK, HU CELL lN VITRO + 0 5.2000 MCL ET AL., 1982D DIH STR BRE/X-LINK, HU CELL lN VITRO + 0 o . 5200 HALTON-KOC ET AL., 1986D UHF uns, HU FIBROBLATS lN VITRO - 0 104.0000 BlANCHI ET AL., 1983D UHF uns, HU FIBROBLATS lN VITRO - 0 104.0000 BlANCHI ET AL., 1982b ~S SHF SCE, HU FIBROBLATS lN VITRO + 0 o .0100 MACR ET AL., 1979 ~S SHL SCE, HU LYMHOCYES lN VITRO + 0 0.0180 GOMEZ-AROYO ET AL., 1981 tTS SHL SCE, HU LYMHOCYES lN VITRO + 0 0.0025 STELL ET AL., 1982 ZS SHL SCE, HU LYMHOCYES lN VITRO + 0 0.1000 OG ET AL., 1978 0-S SHL SCE, HU LYMHOCYES lN VITRO + 0 1.0000 ANERSEN, 1983 ~C CHL CHOM ABERR, HU LYMHOCYS lN VITRO + 0 0.0520 NAO ET AL., 1978 NC CHL CHOM ABERR, HU LYMHOCYES lN VITRO + 0 0.0010 STELL ET AL., 1982G MST MOUSE SPO TEST + 0 3.5000 KNSON, 1980S SVA SCE, ANlMA lN VIVO + 0 3.5000 KATHS, 1981M MV MICRONUCLEUS TEST, MICE lN VIVO + 0 18.0000 FABRY, 1980M MV MICRONUCLEUS TEST, MICE lN VIVO + 0 0.3500 PASCHIN & TOROPZEV, 1982M MVC MICRONUCLEUS TEST, HATERS lN VIVO + 0 7.0000 KATHS, 1981C CHA CHOM ABERR, ANIMA BONE MAOW lN VIVO - 0 o . 7000 PASCHIN ET AL., 1981C CHA CHOM ABERR, ANIMA BONE MAOW IN VIVO + 0 6.0000 NEN & LILLY, 1986C CHA CHOM ABERR, ANIMA BONE MAOW IN VIVO + 0 1.0000 BIGAEV ET AL., 1977bA AVA ANUPLOIDY, ANIMA CELL lN vivo + 0 1.0000 BlGAIEV ET AL., 1977bC CU CHOM ABÉRR, ANIMA LEUCOCYES lN vivo + 0 7.0000 NEN & LILLY, 1986C DLM OOMINA LETH TEST, MICE + 0 o .7000 PASCHIN ET AL., 1982C DLM OOMINA LETH TEST, MICE - 0 0.5300 PASCHIN ET AL., 1981
lDoses are given as concentrations of the element, not the concentration of the compound.
V\-.~
4
uit-..Z:: 2wui00Ll 00-1
-2
8
6
..4
POTASSIUM OICHROMATE 24-JUL-907778-50-9
If EH $ mmIr lB fl llII !I æ im
11 51111 cr 0
5 VVV B. LT Rl1e ll 11
55 5 5e Z e ZGG R r
o DO U lfG $5 in T T 0H HI IßI5 Il i. iiii.e t 1X HR R OOT 015 im 5 l H
$ eIl HFl L
5
e
H
--
- ---
--
---
-
-- -
--- --
--------_.-- ------- -- ------- ------ ------------
- - -- - - - -- - - - - - - - - - - - - - - - - - - - - - - - - -- - ---
-- -----
1
- -- - ------- --- -~ -- ----- - ---- -- ---.L
$IISI
5
e
r
U
H
r
PROKARYOTES 1 LOWER EUKAR. MAMMALS lN VITRO HUMANS 1 F ¡HI l'MMLS lN ViVOlN VITRO
VI-iN
~('s:ozoo
~=ien
â8s:tT.i1.
ir.~
QH~
::wli ø;
80Qw
~
~li
~~ ~
Hli ir
Q~
~HQ~
lSE-
lii-liE-
liWE-
~ ~
W 0
E- U
~ ~
W 2
APPE
ND
IX2
573
~ ~
~ ~ø ~ ø
ø ~~ ø ~ ~
~ ~ .~ M ~ ø M
~~~~ ~~ ø 0 ~ ~u~ ~~~uVø~u ~~~~ ~
~ ~ ~ ø ~ M~~~~O~~~~~~~~~~~~~
ø ~ø~~ " ~ ~ ø ~øøøøøø øøøø~øøøøøøø ~~..~øø.... ~ ~..~~~~~~ ~~~~~ ~~~~~~~ ..
~ ø; ~ ~ ~ ø; ø; ~ .- ø; ~ .- .- .- .- ~ '.-.-.- ~ ~.-.-.-.-.. ~.- ø;~3~~.-33 J 8~ ~q~~~,~~:;~~~~J~~,,~~~ q.r.'~'r.ri~.. ~.t:...... ....~......."'i;
:; ~ :; ~ ~ ~ ~ i t ~ § i :; ~ :; :; :; :; :; :; t:; :; ~ ~ t :; ~ ~ ~ :; :; ~ i ~t ~ t E- t ~ ~ .- H ~ ~ .- t ~ t t t t t t 3 t t t t H t t t t t t t ~ ~
~ ~
~ ~
a ~ ~
~§ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ § ~
~ ~
~ ~
~ ~
~~
ri ~ r. ~ ~ ~ ~ ri ~ r. ri ri ri ~ ~ ~ r. r. ~ ~ ~ r. r. r. r. ~ r. r. ~ r. r. ~ r. r. ~~ ~ ~ ~ ø ~ ~ ~ m
~ ~ ~ ~ ~ re ~ ~ ~ ~ re ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ re ~ ~ ~0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000 0 o~
oo 00000 0 000~
~~
~ ~
~ ~
~ ~
~ ~
~~
~~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~~
~~
~ ~
~~
~o~o 0 ~M~M M~ OM~O MO~~~~~~~~M 0 ~~oo ~ o~o
MM
M ~ ~~ .-
~ ~
00 +00 +
110 +00 +
+00 +
+ 1000 +
1 + +
0 100 + 1001
++
++
++
++
++
++
++
++
++
++
++
++
++
++
++
++
+ Il
~ l2 Ii
i ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~S2
~ HUHHHHHHHHHHHHHHHHHHHHHHHHHHHH~~
'6 61 ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~l ~ ~ ~ ~ ~ ~ ~ ~!!
1:: ~ 11111111111111111111 Il 111111111li E- E- W r. ' ,
'2 Z rz ri .. .. 40 .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. -. .. .. .. .. .. .. ..Il U
'li ~ ~ r. HO 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0000 N N ~ N N N N N M M
~ ~
~ H
Q 000000000000000000000000000 0 ~
~~t E
~~E E
E E
E E
a a a E a a a a E
E E
a a a E E
E a a E
E E
a a
~ ~ ~~ l ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ e e ~ ~ ~ e e ~ ~ ~ e e
:~ ~ ~ ~ l l l l l l l l l l l l l l l l l l l l l l l l l l l l l l
9 ~ ~ E- ø; re re re re re re re æ
æ re re re æ
æ re æ
re æ æ
æ re æ
re æ æ
re f re æ æ
~8 8 ~
t ~~
~ ~
~ ~
~~
~ ~
~~
~~
~ ~
~ ~
~~
~ ~
~~
~~
~ ~
~~
re ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~
m ~ ~ ~ ~ a a a a a a!!! a a a!! a a a a! a a a a a a a a a ai
QQQQ Q øøøø ø øøøøø ~ øøø ø ø ø øøø~ øøøøø ~ øøø
574
(jãr.~
QH" :ir.II ~80Q
r.~
~II
~~
:iII ~
H~
CI
~HQ0II
Zi
8IIi.II8IIr.88 r.II Qr. 08 U
~ ~
r. 2
lAR
e MO
NO
GR
AH
S V
OLU
ME
49
.Q .Q
~ N~~ N N~~ N N NN
~ ~~~ ~ ~~~ ~ ~ ~~
~M~~~ M~ M~~~ M~ ~ M~~
"~""" ~" ~""" ~"~".Q~""
~ ~ ~ ~ ~ ~~
..,........... ..,.... ....CO..CO...... 0\ O\oO\~
~ ,~
;:;: ,~ ,~
~~
,~~
~~
,;:~ :;M
:;::;:;S
.sss .s .sss 'S 'S
,'SS
~":"".-.-
r.~r.r.r.~~r.I\~r.r.r.~~r..r. '~r.r. ~ '""""" "0-.. 1l.-r. II .r.ll
f: t f: f: f: : t f: : t; f:n:i f: : tn:~ -i f: -i t; f: f:: ,~ :- ~ ~ ~ ~~ ~ ~ ~ ~ ~ ~ ~ ~ H ~ ~ ~ ~ H ~ t ~ t H ~ ~ ~~ a ~ ~ t a ~
3~333~~H;:~H3H~~3~H~~HHZ 8~ ~
~ ~ ~ ~ ~ ~ ~ i ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ i i ~~ :~5: ~ a~ ~ H~: ~~
tffr.~r.r.r.r.r.r.~
r.tr.r.~r.~
r.r.r.r. H 0- H
~m~~~Q
m~Q
m~~~C
I~~Q~C
lØ~~ II r. m
0000000000000000000000000000000000000000000000000000000000000000000000000000 00 O
~ 0 0 00 0 M
0 0000000 0 M
0 0 M 0 0 0 0 M
~ 0 0 II 0 N
0 0 0.- .- 0 " 0 .- .-. . . t. . . . . . . . . . . . . . . . . . . . . . . . . . .
II ~ ~
~ 0 " ~
~ " ~
~ 0 ~
.- M ~
0 M 0 II ~
~ ~
M 0 0 0 000
M ~
N
100 + 1000000 1 +
00 +00000000000000
iii ++
++
1 ++
1 ++
++
++
++
++
++
++
++
++
+
E ~ ~
zzzz t: HH
~~
~~
~~
~~
~~
~ 2222 Z
t:t:HHHHHHHHHHHZZZZZ88~8 ~H ZZ
~888~88888800000~~~~ ~ HH
~~~~~~~~~~~~~~55~~~~2 ~àEeEe~~
r.r.r.r.r.r.r.r.r.r.r.~~~~~~~~~~ ~ut:t:::(j(j~
~ ~
~ ~
~ ~
~ ~
~ ~
r. r. r. r.r. ~ ~
i ~ ~
2 ~ ~
~ ~
H H
~ ~
~~
~~
~~
~~
~~
~IIIII ~
~~
~~
~ ~
~Ii IL l l
~Illl~~~~~~~~ ~~~~~ ~~
MM
MM
MM
MM
MM
M "" ,r.r.r.r. r.:o ~
~~
~r.r.
1l1l1l1l~1l1l~1l~~~~~~~§§§§ ~o r.r.r.r.llllaaaa a aaaa a aaaaa ¡----i~~~ ~ ~ ~ ~~~
~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ g ~ ~ ~ ~ ~ ~ ~ ôô
l l l l l l ll l l l ll l l l llll~~~~~ ~ ~ ~ ffæ
ææ
æ æ
ææ
ææ
æ æ
ææ
ææ
ææ
ææ
æ ~ ~ ~Iõõ õõ
~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ 8 8 ~ "" § .s
r. r. r. r. e¡ ei
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
w w
ci II ~ ~
~ ~
u u
II II II ~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ II II II II g N
:i ~ u u u u u u
-i ~~
~ ~
~~
~~
~ ~
~~
~ ~
~~
~~
~ Q
U ~
HH
H H
HH
HII II II II II II II II II II II II II II II II II II II II r. r. C
I Q II II II II U
U
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ C
I II II II II U U
SODIUM DI CHOMATE
END TEST TEST SYSTEM RESULTS DOSE 1 REFECE~POINT CODE NM M (LED OR HID)
~tr
C CIC CHOM ABERR, OlINESE HATER CELL lN VITRO + 0 o .0000 BIANOlI ET AL., 1980 Z0C .OlL CHOM ABERR, HU LYMHOCYES lN VITRO + 0 o . 2000 SA ET AL., 1980 -0 DVA STR BR/X-LINK, ANlMA lN vio + 0 20.0000 TSAAKOS ET AL., 1981 )(0 rNA STR BRE/X-LINK, ANlMA lN vivo + 0 20 :0000 TSAPAKS ET AL., 1983a NC FSC FISH, CHOM ABER + 0 1 .0000 KRSHNA , REGE, 1982
1Doses are given as concentrations of the element, not the concentration of the compund.
VI..VI
U11--Z::wU1CJCJ
LJCJ-l
8
SODIUM DICHROMATE 7789-12-0 24-JUL-90
6
4
2
o
-2
-4
P El !l!m(IR 19 ll fR IIB lI æ mi le
5
1
C
C
H
L
o
V
A
o
""
o
1
ft
-- -
_w_______ _ _ ____________ ____ ---- ------ ---- ----- -- -- - -------- ------- ---- ---------------- - - - --
- - - -- -- ...- -- - - - --- - - - - - - - -- - - - - - - -- - - - - - - - - - -- - - -- - - - - - - - - - - - - - - - - - - - - - - - - - -- - - - -- - - - - -- - - -- - - - - - - - - - - - - - - - --
"
S
R
5
PROKARYOTES 1 LOWER EUKAR. MAMMLS lN VITRO HUMANS 1 F" /HI I1MMLS lN ViVOlN VITRO
VI
~
-~~ozoo
~:iCI
~o8~m.;\0
APPE
ND
IX 2
577
r-r- .- .-
0\ co co
i.- 0\ 0\
.- .-
:ž,
,i.
ia ~ ~..~
:rli E- t
H i.
Z-i ~ ~.
'lH H
§H ~ t
0~ ø ~
~0uQ
000H
000C
I~
:r000
.ii.
000.¡
1I Ø'
80000
~I0\0\0
0C
IN N N
i.~
ini:
~0.,..¡
~1I
ll~
:i000
i..¡i:H
li iC
IC
I+ + +
u~
i:§
0UHl
CI
.i.¡.¡0
~ ~
i:,H
U.¡
U H
i:~ H X
~t1 ~
~C
I.-
~ ~ ~
CI
QI
~ ~ 1
.i.¡~I0i5
~ i..... ..
IIE
-.. H
i:1I
H CI
0:.
i. CI
.,.li
..,
.¡.. ,~
llE
-H
UØ
'i.
liCI ~ i.
.¡i.
Ùll§
i:E
-C
Iu
t! H-
i:~
ie0u
H § H
~ Ø
'II
o i.ll
U li t:
i:ra ai ~
QI
~.,.tJf¡ ~
aßliQ
IW 0
i.E
- Um
lXllII
~ ~
QI
IICI CI CI
82
~
4
U1f-..z
2::wU100
0LJ0-l
-2
8
6
-4
AMMONIUM OICHROMATE 7789-09-5 24-JUL-90
EH
!alI
~- - - - - - - - - - - - - -- - - -- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - --
- - - - - - - - - -- - - - -- - - -- - - -- - - - - - - - - - - - - - -- - - -- - - - - - - - - - - - - - -- - - -- - - - - - - - - - - - - - - - - - -- - - - - - - - - - - - - - - - - - - - - - - - - - - - --
PROKARYOTES 1 LOWER EUKAR. MAMMALS lN VITRO HUMANS 1 F /HI l'MMALS lN ViVOlN VITRO
VI..00
-~a:ozoo
~:iC/
dBa:tr~
i:~~~HlI~
irz~
CI
H~
::i:lI ~80C
I
tj
lI~ :z
li ?i
~¡sE-
li:-liE-
lii:E-
E- i:
li CI
i: 0E
- U
~ ~
i: 2
APPE
ND
IX 2
579
.Q .Q.Q.Q
co co co co
.. .. l' l''" 0\ "" lo 0\ 0\ O' lo lo
COI' ~ n CO loco n n lo n lOco~co
O\CO "".. co 0\ COO\ CO co
0\""0\""nO\ co.. l' ~ n O\n ~ ~ 0\ ~ O\nCOn
co nO\O\O\ 0\ ~ n ~lo~ n lo~ n 0\ "" """"
0\ ~ CO
nn n ~ ~"" ~lo ~i-~ ..~ ~n ~ .."'....n~
:i~ ~
~ ~
gS ~
~ :~
~ 3~
S : ~
S :~
~~
~~
~~
JfJ~i~~~~~~~fJ ~:t:~~i;~:~i;~:fJ~t~~~~~
fJ ¡; ~: fJ ~ ~fJ ~ ~ ~~ ~ i: ~ ~ ~ ~: ~ ~ i:~: ~ ~ i: ~ fJ ~ ~~ ~ ~ ~~
~ i: ¡; Z
~ 0 E
- H ¡; ~
fJ ~ ~
~ ¡; H
i: H ¡; ~
¡; i: H ¡; ~
~ ¡; ~
~ ~
fJ ~ ~
~lIi:~o~o!i:~Oll lI~ZO~O~OllOO~Oll~O~~E- E-E-
~~ g ~ ~ ~ ~ ff ~ ~ ~ ~~ ~~ 0 ~ ~ ~ ~ ~ ~ ~ o~ ~ ~ ~ ~~ 0 ~ ~ ~ ~ ~ ~ ~ ~
o ~i:i:~
H i:i:i: ;~
i:i:~i:i: i:~
i:i: ;i:;~i:~
i:i:~ O~CI~Z ~Clro ~~CI~E-~CI ClE-~CI ~CI~~~~~~
000000000000000.. 0 0 0 0 0 0 0 0000 0000 lo 0 lo lo00000000000000000000000000000 lo 0 N
ON
N000000000000 0"" n 0 0 0 0 0 0000000 n 0 0 '" 0 M
00N
OM
0 0 0 0 0 0 "" 0 0 N N
0 0 0 0 0 "" 0 0 0 lo "" 0 0 0 0 0 MO
n 0 0. . . '. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .OMO co 0 0 0 N M lo N 0 0000 N n lo lo NON N lo N 0 0 0 000 0 00
n n"""'MlO
n 0 nMn M
lo n
00++
+000010+
00000101000010000010000+
++
++
++
++
++
++
++
+ il +
++
++
++
++
1 ++
1 ++
++
~~~~ ZZ~
~~~~ :-:-:-ZZZZZZZ~~~~~~~~ ~~~
1111 E-E-E-OOOOOOOHHHHHHHHZZZZ~~~
~~~~ HHHHHHHHHH~~~~~~~~OOOO~~~
~~~~EË
~~~~~~~~~~~~~iii~~~~~~~~~~ 2~
~~
~H
H i:i:i:i:i:i:i:i:~
~~
~lIlI ~
~rorororoxx~~~i:i:i:i:i:i:i:~~~~~~~~ ~~ ~zz~~ ~ ~~ ~ ~ ~ ~ ~ ~m ~ ~ ~ ~~ i i iii i i i ~~~ ~ i i~~ ~~ ~
~~~~i i ~ ~ ~ !!!!!!!~~~~~~ii~ ~ ~ ~~~~~ ~! ~
o 0 0 0 ~ ~ H H
H 0 0 0 0 0 0 0 lo lo lo lo lo lo io lo co co co co § § ~ ~ ~ ~
~~~~~ ~ :::E a E E E E E a a E E E a E E B B B ~ ~~~ i~ ~ ~
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~§5 ~ ~~~ ~ ~ ~~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~~ ~ ~ ~i:i:i:i: HHHHHHHHHHHHHHHHHHHHHHHH
~ ~ ~ ~ ~ ~ E- 8 E
- :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: ~ ~ ~ ~ ~:: :: :: :: - - ro § ro ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ _ _ _ _~
~ ~
~ 8 8 ~
li ~ ~
~ ~
f: ~ ~
~ f: ~
f: ~ ~
~ f: f: ~
~ ~
~ ~
~ 8 8 8 8 8
~~~~.............................. .~ ~ ~ ~ i: i: ro ro ro li li li li li li li li li li li li li li li li li li ~ li li i: i: i: i: i:
re re re re ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~
CI C
I CI C
I CI C
I CI C
I CI ~
~ ~
~ ø
ø ø
ø ø
ø ø
ø ø
~ ~
ø ø
ø ~
ø ø
ø ø
~ ~
ø
580t.~8~Hli~
(jZ~t.p.~
CI
H~
:it.li ø:
8 aC
I
el
li~ ~
li ~~rJe-li~lie-lit.e-e- t.li CI
t. ae- U
~ ~
t. ~
lAR
e MO
NO
GR
AH
S V
OLU
ME
49
.Q\l~ 0 0
0\ ~ ~O\
~ M 0\ O\~M
~~ M MMO\~ ~
0\1' M~' 0\ 0\ 0 0\0\0~ MO\ 0\ MO\ 0 1'0
MO
\ ~~ 'Ni-O
\~ N~ ,~~~O
\, M l' ~~0\~0\0'~
M O\O'H~O'~O\ M~O' 'o\O'O'M ., 0'0' O'O\~O'i-MO\
, MM..O'MO'MN~O'MHMMM Hi ,i-M MMO'MO' M
., M M ~O\M.. ,.. ø:0' MM'
~~:; :..t,~ 'fi~M, :e-ii~ :~e- ~M
: ::,:,~:e- ~~~H..~..O' :..~t.o~~~t.:i~ :~~~~..~.. ~
i.e- o:...~..'J 'H
.. lI'Jø: lIt/lIH
O' ....t M
~~ :t~~t,¡t~~:tt~~,¡t ~~,¡:t~tttttot~~
~I~t.:i ,¡8t. H~,¡ H,¡~,¡~t.~t.t.~ ~ I~ M
t/ uø:U~t.e i. t.:i1 t.:i 1 Z
UU
Ze ë '
~ e-~~~~z t/ ~ZU
t.t/ZU
Ht.~ gH
~~H t/ ,
~ ; ~ ~ ; ~ä ~ § ~ ~ ä ~ ~ § ä ~ B ~ ~ ~ B i ~ ~ i ~ R ~ R 1 ~
00000000000000000000000000000000000000000000000000000000 0000 o~
ooo 0 00~
ooo 00 o~~
~o M
~O
M ~
~O
OM
~ ~
ooo 0 ~ O
O~
O 0 00
\l 0 0 M ~
0 0 MO
N ~
0 0 0 M N
MO
M M
M M
MO
I' M 0 0 000 0 ~
~" " " .. " " .. " , " " " .. " " " " " " " " .. .. " " " " " " " .. " " "
o ~ 0 M
M 0 M
0 0 0 0 0 0 0 0 00000000 \l N M
0 0 NO
N M
N \l
o M N
N~
0000000000000000000000000000000000+
+ 1 +
++
++
++
++
++
++
++
+ 1 +
1 ++
++
++
++
++
++
~ ~ ~
H H H
t- t- t-
Z Z Z
H H H
~~~~ ~~~
HHHH HHH
t-t-t-t- ~ ~t-t- ~~~Z
ZZ
Z 8~ Z
ZZ
e-e-8Z
ZH
~~~~~~~~~~~~~~~O~~~~~~ ~~~
OOt.t.t.t.iiHHHHHHHH~~~~ø:H~~~~~ HHH
~ ~ d U U U B t- t- t- t- ~ ~ t- t- ~ ~ ~ ~t ~ ~ ~ ö ~ ~ i i ~ li lI t/ g
~~O~~~O
ZZ
ZZ
ZZ
ZZ
t- a 8e-~e-t.t. H~
~Z
~H
HH
HH
HH
Hø
:ø:ø
:ø: ~
t.!!!HH
HjE
E t-
o t.t.t.t.Zt.u:i t-t-t-
ÔHHH:'~~~~~~~~88e-e-HU lI Z
t.t.~~
~~
e-~~
~~
~~
~~
~~
~~
~ci~
~ ~
~~
~gg:
¡Q¡Q
",~~~~~~~~~~~~~~~ff~" ,t/lIlJm~~ u
~~
tl~~
~~
ø:ø
:ø:ø
:ø:ø
:ø:ø
:t.t.t.t.~O
- ,~~
~~
~~
~¡.¡.e~
~ ~ B ~ ~ ~ ~ ~ ~ i i ~ ~ Il ~ ~ ~ ~ ~ ¡ ~ ~ ~~ ~ ~ ~ g 2 ~ ~ ~ ~
~ ~ ~ ~ ~ ~§ ~ ~ ~ ~ ~ ~ ~ ~ E E
d d ~ ~ ~ ~ ~~ ~ § § ~ § ~ ~ ~ ~~~~~~~~~~~~~~~~~~~~ ,~22~~~p.p.~~~~~~~~~ ~ ~ ~ ,~~ ~ ~ ~ ~ ~ ~ t. t. t. t. ~ t.t/ ~lI ~ ~ ~ ~!!! t. t. t. ~ el6mmmZHHHHHHHH~~~~H~ mmm ~~~Hg
~~~~~~~õoddõoõd~~~~~~ I~I ~~~~~
UU
~ ~~~~~~~~~~~O~O
~O~O
~OO
~~~ ~ tl~~~a~o~o~5. . U
UU
UU
UU
U t.t. e- C
lUU
UH
t.t. lIlIt/ lIlIt/lIlIlJlJlI UUlJlIlIOt/lJ lIE
ø: ø
: H ~
~ ~
~ U
U U
U U
U U
U U
U U
U ~
8 t/ lI :i :i :i p. p. ~ p. H
H ~
~U
U lI H
H H
~ H H
H H
H H
H H
H H
H H
~ H U
~ H H
H :i :i :i :i :i :i ~
t. t. e- 0 0 0 ~ lI lI t/ lI lI lJ lI t/ U U
U U
.. U e- e- C
I 0 0 0 t/ lJ U U
U lJ
~ ~ ~ 0 0 CI ~ lI lI lI lI lI lJ lI t/ U
U U
U ~ U
e- e- 0 0 0 0 u: lJ U U
U u: ~
APPE
ND
IX 2
581
\0 co
co co
01 01
.- .-
~ ~
~ ~
CI CI
Ni:
E ~ ~
~a' (J (J
rz~ ~ ~
~H
H.-
E- ~ E- co
i: ~ ~
Uh
'0§0~00
u0000
H0000
QI
~ :i
0000.i
i:0000
+J
(J ø:
. '.80
o co co 0
'lL
i.-
00
i:~
i:
~0'ri+J
~
(Jn:
~ ~
0000i.+Ji:
Š(J §
QI
+ + + +
u~
i:H
0(J
u
~Q
I.i+
J
+J0i:,+J
gi:Q
IH
a~
Q)
g g g Z
r-QI
H H H H
~ ~ ~
Q)
z z z ~
.i+J
H H
H i:E
-'l
i: i: i: ~0
f5uv u
~ ~ ~
lnE
-i:
(J0
~.. .. .. ..
-ri(J
E- E- E- E-
+J
(J (J (J (J
n:E
-i: i: i: i:
i.(J
E- E- E- E-
+J
i:i:
E-
(J (J (J (J
QI
~ :: :: ::
u~ ~ ~ ~
i:0uv v u
u~ ~ ~ ~
ln
Ô Ô Ô Ô
n:i:~ ~ ~ ~
Q)
::'MlJE
- i:
~ ~ ~ ~
(J 0Q
Ii: 0
i.E
- vn:ln
§ ~
Q)
ln~ ~ ~ ~
8i: ~
~
4
11f-..Z:: 2w1100LJ
00..
-2
8
6
-4
POTASSIUM CHROMATE 7789-00-6 24-JUL-90
P EH $ !m inR Il lf fl lnB ID æ~\Ø
G 5 C C5 1 1 1Tee T
T OU $ cr7 IH ~ ~5 HF FL FL
SHH
VV V
AHe
--
-- =
--= --
=--
-- -- .. - - -- -- ----- - -- ----- ---- -- - - - - - -- ---- - ---- - ----- - --- -- ------------- -- - --- - - --------_.1111
t.-- - ---- -Á- --- ---- - --- ----- -- -- ----
-- --- -- - - - -- - - -- - - -- -- -- - -- -- -- ----- --- - - -- - - - - - - - - - -- - ----- -- ---- - --------
5
A
5
T
5
i
PROKARYOTES 1 LOWER EUKAR. MAMMALS lN VITRO HUMANS 1 F /HI l'MMALS lN ViVOlN VITRO
tJ00N
-~~ozoo
~~CI
ât"
. c:~m,l\0
wl~~l-~~
tjz~wr.~
Ql-~
::w~
ø;
80Q~
CI~ :E
CI fi
~~E-
CI
~CI
E-
CI
~fi ~~ 8
~ ~2
APPE
ND
IX 2
\0co01l' .-
1"01 co ,
10 .-l"coco 01
CI
.-.-CO COCOOlOlO 0I01"Ø;
CO
C
O
01 0; 0; 'OIO\.-l"co l'coO\w
01 0\ .- 1" 1" ø; .-.- 01 01 i" 0\ 0\ .- Q
.-.- 0\ 01 W '.- .- co .-.- ,.
'.-.-Cl "~
01 '0". Ø:..::".-"~:;
~~=§§~:=
!~~J!~~~~ ~ ~ ~ ~ : ~ ~ E
- ~ l- t ~ l- 3 :l-l-l-E
:i: ~~~CIÕ
~CIõQ
~~g¡S~~gg§~~~~~e:~C
I CI 3 !:n~
lE C
I CI lQ
:: lQ r. :: lQ
Q ~
00001000000000000O
OO
ON
OO
O\O
ooooooo00000000.-1001"10000o 0 0 0 0 0 \0 \0 0 N
0 0 N 0 .- 10
. . . .. . . . . . . . . . . . .O
O\O
OO
\ON
NO
OO
OO
OO
Ol'l' 10 N
.- .- N
00 +0000000000000
++
++
++
++
++
++
++
++
ß ß
E- E
- ~ ~
~ ~ ~ ~
~. E ~ f: f: 0 z z ~
l- U l- . ~
l- l- CI
~~~~ ~~. ~~~~~~~~o~
~5::; ~
tjtjf::;~t-tjtJ5a~
~ l- ä ~
~ i ~
~ ~
f: f: f: e &í ~
~
~ 1 ~
w:; r. ~
~ tj ~
~ ~
~ ~
ri f:Br. ël~gi, ,~tjtjtJ~~CI~
S ~
g' ~ W
~ ~
~ ~
&í ø
; ø; ti fg z tj
Q ,~
,a~~
~~
E-~
~~
~~
~&í;~~~~~&
í!!!E8ii
3~P1¡~~~~~~~~~B~~
l- JO ~
lQ lQ
Z l- l- i- ø
ici: ~ i-
~~if~~~~~~ÕÕ
Õ~o&
~3~
E~
888 .:;" ,êS~
:j~.04 . . .. ~tltJtJe¡l!w~
lQ ø
i CI w
w r. C
I CI 5: C
I CI C
I 0 0 U ~
O~N
Ø;..JO
..UU
UU
UC
I::CI ø; JO () U U t- i- t- i- l- i- i- H U i-
lQ lQ tI ww r. Q Q CI CI CI CI U U E- o&
Q Q
CI C
J CJ C
J Q Q
CJ C
I CI tI U
U E
- JO
583
't§oß'ouQ)
.i.l'loi:o-ri.lIIi..li¡Ui:ouQ
)
:5.loi:,.li:æQ)
r-Q)
Gl
.i.l'loIIi:o.ri.lIIi..li:Q)
ui:ouIIIIi:Q)
::-rit¡Q)
i.IIIIQ)
II8~
584IA
RC
MO
NO
GR
AH
S V
OLU
ME
49
0cr1
-l(J 0
::z :;
-i~
:;1
:: z~
i _
rua:;:;~ln..C
I1:1:~i..i.
=_::
ln 0Z
a:CI !:
1: :;::i
=
1"1....
a1
i- L. i.
a:!:L
O:;
f"~
f"f"ln..C
Ii. - L.
1:=
-=1:~
=-=
1-UW(J~ln1-ZCI
..IlciCI
:.::w
Wa:
l-w
a:~a
L..
00:li EHIl
:rln
UW1-a
L)-a:
::i.=
=C
I-
:.0
EB Bi E3
aa:0
IlU
l
c:lD
~ru
oru1
~1
51INn 3500 ~OL
~~B!jl
~ac.~
QH~
:i~C
I ø:
80Q:J
CI
~ ~
CI ~
~~E-
CI
~CI
E-
CI
~E-
fi ~~8~ ~2
APPE
ND
IX 2
II U
qo r-co co
0' 0'
.- .-" ,
. tU . l1 cU cU tU .
H .- H
.- .- .- .- H.c co .c co co co co .c
0' 0' 0' 0' 0'
E- .- E- .- .- .- .- E-
~ ~ f&
lll~llllc. i. c. c. c. c. c. c.
!: !: !: f: f: !: !: !:00000000oinoininininoo .- 0 .- .- .- .- 000000000C
OO
\DO
OO
OO
M+0+
00000+
++
1 ++
++
z z z ~~~gggz~
~~~~~i~~~~~~~~~~
~~~UI~~
~ ~ ~ . . .L~Ò
Ò~::~ ..§
r3ooinininco§t:~~a~~~-HQ
!j!j!j!j!j!j!j
~lllllll:: if if if if if if if8~~~~~~a:~ CI CI CI CI CI CI CI
B~~~a~~a
Q~~C
JCJ~C
J~
585
IIqoco0'.-
't§~ouCI
.i.i\Ioi:o....iIIi..ii:CI
ui:ouCI
.i.i.ioi:,.ii:CI
lECI
r-CI
CI
.i.i\Ioeni:o....iIIi..ii:IDui:ouentUi:CI
::...tJCI
i.tUenCI
en
8~
4
Ln1--Z:: 2wLn00Ll 00..
-2
8
6
-4
AMMONIUM CHROMATE
E 5 !tR A flo 0 Ml
7788-98-9 24-JUL-90
_ _ __ _ _ ~ _ ~ w _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ _ __
- - - - - - - - - - - - - - - - - - -- - - - - - - - - - - - - - - - - - -- - - - - - - -- - - - - - - - - - -- - - - - - - -- - - - - - - - - - - - - - -- - - - - - - -- - - - - - - - - - - - - - - - - - -- --
PROKARYOTES 1 LO\/ER EUKAR. MAMMALS lN VITRO HUMANS 1 F /HI l'MMALS lN ViVOlN VITRO
Ut~
-~a:ozoo
~::en
â8a:m.¡\0
CHOMIUM TRIOXIDE
ENO TEST TEST SYSTEM RESULTS OOSE i REFERECEPOINT CODENM M (LED OR HID)
D PRB PROPHAGE, lNOUCI/SOS/STR BRE/X-LINK + 0 26.0000 LLGOSTER ET AL., 1986D ERO E. COLI REC, DIFFERENTIA TOXICITY + + 50.0000 DE FLORA ET AL., 1984aD BSD B. SUBTILIS REC, DIFFERENTIAL TOXICITY + 0 83.0000 NAO ET AL., 1978D BSD B. SUBTILIS REC, DIFFEREIAL TOXICITY + 0 26 ;0000 KA ET AL., 1980D BSD B. SUBTILIS REC, DIFFERIAL TOXICITY + 0 130.0000 GENILE ET AL., 1981D BRO BACIERIA (OTER), DIFFERENTIAL TOXICITY + 0 130. 0000 GENILE ET AL., 1981G SAF S. TYPHlMUIUM, FORW MUATION + 0 0.0200 RUIZ-RUBIO ET AL., 1985G SAO S. TYPHIMUIUM TAlOO, RERSE MUATION + + 3.2500 PETRILLI & DE FLORA, 1977G SAO S. TYPHlMUIUM TAlOO, RERSE MUATION + (+) 3.9000 NESTM ET AL., 1979G SAO S. TYPHlMUIUM TAlOO, REE MUATION + a O. 0100 DE FLORA, 1981aG SAO S. TYPHIMUIUM TAlOO, RERSE MUATION + a 52. 0000 TSO & FUNG, 1981
~G SAO S. TYPHlMUIUM TAlOO, RERSE MUATION + (+) 5.2000 DE FLORA ET AL., 1987c ~G SA2 S. TYPHlMUIUM TAl02, REE MUATION + + 2.6000 BENNICELLI ET AL., 1983 trG SA2 S. TYPHlMUIUM TAl02, RERSE MUATION + 0 2.5000 PETRILLI ET AL., 1985 ZG SAS S. TYPHlMUIUM TAl535, RERSE MUATION - 0 0.0100 DE FLORA, 1981a UG SAS S. TYPHIMUIUM TAl535, RERSE MUATION 52.0000 PETRILLI & DE FLORA, 1977 ~- -~G SA7 S. TYPHlMUIUM TAl537, RERSE MUATION + + 13 . 0000 PETRILLI & DE FLORA, 1977 l'G SA7 S. TYPHIMUIUM TAl537, RERSE MUATION (+) 0 0.0100 DE FLORA, 1981a
G SAS S. TYPHlMUIUM TAl538, RERSE MUATION (+) 0 0.0100 DE FLORA, 1981aG SA9 S. TYPHlMUIUM TA98, RERSE MUATION + + 3.2500 PETRILLI & DE FLORA, 1977G SA9 S. TYPHlMUIUM TA98, RERSE MUATION (+) + 3.9000 NESTM ET AL., 1979G SA9 S. TYPHlMUIUM TA98, RERSE MUATION (+) 0 0.0100 DE FLORA, 1981aG SAS S. TYPHlMUIUM (OTER), RERSE MUATION + 0 0.0000 DE FLORA ET AL., 1984aG ECW E. COLI WP2 UV, RERSE MUATION + 0 o .2500 NESTM ET AL., 1979G EC2 E. COLI WP2, RERSE MUATION - 0 o . 0000 KATSU ET AL., 1980R SCG S. CEREISlAE, GENE CONVRSION + 0 52.0000 FUKGA ET AL., 1982G SCR S. CEREISlAE, RERSE MUATION - a 52. 0000 FUKGA ET AL., 1982M TSI TRESCAVIIA SPECIES, MICRONUCLEI - 0 26.0000 MA ET AL., 1984M TSI TRESC.IASPECIES, MICRONUCLEI + 0 5.0000 ZHG ET AL., 1984G OM D. MELAOGTER, SEX-LINKD RECESSIVS + 0 52.0000 RODRIGUEZ-ARZ & MOLlNA-MATlNEZ, 1986A DM D. MELAOGTER, ANUPLOIDY - 0 156.0000 RODRIGUEZ-ARZ & MOLINA-MATlNEZ, 1986D DIA STR BRE/X-LINK, ANIM CELL lN VITRO + 0 52.0000 WEDRYCHOWKI ET AL., 1986aS SIC SCE, CHlNESE HATER CELL lN VITRO + 0 0.1000 LEis & MAONE, 1979S SIC SCE, CHlNESE HATER CELL lN VITRO + 0 o . 0400 KOSHI, 1979 lJS sic SCE, CHINE SE HATER CELL lN VITRO + 0 0.3200 OHNO ET AL., 1982 00-i
ciOMIUM TRIOXIDE
END TEST TEST SYSTEM RESULTS DOSE 1 REFERCEPOINT CODE NM M (LED OR HID)
S sic SCE, CHlNESE HATER CELL lN VITRO + 0 o . 0000 BlANCHI ET AL., 1980
C CIC ciOM ABERR, CHlNESE HATER CELL lN VITRO + 0 0.1000 LEIS & MAONE, 1979C CIC ciOM ABERR, CHlNESE HATER CELL lN VITRO + 0 0.1000 KOSHI, 1979C CIC ciOM ABERR, CHINESE HATER CELL lN VITRO + 0 o~oooo BlANCHI ET AL., 1980C CIS ciOM ABERR, SYRIAN HATER CELL lN VITRO + 0 o .0400 TSUD & KATO, 1977C CIT ciOM ABERR, TRSFORMD CELL lN VITRO + 0 o .0500 UMDA & NISHlMU, 1979S SHL SCE, HU LYMHOCYES lN VITRO + 0 o .0170 GOMEZ-AROYO ET AL. 1 1981C CIH ciOM ABERR, OTER HU CELL lN VITRO + 0 1. 0000 KAKO, 1976
lDoses are given as concentrations of the element 1 not the concentration of the compound.
VI0000
~
~~ozoo
~::CI
âB~tr+:\0
8
4
lJl--Z:: 2wlJ00t. 00-.
-2
6
-4
CHROMIUM TRIOXIOE 1333-82-0 24-JUL-90
P 9I!Æ!ÆER IBflimCB rIftimV
s sc CG R
T
5
i
o 0H iX A
r cr
1 IlC sr
S
H
L
ri
H
- - r-
-
-
- - - - ----- -- ------------- ----- ---- ------ --- - ------------- ---- ---- - -- -- -- --- - - - - - - - - - - --- - -- --
111-------- - - - - - - - - - - - - - - - - - - - - - - - - - -~ - - - - - - -- --- ----- -- - - - - -- - ---- - -- ----- - ----- - - -- -- -- - - - - - --- --- - - --- --- - --1..
5
A
5
o
H
N
PROKARYOTES 1 LOWER EUKAR. MAMMALS lN VITRO HUMANS 1 F /HI I1MMALS lN ViVOlN VITRO
~~trZU-~N
Ui00\0
590
¡.~~~~
iCz
~
oH~
:i¡.8 êjo~tI~ ~
tI ~~.~E
-tIi-tIE
-tIWE
-
~ ~
¡. 0E
- U
~ ~
¡. g
lAR
e MO
NO
GR
AH
S V
OLU
ME
49
i- i- i- i-i- i- i- i-m M m m m
Il.- U C
O.- .- .- II
~ i-m~ ~ ~ ~~
COM' .Q CO.-CO' MM' M' COO i- NqtCCCC
~CO~ ~~m ~~ CO~CO~ ~ qtCO~ ~~i-qt~~ COCO~~
i- .- m ø: co CO.- '.- ø: ~ co m ø: co co m ø: CO.- m co i- .- m m .- .-
co .-0 ~~
. 0 .-~.-0 ~
m.-O
~ .-m
m .-.-
m, .. .-.- ,.. ,.. .-":.-.-":.-'.-.-' "
.-"Cz1l .-i.C
zIl' 'Cz1l II 'C
z1l ., 'MM
"~',~
~¡.~
: :~E
-~¡.~
~ :~
¡.~ :~
:~¡.~
:~~
:~~
~~
~~
~:.
~fj O
~~
~E
-¡.E-o~
-i~ O
~~
~~
O~
~E
--i~~
E-.-.--i-i8fj
ti. 'E-E-¡.~¡.i. ,tïE-ti. 'E- 'E-ti. 'E-¡.te. t4cìcìtti.
t~ H~WW~":HH~ W H~W~W H~W~ ~i.ZZZ t4
3~~
3~~
ŠÖ
~~
Š ~
":~~
Š ~
Š":~
~Š
": Š~
..~g ~
~~
~ ~
~~ Cz ~~ ~ Cz ~ ~ Cz i ~ ~ Cz ~ø: ~ ~~ ~ Cz ~ Cz ~ ~~ ~ Cz ~ Cz ~ ~ ~ ~ ~ ~ ~ ~ ~ ~
~t4 ¡.w~§¡.w
¡.¡.t4 § ¡.¡.~¡.~ ¡.t4§¡.O§~~H
HO
O ~
mo ~o~oom~~o 0 ~oooo ~OOOUO~t4NNø:ø: 0
OOOO~OO oooo~ oooo~o~ooo~o ooo~ 0 00000 0
o 0 00 i- 0 0 0 0 0 0 i- 0 000 i- 0 i- 0 0 0 i- 0 0 0 0 N 0 0 000 CC 0
0000000000000000000000000000000000000 O
OO
MO
OM
OO
O 00000 00 0000 0 0000 0 O
OM
O 0 0
. . . Il . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .N M ~ co 0 M i- N M co M 0 ~ i- ~ co 0 i- 0 i- M co 0 i- 0 M ~ 0 0 i- i- .- ~ 0 ~
MCO .-.- M .- .-.- .- M~ ~~~.- .-
1 ++
+0 1 +
++
0 10111 +0101 +
+01,.00+
000000001 +
++
++
++
++
11111 ++
1 + 1 +
++
1 + 1 +
++
++
++
++
~
~ ~
~ ~
~ z~ ~~~~
~ Z
ZZ
ZZ
ZZ
Z~
~~
~~
~~
~~
~ S
~ Z
ZZ
Z1 OOOOOOOOHHHHHHHHHHZZZZE-~ HHHH
~ H H
H H
H H
H H
E- E
- E- E
- E- E
- E- E
- E- E
- 0 0 0 0 ~ ~
~~~~~~~~~~~~~~~~~~~~~~~~~~~ ~~~~
~g~
~~
~~
~~
~~
~~
~~
~~
~~
~~
iii~~
~ ~
tltl~~
¡ ~im i ä m
måm
~ ~ ~ ~ ~a ~ ~ ~ ~ ~ ~ ~ ~ ~ ~~ ~ ~ ~ ~~~ ~ ~~ à ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~IIII ~~m
~ ~! ~ ~ ~ ~ ~,~ ""'" ,~~~~i-i-i-i-coco ø:.-~ lo~~~~~
tI~OOOOOONNMMMMMMMMMM '" ,¡.~ ¡. ~~
o~oooooooo~~~~~~~~~~cocococo~ ~ O~
~t:aaaaaaaaaaaaaaaaaa~~~~~~i~2 ,,~~:ti~
~~
~~
~~
~~
~~
~~
~~
~~
~~
~~
~~
~~
Bg~
,aa~~
~~
:~~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~~
~~
~ ~
1111~ ~ re re re re re re re re re re re re re re re re re re re re re re re ~ ~ ~ ~ ~ ~ ~ ~ ~ ~
~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~. ~ ~ ~
~ t4 tI tI tI tI tI tI tI tI tI tI tI tI tI tI tI tI tI tI tI tI tI tI tI ¡. ¡. ~ tI 0 0 tI tI tI tI
re ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ M ~ ~ ~ ~ ~ ~ ~ ~ ~
o 0 ~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ U
~ 0 0 0 0
~~~~~
ir.ti
QH~
:i~en ~80Q~
en~ ~
en ~tilSE-
en:;enE-
en~E-
fi ~~ 0
E- Ut§ H~ 2
APPE
ND
IX 2
1.co.- mQ) ..
Q) 0\
.Q Q
) .Q.- ,
~ Q)~ Q
) M Q
) 0\ ~ enQ)~coCOQ)Q) .Qm Q) co ~M~.- Q) ,~
O\Q)O\mcoO\ ~~ 0\ .-0\.-~Q)Q).. O\.~
.- 0\ .- .. O\.- co 0\ .- Q).. co 0\ 0\ 0\ 'co.- 0\ .- H Q
.- .- ~ 0\ .. 0\ 0\ .- .-.- . 0\ co l" .. H
, , Q).. ~'l".-, .- H .- .m 0\' 0
. ... . .. -0\ -"COHCO . .."...i ...- -E-:;
~~~~~~.- :~~~~ :~ :~~~E- :, '~~a
E- E
-E-Ø
íE-ii~
~,~
'~E
-~ ~
~~
....E-ß
en.-o.-fatt&
~~~~ !E'~' t&
tE-enH
....c.oø:CO
Q)Q
)~ o~uo~t ~ ~tot ~~õtE-E-~~~~~~
~~~g~~U~~E
-~E-H
~H~~Z
~H~~~1~" ,
~en~ti ~~~en~H~~~~~u~~~§g~N
en~en~~ i ~ ~i~~ § ~ ~~8 i 8~~~~ 8 ~ B
~~~ ~~~00000000000000000000000000000000 O
ON
00 0 0 00 0 0 000 000 OO
M 0 0 00
~ 0 0 0 0 0 ~ ~ 0 0 0 ~ M 0 ~ Q
) 000 N M
0 ~ 0 0 00000 0 ~ Q) 0 0 0 ~ M ~ N 0 ~ .- 0 N ~ ~ 0 0 M 0 0 ~ M 0 M
. . l.. ... ... . ....- .- M
0 0 ~ 0 0 0 .. 0 0 0 N
0 0 N N
~ 0 0 0 .- 0 0 M
0 M~
.-
000 + +
00000000000000000000000+
++
++
1 ++
++
++
+ 1 +
++
++
++
++
++
+ il
~~ ~~~ ~
~ HHH H
z~ ~~~ ~ ~
H~ 0 zzz ..enenenen zH ~ HHH ~~en~~~~~~ H
3: ~~~~~~Qa~~~~~~~~~~ ~
~H enen H
H~~~~U
Ö~ ~~~~ 0 ~
U e8~~~ÖÖÖ~MN2~~~~~~ÖÖ~~ gz
~3oss~~~~~~~~~êöÖÖÖ~~~!~~ ~H
~Ö~~~~~~~~~~~~ ~~~~~~ff ~z z~
~ HE
-E-Ö
~~~~~ ~.- 't.~t.~"", ""H H
~, g ; ~ 3' ~ ~ ~ : : : ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ '~à 0 ~ ¡~~~~~H~~enenen zzzzzzzzzz~~u~
~ ,~UU
~E-E
-~~~~22SS222S22~g ~88~~ ~ § § C
i ~ ~ d d d § ~ ~ l ~ ~ ~ ~ l ~ ~ ~~! ~ ~ ~~r.:i~~¡i~~ '" 'oooooooooo~¡. ~enen
~U
HH
oenen~~
~~
r.r.r.r.r.r.r.r.r.r. ,~~
~ "z' '~~~~~~~~~~~~~~~~ ~~ ~~~
~~
~ 2 ~
dd~ ~
~~
~~
~ ~
~~
~ ~
~ ~
~~
3 ~ ~
~~§ ~~~ ~~ ~~~ ~~~ ~~ ww~§~ ~o ~§ ã~ ~ ~ j ~ ~ ~ ~ j j ~ ~ w~~ we e
~ UU. ~~~~~c.~~~~~u u~~
en en
en UUUUUUUUUuenen en~~
~ ~ 0 E- E
- ~ U U
U U
U ~ ~ ~ en H
H H
H ~ ~ en :i H
:i ~ ~ u~H
HU
~~
HH
HH
HH
H~
UU
UU
UU
~H
:i~_
Q ~
~ ~
~ ~
en en U U
U U
E- E
- E- E
- E- E
- E- E
- Q en .. en
Q Q
~ ~
~ ~
en en U U
U U
E- E
- E- 8 E
- E- E
- E- E
- E- Q
en ~ en ~
~
591
'0§o~oUQI
.c+1
IIo~o"ri+
1nli.+1~QI
U~oUQI
.c+1
+1o~,+1~QI
El
QI
.-QI
QI
.c+1
\loui~o"ri.+
1nli.+1~QI
U~ouuinl~QI
::"rit¡QI
i.nluiQI
ui
8~
U11-.-Z::WU1ooLlo..
a
6
4
2
o
-2
-4
CALCIUM CHROMATE
£ $!H£IR fllRa:o C2i1i
D DIR G G11 1111 e 5
e Nfl D T
5
er
- -.
ft
13765-19-0 24-JUL-90
cr TT TITIl Be 017lJ 115 LAS
5
H
L
R
1
H
5
V
R
-
_ _~_ _ - N-~H- ~~ - - - - -- -~ - - - - - - - - - - - - - - - -- - - -- r - r H- - r - r - r - - -1t - - - t t ~L L - -- - - - ~- - - - - L- - - - - - - -- - - ~ - - - - - - - - - - -- - - - - - --
1 L"" L
,_______ ~ _ ____ __ ___ _____ ________ ______ _____ -- - - --l- - - - -- - '1.. ~ --------------------------------i -----------------
P
R
B
5 £R e5 r
PROKARYOTES 1 LOWER EUKAR.
G
1
R
T
e
11
1111
V V
I1C
MAMMALS lN VITRO HUMANS 1 F /HI l1MMALS lN vivolN VITRO
UI\0N
-~~ozo
~::CI
~oB~tT~\0
APPE
ND
IX 2
593
00.0 .0 00
IIlim
i00 00 .-m
mM
.-~
~ ~ ~
. .rs
~ ~ t
~E- E-
c. c. 0.
~ ~ ~
'0c. c.
§
l H H
Z ~
0~
ø.
ß'0~
U000
Ho II 0
QI
.. =o N
O.i
tl ~II 0 0
~80
NO
.-Il0
~c.
~i:
~
0..-~tJ
ni~ lE
100i.~i:
tJ i
Gl
~+ + 1
U~
i:H
0
~
UQI
.i~tJ
~0i:~
,H ~
~i:
~ ~ ~
mQI
.-N
QI
c. Z "-
I~~Q
I.i~Il
~ 0
0¡s
VI
E-
o ~ '
i:tJ
o ~ ~
0~
..-tJ
~ ~ ï
~niE
-i.
tJ~
c.i:
E-
H c. e
QI
U~
ui:0uif õ
VI
~ni
w:j
i:. u ~
QI
tJ tJ
:-..-t:~ ~
o U ~
QI
~ 8
.( Hi.
tJ tJ E-
niVI
~ ~
QI
VI
CI tJ E-
8c. 2
..
4
U1f-0-Z:: 2wU100LJ
00.-
-2
8
6
-4
STRONTIUM CHROMATE
S
A
o
7446-14-2 24-JUL-90
------~---------------------------------------------~---------------------------------------------------------
- - - - - - - - - - - - - - - - -- - - - - - - - - - - - - - - - - - - - - - -- - - - - - - - - - - - - - - - - - - - - - -- - - -- - - - - - - - - - - - - - - - - - -- - - -- - - - - - - - - - - - - - - - - ---
PROKARYOTES 1 LO\oER EUKAR. MAMMALS lN YITRO HUMANS 1 F /HI t1MMALS lN YLYOlN VITRO
~.i
~n~ozoo
~en
â8~tI.i\0
§fi:.~HN
fi~~fir.~
QH~
:ifiU
) ø:
80Q~
~ :i
~ ~
~~E-
U)
:.U)
E-
U)
fiE-
fi ~fi 0E
- U
~ ~
fi ~
APPE
ND
IX 2
..00l'~.-
.. ..00 00
r- r-
~ ~
.- .-
..00r-~.-
~~ ~
33~3
000000000000000000000000o
t"t"00t"t"0 t"O
NO
00000000000000. '.. .
000000000000
100110010000+
+ il +
++
++
++
+~HZ
ZZ
ZZ
:;~~~~~~~zz Z
HHE-E-E-E-E-OO H
~~~~~~~~~~~àfififififi!Ei: U
~~~glglgl~fifi~~ø:
§§§~~~§~~~~~"",~~tJtJ~
., 'U"i.r-r-oo
OO
t"t"t"t"M ,'ø:ø:fi
o 0U
"i.i.i.U"00
00 fi
fi U)
aaaaaaa~~i~~!3!3!3!3!3!3!3!3!3 :ãõH
HH
HH
HH
HH
fifi '~~~~~~~~~~~~H
HH
HH
HH
HH
HH
i::i :i :i :i :i :i :i :i :i :i :i ..p. p. p. p. p. p. p. p. p. U
U~~~a::~~~~~ .,.,~
fi fi el
ai ai ai ai ai ai ai ai ai ~ ~ tl
~~~~~~~~~~~~U
) U) U
) U) U
) U) U
) U) U
) U) U
) U
CI C
I CI C
I CI C
I CI C
I CI U
) U) U
595
'Ö§o~o()QI
.c+J
~oi:o..-+J11i.+Ji:QI
()i:o()QI
.c+J
+Joi:.,
+Ji:QI
i;QI
.-QI
QI
.c+J
~oCI
i:o..-+J11i.+Ji:QI
()i:o()CI
IIi:QI
:...-t¡QI
i.11CI
QI
CI
8~
596lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
co1D
-.ru
aru1
-.1
51INn 3500 :JOL
APPE
ND
IX 2
597
M,Q O' ,Q co ll
ll i- ll 0' co
~co 0' 00 .- 0' O'
O' .. O'
.- i-..
..~
O'
~H
~ ..
i.:~:~~~
rz
~t~~~~~
t t loE-
~ lo i.
'0C
í1CiH
I;g§
! !~~B
0~0UQ
000000H
000000C
D.. =
OIlM
OO
M.c
i.O
..OM
.-...¡
ti p:
.. "
. .80
M..O
OM
O'l'0
Q~i:0.ri
i.¡
tiII
~ ~
+00000
~.¡
~
i:ti §
CD
++
++
++
u~
i:0~
U
HC
DN
.c
~.¡.¡
~0i:
~Z
ti,
H H ~
.¡f- 0
i:
~ e~~~
~CD
:: fo :j i..-
u U
CD
i~¡¡~tJ!:
CD
.c
~~ ~ 1 ~
.¡'l0f5
~~
(j ti\Q
E-
O(j~fo ~ ~
i:ti
o tlZZ
0i;
;;0'!~22....¡
~\; ~
¡¡II
E-
~ti
.¡i.
i:E
-H
(5i. ~ooQ
I~ ti a rz rz
u
red~Ui:0u\Q
~¡riB:j:j
IIi:. U
fo (jQ
Iti ti U
~...l:ti ~
~g;~~d~Q
I
~ 8i,
ti el ti U E- E-
II\Q
~ ~
QI
\Qel el ti U E- E-
B2
pO
4
UJ1-Z:: 2wUJ00Ll 00-l
-2
a
6
-4
ZINC CHROMATE
5
A
o
13530-65-9
S
1
C
24-JUL-90
r r
C 7
L 5
-- - - - - ~ - - - - - - - --- - - -- - - - -- - - - - -- - - -- - - -- - - -- - - - - -~ - - ~ - _ __~_ _ _ __ _M ~__ _ _ _ __ _ __ _ _ _ __ _ _ ____ _ _ _ _ _ _ _ ___ _ _ ___ ___ __ ___
- -- - - - - - - - -- - - - - --- - -- - - -- - - - - - - - - - - - - - -- - - -- - - -- - - - - - - - - ---- - -- - - -- - - - - - - - - - - - - - --- --- - - -- - - - - - - - - - ---- -- - ---
PROKARYOTES 1 LOWER EUKAR. MAMMALS lN VITRO HUMANS 1 F /HI l'MMALS lN ViVOlN VITRO
VI1.00
-~~ozoo
~::en
â8~tr+:1.
tl~ii~
¡,~o!i~e
oH.. :ifiII ~80o~II~ ~
II ~~iSE-
IIi.IIE-
II¡,E-
t; ~¡, 0E
- U
~ ~
¡, 2
APPE
ND
IX 2
.Qco"O'
.-~I~I ~I ~I ~I ~I
í:' .Q .Q
co co co co co .- .- co .- .-~I ~I O
' O' O
' O' O
' co co O' co co
co co .- .- .- .- .- O' O' .- O' O'
o O' O
' .-.- .- .-.. .-.-', , " ,ii Il Il .. Il ft . ft Il . Il Il . ft Il ' , . , ,
¡,~~
: :~~
~~
~~
~~
~~
~~
~~
~~
~~
o O' O
' .. .. O' O
' O' O
' O' O
' O' O
' 0 0 0 0~~~: ~ t t~~t~~t ~~t~~~ ~ t ~ ~3 í: í: ¡, t S
~ í: í: S
í: í: g í: í: g í: í: ~ ~
g ~ ~
H 3 3 ~
~ H
~ 3 3 H
3 3 ~ 3 3 ~
3 3 II II ~ II II
~ ii ii ~ ~ ~ ~ ~ii ~ ii ii ~ ii ii ~ ii ii H H ~ H H
re ~ ~ ~ ~ 3 3 ~ ~ 3 ~ ~ 3 ~ ~ 3 ~ ~ ~ ~ 3 ~ ~00000000000000000000000000000000000000000000000000~I000000000000000000o 0 0 ~
O' 0 0 0 0 0 0 0 0 0 0 0 0 0 ~
I .- .- ~I .-
" 1_ . .. . ..o 0 0 " 0 co co 0 0 co 0 0 co 0 0 co 0 0 0 0 000
O' i" i" O
' i" O' M
O' i" O
'.- .-.-.-.-
10011110010010010000000+
++
1+111+
11+11+
11++
++
++
N
~ ~
:z:zzzž:Z~~~~~~~~H
~H__~ t~
OOOOOOHHHHHHH ~~~ ZZ
HH
HH
HH
E-E
-E-E
-E-E
-E-E
-E-O
OO
N H
H
~ ~
~ ~
~~
~ ~
~ ~
~~
~ ~
~~
~~
e e E~
~~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
¡, ~ ~
~ ~
~ ~
~ ö ö
i i i i i i ~ ~ ~ ~ ~ ~ ~ ~ ~i i i ¡ ¡ ¡ Il
~"" ,~~~~~~~~~
OOOOOOMMMI"I"MMMM "'~~~¡,¡,
o 0 0 0 0 0 ~I ~
I ~I ~
I ~I ~
I ~I ~
I ~I co co co ¡, ¡, ¡, II II
aaaaaEE
~aaaaa E
E~
~~
~ ~
~Ë
Ë!i !i !i !i !i !i !i !i !i !i !i !i !i !i !i !i !i !i ~ ~ ~ 0 ÕH
HH
HH
HH
HH
HH
HH
HH
HH
H¡,~
¡, "~~~~~~~~~~~~~ ~~~~~ ~ ~~~~~~~~~~~~~:i~~~ ~~~~~ ~ ~ ~~~~~~~~~~~~~~~~~~~~~uuu~
~~
~~
~~
~~
~~
~~
~~
~a:~
"'o~::o~
::~
¡, ¡,. . . . . . . . . . . . . . . . . . u u u
II II II II II II II II II II II II II II II II II II II II II
o 0 0 0 0 0 ~ ~ ~ " " " co co co ~ ~ ~ u u u u U
~~~~~~~~~~~~~~~~~~HH
HH
HII II II II II II II II II II II II II II II II II II II II II U
U
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
II II II U U
599
't§olloUQI
.i..~oi:o-ri..fti...i:Q
Iui:ouQ
I.i....oi:,..i:Q
Ii:Q
Ir-Q
I
QI
.i..~oUl
i:o.ri..Ili...i:QI
ui:ouUl
Il :ioi: 11
QI Z
::.ri i:oi -ri
QI 't
i. (J
Il ::.-U
l 0QI Ul
Ul ui
8.a
Ul~-z::wUlooLJo-l
8
6
4
2
o
-2
-4
CHROMIUM ORANGE
5
R
o
18454-12-1 20-JUL-90
- - - - - - ~- - - - - -- - - - - - - - -- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - ~ - - - ~ - - - - - - - - - - -- - - - - - - - - - - - - - - - - - -- - - - - - - - - - - - - - - - - - - - - --
lll
- - - - - -1/-,
Il
--- ---- -- - - - - - - - - - - - - - --- - -- -- - -- - - -- - - - - -- - - -- - --- - - - - - -- - --- -- --- --- - - -------- - - - --- - ---- -- ------
!mlH~
PROKARYOTES 1 LOWER EUKAR. MAMMALS lN VITRO HUMANS 1 F ¡HI l'MMALS lN ViVOlN VITRO
§
~n~ozoo
~::C/
ã5~tI~\0
~;lQ~~
ic.fi
CI
H- :ifoU
) ~80C
I
~U
)
~ ~
U) ~
fii5E-
~U)
E-
U)
foE-
~ ~
fo 0E
- U
~ ~
fo g
APPE
ND
IX 2
.- .- .e .. .-
0) 0) in co co
0\ 0\ co 0\ 0\
.- .- 0\ .. .-
.-." II ." ." ." ." ." ." ."." ~
,.- .. .- .- .- .- .- .- .- .- r. r. ~ r. fo
o)cocoo)coo)cocoo)o)zz 'zz
0\ 0' 0' 0\ 0\ 0\ 0\ 0' 0\ 0\ 0 0 .. 0 0.- .- .- .- .- .- .- .- .- .- ~ ~ l' ~ ~~,~~"""~~E
-~~~~~~~~~~~~.¡.¡r..¡.¡3SSS338S33U
)U)C
iU)U
)c. c. c. c. c. c. c. c. c. c. H
H H
H H
~~~~~~~~~:n~§§!§§0000000000000000000000000001'00000000000000000oooO
OO
OO
OO
N.-O
~.-. '. ....
0000000000000000' 0' 0\ 0\ 0\
000000000000000+
+1+
1+1+
1++
++
++..
~ ~
N N N HH
zi~~
~~
~~
.. ::::O
OH
HH
HH
HZ
Z zz
~~~~~~~~22oõOH
H~~~~~~~~~~eee~~~
~ ~
~::::::foto
UunU
;~~~~ëë-- -- - JltltltlH
, ,in in l' l' co co
OO
f"f"MM
f"f" "~~
~fofo
o 0 in in in in in in co 0) r. r. fo U) U)
~~~~aa~~~~~~~~~~~~~~~~~~~~~~Õ
Õ§ rg ~ ~ §~ ~ ~ ~ ~ i i i à à
tS ~ tS H tS H
H H
H H
H H
H ø: ø:
if if if if if
if if if if if õ õ õ l' l'~
~~
~~
~~
~~
a: "'~~
o§r. r. fo ~
. . . . . . . . . . u u u
U) U) U) U) tI U) U) U) U) U) U) tI U)
o 0 II II l' l' co co Ol O
l U U
U U
u.i .i l' l' .i .i .i .. i' i' H
H H
H H
U) U) U) U) U) U) U) U) U) U) tI tI U) U U
CI C
I C) C
I CI C
I CI C
) C) C
I U) tI U
) U U
601
"0§o~oUQI
.c.¡'loi:o....¡."i..¡i:QI
ui:ouQI
.c.¡.¡oi:,.¡i:QI
¡:QI
.-Q)
Q)
.c.¡'lo1/i:o....¡."i..¡i:Q)
ui:ou1/." ãi: IlQ
) Z::... i:tl ...
Q) "0
i. Q)
." ~..1/ 0Q
I 1/1/ 1/
8 B.. CO
602lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
aDl1
-.ln a
:Jz:;
~~
:;1
:: za
:i _ru
a:;:;~ln-iÈ~:i..Li
ln azO
:~~::
!':i ~
1
CO
Dl1
aD
l0:1-
a:;
!'~
ru..-..
..ln-ia:ti1-Ui.ln~ln1-Za:-ia.ci
Wiili
Ll
::Z
i.a:
0:i:
i.::0
a-iL:J
lnZ
i.W
lfl~1-a
0~
inU
la:O0:
ra:li
-.a
00:a.
L
CO
lD"f
rua
ru1
0;f
51INn 3500 ~OL
APPE
ND
IX 2
603
.Q .Q .Q
i. i. i.r.
co 00 00
~0' 0' 0'
.- .- .-
a. . .
~~ ~ ~
¡;E- E- E-
r. r. r.
p: p: p:
§r. r. r.
H H H
Z Z Z
0~ ~ ~
~0uQ
000H
00 M
Q)
- =
00 N
..r.
000.¡
l/ p:
80\D
\DO
~\D \D
0Q:3
~0r.
..-
~.¡
l/tU
~ ~
110
i.
~~
l/ ~Q
)1
1 +
u¡;
~¡§
0u
~Q
)...¡.¡0
N~
~ ~
,H H
.¡
~ ~ ~
~Q)
El
~ ~ ~
Q)
..Q)
r. r. Z~ ~ H
Q)
..
~ ~ ~
.¡~0~
U1I
E-
oOP:
~l/
00 r.0
::E E ~
..-l/
.¡tUE
-i.
l/¡§ ¡§
.¡r.
~E
-H
H r.
Q)
~ ~ ~
u~0H H H
U
= =
Õø. ø.
1I
~ ~
tU =
,0
r.~ tU
. U
Q) Z
l/ l/ l/~..- i:0\ 'ri
E- r.
00 U
Q) '0
l/ Q
r. 0-i -i H
i. Q)
E- U
l/ l/ l/tU
~..1I 0
~ ~
Q) ui
1I ui
øøl/8 '13
r. 2
60lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
aDl1
~ui a
::z ~
ii ---
1: ~1
:: za
:i_ru
a2:~=ui-iii1:1:~:i"-~ui az iicr t:
1: ~::
1':i z
1
aa-la
a-iit:
Dl
~ru
=a
ui-iii1:1:cr1:t-UWui=uit-Zcr-ia.a:iii-::wW
iif-
wcr
~aL
-i00::r
uiU
Wt-aL
~i:::
en a: 0iii-
0:ai:
cra.
DJ
co1O
a-ru
aru1
a-1
51INn 3500 ~OL
fi~§~
öz~i:~
oH~
:ifiui ~80ot1
ui~ :i
ui ~~~8ui~ui8uifi88 fiui 0fi 08 U
§ ~
fi 2
APPE
ND
IX 2
605
~ ~ ~
~ ~~ ~~~~~~~~ ø Ø~~~MØ
~ ~ø~~ø~~~~~~~ oø~~øøøøøø~
~~~~~~~~~~~~~~~~ ø~~ø~~~~~~ø
ø M ø ØMM ø ø MMMM M M MMØ ø ~ M ~~ M M M MMM ~
~ ~~ ~~ ØØM MM M
~"'''.-''''''''''''''''''''''''0'0\ .. ............
~~ : :~~ : :~~~~~~~~-:~J~JJ~~~~~~ri~ t~~tt~~ tttt tttt~~8ttttt tt~t~
:I::~~:: ~llllllltt; ~~H~~aa ~~;
fi fifi~Hfifi3 ~~~fil~fiH~~Hfifi
H H
H8~
HH
i: 88ØH
H~
88:iHui
~~~~~3~~~~~~~~~~888~ Ö~3~~~~~
00000000000000000000000000000000000000000000000000000 NOOOO
0000000000 00 OO~O~~OOOOON~OØO 0
00 00000 ~ 00000 ONOOOO O~OOO 0 NOM 0
~~ØO
NM
M M
O~N
~ N~ O
OO
O~~M
~ ~O 0 ~O
M N
~N MMM M~MMMM M M
N 0
M
1000+01 +
01 ++
+00+
00000000000001111111+
11++
+1+
+1+
11111++
++
++
..
.. ~ ~ ~
~.. 0.. .. ZZ
Z S..~ ~n~
7~~~SSS~~~~~Z~ ~~~ 0 Z
Z ui
~~~OHHHHH~880~ ~~ ~ HH~~
~~~~~~~~~iii~~~ ~~j ~~~jj~~
~XX
X~~~~~ ~fiS" Ö
ÖÖ
Z~~fifi j
m~~~fififififi~~~ ~~S~~~ 88H
ZZ
~~~fi~~~~~~~~fi~~H ~O~~~HH~~MU
1 ~ ~
~ § § § § § § § § ~
: ~ ~
l l ~ ~
~ ~
~ à à ~
~; ~
~ ~ fi ~ , , ,. , ,~' i- .; i 0 § 8 7 7 '~j j ~ U U
~ ~ u ~uififii:oOOONMMM '1 xx~ fifi~~~fifi"
oi:i:i:ooooo~~
~ø
fififiZ~
UU
HfifiuiuiZ
Zui i: i: i: ~
~ ~
~ ~
~ ~
~ ~
Z ui ui H
~ ~
88 ~ ~
0 0t1~:nn::888888888 ii~' ,7fi~~ ~~HH~~
~~~~ŠŠŠŠŠŠŠŠŠ2~ ,~~~~~~~~~ÕO~&
E...... ~
~ ~
~ ~
~ ~
~ ~
iN ~
~ ~
~ 0 Õ
0 ~ ~
~ ~
~~
~,222~~~~~~~~~:'~H
88~ '" '~~fifi~~fi HHHHHHHHH ~jjmZZZZHHmm
~~~~:i:i:i:i:i:i:i:i:i~~ oooo~~~~
~___~~~~~~~~~__ ~HHHHUU
~ 8 8 8 ~ ~ ~ ~ ~ ~ ~ ~ ~ 8 8 Ö ~ ~ ~ ~ ~ ~ ~ ~~g g ~ j
re ~ ~
~ ~
~ ~
~ ~
~ ~
m m
~ ~
m ci ci ui ~
~ ~
~ ~
~ u u Ö
~
~ e è Ö~~~~~~~~~ ~~8~ g~ 8~~ ~ ~~ ~~õö
~ fi fi fi ui ui ui ui ui ui ui ui ui fi fi ui C
I a 0 ø ø
ø ø
ui ui U U
8 8
o 0 0 0 ø ø ø ø ø ø ø ø ø ø ø ~ ø ø 0 ø ø ø ø ui ui U U 8 8
LE CHOMATE
END TESTPOINT CODE
TEST SYSTEM RESULTS DOSE iNM M (LED OR HID)
REFERCE
T T7S CELL TRSFORMTION, SA 7/SHE CELL + 0 2.0000 CATO ET AL., 1979S SHL SCE, HU LYMHOCYES IN VITRO 3 + 0 0.0250 DOUGLA ET AL., 1980M MIH MICRONUCLEUS TEST, HU CELL IN VITRO + 0 0: 5200 MONTALI ET AL., 1987bC CHL CHOM ABERR, HU LYMHOCYES IN VITRO 3 + 0 o .7000 DOUGLA ET AL., 1980M MV MICRONUCLEUS TEST, mCE IN VIVO + 0 160.8880 WATANE ET AL., 1985
lDoses are given as concentrations of the element, not the concentration of the compound.2Dissolved in HCl3Dissolved in NaOH
§
~n~ozoo
~:icr
dt~tr.;1.
Ul1--Z::wUlooLla..
8
6
4
2
o
-2
-4
LEAO CHROMATE
5 !H EA ff Co ;l v
5
C
G
o
H
X
7758-97-6
5
1
C
T T rC C 7
H L 5
20-JUL-90
5 H C
H 1 H
L H L
--- -- --'- - .1... .._____1__ ---- -- __ _ _.. _.. _ _ _ _ __ __.. _ ___ _ __ _ _.. -1- _ __. _ _ __.._.. -i_ _ _ _ __ _.. _...._ _ _ _ __ _ _ __ _ _ __ _ _ __ __ _ _ _ _ _ _ _ _.... _ __..
-- ------ -------- - ---- -- -- - - -- - --- - - -- - - - -- - - --- -- --- -- --- _.. - - - - - - ---- -- - --- - - -- - - - - - - - - - - -- - -- - - -- - - ---
P E
R C
B 0
5 5 ER R C2 5 K
PROKARYOTES 1 Lm/ER EUKAR.
o II G1 i: iR 01 R
MAMMALS lN VITRO HUMANS 1 F' /HI /'MMALS lN ViVOlN VITRO
~'"trZU-~N
gi..
608
~r.~i§~
lAR
e MO
NO
GR
AH
S V
OLU
ME
49
i..~
QH.. ::r.8 ~Q~
~.~tf ~~~E
-tf~tfE
-tfr.E
-
fi ~~ 8
~ ~~
.- .- .Q .- .-
co co II co co
0\ 0\ co 0\ 0\
.- .. 0\ .- .-
.-II II II II ft ft II ft II II ' ,
.- .- .- .- .- .- .- .- .- .- r. r. ,r. r.co co co co co co co co co co Z
Z . Z
Z0\ 0\ 0\ 0\ 0\ 0\ 0\ 0\ 0\ 0\ 0 0 .. 0 0.- .- .- .- .- .- .- .- .- .- ~ ~ .i ~ ~-. .. .. .. .. .... .. .. ..~
2 t 2 ~Ø1 Ø1 Ø1 Ø1 Ø1 Ø1 Ø1 Ø1 Ø1 Ø1 ~ ~ ~ ~
3333333333tftf~tftf....................H
!;~HH
~ ~
~:H
:i ~ rn:i ~
:n:H:i ~
~ ~
~ ~
0000000000000000000000000001100000000000000000oooO
OO
OO
OO
M.-O
M.-
. . . ,. . . .. ......000000000000000
0000000000000001+
1+1+
1+1+
++
++
+..
~ ~
N N
H H
l-zzi5i5i5i5i5i5 N
~~
OO
HH
HH
HH
ZZ
ZZ
~~~~~~~~~~~~~~~~ i r. r. r. r. r. r. ~ ~ !; !; ~ tJ tJ
nunu~~~~~eeH
. __ .htltltlU, 'il II " " co co
OO
MM
MM
MM
"ø:ø
:ø:r.r.
o 0 II II 10 10 II II co co ~ W W tf CI
~ ~ ~ ~~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~i§~~~~~~~~~~~~Õ
Õillliilili~~~SBif if if if if if if ~
Uf æ
Õ Õ
Õ ~
~
~~~~~~~~~~ötftf~~tf tf tf tf tf tf tf tf tf CI tf tf tf tl tl
~~~~~~~~~~~~~~~tf tf tf tf C
I tf tf tf tf CI tf tf tf U
U
~ ~
~ ~
~. ~
~ ~
~ ~
tf tf tf U U
.'0§o~ouC
D.i.¡'4oc:o-ri.¡ft'"~C
DUc:ouC
D.i.¡.¡oc:,.¡c:~C
D.-C
D
CD
.i.¡'4ouic:o'rl.¡ft'".¡c:CD
uc:ouuiII ::o
c: IIC
D Z
:;'rl c:
tT -ri
CD '0
'" CD
ft :;.-ui 0C
D ui
ui ui
-8 -a.. N
APPE
ND
IX 2
60
0Dl1
-lui 0
::z
~--
ccs;
i:1
::~
0:I
ru0:;s;~ui-lcci:i:~:I..l4ui 0z
a:cc
1-i:
~:::I
~L
O1
1'Dl
01
a:1-co
S;L
O
~1'1'
ui-lcci:i:cci:1-uLU
ln~ln1-Zcc-la.ricc~::LU
:3a:
0L
U~
-l0
-l-l
w::ln
L:
LU
1-::
0~L
:a:cc
0~
0:0a:
:ia.
U
coL
Oo:
ruo
ru1
o:1
51INn 3500 ~OL
610lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
~HŠÕ~~B
iiif;
QH.. ::~ ~
80Qt3
CI~ lE
CI ~
f;~E-
CI
~CI
E-
CI
~fi ~r. 0E
- U
~ ~
r. 2
ocoC7
..II '1l1ll\1l.. ~
.. .. .- ..co
f'coco co
coC
7 C7 0\ 0\ C
7.. t.. .. .- ..
~~~~~~ii ii ii ii ii ii~~~~~~000000000000N
ON
NN
N00000001'0000
..
0+0000
++
1++
+
z z z~~~~~zH
HE
-E-~O
i~ii~~~ r. r. r. ~
U~~~i
.. "'10 1" co
OO
MM
M'
ooininincoE
EE
Ea~
!i !i !i !i !i !i
iiiiiiH
HH
HH
H:: :: :: :: :: ::ø. ø. ø. ø. ø. ø.
¡: ¡: ¡: ~a:: ¡:
CI CI CI CI CI CI
~~~~~~
CI CI CI CI CI CI
'Ó§oIrol)IV.i.¡\Ioi:o....¡C
I~.¡i:IVl)i:ol)Q
I.i.¡.¡oi:,.¡i:mQ
I..Q
I
QI
.i.¡\IoIIi:o....¡CI
~.¡i:QI
l)i:ol)Ul
IIi:QI
:-...01QI
~CI
IIIVoi
8..
APPE
ND
IX 2
611
0Dl1
-lU
l a::
z~
-,C
I::
1L:i
"\:i
~ru
a~::~Ul
..CI
LL~:i"-u.Ul a
z0:
CI
l-L
:;:i
et:i
~1
..LÜ1
ai"
0:l-i"
:;D
l
~"'
Ul
..CI
LLCI
Ll-UWUl
~Ul
l-ZCI
..a.ciCI
:.:iW
w0
0:-
w0:
,0
a-l
..:rU
Ul
W-l
tjHE
~l-a
)-)-
LU
l a: =0:C
I0
:.0:
a0::r
a.U
etlO
"'ru
aru1
"'1
51INn 3500 ~OL
612lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
APPE
ND
IX 2
613
0011
-lU
10
::z
;:--
cr;;
L1
::~
'Ç:i
ruD;:;:~U
1..cri:L~:i"liU
10
Z0:
crl-
L;;
::L
I:i
~1
LI
01
D01
CI
!:'Ç
;:0
'- ~ Ul
~0
U1
..crLLcrL
=~=
1-UWU1
~in1-zcr..a.cicrW
:i::0
w0:
CI
w0
:J-l
D..:iU
U1
U1
w::
l-D0
;)L
CI
cr0
:iD0:
CI
:ia.
U
colD
'Çru
oru1
'Ç1
51INn 3500 90l
614lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
..1§!ËB
iiifi
Qi-~
:ii&tI p:
80Q~
tI~ ~
tI §fi~tIi-tIE
-tIi&E
-
E- i&
ti Q
i& 0
E- U
~ ~~
IIqt000\.., ,
. II II II II II ... ...... .. .. ..04 00 00 00 00 00 04
0\ 0\ 0\ 0\ 0\
E-..........E
-i& i&
~~~~~~~ii ii ii ii ii ii iiI: ~H
:H:n~ ~n~
000000000000000000000O
NN
NN
NO
. . . l. .0000000..M10000001 1 1 1 1 1 1
z~~~ ~
o i- i- i- Z ~
~~iii~~u~ ~i&
i- i& i& i& ~ ig
:IIUm
~E
- "'~~Z '10..00 P:
i&O
MM
M 'i&
Cioinininoo§
taaaa~~i-Q
§§§§§§
~llllll~g:rerereg:re8¡:¡:~~~~i& ti !I ti ti ti !I
~~~~~~~
QC
JCJC
JCJC
1CJ IIqt000\..
"e§~oUQI
...¡'Ioi:o-ri.¡nii..¡i:Q
Iui:ouG
l...¡.¡oi:,.¡i:G
l~Q
I..Q
I
QI
...¡\ioIIi:o-ri.¡IIi..¡i:Q
Iui:ouIInii:Q
I~-rit1G
li.IIIIG
lII8~
APPE
ND
IX 2
615
a(J1
-lUl CI
:Jz :;
-,a: -
1~
:;:: z
~:I _
ruC
I:;:;~U
l-ia:~~~:I"'U
.
ln CI
Z a:
~~::in
:I~
1
ru(J1C
Il'
a:1-a
:;a
2;1"..
Ul
-ia:L~a:~1-UUJ
Ul
~Ul
1-Za:-i0-cia:-l
:1::r
UJ
Za:
0U
Jm
:iCI
0:-i
crUU
lL
i.1-:J
CI
~i:
a:a:0
:10:
CI
..==
a::i
0-u
coin
~ru
oruf
~f
51INn 3500 ~OL
NICKEL OCCUATIONA EXPOSUR
END TEST TEST SYSTEM RESULTS DOSE REFERENCEPOINT CODE NM M (LED OR HID)
S SLH SCE, HU LYMHOCYES IN vivo - 0 0.1400 WAIK ET AL., 19841S SLH SCE, HU LYMHOCYES IN vivo - 0 o . 0680 ~VIK & BOYSEN, 1982;S SLH SCE, HU LYMHOCYES lN vivo - 0 0.0280 WAIK & BOYSEN, 41982S SLH SCE, HU LYMHOCYES lN vivo (+) 0 0.-0140 DENG ET AL., 1983 5S SLH SCE, HU LYMHOCYES lN vivo - 0 o .0000 DECHENG ET AL., 198\C CLH OIOM ABERR, HU LYMHOCYES lN vivo + 0 0.1400 ~VIK ET AL., 1984C CLH OIOM ABERR, HU LYMHOCYES IN vivo + 0 0.0680 ~VIK & BOYSEN, 1982;C CLH OIOM ABERR, HU LYMHOCYES lN vivo + 0 0.0280 WAIK & BOYSEN, 41982C CLH ciOM ABERR, HU LYMHOCYES lN vivo + 0 0.0140 DENG ET AL., 1983C CLH ciOM ABERR, HU LYMHOCYES lN vivo - 0 o . 0000 DECHENG ET AL., 19875
lNiO and Ni3S2/NiC12, NiS04 (crushing, roasting, smelting and/or electrolysis)
2NiO and Ni3Si (crushing, roasting, smelting)
3NiC12 and Niso 4 (electrolysis)
4Ni and chromium (electroplating)
SNi (CO) 4 (production of nickel carbonyl)
0\..0\
-~a:ozoo
~=en
âBa:tT+:1.
4
Ult--z2::
WUl00
0L)0--
-2
8
6
-4
NICKEL OCCUPATIONAL EXP05URE 7440-02-0 24-JUL-90
5 CL LH H
-- - - - -- - - --- - - - -- -- -- - - - - - - - - - - - - - -- - - -- - - -- - - - - - - - -- - - - - -- - - - - - - -- - - - - - - - - - - - - - -- - - - - - - - - - - - - - - - - - -- - - ~ - - ~ ---
- -- - - - - - - -- - - - - - -- - - - - - - -- -- - - - - - - - - - - - -- - - -- - - - - - - - - - - - - - - - - - - - - - - -- - - - - - - - - - - - - -- - - -- - - -- - - - - - - - - - - - - - - - - - --
PROKARYOTES 1 im/ER EUKAR.
5 CL LH H
MAMMlS lN VITRO HUMANS 1 F /HI l'MMAlS lN ViVOlN VITRO
~~tTZU-~N
0'1--i
618lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
N"" ,.
.Q co O'
~... O
' ..co ..
O'
a.. 'Ii,~ ~
r.. H
~~ ~~.t ~ ~
~ali'0
~tI~§
8 ~ PO
0ß'00
0000
H000
QI
" ::000
~r.
000#
tI ~80
000'W
NO
00
Nel
i:0l-
.rI
~#
tIII
U~
:z000
i.~
#i:ti Jå
QI
U+ + 1
0
~
~i:00Q
I~##0
0i:
~ti~,#
~ ~ ~
i:QI
:: Iia
~ :j :
QI
..QI
§ ~ ~
QI
~#,r.om s ~
'W
~0U
l8
' 'l-
i:ti
1515!0
~.rI
ti
~ ~
#II8
i.ti
#r.
i:8
00 'Q
Ir. r. ~
u
~ ~ ~
i:0uUl
:j:j§IIi:
r. r. ~Q
IU U
::.rIt¡8 r.ti 0
ti l- l-
QI
r. 0U
U Õ
i.8 U
88IIU
l
~ ~
QI
Ul
8E-U
8r. g
"
U11--Z::wU1oCI
Llo-i
8
6
4
2
o
-2
-4
METALLIC NICKEL 7440-02-0CM)
T T
C C
5 L
24-JUL-90
-- - - - - - - - -- - - - -.. - --- - - - - - - - - - - - - - -- - - -- - - - - - - - - - - - - - - - - - -- - - -~- ~ -- - - - - - - - - - - - - - - - - - -- - - - - - - - - - - - - - - - - - - - - - - --
- -- - - - - - - - - -- - - - -. - - -- - - -- - - -- - - - - - - - - - - - - - - - - - -- - - - - - - - - - -. - - - - - - - - - - - - - - - - - - - - - -- - - - - - - - - - - - - - - - - - - - - - -- - - --
PROKARYOTES 1 LOIoER EUKAR. MAMMALS lN VITRO HUMANS 1 F /HI f1MMALS lN ViVOlN VITRO
2;~trZo-~N
0'~\.
NICKL OXIDES
END TEST TEST SYSTEM RESULTS DOSE 1 REFERNCEPOINT CODE NM M (LED OR HID)
D BSD B. SUBTILIS REC, DIFFERIA TOXICITY2 - 0 1475.0000 KASU ET AL., 1980D BSD B. SUBTILIS REC, DIFFEREIAL TOXICITY' - 0 2950.0000 KATSU ET AL., 1980T TCS CELL TRSFORMTION, SHE, CLNA ASSAY 2 + 0 16.0000 COSTA ET AL., 1981b
T TCS CELL TRSFORMTION, SHE, CLONA ASSAY' + 0 14 ;0000 COSTA ET AL., 1981b
T TCS CELL TRSFORMTION, SHE, CLONA ASSAY' + 0 7.9000 SUNER ET AL., 1987T TCL CELL TRSFORMTION, OTER CELL LINES 2 + 0 30.0000 HASEN & STERN, 1983T TeL CELL TRSFORMTION, OTR CELL LINES' + 0 4.0000 HASEN & STERN, 1983C OlL CHOM ABER, Ht LYMHOCYES lN VITRO' - 0 o .0000 PATON & ALI SON , 1972
T TIH CELL TRSFORMTION, ~ CELL lN VITRO' + 0 3.0000 BIEDER & LALPH, 1987
lDoses are given as concentrations of the element, not the concentration of the compound.2Nickel trioxide
'Nickel monoxide
0'~
~(j~ozoo
~~en
â8~tr~\0
4
lJt-..z2::
WlJ00
0LJ0..
-2
8
6
-4
NICKEL OXIDES 1313-99-1 24-JUL-90
T T
C C
5 L
-- --- - - - - - - - -- - -- - - -- - - - - - - -- - - - - - -- - - -- - - -- - - - - - - - - - - - - - - - - - -~ - - - - - - - - - - - - - - - - ~ - - - - - - - - - - - - - - - - - - - - - - - - - - - - --
- --~ - - - -- - - - - - - - -- - - -- - - -- - - - - - - - - - - - - - --- - -- - - - - - - - - - - - - - - - - - -- - - - - - - - - - - - - - - - - - -- - - -- - - - - - - - - - - - - - - - - - - - - - --
B
5
o
PROKARYOTES 1 LOWER EUKAR. HAMHLS lN VITRO HUHANS 1 F ¡HI l'HHALS lN ViVOlN VITRO
~~trZo-~N
0'Nl-
NICKL SULIDES (AMRPH.)
END TEST TEST SYSTEM RESULTS DOSE 1 REFERCEPOINT CODE NM M (LED OR HID)
D DIA STR BRE/X-LINK, ANIM CELL lN VITRO - 0 6.5000 COSTA ET AL., 1982D RIA OTER DN REPAIR, ANIMA CELL lN VITRO - 0 6.5000 ROBlSON ET AL., 1983G GCO MUATION, CHO CELL lN VITRO (+) 0 1.0000 COSTA ET AL., 1980
T TCS CELL TRSFORMTION, SHE, CLNA ASSM - 0 3.-2500 COSTA ET AL., 1979
T TCS CELL TRSFORMTION, SHE, CLONA ASSM - 0 6.5000 COSTA & MOLLUE, 1980aT TCS CELL TRSFORMTION, SHE, CLNA ASSM - 0 6.5000 COSTA ET AL., 1982
lDoses are given as concentrations of the element, not the concentration of the compund.
0'~
~(j~ozoo
~=i(/
â8~t'+:i.
4
uit---Z:: 2wui00Ll 00..
-2
8
6
-4
NICKEL 5ULFIOE5 CAMORPHJ 12035-51-7A
G
C
o
24-JUL-90
-. - - - - - - - - - - - - - -- - - -- - - - - - - - - - - - - - -- - - -- - - -- - - - - - - - - - - - - - -- - - -- - - - - - - - - - - - - - - - - - - - - - -- - - - - - - - - - - - - - - - - - -- - - ---
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -- - - - ~ - - - - - - - - - - - - - - - - ~ - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - --
PROKARYOTES 1 LOIJER EUKAR.
IR
IlIl
T
C
5
HAHHALS lN VITRO HUHANS 1 F /HI t1HMLS lN ViVOlN VITRO
~~tTZU~~N
0'tj
624
E-
ti~ti~CI
~..8Hl2
lAR
e MO
NO
GR
AH
S V
OLU
ME
49
iiifi
CI
H.. :ifi ~80C
I
~ti~
:E
ti §fi~E
-ti~tiE
-tirzE
-fi f:
rz 0E
- U
~ ~
~ 2
l"co0\.-l)oco
0\ 0\ 0\
&1 "" .-
NC
ON
0 0\0\ coco 0\ co M 0\ .- .- ' co
0\ .- 0\ co 0\ ~ 0\tM
~.- ,.- ~
.- \0 &1 i' .i ~
~ .-
COO\ '!'' 'COCO" aO\~'
~0\.-!'E- . ,.O\O\CO £:.-l2'
2-: :f¡8~~~-:-:~:is :~~i: ...8 E- E-!'o( ,tI.i..:3E-
2!~.i....~tr.f¡f¡'~ .i~r.g t t l2 ~ ~ l2 ~ 8 8 ~ .. ~ t .. ~
d: !'8CHggfi....&Li:H!'!'fi
E-,(E
-HH
HH
H a:iE
-E-B
~.~ ti ø: E1 ø: ø: eí ~ ~ ~ £: ti 3 3
ûi ti 8 i s: i i 0 ti ti ti S ~ U U
.
~0000000000000000000000000000000000 0 &
1 0 0 in 0 in 0 0 0 0 0 in 0l" 0 in \0 &
1 M \0 0\ \0 N
\0 0 0 in N 0
. . . 1. . . . . . . . . . . . .
o "" \0 0 \0 " 0 "" 0 l" .- co "" \0 M 0
.- MN in
.- N
0000000000000000+
++
++
++
++
++
++
++
+
~~~~~ ~
:::::::::: ~ 0~~~~~~ l2 ~e¡~~~~3333~ ~H o~~~~;
(jtl(jtHjH
~àe¡HH
~~1~~~~~3t!~~~33s§à.i~2~22rzPi ~z~rzuuufs ~ ~ ~ ~ ~ ~:i3 ~ ~ ~ ~ i.!i~
~ "" ,2~tl~:3~~5itlH
,~~ ~ ~ ~ ~ tl Ci fi tl e 2 ii~
tlH~H
~H E
-r-rztltIOO
~rz.......... 'O
\~l2tI~
~H
H~
M ~ ~ ~ ~ ~~ £: ~ d § ~ ~ ~ ~ §
~ ~
~ ~
~ ~
~ d fi ~
~~
~~
~ ~
~~~~~~,( '~~~rzrz~~~
tj ø: ø
: ø: ø
: CQ
S S
8 ~ ~
~ ~
~ ~
~
nnnn~U~h~~
U .i .i .i .i .i .i :i u U :E E- E- ti ti .c
tlHH
HH
HH
O\H
HH
HH
UU
:;ø. C
I CI C
I CI C
I ~ c: ti U U
U U
fi E- U
U C
I CI C
I CI C
I CI c: ti U
U U
U E
- E- U
.'t§o~ol)Q
).i.¡\loi:o.,..¡IIi..¡i:ol)Q
).i.¡.¡oi:,.¡i:Q
)eQ
).-Q
)
QI
.i.¡\loUl
i:o.,..¡IIi..¡i:QI
l)i:ol)Ul
IIi:Q)
~.,.'"QI
i.IIenQI
Ul
8..
APPE
ND
IX 2
625
cow
"Iru
aru1
"I1
SlINn 3500 ~OL
626
CI
~5CI
§CI
..BHZ
IAR
C M
ON
OG
RA
HS
VO
LUM
E 49
irz~
CI
H.. :i~C
I ~80C
I
~C
I
~ ~
CI ~
~~8CI
:.CI
8CI
~8t; ~~ 8
~ ~
~ 2
M00 l' l'0' tU 0 00 00
.- 0 0 0' 0'
an an 00 00 .-.-00 00 0' 0'
. 0' 0' .-.- 0'' ,H .- .- 0' oo:i:i
-i M .- l' " M 0' ø. .- ø.
00' '000' ~~OO.-HOO..
:~~~~~~~~~~Jl~l2~: ::~B
:~~ët..~..h~~~t.~'H
!"'~~tl~§ã:a~~~~~~ia~~~cil-lQl;cil; ØíClCICI~I;~ ~
~ ß lí 8 lí CI a 8 8 8 ta lí S CI S
000001'000000000O
OO
OO
OO
MO
OO
OO
OO
OO
OO
OO
MI'M
OO
OO
MO
~ ~
~ ~
r: ~ r: ~
r: r: r: ~ ~
r: ~o l' 0 .- M
0 0 0 0 M M
.- 0 0 0N
000000000000000+
+ 1 +
++
++
++
++
1 ++~
~ 0 ~~~~CIui !;
!; ~~~~~~~~ f:z!;tJ ..~
g!H ~N~~~~~~o~~
~ ~ CI 0 ~ ~§ S S § tJ tJ ~ ~ tJ
~ ~ ~ ~ tJ ~ !i~~!i;! ~ ~ ~Õ~~ZlUCIuiClCI~~ CI~
uì~ a ~
~~
~~
~~
~ao ö~
~~, :: HHHHHHHU H
~~¡~~iii¡¡i¡~~¡C
I~~õ§ooooo~o~;.ohi~~~nnihi~~~ ~~ ~~ ~ uì~ ~ ~ ~ ~ ~ ~ ~ ~ ~ r.~
Øí 0 § !i !i tJ tJ tJ tJ tJ tJ tJ !i ~ tJ
U ~
§ 0 ~ ~
CI ui C
I ui H .. :i H
:iCI UHUUUUUUUi-:iH
ø. ~ ~ E- 8 8 8 E- E- E- ~ CI E-
U CI CI ~ ~ E- E- 8 8 E- E- E- ~ CI E-
."l§olfooII...¡I¡oi=o.ri.¡nii..¡i=Q
Ioi=ouC
I...¡.¡oi=,.¡i=C
IsC
I.-Q
I
CI
...¡I¡oIIi=o.ri.¡nii..¡i=CI
oi=ooIInii=41:;.rit¡CI
i.niII41II8..
APPE
ND
IX 2
627
co1O
a-ru
aru1
a-1
51INn 3500 ~OL
628
~Hii3o..!2UHZ
i(irz~
QH~
:i(itf ii80Q~tf~ ~
tf ~~iSe-tf:.tfe-tf(ie-~ ~
(i 0e- U
~ ~
(i 2
lAR
e MO
NO
GR
AH
S V
OLU
ME
49
0\co0\.-'0
II co 0 i. II i. II i. II i. tG i. tG
tG i. .
~ O\CO CO~'DCO'D~co~CO'D~CO~ 'D~ NO\ NCO i
CO.-O\ 0\
co co
0\ co
co 0\
co 0\
co co
0\ co coco co~ COO\N~M
O\.-.- .- 0\ 0\ .- 0\ 0\ .- 0\ .- 0\ 0\ .- 0\ 0\ 0\ 0\ 0\ 0\ .- co co co 0\
.- co . .-.-.-.-.-.- .- .- .- .- '0 .- .- .- 0\ 0\ 0\ ~
O'~.. .. .. ...... l" ....-l'-Olo\
.i ~ (i ~
i. ~ ~
.i i ~ i .i ~
.i ~ ~
~ .i ~
.i ~ i .i ~
.i .i i. ~. ~
: : : ~ ~
f'.:; ~.- f'tf tff' f' tff' f'.-Ulf' 'f'f'co UlO:;:;~ .
(it:;:st~
.te-8t8e-ttt8e-te- ~8e-~
te-~'D
8u ::;~t :: ~~~(io.~o.(i~ ~o.(i~(i~o.(i (i ,~o.o.ttt~to.
~ Ul : lul ~ rz ~ ~ E-~ ~ ~E- ~ ~ ~ ~ E-~ ~ ~ ~ ~ E-~ ~ t ~ g g ~ ~ ~ ~ ~ ~ ~ ~
~ïZ
Ho.~
.. ~ ..~
3~ ..~
..o. 3Z~
tf~~
Ul~
tftftf ö.~- H :i ~rz ~ rz~rz~ rz~rz rz(i§..~~HHHHH~~
~ B ~~~~~~~~~~~~~~~~~~ffrz~~~~~~~~~~
0000000000000000000000000000000000000000000000000000000000000000000000oo.- 0 0 0 00000000000000000 0 0 00 i. 000000000 0 0 i. 0 0 0 0000000000 000 Ó
i. 0 0 0 0 ~ 0 0\ 0 0\ 0 0 i.
. . . 1. . . . . . . . . . . . . . . . . . . . . . . . . . . .'. . . .
~ 0 0 i. ~
~ 0 0 0 0 co 0 0 0 0 co 0 0 0 0 co 0 ~
'0 i. N co 0 0 i. 0\ i. 0 M
0\'00\ ~~co O\.- .- O\.- ~M.-~ i. i. NN
i. ~ .- i. i..- .- i. .- .- i. N .-
.- .-
1000000 1000 10 100 10 100100000000000001 + 1 1 1 1 1 1 1 1 1 J 1 1 1 1 1 1 1 1 1 1 1 + + 1 1 + + + + +.:.: +
~ ~ ~ ~
zzz ~~
t;t;:.:.ZZZZ~~~~~~~~ 222 ulZZZZ~
E-E-OOOOHHHHHHHHZZE-E-E- ~~HHHHE-
HHHHHHE-E-E-E-E-E-E-E-OO~~~ ~:; H
~~
~~
~~
~~
~~
~~
~~
~~
~~
~~
~~
8~~
~~
~:
ööögg~~
~~
~~
(i(i(i z~Ö
tltlfjtlH~
~ ~
~ ~
(i (i (i (i ~ ~
~ ~
i ~ ~
~ ~
~ 8! 8! 8! Z
~ 2 ~
~ ~
~ ~
~ ~
~ ~
~ ~ ~ t ~~~ ~ ~ ~ ~~ ~ ~ ~ ~ ~ ~ ~~ ~~ ~ m 1 ~ ~ ~ ~ ~ ~ ~ ~~~
~~
~aa "..." '~
~'-'-'-~
§(i~~
". .~z~
~zzzrzrz '" .i.i.i.l"l"cococo iiiiii UlIii 1 ~~~~~H::::
i:i:i:rzrzOOONMMMMMMMM' .
(i (i
(i (i ii~~ (i
(iii ii ii H
H 0 0 0 0 i. i. i. i. i. i. i. i. co co § § § 8! ~
~ 0 ~
~ U
UE ~ ~ ~ ~E E E E E E E E E E E E ~ ~ ~~~~ ~ ~ ~ ~i i ~ ~ i(i~ ~
~~
~~
~~
~H
3~~
~~
~~
~~
~~
~~
~~
t!. ,~~
~~
~~
~~
~~
~ ~ ~ ~ ~ i i i i i il 1 1 1 1 1 III i 1 ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~
HHHHHHHHHHHHHHHHHHH ~~~~~~~~~zzz
~ ~ ~ § § re re re re re re re re re re re re re re re re re ~ ~ ~ ~ ~ ~ ~ ~ ~ 0 2 2 2888 tf tf ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
8 tl tll~ ~
~ ~
~ ~
~ ~
~w
w w
~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ w ~ ~ ci ci tf li li li § ~ ~ ~
Q Q
Q Q
Q 0 0 0 ~ ~ ~ ~ l" l" co co co ~ ~ li tf tf N
~ ii ~ ~ ~ ~ ~ ~ ~ 0 :i ~ii ii ii li ul ~
~ f' ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ U
U U
H H
H H
H U
O\ 0\
(i i: (i ~ ~
tf tf tf li tf tf tf tf ul ul ul tf li tf li tf ul (i tf li Q Q
Q Q
ii ~ ~
~
Q Q Q Q Q ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ii ~ ~ ~ Q Q Q Q Q ~ ~ ~
MoH3õH~U~
ir.~
oH.. ::Mti ~80o~
ti~ ~
ti i~lSE
-ti~tiE
-tiME
-
fi ~~ 8
~ ~2
APPE
ND
IX 2
O'
coO'
ii ri
o co 0'0' NN N
co co O' ' r- r- r- co co
O' co ri ~ O' O' co O' O' O'
ri O' ~
ri ri co ri ri M ri
~;~~~a~~~~~~~;f~ ~
i;~~riri~ri~H~1 : :E-O~r-o
.: "ii,:: HHMMOCOfi
Øl ~'!' !' ,ti~ .:.: HUO'H
:: ~ ~ ~: ~ ~: i ~ t t ~ I~ ~ ri~'i~
B~a ~~~tl§H
ø~l:5 ~~
§~~
~~
~~
~~
~Ö
~M
~ fi
~iimotl=tItISz~~ iioÕ~Q
00000000000000 000
000000000000000000000000000 O
ii 0 0 00000o~oo~r-~O
OO
NO
~OO
Mr-O
t. . . . . . . . . . . .o N
ii co 0 r- 0 ~ co ii N
M 0 M
ri N N
~ri ~
ri MM
Nri ~
000000000000000000+
++
++
++
++
++
~+ il +
+ 1
~ ~ ~!- H
H::~ßß~~ ~~
~~ ~~H~~~~ ~::
~~~~~~~:z~~ à ~~
fi l-HH::::HH!::: U
8~~::~~tltl ztl~~~~~
3~~~~~~~~~3iHH
~~~~~~~~~~~~~tl~~ :g~~~tl
uu~~:: ~OM HU ~~~
~!:!:~~~ ~~ff '~~~22 '
::ilil~~~fiMOO '~E'~ E-
MHH~MMfItlr.r.ZZ ~ !:
!: fi
U ~ ~ E- E- E- ~ ~ ti ti S ~ 0 ~ ~il il ~
~ ~ ~ ~ ~ ~ ä ä ~ ~ 1 ~~ ~ E ~ ~ ~
~ § § ~
~ ~
~~
~~
~ ~
,. ~ ~
~~
~" '~~~fiMMM~~~H~MM
~~~ddd~~~~~ii~~~~~~~~~ "'~~~~:j~ ,~Ô~~
~~~~~~~~~~~fI~ß~~~~E- ~ ~ U U U U U E- E- ti :: H ~ ~ ~ ~ ~
iiHH
HH
HH
HH
HU
H:: lxlx":
øøøtltItIUUUUE-Ofl UUO
ø ø ø ti ti ti U U U U E- 0 ti :: ~ U U U
629
.'0§~ouC
I
-ß'Ioi:o-...itØ~.ii:CI
Ui:ouCI
.i.i.ioi:,.ii:CI
aCI
o-CI
CI
.i.i'Iouii:o....itØ~.ii:CI
Ui:ouuitØi:CI
:--..t¡CI
~tØuiCI
ui
8..
8
6
4
uit-..Z:=
wuiooL)o..
2
o
-2
-4
NICKEL CHLORIOE
rR
o
s sC CG R
IR G GGSIl 9 51 1
ff H T RC
7718-54-9
C T1 CT 5
S
H
L
24-JUL-90
C
B
R
-- - ~ - - - - -- - - - - - -- ~ - --~ - - - - - - - - - - - - -- - - - - - - - - - ~~ - - r 111- - - -r - r - -~ - - -- - - - - - -~ - - - - - - -- - - -- - - - - - - - -r - - - - -- _ _ __ _ _ ___
..
,.
- -~~ - - ~-~~ ~ -~ - -- - - - - -- -- -- - - - - - - - - - - - - - -~- - -- - - -- - - - - - - - - - - - - - -- - - -- - - - - - - - - - - - - - -J- - - - - - --1- - - - - ~ - - - - - - - - - ---111111
A
B !I SSS E5 ff RRR Co lE 585 2
ID
ll~
PROKARYOTES 1 Lm/ER EUKAR. HAMMLS lN VITRO HUMANS 1 F ¡HI t1MMALS lN VIVOlN VITRO
H
H
H
H
V
H
o
L
H
~o
-~s:ozoo
~=CI
âB~tT.¡1.
¡q~~ti..a~
tJ~¡qri~
QH" ::¡qti ø:
8 °Q~
ti~ :E
ti ~~~ti~tiE-
ti~El ~
r& 0
E- U
~ ~
¡q 2
APPE
ND
IX 2
\0 \0
co co
0\ 0\M M ~N co
co 0\ti ti 0\ M
~~~~~~~~o ~ ~o M ~ ~ '
CO
co
co co
co co COO 0\ O\co 0\
co , 0\ O\::
00\0\0\0\0\0\ 0\0\ M M
O\ ~coz M
M~~
~MM
MM
MM
MO
\ M~O
\O\~ co..coco
0\ I.l. M "~M
MH
' ,O\~~i-
M""" , N' "0\ ø: . 'M O\oii-
......t't'ø:, co ~ ~ø:M"~ ~ ~ MMCO
~~~~~~~~~~~~~M M ~ ,gi~ ~M ~ "~
~tttttt~~~ ~ ~~t~t~~6 8~ t~~t~I.~~:
E- Il t,~ ~ ~ iäMO~' ~E-~ ~
¡q~~~~~~§§I.¡q& i~i~l.tl. i. '~~&i~¡q~tt
1 ~ ~ ~ ~ ~ ~! i IL i ¡ l 1 l IL ~ 1 i ~ i ~I i l IL ~ Il;
00000000000000000000000000000000000000000000000000000000000000000000000000000 i- 0 0 0 0 0 0 0 0 0000000000000o 0 0 0 0 0 0 0 0 0 0 M 0 0 N 0 0 ~ 0 0 0\ 0 0 ~ \0 M \0 0 0 \0 MM 0
.. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. . .. .. .. .. .. .. .. .. .. , .. ..
~ 0 0 0 0 0 0 ~
0 M \0 0 co \0 0 \0 M
~ 0\ M
M ~
\0 MO
0 0 M ~
0 M M
0M ~O\ ~ \0
M0000000000000000000000000000000001111111 +
+ 1 +
++
++
++
++
++
+ 1 +
++
++
++
il +
o~ ~ 00
zzz ~ ~~ o~~o ~
~~~~z ti 0 ~~~~~E-Z ~~~~ ¡q
H~~~O
~ 2ø: ZtItItItItIH
~ S U~~'('(~ ~ ~~~~ H
~~~~~~ ~~~~ ~~~~~~~ ~ ~~~~ ~~~~~~~~~~aaa:~~~~ ~
Ei¡q~~~¡q~ ~~~~ z~ 3333~iHHHH~tJtJ
~ §§§~HQ~~~ H ø:uuuu ~~~~G i
~ §~¡!£~;q~¡qr&~~03~~ '" ,fj zzzzo!! öi30
f ~zouu~~ø: ~¡qr&¡q¡q~ HHHH~ r& H
H.. ¡qr&E- 3 ~:::::: ~ Z ~
L '" ..~~~U
UH
¡q tItItItI ,tICIC
Iti o;c'~i-co i:: ~u ~¡q¡q¡q¡q aiou
OMMM ,¡qfj~ ø:ø: ¡q "" 'z!;~~!;¡. " ~H
o ~ ~ ~ co 1 ti ~ ~ Z ~ ~ ~ ~ u ~ ~ ~ ~ ~ ~ H
g g g g i ~ ~ ~ ~ ~
g~~
~~
~ ii::~
~~
~~
E~
~~
~~
~~
~:::::: ~
~~
~l
~~~~~~ ~~r&¡q~~~~Hm~~~~ ~~~~~ ~~~CIU
~ H H ~ H H '~~ ~ ~ ¡q r& U ~, 0 0 0 0 ~ ¡. .. ¡... '0 o. 'i..
::~~
~~
N 88t1C
I ~ ~
ririririri ~ririm
ø:..
~ ~ ~ ~ S ~ : ~ ~ ~ ~ ~ ~ ~ E ~ ~ ~ ~ ~ ~ ~ al ~ ~ ~ ~ ~ ~ ~ ~ ~ ~
~~~~ ~ ~.. ~~ H H Õ Õ£ CI
8 ~ ~ ~~~ ~~ ~;~ ~ ~ ~ ~~~ ~t~~~~~8~~~~~ '~~ '0:j:j:j:j:j ti~~~0:j:j00H~....... .~~utJuutJ~¡q¡q¡qr&r& uuuu~¡q¡q~~i
ai ti CI ti ti m
r& Q
Q f f ti ti ti ti ti U
U U
U U
umm
CI ti ti U
U U
U U
H
ri 0 ~ i- co ~
N ~
~ ~
~ u u :E
CI ~
m ti m
CI C
I ~ ~
.. .. .. .. .. :: :: ~ U
u ø:
~~~~~~u HHHHHHHHUUUU~H~::::~~HHai u
al ti ti ti ti ti r& ~ ~ ti ti ti ti m u E- E- E- E- E- Q ti CI m ti U E- E- U U H
~ ~
~ ~
~ ~
~ ~
~ ~
~ ti m
ti m ti U
E- E
- E- E
- E- Q
ti ti m ti U
E- E
- U U
H
631.'0§~ouai
:5\Loi:o-ri+
Jnii.+Ji:aiui:ouai
.i+J
+Joi:,+Ji:æai
Maiai.i+
J
\LoUl
i:o-ri+
Jnii.+Ji:aiui:ouUl
nii:ai;.'ri'"aii.niUl
aiUl
8
632lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
cotD
a-ru
oru1
a-1
SlINn 3500 ~OL
~HZ,.~UHZ
tjZ~t.ri~
QHrl ::t.II Il80Q~
~ ~
~ ~
~fJE-
II~IIE-
IIt.E-
E- fi
li Q
fi 0E
- U
~ ~
t. 2
APPE
ND
IX 2
"'lltUtU
tU"'''
." ." "" "" ." ." ."
co co co 00 00 co co
0\ 0\ 01 01 01 0\ 0\
.- .- r- r- .- r- .-
N N
CO
CO
N01 01 CO
r- r- 0\.-
J ~~ i ~' i i i ~ ~ l l ~
01 0' tq tq ::tH.1 t t tH;~ t r-r-~":": ~
~ ~ 0\ i. i.
~~~§~~~~~:~~;.ri ri ri c. ri ri ri ;i ;i t. ~
~ s
f:H~
~ ¡:n:~
~ ~
~ ~
~ ~
:H~
~00000000000000000000000000000000010100000O
OO
OO
OO
NN
OO
OO
. . " .100
0000 0
CO
00..
CO
"' 00
o O.-M.-
\0 ""1 1 1 1 1 1 1 000000
1 1 1 1 1 1 1 1 1 1 1 1 1
zzz êlZ
OO
O H
lIll2H
~~êl~~~~~~iii5~8~~u~ t!t.~UUO
H t. t. t. f II E
.qil fi ::~
t. ~ ~
~ t. ø
: -i ø: ø
: ~
~~iii~i~~~~tjtj;:~ ~HHHt.~~
E- ~ ~ ~ ~E-":":U
Z ~IO""CO ø:;; IIH ~ ~
tiOM
MM
~t.:i~
~;iE
-E-
ø: 0 10 10 10 CO ~ 0 t. t. li li
~~~:;:;~8l1llll~~~~ e.q.q.q..¡ E
- - ~~~~ ~ ~O
§§§§§§~~~E-~~
~iiiiii~~~~~~H
HH
HH
H;;;U
~~::H
f if if if if if :J :J :J ~ ~ ~8~~~a:~~~~~5~~iz ui ui ui ui ui ui ci ci ci ~
8 8
~~~~~~~l~~~~~o C
J CJ C
J CJ C
J CJ C
J CJ C
J ~ U U
633
't§oIfoUQI
.i.¡IIoi:o"ri.¡IIi..¡i:evui:ouQ
I.i.¡.¡oi:,.¡i:eveevr-evQ
I.i.¡IIoIIi:o.ri.¡tUi..¡i:evui:ouIItUi:Q
I::.riO
'
QI
i.'"IIQI
II8rl
634lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
co1.
.,ru
oru1
.,1
51INn 3500 ~OL
r.~t~Hr:uHZ
r.~a..~
QH~
:ir.lJ ¡i
80Q~
lJ~ ~
lJ §~iS8lJ~lJ8lJr.88 r.lJ Q
r. 08 U
~ ~
r. ~
APPE
ND
IX 2
0\ 0\
lllllllllllllll"l' ,0: "" "" "" 0: 0: "" 0\ 0\ :i
0: co co co co co co co .- .- M ii
co 0' 0\ 0\ 0\ 0' 0' 0\ co H0' .. .- .- .- .. ...- ' '0' ~
.. l-i..""'" Q
J~~~~~~~:i~~~8e-e-e-8e-e-lJ~8
i;r.r.r.tqfzt&r.H lJ~
~~uuu;I~~lJ ~lJ~r.
9 W r. r. r. r. r. r. H
H....Q
Q Z
ai0000000000000000000000000000000000000:0000000000\0. .... .
O'l"oooooocoirM
o.. MM M
""
011111110000+
1111111++
++
~ zzz ~oo ~
H ZOOO H~~ H
~ ~~~~~~t-H~::
"Eii~~~~;~~~
~~
r.r.r.~~
~~
:j~ai g ~ i2 i2 i2 r. ¡i :: :: tj tj
~~~~nl~~~n~
t 'ir' i- co' ~ ~
~lJr.OMMM ,r.oo "
o ¡i 0 ir ir ir co r: .. .. z zlJ r..;.;;;.;0) 5lJ lJ 0 0
~~::~::i~~¡¡§ 'HHHHHH "00
~~~~~~~~~~~ti~::æ
ææ
ææ
æ~~~~
~~~~~~~~gg~~ii r. lJ 1I 1I 1I lJ 1I U
U U
U
gi~~~~~~~~~tJiSii r. 1I 1I 1I 1I lJ lJ U
U e- 8
~~~~~~uue-e-
635
l'co0\.-
'0§oIroUQI
.t.¡~oi:o-ri.¡IIi..¡i:Q
Iui:ouQ
I.t.¡.¡oi:,.¡i:Q
Ii:Q
I.-Q
I
QI
.t.¡~ouii:o-ri.¡IIi..¡i:Q
Iui:ouuiIIi:Q
I;..rit¡Q
Ii.IIuiQ
Iui
8..
636lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
0m1
-lU
l a:J
z ~
a: ---
:i ~1
~z~
:i_ru
a~:;3Ul
.Ja::i:i9::i"-i.Ul a
z a:
II !::i ~~:i 3
m1
mOJ
a1
a:1-O
J:;
..3
0lDU
l.JII:i:iII:i1-uWU
l3U
l1-ZII.J0-cia:i.~wa:
Ww~
1-a
cr.J
1-WUU
l
crW1-a
-l)-a:
WIIi.
~a
U..=
=a:0-
Z0.=
=
OJ
lD~
ruo
ru1
~1
51INn 3500 ~OL
..~UHZ
~UZ~~i.~
~iUll~§
oH.- :i~ti ll80o~
ti~ ~
ti ~~~E-
ti~tiE-
ti~E-
ti ~~ 0
E- U
~ ~
~ 2
APPE
ND
IX 2U1Nco
"' 0'
U .-
o
N N N N M~ ~ I~
MM
M",.-, .-
co co co QJ ll
0' 0' 0' 0' '¡i ~ '.- .- .- .- ~ ;: ~
:i:iÙ!!!~
tttt ~33
~~~~l:ää~~~~~~Ö
Ö00000000000000000000000000000\C
0U1
. . . ,. . . . .O
OO
l-NN
U1l-
U1 U1 U1 \0 .-
.-
1 1 1 100001 1 + + + +
Z Z
0~88z~~ggH
E-E
-OH
tIHH
E- ~ ~ H
:: ti :: ::~~~~zl'zz~~~~H
~HH
~~~~~§~~~~~~u HH
ri~~§~~~~0' ~
~ '0 ,~
~O
U1U
1CO
i.ZZ
ZE
EE
B~~~~
~?3?3š~~~~H
.~HH
gf~~~
llll~~""~~~~~~Uti U) ti U) ~ U ti ti
o it l- 0) E- U) !' !'
.(1'.(I'UH
~~~ti ti ti U
) ...... .
C)C
)C)C
)UE
-QO
637
'U§o~ooQI
J:.¡~o~o-.-.¡II~.¡~QI
o~ooQI
J:.¡.¡o~,.¡~QI
¡;QI
.-QI
QI
J:.¡~oln~o QI
-.- ~
.¡ -.-II r-
~ r-
.¡ lU
~ .¡
QI Q
I lng ~ ~
o ~ u
o lU ~
ln iJ QI
II 'U
~ § -a 1:
QI -.- QI lU
;: lnr-i:
-.- ln CI 0
t¡ CI lU
ln .CQ
I~-g.g~~uo.lnOII 0r- r- r- r-
ln C
I Q
I C
I Q
IQI .i .i .i ..
lnOU
UO
8'~-~~-~.-N
M""U
1
638lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
coL
Oq-
ruo
ru1
q-1
51INn 3500 ~OL
MILD STEEL WELDING (MEAL lNET GA)
EN TEST TEST SYSTEM RESULTS DOSE REFERCEPOINT CODENM M (LED OR RIO)
0 ECO E. COLI POL A, DIFFERIAL TOX (SPO) - - o . 0000 HEDENSTEDT ET AL., 1977
~G SAO S. TYPHIMUM TAlOO, RERSE MtATION - - o .0000 HEDENSTEDT ET AL., 1977G SAO S. TYPHlMUUM TAlOO, REE MtATION - - 4000.0000 MAILD ET AL., 1978 "'G SAO S. TYPHIMUM TAlOO, REE MtATION - - 10000.-0000 ETIEN ET AL., 1986 mG SA2 S. TYPHIMUM TAl02, REE MUATION - - 10000.0000 ETIEN ET AL., 1986 Z0G SA9 S. TYHIMltJ TA98, REE MUATION - - 4000.0000 MAILD ET AL., 1978 ~G SA9 S. TYPHlMUIUM TA98, REE MUATION - - 10000.0000 ETIENN ET AL., 1986 ~G SAS S. TYPHlMUIUM (OTER), REE MtATION - - 10000.0000 ETIEN ET AL., 1986 NS SIC SCE, CHINESE HATER CELL lN VITRO - 0 750.0000 DE RA'I & BAR, 1988C CIC CHOM ABERR, CHlNESE HATER CELL lN VITRO - 0 1000.0000 ETIEN ET AL., 1986T TCL CELL TRSFORMION, OTER CELL LINES - 0 600.0000 HASEN & STER, 1985S SVA SCE, ANIM lN VIVO - 0 26.0000 ETIEN ET AL., 1986C CBA CHOM ABER, ANIMA BONE MAOW lN VI - 0 26.0000 ETIEN ET AL., 1986C CL CHOM ABERR, ANMA LECOCYES lN vio - 0 26.0000 ETIEN ET AL., 1986
0'W1.
4
1I~..z2::
W1I00
0Ll0-.
-2
8
6
-4
MILO STEEL \.ELOING CMIGl
!b !bIl Ilæ !IPROKARYOTES 1 lOWER EUKAR.
100-00-2
c
i
c
MAMMAlS lN VITRO
5 IIV B-A Il
24-JUL-90
HUMANS 1 F /HI l'MMAlS lN ViVOlN VITRO
~o
~("a:ozoo
~:iCI
âBa:tr~
~~~i~H~~..wwEo
lI~~
~r.~
CI
H=w8 ~C
I
tl
lI~ ~
lI ~~i5Eo
lIt-lIEo
lIWEo
fi ~w
0E
o U
~ ~
w 2
APPE
ND
IX 2
.. .... .. CI CI
.... 0101 CI
01 01 l- l- CI
l-l- ~~ .. ~~~OI~~~~~
CI CI CI , 'co CI CI CI co l- CI CI CI CI co
"..OIOIiiOl..OIOIOI 0101010101
. . 01 l- l- l- 01 l- l- l- 'l- l- l- l- l-~
~l-" ,l-"'~
"'"ttJ~~~~~J~~~~~~~~~~ ~ Eo t t ~ ~ t Eo t t t ~ t li t t t
w w r. w ~
ii§il~~~§iil~I~lli~~~ttssS~tE
E~t~ttE
000000000000000000000000000000000000000000000000000000~~~~~~~~~~~~~~~~~~0000000000 0 0 0 N
0 01 01 01000 IOOOOOOMOMMM
000 OOOMM ~
"'00 "'00
l- l- l- l-1111100+
11100000001 1 1 1 1 + + + 1 1 1 1 + 1 1 1 1 1
~
~~~~~~~šzz~ :li ~g~HHHH~~~OO~ H~ ~H
e~~
~~
~i~
~~
~ ~
~~
:~g w
w w
~ ~
ã : (j:j Q v.
~iiil~~~li=~il¡ !~
~",,~CIC
O P:H
ßtlWOOONMMM ,'w P:w'o
r. 0 0 0 0 ~ ~ 10 CI CI ~ ~ w li ~ ~ ~ ~
aaaaaaaaBB
~m~~~~~~
~~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ Õ ~ ~ ~ ~
2 i l i ~ ~ i i j ~ j ~i ~~ ~ ~~~ ~ re ~ re re re ~ ~ ~ re Š 5 ~ ã ~ ~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ ~
~~
~ ~
g ~w
li li li li li li li li li li ~ li 0 U li 0 0
e~~~~~~~~~~8~~Ö~~j
w li li li li li li li li li li ø li U Eo li U U
CI ø
ø ~
ø ø
ø ø
ø ø
ø ø
li U E
o li U U
641
~~i: l-o i:oQ
IVI VI
Il QI
~ +J
0. Ill-V
I :::: 0o 'rlQI +J
VI i.
Il Ilø
Øi
.. ..
642IA
RC
MO
NO
GR
AH
S VO
LU
ME
49
a(J1
-.ui 0
::z:;
-i~
:;1
:: z"J
::_ru
0~:;
t::h"jlE~ui.J.
ui~a:a:i:i:~::"i.ui 0ziia: !:i: :;
:::: ~
..1
al- '- -'
0a
ii~1
;:a
~a..
ui.Ja:i:i:a:i:U
) '- =
~uwui~ui~za:
cr.Ja.
LLci
LJ
a:l£
Z::w
0ii
-.w
W~0
:3.J
-.Wui
Ww
tflE ~
~~
en a: =0
lJ)-ii
t: lE e:
a:
0l£0
-.ii
-a.
L
coln
o;ru
aru1
"J1
51INn 3500 ~OL
~~H~~H8~i-ra~IIII;~II
~ar.tJ
CI
H=raII ø;
80CI
:3
II~ lE
II ~tJ
i5Eo
II:-IIEo
IIraEo
fi f:
~ 8
å ~2
APPE
ND
IX 2
t" t"
t" t" co
0\ 0\ co~~ ~~ ~~O\ ~~~~~~
cocococococo~ co
coco co
coco"t"0\0\t"0\0\ 0\0\0\0\0\0\""""
. .O\~~O\~~, ~~~~~~coco
~~~"~"~ """~~
ttJ~~ :~~~O\O\~ëë~~~ ::
~~ tt~tt~~~tllllttt~~~~t t M~ ~~ tt
~ ~
8 ~ ~
8 ~ ~
~ ~
H~
fj fj ~ ~
~ H
HW
W H
~ ~
H fj fj ~
= =
ra II II ~ ~
~ =
=C
lCI~H
H~H
H IIIlH
~~HH
HIIIi
~ ~ 2 t t 2 t t f: g ß t = = t t t ß ß
0000000000000000000000000000000000000000000000000000000000000000000000000000. . . .. . . . . . . . . . . . . . . .oooooooooooocoo~~~oo
OO
OO
OO
OO
~~l"~O""""""
~O
~O
~O
~l" .. ""
~t"~
ot"M
1111 + +
11000000000001 +
++
++
++
++
++
++
iii ++
~ ~
~ ~~ 0 õ
~~~~~~~~ ~~~ii ~g ~~
HH
HH
OO
!' HH
fl~ s:~
¡;~~~~~55~~~~~~~ ~~ ~
x ~ . ~ ~ ~ ~ ra ~ ~ Ö öll ~ ~ II Õ
II
;1111~il;;II~: lB!~
~ ,,' ,t!~iöö~~mg !§:l
~ g g g ~
~ ~
~ ~
~ ~
~ ~
~ ~
~ i ~
i-gEEaaE~-~~~~~~~ =~
~~~~~~~~~~õõg~~~ ~~
2 j j i l l i i ~ ~ àà¡ ¡ ~ àà~ à~ re re ~ re =
re re E E
~ ~ ~ ~ ~ ~ ~ ~ ~8ia:e~e~~ "§§~:j ,§§ 'ô
. . . . . . . .ÖÖeieiraraÖeieiÖl!
ra II II II II II II II II II 0 0 u U II 0 0 II 0
CI 0 0 0 ~ ~ ~ ~ u u u U II i- ~ ~ j 5 ~
~ ~
~ ~
II II II II ~ ~
ö ö ~ ~
~ 0 U
II Ü
CI ø øø ø ø ø ø II II U
U E
o Eo II U
U II U
643
ui.f(ro."+1
~ro."ê~o+1oCI
ro."CI
i.::CI
o0.xra..
644IA
RC
MO
NO
GR
AH
S V
OLU
ME
49
co1O
"Iru
oru1
"I1
51INn 3500 ::O
L
STAINLSS STEEL WELDING (MAAL MEAL ARC)
EN TEST TEST SYSTEM RESULTS DOSE REFERCEPOINT CODENM M (LED OR HID)
D ECD E. COLI POL A, DIFFERIA TOX (SPO) + + o .0000 HEDENSTED' ET AL., 1977G SAO S. TYPHIMUM TAlOO, REE MUATION + - 100.0000 HEDENSTED' ET AL., 1977G SAO S. TYPHlMUIUM TAlOO, REE MUATION + + 100.0000 MAILD ET AL., 1978G SAO S. TYPHIMUM TAlOO, REE MUATION + + 250; 0000 ETIEN ET AL., 1986G SA2 S. TYHIMUM TAl02, REE MUATION + + 50.0000 ETIEN ET AL., 1986G SA9 S. TYPHIMUM TA98, REE MUATION + - 100.0000 HEDENSTED' ET AL., 1977G SA9 S. TYPHlMUUM TA98, REE MUATION + + 100.0000 MAILD ET AL., 1978G SA9 S. TYPHIMUM TA98, REE MUATION + - 125.0000 ETIEN ET AL., 1986G SAS S. TYIMIUM (OTER), RERSE MUATION + + 125.0000 ETIEN ET AL., 1986G GeO MUATION, CHO CELL lN VITRO ? 0 10.0000 ETIEN ET AL., 1986
~G G9H MUATION, CH V79 CELL, HPRT ? 0 10.0000 HEDENSTED' ET AL., 1977"tG G9H MUATION, CHL V79 CELL, HPRT + 0 3.0000 ETIEN ET AL., 1986 tIS SIC SCE, CHlNESE HATE CELL lN VITR + 0 3.5000 DE RATT & BA, 1988 ZS SIC SCE, CHlNESE HATER CELL lN VITRO + 0 o . 7000 BA ET AL., 1986 t:-S SIC SCE, CHlNESE HATER CELL lN VITRO + 0 1.0000 KOSHI, 1979 ~C CIC CHOM ABER, CHlNESE HATER CELL lN VITRO + 0 1.0000 KOSHI, 1979 NC CIC CHOM ABER, CHlNESE HATER CELL lN VITR + 0 o . 3200 ETIENN ET AL., 1986T TFS CELL TRSFORMION, SHE, FOCUS ASSAY + 0 5.0000 HASEN & STER, 1985T TCL CELL TRSFORMTION, OTER CELL LlNES + 0 50.0000 HASEN & STER, 1985
G MST MeUSE SPO TEST + 0 100.0000 lISON, 1980S SVA SCE, AN lN VIVO - 0 18.0000 ETIEN ET AL., 1986C CB CHOM ABERR, ANIMA BONE HAOW lN VIVO - 0 18.0000 ETIEN ET AL., 1986C CL CHOM ABER, AN LECOCES lN vio - 0 18.0000 ETIENN ET AL., 1986S SLH SCE, HU LYMHOCS lN VIVO - 0 0.0000 HUSGAIrPURIANN ET AL., 1982S SLH SCE, HU LYMHOCES lN VIVO - 0 o . 0000 LITTRIN ET AL., 1983S SLH SCE, HU LYMHOCES lN VIVO 1
(+ ) 0 o . 0000 KOSHI ET AL., 1984M MV MICRONUCLEUS TEST, HU CELL lN vivo - 0 o . 0000 LITTRIN ET AL., 1983C CL CHOM ABERR, HU LYMHOCES lN viO - 0 o .0000 HUSGAIrPURIANN ET AL., 1982C CL CHOM ABER, HU LYMHOCES lN viO - 0 o . 0000 LITTRlN ET AL., 1983C CLH CHOM ABER, HU LYMHOCES lN VIOl (+) 0 o . 0000 KOSHl ET AL., 1984.
lExposure also to Metal Inert Gas
~Ui
lfl---z2::
wlfCJ0
0Ll0-l
-2
8
6
4
-4
STRINLESS STEEL 'wELDING (MMA)
!I !Ifl flæ !IG 59 1H C
100-00-4
TT
FeSl
24-JUL-90
"5
T
5 CL LH H
. - - __ - _~_ _.~ - - __ - - - - - - __ - - __ - - - - - - - - - - - - - __ - - __ - - 4. _ _~ _ _ _. - - - - _.4_ - - - - - - -- - -- - - - - - - - - - - --- - ..- - - - -- - - - - - - - - -- - _.
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - ~- - - ~- - - - - - - - - - - - - - _.
PROKARYOTES 1 LOWER EUKAR. MAMMLS lN VITRO
5 a: SHV B. L VlR II H H H
HU MANS 1 F /HI l"MMLS lN ViVOlN VITRO
~
-~3:ozoo~:ien
â83:tr~\0
CI
1e3fiÕ~a~¡s~~9~~HE-
5c.
,.fi~CI
~~
ii.t!
QH:ifi8 ljQ~
CI
~ :i
CI ~
t!Zi
E-
~CI
E-
CI
~tn:i~ 8
~ ~
fi 2
APPE
ND
IX 2
647
'D'D
'D'D
'D'D
""O'D
'D'D
co co co co co co co co co co co
01 01 01 01 01 01 01 01 01 01 01
l- l- l- l- l- l- l- l- l- l- l-,..._,--",~~~~~~~~~~~
E-
ttfJfJttCltttt
iiiliii~liiE
EE
EE
E~~E
EE
00000000000000000000000000000000000000000000. . . '. . . . . . . .00000000000O
OO
OO
NO
l-l-l-O
OO
Ol-M
l-0000l- l- l- l-
111100000001 1 1 1 1 1 + + 1 1 1
~~
!;~~R:~ ZCI g~
HH
~!' H
ri !;¡;~~~~ ~~ ~~
!i!i~fi tJ:j~ ~CI
ä~mh~ilj: ~§
~ti~
~~
H riu
"t!g~~ ~ ߧ
g ~ .; § ~ i ~' lj ~ ~ ~
~~~~ H~i~2~
§§§§~õg ~~~
iilj~à~~~àà~~:i~~~~r;z~~ii ii ø. ii H
g¡ S -i~~~~~~:j' ,~~
. . . .~i=filjlje¡ei
CI CI CI CI !i 0 u CI CI 0 0
~ ~
~ ~
8 ~ tH
S ~
¡: :5C
I CI C
I CI C
) U E
- CI 11 U
U
CI C
I C) C
I C) U
E- C
I .CI U
U
648lA
Re M
ON
OG
RA
HS
VO
LUM
E 49
cotD
"fru
aru1
"f1
51INn 3500 :JOL
![Appendix II. Publications · Appendix II. Publications Gemini Staff Publications Papers in Peer-Reviewed Journals: Trujillo, Chadwick A.[2]. Detection of a Trailing (L5) Neptune Trojan](https://img.dokumen.tips/doc/110x75/5e42b3fd800daf0223299322/appendix-ii-publications-appendix-ii-publications-gemini-staff-publications-papers.jpg)
