Einladung zum VO R T R A G

Gesellschaft Österreichischer Chemiker

Institut für Organische Chemie

“NMR in drug discovery. The power of resolution.”

Dr. Andras BoeszoermenyiHarvard Medical School Boston, USA

Dienstag, 07. Mai 2019, 16:00 Uhr.

HS H, „Ulrich Santner“ NTEG230E

Technische Universität Graz

Kopernikusgasse 24, Erdgeschoß

Nuclear Magnetic Resonance (NMR) spectroscopy is a highly versatile technique to monitor function, structure and dynamics

of biomolecules. Its unique ability to directly observe nuclei in solution, enables the simultaneous monitoring of hundreds of

probes in biomolecules (the nuclei) as they respond to environmental queues (e.g. ligand binding, conformational changes,

immersion into a membrane environment, or changes in dynamics). I will discuss (i) how we used NMR spectroscopy to

elucidate the mechanism of T-cell receptor signaling [1], (ii) the re-discovery of fluorine in biomolecular NMR and its

implications [2], and (iii) how NMR studies of transcription factor / co-activator complexes drive drug discovery projects [3].

[1] Brazin KN, Mallis RJ, Boeszoermenyi A, Feng Y, Yoshizawa A, Reche PA, Kaur P, Bi K, Hussey RE, Duke-Cohan JS,

Song L, Wagner G, Arthanari H, Lang MJ, Reinherz EL, Immunity 2018, 49, 829-841.

[2] Boeszoermenyi A, Chhabra S, Dubey A, Radeva DL, Burdzhiev NT, Chanev CD, Petrov OI, Gelev VM, Zhang M, Anklin C,

Kovacs H, Wagner G, Kuprov I, Takeuchi K, Arthanari H,

Nature Methods 2019, 16, 333-340

[3] Nishikawa JL, Boeszoermenyi A, Vale-Silva LA, Torelli R, Posteraro B, Sohn YJ, Ji F, Gelev V, Sanglard D, Sanguinetti M,

Sadreyev RI, Mukherjee G, Bhyravabhotla J, Buhrlage SJ, Gray NS, Wagner G, Näär AM, Arthanari H, Nature 2016,

530,485-489.