Embed Size (px)
Citation preview
1
“Immunological Memory in Infection and
Vaccination: Current Knowledge and Future Directions”
September 23-26, 2019
Salón Dalmacio Vélez Sarsfield, Facultad de Derecho Córdoba, Córdoba, Argentina
2
Welcome! Dear colleagues and friends, After the great success of the first edition, we are pleased to announce the Second ARGENTINEAN SPRING COURSE IN ADVANCED IMMUNOLOGY that will be held in Córdoba (Argentina) September 23rd-26th, 2019. In this occasion, ASCAI2 will receive the support of the Education Committee of the International Union of Immunological Societies (IUIS). This Second Edition is focused on “Immunological Memory in Infections and Vaccination: Current knowledge and Future Directions”. The activities have been organized to cover the requirements of an Advanced Course valid for PhD programs as well as a Symposium for participants interested in the topic. We greatly value the effort of all the Lecturers have confirmed their participation, taking time off from their busy schedule to join us in Córdoba City. We have top scientists coming from Argentina, Australia, Brazil, England, Germany, Sweden and United States of America that will share their knowledge and expertise with the participants. We appreciate you commitment to foster Immunology knowledge in young students and local researchers. We are aware that for many of the attendees the participation in this symposium/course will represent an important effort, considering the distances, the economic costs, the different languages, etc. Therefore, we have been working hard to develop a Scientific Program of excellence that will cover critical aspects of the field of Immunological Memory in the context of infections and vaccination. We have ahead one year full of work to continue with the organization of the ASCAI2, we will do our best to achieve the best academic level and a rich and warm scientific atmosphere. We will be happy to host participants coming from Argentina, Latin America and the rest of the world. Our highest priority is to seek financial support to cover not only the course costs but also travel grants for students. We are greatly committed to gender equality and promoted equal representation of women and men within the Lecturers and the students attending to ASCAI. We are confident that ASCAI2 will fulfill your expectations and be very stimulating for sharing data, generate ideas and foster collaborations. See you soon in Córdoba!! The Organizing Committee
3
Organizer Institutions • Escuela de Posgrado, Facultad de Ciencias Químicas, Universidad Nacional de
Córdoba. Posgraduate School, School of Chemical Sciences, National University of Cordoba
• Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET) Center for Research in Clinical Biochemistry and Immunology (CIBICI), National Council for Scientific and Technological Research (CONICET).
• Education Committee. International Union of Immunological Societes.
Haya de la Torre y Medina Allende, Ciudad Universitaria X5000HUA - Córdoba – Republica Argentina TEL: ++5353850 y 5353851, Interno 3149 Web: http://www.fcq.unc.edu.ar
Contact
• [email protected] • https://www.facebook.com/ASCAI2 • Instagram: ASCAI2 • Twitter: @ascai2019
4
Introducing Córdoba
It is located 700 kilometers northwest of Buenos Aires, in almost the geographical center of Argentina, in an area of great natural beauty lies a modern city with a fascinating past. Córdoba city, capital of Cordoba province, was founded in 1573 and is the second largest city in Argentina (1.4 million inhabitants). It is the capital of one of the country's most densely populated and wealthy provinces, with a lively student population and buzzing atmosphere. It lies on the Río Suquía, extending over a wide valley, with the hills visible in the west. The city has been an important trade center since the area was colonized in the 16th century, and retains an unusually fine set of colonial buildings at its heart, the astonishing Manzana Jesuítica (Jesuit Block), complete with its temple still intact. Córdoba is known by many as La Docta because of its many universities and science institutes. It is the seat for the first university in the country (which celebrated its 400th anniversary in 2013) and currently has six universities. Around 200,000 people study here, which makes the city's population one of the youngest and liveliest in South America. There is much cultural and night life, primarily in
the downtown area (centro) and the neighborhoods of Güemes, Nueva Córdoba, Cerro de las Rosas and Alta Córdoba. Córdoba is a very important industrial center, the home of Argentina’s motor industry and a busy modern city with a flourishing shopping centre. Córdoba has an entirely different character from Buenos Aires. The sparky Cordobeses are known for their quick wit, warm welcome, and are understandably proud of their city's history. The Jesuits established the country's oldest university here in the 17th century, with a centre of learning funded by estancias all over the province. These magnificent estancias, tucked away in the Sierras Chicas (Small Hills), are the main tourist
attraction and best visited by car, while the mountains themselves are best explored on horseback or doing hiking. Cordobeses are renowned throughout the country for their sharp sense of humour, defiant attitude and a lilting accent that other regions delight in imitating. However, along with their strong sense of civic pride, their warm welcome makes Córdoba one of the most hospitable areas in the country.
5
Manzana Jesuítica (Jesuit Block) The Jesuits block is in the very center of the beautiful city of Cordoba and was constructed as a place for prayer and learning in the city. Together with the Estancias Jesuíticas (five farming states and indian reductions distributed along a 250 km road), the Jesuit Block illustrates the unique religious, social, and economic system developed during the missionary activities of the Jesuits in South America. The Manzana Jesuítica and Estancias de Córdoba were named an UNESCO World Heritage Site in 2000. The Manzana Jesuítica contains the University of Córdoba, Argentina’s first University and one of the oldest in the in South America. Within the Jesuit Block and one of the highlights of Cordoba is the stunning church, Iglesia de la Compañía de Jesus and the beautiful Capilla Doméstica (domestic chapel) whose roof is made out of stretched cowhide and ornately decorated using pigmentation made, in part, from bones. Another highlight of course is the university itself, the Universidad Nacional de Cordoba, whose library is a must see and is the oldest in Argentina, housing some of the original books brought over by the Jesuit Missionaries.
Around Córdoba City The Sierras de Córdoba, the hill district west of the city, is the second most popular tourist destination of Argentina after the Atlantic Coast. The nearest resorts are only 20 km (12 mi) of the Circunvalación ring road. The Sierras have a vegetation with dense bushland and some small woods. There are many little canyons and several reservoirs and rivers with pleasant swimming. Punilla Valley The Punilla valley is situated about 25 km west of Córdoba. In the valley you will find mountainous rocky villages like Bialet Massé and Villa Giardino with picturesque sights, small rivulets, small waterfalls and rivers, environmentally-friendly people and pure air. There are also some larger towns like Villa Carlos Paz and La Falda which can get very crowded in summer holidays in January and February. There are many hotels, hostels, cottages and camping sites. The way to the valley is sinuous and it is surrounded by Sierras Chicas and Sierras Grandes with their naturally beautiful landscapes, which are very attractive for tourists.
Rectorate of the National University of Córdoba (Jesuit Block)
6
Calamuchita valley The Calamuchita Valley is located south-west of Córdoba. There, you find the attractive German-styled town of Villa General Belgrano and nearby Santa Rosa de Calamuchita with a good river beach. Other towns are La Cumbrecita, Los Reartes and Yacanto near the Champaquí mountain, the highest of the Sierras. Traslasierra valley The Traslasierra Valley is 120 km / 74 mi west of the city. On the way to the valley, you can visit the highland plains and the deep gorges of the Quebrada del Condorito national park, located near the Altas Cumbres road between Carlos Paz and Mina Clavero. It has few services, but a very pleasant scenery, with superb views of the whole surroundings of Córdoba and condor watching. Traslasierra Valley will engage the visitor in a wonderful experience. It is located in the middle of the vast valley. Surrounded by mountains, it will offer a spectacular view of its natural landscape. The abundant flora contrasts with the arid stony mountains, providing an extraordinary panoramic view. Most towns offer river beaches and entertainment areas that you can enjoy after a walk. The favourable climate and fresh air will be a temptation to leave the pollution and traffic of the big city. Other destinations Jesús María 50 km on the way north, is an attractive little town. There you can visit a Jesuit Museum inside an baroque estancia. The picturesque and green suburb of Colonia Caroya is known for its local food. The Sierras Chicas district begins in Villa Allende, a pleasant suburb with 30.000 inhabitants located inmediately north-west of Córdoba. Other large towns of this part of the metro area are Río Ceballos, Unquillo and La Calera. In Río Ceballos, you can swim in the La Quebrada lake and trek to a little waterfall, the Cascada de los Hornillos. Unquillo is famous for being home of many artists. Alta Gracia, 30 km south-west, on the road to Calamuchita valley. The 50.000-inhabitant town hosts a baroque Jesuit estancia, located very beautifully near an artificial lake, and a Che Guevara museum. Nearby there are pleasant little towns like Anizacate and La Serranita with river beaches.
Quebrada del Condorito National Park
7
Course/Symposium Venue The lectures of the Symposium/Course will take place at the Dalmacio Velez Sarsfield Room, School of Law, located in the first floor of the Old Rectorate in the Jesuit Block (Obispo Trejo Street 242, Córdoba). The poster sessions will be accommodated in the galleries that surround the lecture room. The Course/Symposium Venue is located at the center of Córdoba downtown (microcentro), very close to the main square Plaza San Martin and local business and commercial area. The Rectorate is surrounded by lots of restaurants, cafes and bars covering different categories (and prices). Many lodging options are available in downtown (Centro) and the closest Nueva Córdoba neighborhood, typically populated with university students. Güemes neighborhood, ten blocks from the Venue, gathers most cultural and night life of the city and hosts an Arts and Crafts market on Saturdays and Sundays. September is one of the best months to visit Córdoba. The climate is pleasant with average temperatures around 23/10⁰C (73.4/50⁰F) and little rain. If you are planning to visit the hills, you may want to bring warmer clothing as the in the hills temperatures are low during the nights.
Courtyard of the Old Rectorate
Arts and Crafts Market (Guemes Neighborhood)
8
Course/Symposium Description Immunological memory is a hallmark of the immune system. This fundamental property of the immune system is the basis for vaccination, and the goal of a successful vaccine is to induce long-term protective immunity. This course will focus on integrating current knowledge concerning the cellular and molecular protagonist involved in the induction of long-term immunity. The program includes topics about the characterization of memory NK, B and T cells, in mice and humans, and their role in mediating protection against infections and upon vaccination. Particular emphasis will be placed on the therapeutic and pathogenic roles of the different subsets during chronic infection and the basis of vaccine designs. The course is also aimed at fostering multidisciplinary collaborations and scientific and student exchange. Intended Participants - Why to participate: This course is open to talented graduate students enrolled in academic PhD programs as well as to young postdocs and scientist, engaged in research in the area of fundamental, applied and clinical immunology. Students, postdocs and scientist all abroad Latin America are encouraged to participate. The candidates should have sufficient scientific background and comprehension of English to benefit maximally. Participants must send a CV resume and a letter of proposal explaining why they want to participate in this course and in which way it will help their work and studies. In the case that the number of participant exceeds the established maximum (up to 100), a selection will be performed based on their academic and scientific antecedents. Before course starts, selected students must complete one short pre-course on basic immunology that will be posted online in Immunopaedia. The organizers aim to ensure benefit from this course, therefore:
• The course will be held in a relaxed and intimate venue and size of the meeting will be kept small to facilitate maximal interactions.
• Invited speakers will present late-breaking science while participants will be able to discuss their research in short talk or poster formats.
• Recreational experiences, social hours and free time will be available to promote interactions and forge collaborations.
Course Fees
• PhD students from the Universidad Nacional de Córdoba: Free of charge (the course is recognized by the Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, as valid for the PhD Program).
• PhD Students and Researchers: Until March 15th 2019: ARS 3500 Until June 30th 2019: ARS 4500 Until August 31th 2019: ARS 5500
• For Biochemists and Medical Doctors: Until March 15th 2019: ARS 4500 Until June 30th 2019: ARS 5500 Until August 31th 2019: ARS 6500
Payment should be done by bank tranfer to the account of the Facultad de Ciencias Químicas. International students are adviced to pay once they arrive to Argentina to avoid transfer surcharges. For details: contact [email protected]. According to the funds raised in the next months Travel awards for student may be offered.
9
Organizing Committee Local Organizers
Eva Acosta Rodriguez ([email protected]) is Biochemist and PhD in Immunology from the Universidad Nacional de Córdoba (UNC) in Argentina. Professor of Immunology at the School of Chemical Sciences-UNC. Independent Researcher of CONICET (Council for Scientific and Technological Research). Her group is focused to investigate the mechanisms involved in the development of effector and regulatory immune response during infections. Using the experimental infection with T. cruzi as a model, Dr Acosta study basic immune mechanisms involved in protective and pathogenic responses. At present, she is expanding her interests to other models of chronic diseases such as cancer and autoimmunity.
M. Carolina Amezcua Vesely ([email protected]) is Biochemist and PhD in Immunology from the Universidad Nacional de Córdoba (UNC) in Argentina. Associate Research Assistant at Yale School of Medicine. She is currently performing her postdoctoral stage in the laboratory leaded by Dr Richard Flavell at Yale University. Dr Amezcua main interest is to understand de biology and role during infection of tissue resident memory CD4+ T cells that are originated after Th17 immune responses.
Adriana Gruppi ([email protected]) is Biochemist and PhD in Immunology from the Universidad Nacional de Córdoba (UNC) in Argentina. Professor of Immunology at the School of Chemical Sciences-UNC. Superior Researcher of CONICET (Council for Scientific and Technological Research). She focused her lab research program on B cell immunity. Dr Gruppi has made significant contributions to the field of B cell response in non-infection conditions as well as in Trypanosoma cruzi infection. She identified molecules involved in B-cell survival and differentiation. Nowadays, her lab members are characterizing the antibody-independent role that B-cells play in T. cruzi infection and autoimmunity. Carolina L. Montes ([email protected])is Biochemist and PhD in Immunology from the Universidad Nacional de Córdoba (UNC) in Argentina. Professor of Immunology at the School of Chemical Sciences-UNC. Independent Researcher of CONICET (Council for Scientific and Technological Research). Dr Montes´s group is focused in the study of the immune response mediated by tumor- induced dysfunctional T cells such as Senescence and Exhausted T cells. Moreover they evaluate the potential of these cells to act as modulator of other cell populations. The development of the research project involves murine models of melanoma and breast cancer as well as the study of tumor samples from patients with breast cancer.
10
IUIS Education Committee members
Dieter Kabelitz ([email protected]) is the former director of the Institute of Immunology at the University of Kiel, Germany. He is now a senior researcher in the same department. The focus of his scientific interest is the characterization of human γδ T cells and their role in immune defense against infection and cancer. He is the Chair of the education Committee of IUIS
Hanne Ostergaard ([email protected]) is currently appointed as Professor, Assoc Dean Rsch/Grad Program in the Department of Medical Microbiology & Immunology in the Faculty of Medicine and Dentistry. University of Alberta, Canada. Dr Ostergaard’s research interests include: Mechanisms of cytotoxic T lymphocyte (CTL) killing, Regulation of CTL cytoskeletal rearrangements, CTL responses to cancer, Contribution of the tyrosine kinases Pyk2 to CTL migration and killing, Role of the cytoskeletal adaptor proteins paxillin and leupaxin to leukocyte adhesion and migration.
11
Faculty Members/Speakers
Dr Shane Crotty. [email protected]. La Jolla Institute for Allergy and Immunology. USA. Positions: Professor with tenure in the Vaccine Discovery Division. Publications: 160 publications in international peer-reviewed journals. Selected publications: 1) Abbott RK, Lee JH, Menis S, Skog P, Rossi M, Ota T, Kulp DW, Bhullar D, Kalyuzhniy O, Havenar-Daughton C, Schief WR, Nemazee D, Crotty S. Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens. Immunity. 2018 Jan 16;48(1):133-146.e6. doi: 10.1016/j.immuni.2017.11.023.
2) Havenar-Daughton C, Lee JH, Crotty S. Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem. Immunol Rev. 2017 Jan;275(1):49-61. 3) Havenar-Daughton C, Lindqvist M, Heit A, Wu JE, Reiss SM, Kendric K, Bélanger S, Kasturi SP, Landais E, Akondy RS, McGuire HM, Bothwell M, Vagefi PA, Scully E; IAVI Protocol C Principal Investigators, Tomaras GD, Davis MM, Poignard P, Ahmed R, Walker BD, Pulendran B, McElrath MJ, Kaufmann DE, Crotty S. CXCL13 is a plasma biomarker of germinal center activity. Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2702-7. 4) Havenar-Daughton C, Carnathan DG, Torrents de la Peña A, Pauthner M, Briney B, Reiss SM, Wood JS, Kaushik K, van Gils MJ, Rosales SL, van der Woude P, Locci M, Le KM, de Taeye SW, Sok D, Mohammed AUR, Huang J, Gumber S, Garcia A, Kasturi SP, Pulendran B, Moore JP, Ahmed R, Seumois G, Burton DR, Sanders RW, Silvestri G, Crotty S. Direct Probing of Germinal Center Responses Reveals Immunological Features and Bottlenecks for Neutralizing Antibody Responses to HIV Env Trimer. Cell Rep. 2016 Nov 22;17(9):2195-2209. 5) Locci M, Havenar-Daughton C, Landais E, Wu J, Kroenke MA, Arlehamn CL, Su LF, Cubas R, Davis MM, Sette A, Haddad EK; International AIDS Vaccine Initiative Protocol C Principal Investigators, Poignard P, Crotty S. Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses. Immunity. 2013 Oct 17;39(4):758-69. Research Expertise: Shane Crotty and his team study immunity against infectious diseases. They investigate how the immune system remembers infections and vaccines. By remembering infections and vaccines, the body is protected from becoming infected in the future. Vaccines are one of the most cost-effective medical treatments in modern civilization and are responsible for saving millions of lives. Yet, good vaccines are very difficult to design, and very few new vaccines have been made in the past 10 years. A better understanding of immune memory will facilitate the ability to make new vaccines, particularly against deadly diseases like HIV, malaria, and tuberculosis.
Dr Donna Farber. [email protected] Columbia Center for Translational Immunology. Columbia University. USA. Position: II Professor of Surgical Sciences (in Surgery), Chief, Division of Surgical Sciences and Professor of Microbiology and Immunology Publications: 122 publications in international peer-reviewed journals. Selected publications: 1) Kumar, B.V., Ma, W. Miron, M., Granot, T., Guyer, R.S., Carpenter, D.J., Senda, T., Ho, S.-H., Lerner, H., Friedman, A.L., Shen, Y., and Farber, D.L. (2017) Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites. Cell Reports 20: 2921-2934.
2) Zens, K.D., Chen, J.-K., Guyer, R.S., Wu, F.L., Cvetkovski, F., Miron, M. and Farber, D.L. (2017) Reduced generation of lung-tissue resident memory T cells during infancy. J. Exp. Med. 214:2915-2932. 3) Meng, W., Zhang, B., Schwartz, G.W., Rosenfeld, A.M., Ren, D., Thome, J.J.C., Carpenter, D., Matsuoka, N., Granot, T., Farber, D.L., Shlomchik, M.J., Hershberg, U. and Luning Prak, N.T. (2017) An atlas of B cell clonal distribution in the human body. Nature Biotech. 35: 879-884.
12
4) Granot, T., Senda, T., Carpenter, D., Matsuoka, N., Weiner, J., Gordon, C.L., Miron, M., Kumar, B.V., Griesemer, A., Ho, S.-H., Lerner, H., Thome, J.J.C., Connors, T., Reizis, B., and Farber, D.L. (2017) Dendritic cells display subset and tissue-specific maturation dynamics over human life. Immunity 46: 504-515. 5) Gordon, C.L., Miron, M., Thome, J.J.C., Matsuoka, N., Weiner, J., Rak, M., Igarashi, S., Granot, T., Lerner, H., Goodrum, F. and Farber, D.L. (2017) Tissue-reservoirs of T cell immunity in persistent human CMV infection. J. Exp. Med. 214: 651-667. 6) Thome, J.J.C., Grinshpun, B., Kumar, B.V., Kubota, M., Ohmura, Y., Lerner, H., Sempowski, G.D., Shen, Y. and
Farber, D.L. (2016) Longterm maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites. Sci. Immunol. 1: eaah6506.
Research expertise: Farber’s lab is focused on immunological memory and specifically on resident memory T cells as essential mediators of protective immunity. As a pioneer in translational studies, her lab study the tissue compartmentalization of human memory lymphocytes and maintenance in human tissues throughout the human lifespan.
Dr Mercedes Fuertes. [email protected] IByME-CONICET. Buenos Aires. Argentina Positions: Research from the National Scientific and Technical Research Council – Argentina. Assistant Professor. School of Medicine. Universidad Favaloro. Publications: 27 publications in international peer-reviewed journals. Selected publications: 1) Host type I IFN signals mediate awareness of tumor and are required for CD8+ T cell responses through CD8α+ dendritic cells Fuertes M.B., Kacha A.K., Kline J., Woo S.R., Kranz D.M., Murphy K., Gajewski T.F. Journal of
Experimental Medicine. Vol 208:2005-2016 (2011) 2) STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Woo SR, Fuertes MB, Corrales L, Spranger S, Furdyna MJ, Leung MY, Duggan R, Wang Y, Barber GN, Fitzgerald KA, Alegre ML, Gajewski TF. Immunity. Vol 41: 830-842 (2014). 3) NK cells restrain spontaneous anti-tumor CD8+ T cell priming through PD-1/PD-L1 interactions with dendritic cells. Raffo Iraolagoitia X.R., Spallanzani R.G., Torres N.I., Araya R.E., Ziblat A., Domaica C.I., Sierra J.S., Nuñez S.Y., Secchiari F., Gajewski T.F., Zwirner N.W., Fuertes M.B. Journal of Immunology. Vol. 197:953-961 (2016). 4) Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-β and Engagement of CD85j. Nuñez S.Y., Ziblat A., Secchiari F., Torres N.I., Sierra J.M., Raffo Iraolagoitia X.L., Araya R.E., Domaica C.I., Fuertes M.B., Zwirner N.W. Journal of Immunology. Vol 200:1008-1015 (2017). Research Expertise: The general aim of our laboratory is focused on the study of different factors that regulate the activity of the cells of the innate immunity known as natural killer cells or NK cells in different physiopathological situations. This interest originates in the fact that NK cells are essential players during immunity against viruses and tumors, and in shifting the adaptive immune response towards a Th1/pro-inflammatory profile. Our studies have translational implications because the knowledge that we intend to generate, we aspire to contribute with the development and optimization of therapeutic strategies for patients with cancer and pathologies with immunological background trough the manipulation of the biological activity of NK cells.
Dr John Harty. [email protected]. Department of Microbiology. University of Iowa. USA. Positions: Mark Stinski Chair in Microbial Immunology. Professor in the Department of Pathology. University of Iowa College of Medicine Publications: 177 publications in international peer-reviewed journals. Selected publications: 1) Kurup, S. P., N. Obeng-Adjei, S. M. Anthony, B. Traore, O. K. Doumbo, N. S. Butler, P. D. Crompton and J.T. Harty (2017) Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4. Nature Medicine, 23(10):1220-1225. PMCID: PMC5649372
13
2) Van Braeckel-Budimir, N., S. Gras, K. Ladell, T.M. Josephs, L. Pewe, S.L. Urban, K.L. Miners, C. Farenc, D.A. Price, J. Rossjohn, J.T. Harty (2017) A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene. Immunity, 2017 DOI:10.1016/j.immuni.2017.10.013 3) *Slutter, B, *N. van Breackel-Budimir, G. Abboud, S. Salek-Ardakani, S. M. Varga and J.T. Harty (2017) Dynamics of influenza-induced lung-resident memory T cells underlie waning heterosubtypic immunity. Science Immunology, 06 Jan 2017: Vol. 2, Issue 7. PMCID: PMC5590757 [Available on 2018-01-06] DOI:10.1126/sciimmunol.aag20131 4) Richer, M. J., L. L. Pewe, L.S. Hancox, S. M. Hartwig, S. M. Varga and J. T. Harty (2015) Inflammatory IL-15 is required for optimal memory CD8 T cell responses. Journal of Clinical Investigation. Aug 4. pii: 81261. PMCID: PMC4588296 Research Expertise: Research in the Harty laboratory is focused on understanding the dynamics of the T cell response, how effector and memory T cell differentiation are regulated, how memory T cell populations are maintained and how they can be generated and manipulated to enhance protective immunity. We then use this basic information to manipulate immune responses for optimal protection against Plasmodium infection of the liver and blood and Influenza virus infection of the lung. The major approaches in the lab involve identification of new questions through sophisticated analyses of in vivo T cell responses to various pathogens or immunization regimens. These observations are then dissected at the cellular, biochemical and molecular levels to generate a comprehensive mechanistic view of T cell regulation. We recently initiated projects to use intravital 2-Photon imaging to further dissect immunity to infections of the liver, brain and lungs. Ultimately our goal is to provide fundamental insights that will inform vaccine design and therapeutic interventions for major human infectious diseases.
Prof. Dr. Ralf Küppers. [email protected] Institute of Cell Biology (Cancer Research). Faculty of Medicine- University of Duisburg-Essen, Germany Positions: Professor (C4) in Molecular Genetics. Publications: 265 publications in international peer-reviewed journals. Selected publications: 1) Weniger MA, Tiacci E, Schneider S, Arnolds J, Rüschenbaum S, Duppach J, Seifert M, Döring C, Hansmann ML, Küppers R. Human CD30+ B cells represent a unique subset related to Hodgkin lymphoma cells. J Clin Invest. 2018 Jun 11. 2) Küppers R, Stevenson FK. Critical influences on the pathogenesis of follicular lymphoma. Blood. 2018 May 24;131(21):2297-2306.
3) Küppers R. CD83 in Hodgkin lymphoma. Haematologica. 2018 Apr;103(4):561-562. 4) Tucci FA, Kitanovski S, Johansson P, Klein-Hitpass L, Kahraman A, Dürig J, Hoffmann D, Küppers R. Biased IGH VDJ gene repertoire and clonal expansions in B cells of chronically hepatitis C virus-infected individuals. Blood. 2018 Feb 1;131(5):546-557. 5) Schwartz FH, Cai Q, Fellmann E, Hartmann S, Mäyränpää MI, Karjalainen-Lindsberg ML, Sundström C, Scholtysik R, Hansmann ML, Küppers R. TET2 mutations in B cells of patients affected by angioimmunoblastic T-cell lymphoma. J Pathol. 2017 Jun;242(2):129-133. Research expertise: B-lymphocytes are the white blood cells responsible for the production of antibodies and therefore play a central role in immune responses to infectious agents, e.g. Bacteria and viruses, play. Such immune responses usually take place in specific structures, the germinal centers, in lymph nodes and other organs of the immune system. In the context of such immune responses, long-lived memory B cells are formed which protect the body against disease on renewed contact with the same pathogen ("immunity"). We are currently investigating which subpopulations of memory B cells exist, what their specific functions are, and how the populations of memory B cells make up the size and diversity of clones. Dr Kuppers works in the investigation of B cell development and differentiation in the human, particularly in human memory B cells. And also, in the biology of Epstein-Barr virus (EBV) infection of B cells and EBV-associated diseases and pathogenesis of human B cell lymphomas, in particular Hodgkin's lymphoma.
14
Dr Michelle Linterman. [email protected] Babraham Institute, Cambridge. United Kingdom Position: Group Leader Michelle Linterman received her PhD in Immunology from the Australian National University in Canberra, where she investigated a novel mechanism of immunological tolerance; a phenomenon by which the immune system fails to respond to an antigen. She is currently a Group Leader at the Babraham Institute and her principle research focus is on how the immune system responds to vaccination.
Publications: 42 publications in international peer-reviewed journals. Selected publications: 1) Linterman MA, Toellner KM. T(FR) cells trump autoimmune antibody responses to limit sedition. Nat
Immunol. 2017 Oct 18;18(11):1185-1186. doi: 10.1038/ni.3856. 2) Bignon A, Watt AP, Linterman MA. Escherichia coli Heat-Labile Enterotoxin B Limits T Cells Activation by
Promoting Immature Dendritic Cells and Enhancing Regulatory T Cell Function. Front Immunol. 2017 May 15;8:560. doi: 10.3389/fimmu.2017.00560.
3) Denton AE, Linterman MA. Stromal networking: cellular connections in the germinal centre. Curr Opin Immunol. 2017 Apr;45:103-111. doi: 10.1016/j.coi.2017.03.001.
4) Aloulou M, Carr EJ, Gador M, Bignon A, Liblau RS, Fazilleau N, Linterman MA. Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells. Nat Commun. 2016 Jan 28;7:10579. doi: 10.1038/ncomms10579.
5) Linterman MA, Pierson W, Lee SK, Kallies A, Kawamoto S, Rayner TF, Srivastava M, Divekar DP, Beaton L, Hogan JJ, Fagarasan S, Liston A, Smith KG, Vinuesa CG. Foxp3+ follicular regulatory T cells control the germinal center response. Nat Med. 2011 Jul 24;17(8):975-82. doi: 10.1038/nm.2425.
Research expertise: Dr Linterman research interest is focused on understanding the cellular and molecular changes that occur in T cells with age that contribute to the age-dependent decline in the germinal centre response. Germinal centres are sites within tissues such as the tonsils, spleen and lymph nodes where B cells proliferate and differentiate during a normal immune response to an infection. Because of the central role of the germinal centre in generating immunological memory, a potent germinal centre response is critical for a successful response to vaccination. With advancing age, the size of the germinal centre response and the efficacy of vaccination diminish, and T cells are one of the primary contributors to this decline.
Dr Karin Lore. [email protected] Department of Medicine, Karolinska Institute. Sweden. Position: PhD, Professor , Group leader. She received her PhD in Immunology in 2001 and thereafter did post doctoral training at the Vaccine Research Center, NIH, Bethesda, MD, USA. She returned to the Karolinska 2006 supported by an Assistant professor salary grant (foass-tjänst) from Vetenskapsrådet. She received her Associate Professorship (Docent) in 2010. From 2011, Karin also holds a visiting scientist position at the Vaccine Research Center, NIH. She was recruited to the Dept of Medicine Solna as a professor in vaccine immunology in 2014.
Publications: 81 publications in international peer-reviewed journals. Selected publications: 1) Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating
Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells. Lindgren G, Ols S, Liang F, Thompson E, Lin A, Hellgren F, et al Front Immunol 2017 ;8():1539
2) Rhesus Macaque Myeloid-Derived Suppressor Cells Demonstrate T Cell Inhibitory Functions and Are Transiently Increased after Vaccination. Lin A, Liang F, Thompson E, Vono M, Ols S, Lindgren G, et al J. Immunol. 2018 01;200(1):286-294
15
3) Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques. Liang F, Lindgren G, Lin A, Thompson E, Ols S, Röhss J, et al Mol. Ther. 2017 Dec;25(12):2635-2647
4) Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake. Liang F, Lindgren G, Sandgren K, Thompson E, Francica J, Seubert A, et al Sci Transl Med 2017 06;9(393):
5) Neutrophils acquire the capacity for antigen presentation to memory CD4 T cells in vitro and ex vivo. Vono M, Lin A, Norrby-Teglund A, Koup R, Liang F, Loré K Blood 2017 04;129(14):1991-2001
Research expertise: Lore’s group has an ultimate goal to expand the on-going efforts to develop a new generation of vaccines against global epidemics such as HIV-1, malaria, tuberculosis and Influenza. They have had a long term focus on central questions in vaccinology related to understanding the mechanisms by which vaccine antigen, adjuvants and viral vaccine vectors influence innate immunity for the induction of strong T cell and B cell responses.
Dr Laura Mackay. [email protected]. Doherty Institute. Australia. Position: laboratory head and senior lecturer at the University of Melbourne. She is a Howard Hughes Medical Institute (HHMI) – Gates International Scholar, NHMRC Career Development Fellow, recipient of the Victorian Young Tall Poppy Science Award, serves on the council of the Australian Society for Immunology and holds an Adjunct Professor appointment at the Singapore Immunology Network (SIgN), A*STAR. Publications: 29 publications in international peer-reviewed journals. Selected publications:
1) Local proliferation maintains a stable pool of tissue-resident memory T cells after antiviral recall responses.Park SL, Zaid A, Hor JL, Christo SN, Prier JE, Davies B, Alexandre YO, Gregory JL, Russell TA, Gebhardt T, Carbone FR, Tscharke DC, Heath WR, Mueller SN, Mackay LK. Nat Immunol. 2018 Feb;19(2):183-191. doi: 10.1038/s41590-017-0027-5.
2) Tissue-resident memory T cells: local specialists in immune defence.Mueller SN, Mackay LK. Nat Rev Immunol. 2016 Feb;16(2):79-89. doi: 10.1038/nri.2015.3. Epub 2015 Dec 21.
3) The developmental pathway for CD103(+)CD8+ tissue-resident memory T cells of skin. Mackay LK, Rahimpour A, Ma JZ, Collins N, Stock AT, Hafon ML, Vega-Ramos J, Lauzurica P, Mueller SN, Stefanovic T, Tscharke DC, Heath WR, Inouye M, Carbone FR, Gebhardt T. Nat Immunol. 2013 Dec;14(12):1294-301. doi: 10.1038/ni.2744. Epub 2013 Oct 27.
4) Different patterns of peripheral migration by memory CD4+ and CD8+ T cells.Gebhardt T, Whitney PG, Zaid A, Mackay LK, Brooks AG, Heath WR, Carbone FR, Mueller SN. Nature. 2011 Aug 14;477(7363):216-9. doi: 10.1038/nature10339.
Research expertise: Her laboratory studies cellular immune responses, with a focus on the genes and signals that control resident memory T cell differentiation, with a view to harness these cells to develop new treatments against infection, cancer, and autoimmune disease.
Dr Belkys Maletto. [email protected] CIBICI-CONICET. Universidad Nacional de Córdoba. Argentina Her laboratory studies memory humoral and cellular immune responses generated by vaccines, with a special focus on the role of novel nanomaterial-based adjuvants. Positions: Research from CONICET – Argentina. Professor at School of Chemical Sciences. Universidad Nacional de Cordoba. Publications: 28 publications in international peer-reviewed journals. Selected publications: 1) Class-B CpG-ODN Formulated With a Nanostructure Induces Type I Interferons-
Dependent and CD4+ T Cell-Independent CD8+ T-Cell Response Against Unconjugated Protein Antigen.
16
Ana L. Chiodetti, María F. Sánchez Vallecillo, Joseph S. Dolina, María I. Crespo, Constanza Marin, Stephen P. Schoenberger, Daniel A. Allemandi, Santiago D. Palma, María C. Pistoresi-Palencia, Gabriel Morón and Belkys A. Maletto. Front Immunol 2018
2) A liquid crystal of ascorbyl palmitate, used as vaccine platform, provides sustained release of antigen and has intrinsic pro-inflammatory and adjuvant activities which are dependent on MyD88 adaptor protein.Sánchez Vallecillo MF, et al. J Control Release. 2015
3) Adjuvant activity of CpG-ODN formulated as a liquid crystal. Sánchez Vallecillo MF, et al. Biomaterials. 2014
Dr Michael McHeyzer-Williams [email protected] Department of Immunology and Microbiology. The Scripps Research Institute. USA Positions: Professor. California Campus. Publications: 69 publications in international peer-reviewed journals. Selected publications: McHeyzer-Williams, LJ*, Milpied, PJ*, Okitsu, SL and McHeyzer-Williams, MG. (2015) Switched-memory B cells remodel BCRs within secondary germinal centers. Nature Immunology 16: 296-305. *equal contribution doi:10.1038/ni.3095 2) Wang, NS, McHeyzer-Williams, LJ, Okitsu, SL, Burris, TP, Reiner, SL and
McHeyzer-Williams, MG. (2012) Divergent transcriptional programming of class-specific B cell memory by T-bet and RORa. Nature Immunology 13: 604-11. 3) McHeyzer-Williams, MG, Okitsu, SL, Wang, NS and McHeyzer-Williams, LJ. (2011) Molecular programming of B cell memory. Nature Review Immunology 12: 24-34. | PMC3947622 4) Pelletier, N, McHeyzer-Williams, LJ, Wong, KA, Urich, E, Fazilleau, N and McHeyzer-Williams, MG. (2010) Plasma cells negatively regulate the follicular helper T cell program. Nature Immunology 11: 1110-8. 5) Fazilleau, NR, McHeyzer-Williams, LJ, Rosen, H and McHeyzer-Williams, MG. (2009) The function of follicular helper T cell (TFH) is regulated by strength of T cell antigen receptor binding. Nature Immunology 10: 375-84. Research expertise: Helper T cells are the master regulators of adaptive immunity that control the development of antigen-specific B cell immunity. Dr McHeyzer Williams research focuses on the cellular and molecular mechanisms controlling follicular helper T cell regulated development of antigen-specific B memory. Recent findings from his laboratory use high-order multidimensional single cell strategies to analyze B cell memory at antigen recall. These studies provide new insight into the cellular organization and molecular control of adaptive immunity that are central to long-term immune protection and have implications for contemporary vaccine design.
Dr Tim Sparwasser. [email protected] Institute for Medical Microbiology and Hygiene (IMMH), University Mainz, Germany. Position: Profesor. Chair of the Biosciences Department. Publications: 197 publications in international peer-reviewed journals. Selected Publications: 1) Puttur F, Francozo M, Solmaz G, Bueno C, Lindenberg M, Gohmert M, Swallow M, Tufa D, Jacobs R, Lienenklaus S, Kühl AA, Borkner L, Cicin-Sain L, Holzmann B, Wagner H, Berod L, Sparwasser T. Conventional Dendritic Cells confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88
Signaling. Cell Rep.2016 Oct 18;17(4):1113-1127. doi: 10.1016/j.celrep.2016.09.055. 2) Berod L, Sparwasser T. pDCs Take a Deep Breath to Fight Viruses. Immunity. 2016 Jun 21;44(6):1246-8. doi: 10.1016/j.immuni.2016.06.005. 3) Mayer CT, Ghorbani P, Nandan A, Dudek M, Arnold-Schrauf C, Hesse C, Berod L, Stüve P, Puttur F, Merad M, Sparwasser T. Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow. Blood. 2014 Nov 13;124(20):3081-91. doi: 10.1182/blood-2013-12-545772. Epub 2014 Aug 6.
17
4) Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, Bähre H, Tschirner SK, Gorinski N, Gohmert M, Mayer CT, Huehn J, Ponimaskin E, Abraham WR, Müller R, Lochner M, Sparwasser T. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med. 2014 Nov;20(11):1327-33. doi: 10.1038/nm.3704. Epub 2014 Oct 5. 5) Arnold-Schrauf C, Dudek M, Dielmann A, Pace L, Swallow M, Kruse F, Kühl AA, Holzmann B, Berod L, Sparwasser T. Dendritic cells coordinate innate immunity via MyD88 signaling to control Listeria monocytogenes infection. Cell Rep. 2014 Feb 27;6(4):698-708. doi: 10.1016/j.celrep.2014.01.023. Epub 2014 Feb 13. Research expertise: Vaccination is the most effective method of countering infectious diseases - and a major success of medical research. Although there are already highly effective vaccines against many pathogens, each year millions of people die from infections of the respiratory and gastrointestinal tract, tuberculosis, malaria and AIDS, where there has been so far a lack of suitable vaccination strategies. A major focus of our lab is to study how different infections impact on the function of specific immune cells and how these cells can be efficiently targeted to improve the outcome of vaccinations.
Dr Thomas F. Tedder. [email protected] Duke University, Department of Immunology. USA Position: Alter E. Geller Professor for Research in Immunology Publications: 348 publications in international peer-reviewed journals. Selected Publications: 1) The Regulatory B Cell Compartment Expands Transiently During Childhood and Is Contracted in Children With Autoimmunity. Kalampokis I, Venturi GM, Poe JC, Dvergsten JA, Sleasman JW, Tedder TF. Arthritis Rheumatol. 2017 Jan;69(1):225-238. doi: 10.1002/art.39820. Erratum in: Arthritis Rheumatol. 2017 Oct;69(10 ):2080. PMID: 27429419 2) Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a
preclinical system to identify resistance mechanisms. Lykken JM, Horikawa M, Minard-Colin V, Kamata M, Miyagaki T, Poe JC, Tedder TF. Blood. 2016 Apr 14;127(15):1886-95. doi: 10.1182/blood-2015-11-681130. Epub 2016 Feb 17. 3) B10 cells: a functionally defined regulatory B cell subset. Tedder TF.J Immunol. 2015 Feb 15;194(4):1395-401. doi: 10.4049/jimmunol.1401329. Review. PMID: 25663677 4) Winer, DA, Winer, S, Shen, L, Wadia, PP, Yantha, J, Paltser, G, Tsui, H, Wu, P, Davidson, MG, Alonso, MN, Leong, HX, Glassford, A, Caimol, M, Kenkel, JA, Tedder, TF, McLaughlin, T, Miklos, DB, Dosch, H-M, and Engleman, EG. "B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies." Nat Med 17, no. 5 (May 2011): 610-617. Research expertise: The focus of our laboratory is the identification, structural characterization, and functional analysis of cell surface molecules and signaling pathways that regulate B lymphocyte development and function. Our studies of B-cell–associated cell surface receptors, including CD19, CD20, CD21, CD22 and CD83, are aimed at determining how these molecules function, what their ligands are, how they generate transmembrane signals and regulate human and mouse B cell development, survival and activation. These studies lay the foundation for investigating mechanisms of immune dysregulation and the pathogenesis of immune disorders, such as autoimmunity, neoplastic transformation, and immunodeficiency syndromes in humans. Current studies are focused on identifying the molecular and cellular mechanisms by which B cells regulate T cell function and autoimmunity, with a particular emphasis on the regulatory B cell subset (B10 cells) that controls immune and inflammatory responses through their production IL-10, a potent negative regulatory cytokine. Current studies also focus on identifying the molecular and cellular mechanisms by which CD19, CD20 and CD22 mAb immunotherapies are effective for treating B cell malignancies and autoimmunity, with translational studies pursuing the development of molecular and cellular therapies for human disease.
18
Dr. Jose Ronie de Vasconcelos. [email protected] UNIFESP, Brazil. Position: Profesor. Chair of the Biosciences Department. Publications: 27 publications in international peer-reviewed journals. Selected Publications: 1) Machado AM, Gazzinelli RT, Bruna-Romero O, Menin Ruiz PL, Ribeiro DA, Lannes-Vieira J, Lopes MF, Rodrigues MM, de Vasconcelos JRC. LFA-1 Mediates. Cytotoxicity and Tissue Migration of Specific CD8(+) T Cells after Heterologous Prime-Boost Vaccination against Trypanosoma cruzi Infection. Front Immunol. 2017 . Oct 13;8:1291. doi: 10.3389/fimmu.2017.01291. eCollection 2017.
2) Spencer CT, Vasconcelos JR, Thornburg NJ, Zimmer SL. Advances in Emerging and Neglected Infectious Diseases 2018. Biomed Res Int. 2018 Jul 15;2018:4619282. doi: 10.1155/2018/4619282. eCollection 2018. 3) Vasconcelos JR, Dominguez MR, Neves RL, Ersching J, Araújo A, Santos LI, Virgilio FS, Machado AV, Bruna-Romero O, Gazzinelli RT, Rodrigues MM. Adenovirus vector-induced CD8⁺ T effector memory cell differentiation and recirculation, but not proliferation, are important for protective immunity against experimental Trypanosoma cruzi Infection. Hum Gene Ther. 2014 Apr;25(4):350-63. doi: 10.1089/hum.2013.218. Epub 2014 Mar 31. 4) Vasconcelos JR, Bruña-Romero O, Araújo AF, Dominguez MR, Ersching J, de Alencar BC, Machado AV, Gazzinelli RT, Bortoluci KR, Amarante-Mendes GP, Lopes MF, Rodrigues MM. Pathogen-induced proapoptotic phenotype and high CD95 (Fas) expression accompany a suboptimal CD8+ T-cell response: reversal by adenoviral vaccine. PLoS Pathog. 2012;8(5):e1002699. doi: 10.1371/journal.ppat.1002699. Epub 2012 May 17. 5) Vasconcelos JR, Dominguez MR, Araújo AF, Ersching J, Tararam CA, Bruna-Romero O, Rodrigues MM. Relevance of long-lived CD8(+) T effector memory cells for protective immunity elicited by heterologous prime-boost vaccination. Front Immunol. 2012 Dec 4;3:358. doi: 10.3389/fimmu.2012.00358. eCollection 2012. Research expertise: CD4+ and CD8+ T cells play a key role in protective immunity against intracellular pathogens, such as Trypanosoma cruzi, the causative agent of Chagas’ disease. Integrins, cell adhesion molecules (CAM) and chemokine receptors may play a critical role in this process allowing these cells migrate to non-peripheral lymphoid tissues to exert their effector function. In analysis of cell surface molecules of specific CD8+ T cells generated by genetic vaccination with T. cruzi amastigote surface protein-2, we found increased expression of molecules LFA-1 and VLA-4 in these cells (Vasconcelos et al., 2012). In view of this, the overall goal of this project is to study the role of the integrins LFA-1 and VLA-4, ICAM-1 and the chemokine receptors CCR5, CXCR3, CXCR4 and others in the migration of CD8+ cells generated by specific genetic immunization with heterologous ASP-2 T. cruzi. This study is very important for the development of vaccines in general, and if it can in fact occur demonstrates the importance of T cell migration, as well as molecules that mediate this process on the immunity induced by vaccination of experimental heterologous prime-boost.
19
Scientific Program Day 1. Monday September 23rd 08:30 Wellcome 09:00 – 09:45 Thomas Tedder Duke University, Department of Immunology, USA. B cell and immunological memory 09:45 – 10:00 Discussion (Discussion Leader: Dra Virginia Rivero, UNC) 10:00 – 10:45 Michelle Lintermann University of Cambridge, UK. T follicular helper cells and the germinal centre response 10:45 – 11:00 Discussion (Discussion Leader: to be determined) 11:00 -11:30 COFFEE BREAK 11:30 – 13:00 Short oral presentations (5 participant talks) 13:00 – 14:30 LUNCH TIME 14:30 - 15:15 Michael McHeyzer Williams (USA) The Scripps Research Institute, USA Deconstructing class-specific B cell memory: one cell at a time 15:15 – 15:30 Discussion (Discussion Leader: Dra Adriana Gruppi, UNC) 15:30 – 16:15 Shane Crotty (USA) La Jolla Institute for Allergy and Immunology, USA. Roles of Tfh CD4 T cells and germinal centers in immunological memory in infections and
vaccination 16:15 – 16:30 Discussion (Discussion Leader: to be determined) 16:30 -18:00 Poster Session (with little bites) Day 2. September 24th 09:00 – 09:45 Ralf Küppers Faculty of Medicine, University of Duisburg-Essen, Germany.
20
Human Memory B cells 09:45 – 10:00 Discussion (Discussion Leader: Dra Laura Cervi, UNC) 10:00 – 10:45 John Harty (USA) Department of Microbiology. University of Iowa, USA. Regulation of effector and memory T cell differentiation 10:45 – 11:00 Discussion (Discussion Leader: Dr Ruben Motrich, UNC) 11:00 – 11:30 COFFEE BREAK 11:30 – 13:00 Short oral presentations (5 participant talks) 13:00 – 14:30 LUNCH TIME 14:30 – 15:15 José Ronnie de Vasconcelos Universidad Federal de Sao Paulo, Brazil.
Study of the immune mechanisms generated by different immunization protocols using Trypanosoma cruzi genes
15:15 – 15:30 Discussion (Discussion Leader: Dr V Gabriel Moron, UNC) 15:30 – 16:15 Tim Sparwasser Institute for Medical Microbiology and Hygiene (IMMH), University Mainz, Germany. Metabolic checkpoints and T cell fate 16:15 – 16:30 Discussion (Discussion Leader: Dra Silvia Correa, UNC) 16:30 – 18:00 Poster Session (with little bites) Day 3. September 25th 9:00 – 09:45 Laura Mackay Doherty Institute, Australia. Genes and signals that control resident memory T cell differentiation 09:45 – 10:00 Discussion (Discussion Leader: Dr Mariana Maccioni, UNC) 10:00 – 10:45 Carolina Amezcua Vesely Yale University, USA. Origin, function and maintenance of tissue resident CD4+ T cells 10:45 – 11:00 Discussion (Discussion Leader: Dra Laura Chiapello, UNC) 11:00 – 11:30 COFFEE BREAK
21
11:30 – 13:00 Short oral presentations (5 participant talks) 13:00 – 15:30 SPECIAL LUNCH ROUNDTABLE DISCUSSION 15:30 – 16:15 Donna L. Farber Columbia University Medical Center, USA. Distribution of Human Memory T cells 16:15 – 16:30 Discussion (Discussion Leader: Dra Carolina Montes, UNC) 16:30 – 18:00 Poster Session (with little bites) Day 4. September 26th 9:00 – 09:45 Karin Lore Department of Medicine, Karolinska Institute, Sweden. Innate immune mechanisms dictating the magnitude and quality of vaccine responses 09:45 – 10:00 Discussion (Discussion Leader: Dr C Cristina Motran, UNC) 10:00 – 10:45 Belkys Maletto CIBICI-CONICET. Universidad Nacional de Córdoba, Argentina. Nanoformulation of the vaccine components: implications for the development of T cell
memory 10:45 – 11:00 Discussion (Discussion Leader: to be determined) 11:00 – 11:30 COFFEE BREAK 11:30 – 13:00 Short oral presentations (5 participant talks) 13:00 – 14:30 LUNCH TIME 14:30 – 15:15 Mercedes Fuertes IBYME – CONICET, Argentina. Natural killer cell memory 15:15 – 15:30 Discussion (Discussion Leader: Dra Eva V Acosta Rodriguez, UNC) 15:30 – 16:15 Hanne Ostergaard University of Alberta, Canada To be confirmed (related to soft skills for PhD students) 16:15 – 16:30 Discussion (Discussion Leader: to be determined) 20:00 Farewell party (Short oral presentations will be selected by the organizers of the course, based on different subjects of immunological memory studies)
