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ANTIMICROBIAL AGENTS ANDCHEMOTHERAPY
VOLUME 18 * NUMBER 6 0 DECEMBER 1980
EDITORIAL BOARDLEON H. SCHMIDT, Editor-in-Chief (1985)
University ofAlabama in Birmingham,Birmingham, Alabama
HERBERT L. ENNIS, Editor (1982)Roche Institute ofMolecular Biology,
Nutley, New JerseyJOEL G. FLAKS, Editor (1981)
University ofPennsylvania, Philadelphia
ROBERT L. HAMILL, Editor (1985)Eli Lilly & Company, Inc.Indianapolis, Indiana
EDWARD W. HOOK, Editor (1981)University of Virginia, Charlottesville
GEORGE A. JACOBY, JR., Editor (1985)Massachusetts Geyneral Hospital
Boston, Massachusetts
Vincent T. Andriole (1981)John P. Anhalt (1981)Donald Armstrong (1980)Robert Austrian (1980)Arthur L Barry (1980)John E. Bennett (1981)Lawrence E. Bryan (1982)Robert E. Brummitt (1982)D. Buyske (1980)Yves Chabbert (1980)Royston C. Clowes (1980)C. Glenn Cobbs (1980)Paul S. Cohen (1980)Naomi Datta (1981)Julian Davies (1980)Lawrence E. Day (1980)R. Gordon Douglas, Jr. (1980)Theodore Eickhoff (1982)Arthur English (1980)David S. Feingold (1981)Robert Fekety (1981)Sydney Finegold (1982)Robert J. Fitzgerald (1980)Anthony J. Glazko (1981)frring H. Goldberg (1982)Harry Gooder (1982)Jack Gwaltney (1980)Maurice W. Harmon (1981)-Michael Hig n (1980)Ronald D. Hinsdill (1982)Richard Hornick (1980)L. H. Huang (1982)Milton Huppert (1980)
George Gee Jackson (1980)Thomas Jones (1980)William J. Jusko (1980)Donald Kaye (1982)Jerome 0. Klein (1982)Vernon Knight (1980)George S. Kobayashi (1982)Jordan Konisky (1980)Matthew E. Levison (1981)Friedrich C. Luft (1981)Joan Lusk (1980)R. Luthy (1980)Gerald L Mandell (1980)Gerald Medoff (1980)Barbara Minshew (1982)S. Mitsuhashi (1980)Robert C. Moellering, Jr. (1982)R. B. Morin (1982)Bernard Moss (1981)John D. Nelson (1980)Harold C. Neu (1980)J. F. Niblack (1980)T. J. Perun (1980)Charles A. Plate (1982)Burton M. Pogeli (1981)K. E. Price (1982)Paul Quie (1980)W. H. G. Richards (1980)Mark H. Richmond (1982)R. W. Rickards (1980)Richard Roberts (1982)Ian M. Rollo (1982)Richard Root (1980)
Jon E. Rosenblatt (1982)Milton R. J. Salton (1981)Merle Sande (1982)Jay Sanford (1980)Arthur K. Saz (1982)F. C. Sciavolino (1982)Oldrich K. Sebek (1980)William M. Shannon (1980)Jerome J. Schentag (1982)John C. Sherris (1980)Charles Shipman, Jr. (1982)Robert W. Sidwell (1981)Walter Siegenthaler (1980)Sigmund S. Socransky (1980)P. Frederick Sparling (1981)R. Sutherland (1982)Vera L. Sutter (1981)Morton N. SwartzL(1982)Richard-B. Sykes (1982)Alexander Tomasz (1982)Ralph Tompsett (1982)-Hamao Umezawa (1981)Donald Van Harken (1982)D. Vazquez (1980)Michael Waring (1981)John Washington 1 (1981)Pamela Waterworth (1982)Jerry A. Weisbach (1982)B. Weisblum (1982)Peter G. Welling (1982)Richard Wenzel (1980)
Giseila Poflock, Acting Managing EditorEleanor Tupper, Production Editor1913 I St., NW, Washington, DC 20006
EX OFFICIOAlbert Balows, President (1980-1981)
J. Mehsen Joseph, SecretaryAntimicrobial Agents and Chemotherapy (ISSN 0066-
4804), an interdisciplinary publication ofthe American Societyfor Microbiology, 1913 I St., NW, Washington, DC 20006, isdevoted to the dissemination of knowledge relating to allaspects of antimicrobial agents, anticancer agents, and chemo-therapy. Instructions to Authors are published in the Januaryissue each year. Antimicrobial Agents and Chemotherapy ispublished monthly, and the twelve numbers are divided intotwo volumes per year. The nonmember subscription price is$65 per year. The member subscription price is $16 per year.Single copies are $6. Correspondence relating to subscriptions,reprints, defective copies, availability of back issues, lost orlate proofs, disposition of submitted manuscripts, and generaleditorial matters should be directed to the ASM PublicationsOffice, 1913 I St., NW, Washington, DC 20006 (area 202 833-9680).El*:{¢Xs i qVo
Frederick C. Neidhardt, President-Elect (1980-1981)Brinton M. Miller, Treasurer
Second clas postage paid at Washington, DC 20006, and atadditional mailing offices.Made in the United States of America.Copyright C) 1980, American Society for Microbiology.All Rights Reserved.The code at the top of the first page of an article in this
journal indicates the copyright owner's consent that copies ofthe article may be made for personal use, or for personal useof specific clients. This consent is given on the condition,however, that the copier pay the stated per-copy fee throughthe Copyright Clearance Center, Inc., P.O. Box 765, Schenec-tady, New York 12301, for copying beyond that permitted bySectiorn 107 and 108 of the U.S. Copyright Law. This consentdoes not extend to other kinds of copying, such as copying forgeneral distribution, for advertising or promotional purposes,for creating new collective works or for resale.
Author IndexAbe, Hiromu, 980Andrews, Jenny M., 844Angehrn, Peter, 913Atherton, Frank R., 897
Baker, John S., 872Barriere, Steven L., 952Bekki, Eiichi, 980Bergstrom, Donald E., 957Bodey, Gerald P., 939Bolton, W. Kline, 933Bowie, W. R., 978Broughall, John M., 844Bywater, Martin J., 844
Cheng, Yung-chi, 957Cherubin, Charles E., 893Cohn, John R., 872Conte, John E., Jr., 952Corrado, Michael L., 893Courtney, Mary-Anne, 926
Dabernat, Henry J., 841De Grandis, S., 948Delmas, Catherine F., 841
Fass, Robert J., 906Field, A. Kirk, 929Fleming, P. C., 948
Gambertoglio, John, G., 952Geraci, Joseph E., 944Gitelman, J., 962Grill, Susan, 957
Hall, Michael J., 897Harris, Patricia C., 922Hashimoto, Ikuo, 980Hassall, Cedric H., 897Hilleman, Maurice R., 929
Hirasawa, Sadako, 980Holmes, Simon W., 897Holt, Alan, 844Hopke, Charles J., 929Hurley, David J., 969
Inbar, M., 962Inoue, Matsuhisa, 853Isaacs, Linda L., 983
Jungkind, Donald L., 872
Karmali, M. A., 948Kohn, A., 962Krontz, Daniel P., 882
Lambert, Robert W., 897Landesman, Sheldon H., 893Lareng, Marie B., 841Lin, Emil T., 952Lloyd, William J., 897Logan, Margaret N., 844Luft, Friedrich C., 983
Matsumoto, Joseph Y., 944Melo, Julio, 926Mikami, Jiroh, 980Miller, James R., 926Minami, Shinzaburo, 853Mitsuhashi, Susumu, 853Mutimer, Malcolm D., 976
Nakamura, Takashi, 980
Overby, Terry L., 933
Panwalker, Anand P., 877Pelzer, Helmut, 887Penner, J. L., 868
Piepersberg, Wolfgang, 863Porembski, Priscilla E., 877Preston, M. A., 868Probst, Peter J., 913
Raff, Martin J., 926Rankin, Laura I., 983Reeves, David S., 844Reiner, Roland, 913Reuter, Wolfgang, 887Ringrose, Peter S., 897Ruth, Jerry, 957
Sande, Merle A., 933Sawada, Yasuo, 980Scattergood, Edgar M., 929Sealey, Lynn B., 922Sheld, W. MichaeL 933Spyker, Daniel A., 933Stocklein, Walter, 863Strausbaugh, Larry J., 882Streips, Uldis N., 926Summersgill, James, 926
Tainturier, Daniel J., 841Then, Rudolf L., 913Trager, Gary M., 877Tytell, Alfred A., 929
Waisbren, Burton A., 969Waisbren, Steven J., 969Washington, John A., II, 944Watanabe, Yasuo, 980Weaver, Susanne S., 939Werner, Rolf G., 858Wilson, Walter R., 944Wise, Richard, 844Woolcock, John B., 976Wright, Alan J., 944
Yum, Moo N., 983
ANNOUNCING
THIRD INTERNATIONAL SYMPOSIUMON
RAPID METHODS AND AUTOMATIONIN MICROBIOLOGY*
26-30 MAY 1981WASHINGTON, D.C.
TOPICAL AREAS WILL INCLUDE
* clinical, medical, and public health microbiology* industrial microbiology* environmental microbiology* food microbiology* quality control* microbiological technology in developing nations
SHORT PAPERS ARE INVITED AND MUST BESUBMITTED ON OFFICIAL ABSTRACT FORMSBY 31 DECEMBER 1980 to ASM HEADQUARTERS,1913 "EYE" ST., WASHINGTON, D.C. 20006.
For further information write:
Dr. Richard C. Tilton, ChairmanISRMA Planning CommitteeUniversity of Connecticut Health CenterDepartment of Laboratory Medicine263 Farmington AvenueFarmington, Connecticut 06032
* Sponsored by the American Society for Microbiology
ACKNOWLEDGMENT
The Editors express their thanks to the following individuals who so kindly refereed the papers
submitted for publication during the past year.
Fred R. AllisonGordon ArcherGeorge R. AronoffRichard H. BaltzR. M. BannatyneM. BarzaJoseph H. BatesHarry N. BeatyGerald P. BodeyW. Kline BoltonT. R. BreitmanCharles S. BryanG. BryceWard E. BullockJoseph H. BurchenalEnrico CabibCharles C. J. CarpenterRoy Cleeland, Jr.D. B. ClewellKenneth W. CochranRoger M. ColeRita R. ColwellBarry S. CoopermanRobert B. CouchJack CrawfordJames CurtinL. Daneo-MoorePatrick J. DavisFloyd DennyW. E. DismukesGerald DonowitzRichard DumaDavid DurackGertrude B. ElionR. EstabrookW. Edmund Farrar, Jr.Martin ForbesCarl J. FriedmanY. FuruichiL. P. GangarosaW. Lance GeorgeDale N. GerdingHoward Goldfine
Robert C. GoodSherwood L. GorbachD. P. GriswoldRichard L. GuerrantLawrence S. GuymonWendell H. HallRobert E. W. HancockWilliam L. HansonJean E. HawkinsJoseph E. HawkinsDavid K. HendersonJ. Owen HendleyPaul D. HoeprichKing K. HolmesEdward W. Hook IIIRobert N. HullL. 0. IngramKeith JensenWarren D. Johnson, Jr.G. KaczorowskiS. KerwarArlyn KinkelNancy KlecknerJ. KnowlesOksana KoreniowskiGeorge P. KubicaCalvin M. KuninS. A. LernerStuart B. LevyCharles E. McCallA. A. MedeirosL. Bruce MellettLouis H. MillerDavid MontgomerieHiroshi NikaidoT. NorthRichard D. PearsonW. PlunkettD. A. PrestonJames RaleighW. B. RedmondMichael F. ReinJ. Robinson
Rial D. RolfeJohn P. RosazzaH. RozenkrantzLeon D. SabathD. S. SalsburgW. E. SandersSam SchefflerMichael ScheldR. A. ScudamoreG. D. ShockmanT. F. SmithWallace SnipesB. G. SprattDaniel A. SpykerVilma StanisichE. 0. StapleyRolf SternglanzGene StollermanJ. StromingerEverett SugarbakerR. L. SwitzerF. P. TallyC. ThornsberryD. J. TipperMarvin TurckB. TylerPaul UnderwoodJ. UnowskyL. WannamakerLawrence G. WayneL. WeinsteinHerbert WeissbachArthur C. WhiteL. J. WilkoffR. WilliamsonD. S. WilsonCarl L. WinelySheldon M. WolffEmanuel WolinskyMartha YowPauline K. W. YuThomas Zimmerman
987
STATEMENT OF OWNERSHIP, MANAGEMENT AND CIRCU'LATION
ITeT-s Ot PULC^T OH i PU; Ll _A t~~~ON NC XDT FtLH
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1913 1 St NW, Washington, DC 20006
1913 St. NW, Washinaton, DC 20006
Ameriran Sne.--ty for Micrnhiology- 101' t- NW- Wachinglon, DC Q0006
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Aomriran Society for Mirrhiology 1010 l Snt NW. Washington, DC 20006
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I enffythtth0 ut-. .d.by _ "*bov,u- otWt_dcompL-0., Acting Managing Editor
I..., nul sns* .--H1 S1_ sTI EG.- ..IE I.-avs .1_s
D 4. .. Actign Managin0 Editonr- (w 197 P) (Sec wtnirions .-. ret)
AUTHOR INDEX
VOLUME 18
Abe, Hiromu, 980Adachi, Kimiko, 513Agee, C. Coe, 243Agyare, Emmanuel O., 832Ahmad, M. H., 798Akiyama, Shin-ichi, 226Alestig, Kjell, 349Amatnieks, Yuri E., 101Andrews, Jenny M., 844Angehrn, Peter, 913Anne, Jozef, 231Apollo, Elaine, 784Arai, Susumu, 1Arango, Maria D., 190Arnaud, J. P., 69Arnett, Gussie, 598Aronoff, George R., 212Atherton, Frank R., 897Atkinson, Barbara, 807
Badal, R. E., 338Badal, Robert E., 773Badaracco, Gianfranco, 50Baker, C. N., 338Baker, Carolyn N., 773Baker, John S., 872Baker, S., 369Baldwin, Jack E., 465Balt, Sijbe, 249Barriere, Steven L., 952Barry, A. L., 338, 716Barry, Arthur L., 88, 487, 616,
773Barton, Nancy H., 709Behar, Caren F., 722Bekesi, J. George, 622Bekki, Eiichi, 980Bennett, Peter M., 200Bennett, William M., 346Bergstrom, Donald E., 957Biron, Karen K., 443Block, Colin S., 493Blomster, Ralph N., 171Bock, August, 798Bodey, Gerald P., 574, 939Bollinger, Mitzi, 474Bolton, L., 137Bolton, W. Kline, 933Bongaerts, Ger P. A., 680Bowie, W. R., 978Braitburg, Janina, 586, 593Brogard, J. M., 69Brook, Itzhak, 164Broughall, John M., 844Bruggeman-Ogle, Kristiane M.,
680Brunken, Jan M., 474Bryan, L. E., 390
Buchanan, Robert A., 709Burd, John F., 264Burdett, Vickers, 753Burgess, Keith R., 829Butzler, J. P., 118Bywater, Martin J., 844
Calhoun, Leslie, 164Came, Paul E., 738Caplan, Ellis S., 448Carp, R. I., 276Carrizosa, J., 564Casero, Robert A., Jr., 317Cassel, Robert, 493Chai, Toby C., 638Chai, Tuu-jyi, 638Chapman, Stanley W., 699Chen, Ming S., 433Cheng, Yung-chi, 957Cherne, John E., 210Cherubin, Charles E., 893Childs, George E., 317Chrystal, Ewan J. T., 568Clavel, Sabine, 357Clement, Frangoise, 357Cobbs, C. Glenn, 709Cohen, Seymour S., 598Cohn, John R., 872Coignau, H., 118Comber, K. R., 182Contacos, Peter G., 289Conte, John E., Jr., 952Coppens, L., 437Corrado, Michael L., 893Courtney, Mary-Anne, 926Coyle, Marie, 814Crowlesmith, Ian, 667, 675Crum, John W., 360Crutzen, Ans Q. H., 521
Dabernat, Henry J., 841Daniel, Muthiah D., 622Dann, Otto, 231David, Hugo L., 357Davis, Henry T., 699de Bolster, Martinus W. G., 249De Clercq, Erik, 231De Grandis, S., 948Delmas, Catherine F., 841Demain, Arnold L., 465Desjardins, Robert E., 317Dessens-Kroon, M., 789Dick, J. D., 158Dickson, Edward T., 27Dierickx, R., 118Diethelm, Arnold G., 709Dobek, Arthur S., 27
Dobeli, H., 111Dobson, Richard A., 738Dornbusch, Kathrine, 220Dorner, M., 69Dougherty, Thomas J., 730Douglas, R. Gordon, Jr., 538Dowell, V. R., Jr., 13Duangmani, Chiraphun, 360
Eda, Yasuko, 37Edberg, Stephen C., 722Edelstein, Paul H., 403Elberg, Svetlana, 586, 593Elion, Gertrude B., 443, 741Elm, Joe L., Jr., 125Engelhardt, J. A., 243Evans, Richard T., 9Eyssen, Hendrik, 231
Falk, Lawrence A., 622Fass, Robert J., 483, 906Fayolle, Fransoise, 504Felsenfeld, Ambhan D., 142Field, A. Kirk, 929Finegold, Carolynn, 586Fique, Dorothy V., 171Fleischaker, Robert J., 130Fleming, P. C., 948Foleno, B., 137Forster, Dieter, 81Fortner, Clarence L., 299Frere, Jean-Marie, 508Fu, Kwung P., 311, 582Fuchs, Peter C., 88Furman, Phillip A., 741
Gabridge, M. G., 243Gambertoglio, John G., 952Garcia, Juan M., 215Gatmaitan, Bienvenido G., 409Gavan, Thomas L., 88Genco, Robert J., 9Georgopapadakou, Nafsika H.,
148, 834Geraci, Joseph E., 944Gerlach, E. H., 716Gerlach, E. Hugh, 88, 616Gerone, Peter J., 142Ghuysen, Jean-Marie, 508Giard, Donald J., 130Gibson, Susan, 142Gilbert, David N., 346Gillett, A. P., 240Ginelli, Enrico, 50Girolami, Roland L., 766Gitelman, J., 962Goldman, Peter, 568
ANTIMICROB. AGENTS CHEMOTHER.
Goldstein, Alma, 761Goldstein, Ellie J. C., 832Gombert, Myles E., 832Gorbach, Sherwood L., 167, 642Gordon, Leon L., 176Gordts, B., 118Goto, Mitsuyoshi, 372Grill, Susan, 957Grinsted, John, 200Groman, Neal, 814Grossberg, Sidney E., 20
Hakenbeck, Regine, 629Hall, Michael J., 897Halstead, Scott B., 125Haltiner, Rita C., 365Hamilton, Bruce K., 454Hamparian, Vincent V., 269Harawawa, Ry6, 58Hardisson, Carlos, 215Hardy, D. J., 544Harris, Patricia C., 922Harvey, Robert J., 323Hashimoto, Ikuo, 980Hassall, Cedric H., 897Hatheway, Charles L., 13Hayden, Frederick G., 538Herbert, Pamela, 355Hewitt, William L., 645Hilleman, Maurice R., 929Hindler, Janet A., 645Hinkle, Anne M., 574Hirasawa, Sadako, 980Hirose, Toshiharu, 377Hirtz, Jean L., 656Holland, James S., 622Holley, H. Preston, 448Holmes, Simon W., 897Holt, Alan, 844Hopke, Charles J., 929Horadam, Victor W., 559Hottendorf, G. H., 176, 746Houghton, Donald C., 346Howe, T. G. B., 667, 675Hughes, John H., 269Humbert, Guy, 656Hurley, David J., 969
Inbar, M., 962Inoue, M., 837Inoue, Matsuhisa, 77, 382, 687,
853Irie, Kenji, 37Isaacs, Linda L., 983Ishizaki, Takashi, 372Iwahi, Tomoyuki, 257Iwai, Yuzuru, 691Izawa, Akio, 37, 41, 45
Jacks, Thomas M., 397Jacobus, Nilda V., 642Jertborn, Marianne, 349Johnson, Paulette, 761
Jones, Benjamin V., 416Jones, R. N., 338, 716Jones, Ronald N., 88, 487, 616,
773J0rgensen, Sigrid Tue, 200Judith, Frederick R., 397Jungkind, Donald L., 872
Kabat, William J., 122Kailasam, S., 661Kampf, Dieter, 81Kaneko, Masae, 226Karmali, M. A., 948Kawahara, Kazuo, 45Kaye, D., 564Kim, H., 780Kim, K. S., 276King, Anna, 292King, Norval W., 622Kinkel, Arlyn W., 709Kisaki, Yoko, 37Kitao, Chiaki, 691Klastersky, J., 437Klayman, Daniel L., 27, 317Klein, Daniel, 508Kleit, Stuart A., 212Kobasa, W. D., 564Kobayashi, George S., 586, 593Koch, Arthur L., 323Koch, Ronald L., 568Koff, Wayne C., 125Kohn, A., 962Koller, Antje E., 730Komatsu, Toshiaki, 37, 41, 45Komiyama, Sohtaro, 226Kondo, Takao, 513Koornhof, Hendrik J., 493Kopferschmitt, J., 69Krontz, Daniel P., 882Kundsin, Ruth B., 738Kurashige, S., 105Kuroda, Kyoichi, 386Kurtz, Terrance O., 645Kuwano, Michihiko, 226
Lambert, Robert W., 897Landesman, Sheldon H., 893Lareng, Marie B., 841Lavillaureix, J., 69Lecaillon, Jean B., 656Lee, Francis H., 746Legeai, R. J., 544Lerman, Stephen J., 474Lerner, A. Martin, 409Levy, Hilton B., 409Lietman, Paul S., 534Lin, C., 780Lin, Emil T., 952Lipsky, James J., 534Liu, Fung Y., 148, 834Livingston, R., 240, 369Llaneza, Juan, 215Lloyd, William J., 897Lobbins, Phyllis M., 9
Logan, Margaret N., 844Lorian, Victor, 807Lubbers, Carol M., 741Luft, Friedrich C., 983Lysko, Paul G., 281, 416
Mandel, Laura J., 722Marcus, Edwin L.; 212Markowitz, Sheldon M., 651Marks, Melvin I., 579Marlin, Graham E., 829Martin, Jerry R., 761Martin, William J., 645Masuyoshi, Shinji, 1Matsubara, Nobuyuki, 195Matsuhashi, Michio, 195Matsumoto, Joseph Y., 944Matsuura, Masayuki, 687Mayhall, C. Glen, 784McCracken, George H., Jr., 476McCroskey, Loretta M., 13McDonough, P., 480McGuffin, Robert W., 471McGuire, Jeffrey C., 454McLafferty, Martha A., 568Means, B., 137Medoff, Gerald, 586, 593Mehl, J. Kurt, 269Meisel, Steven, 206Melo, Julio, 926Menday, A. P., 437Mendez, Francisco J., 215Mendoza, Carmen, 215Merz, W. G., 158Meunier-Carpentier, F., 437Meyer, Richard D., 403Meyers, Joel D., 471Middelbeek, Evert J., 521Migneault, Paula C., 365Mikami, Jiroh, 980Miller, Brinton M., 397Miller, James R., 926Miller, Michael H., 722Minami, Shinzaburo, 77, 195, 382,
853Mitsuhashi, S., 105, 837Mitsuhashi, Susumu, 1, 77, 195,
382, 687, 853Mitsuoka, Tomotari, 58Miyamoto, Masaki, 1Moniz-Pereira, Jose, 357Montgomery, Carol L., 559Moody, Marcia R., 299Morse, Stephen A., 281, 416Mourad, Aly, 696Murakawa, Takeo, 377Murillo, Jorge, 448Mutimer, Malcolm D., 976
Nair, N. G. K., 661Nakagome, Takenari, 37Nakamura, Takashi, 980Nakashita, Einosuke, 386Nakazawa, H., 837
ii AUTHORINDEX
VOL. 18, 1980
Nakazawa, Hisashi, 687Narayana, A. S. L., 661Nauta, Wijbe T., 249Nelson, John D., 476Nelson, Robert L., 212Neu, Harold C., 311, 582Newman, Kathryn A., 299Nishi, Takeshi, 551Nishida, Minoru, 377Nord, Carl Erik, 220North, Thomas W., 598Nuesch, J., 111
O'Callaghan, R. J., 544O'Connor, John R., 738Oden, E., 780Ohkawa, Mitsuo, 386Oill, Phyllis A., 355Oliva, Brunello, 200Olsson-Liljequist, Barbro, 220Omura, Satoshi, 691Orito, Matsuo, 386Ortiz, Jose M., 215Overby, Terry L., 933Owens, Lynn M., 610
Packer, R. R., 338Packer, Richard R., 773Panwalker, Anand P., 877Parker, Richard A., 346Parks, L. W., 822Pass, Robert F., 709Pearson, Richard D., 699Pelzer, Helxnut, 887Penner, J. L., 868Percheson, P. B., 390Pesanti, Edward L., 208Peterson, Lance R., 210Petrucelli, S., 137Phillips, Ian, 292Pieper, John A., 604Piepersberg, Wolfgang, 863Pijper, Pieter J., 249Plevani, Paolo, 50Pohlod, Donald J., 353Porembski, Priscilla E., 877Porter, George A., 346Poulin, Sharon A., 738Preston, M. A., 868Privitera, Gaetano, 504Probst, Peter J., 913Prusoff, William H., 433Pupkoff, Robert, 206
Quinn, Edward L., 353
Raff, Martin J., 926Raghupati Sarma, G., 661Ralph, Edward D., 101Rankin, Laura I., 983Rechenmacher, Angelika, 798Reeves, David S., 844Reiner, Roland, 913
AUTHOR INDEX
Restrepo M.Angela, 190
Reuter, Wolfgang, 887Ringrose, Peter S., 897Roberts, Marilyn C., 610Robertson, Richard G., 365Robinson, Roy G., 493Rodriguez, R. J., 822Rogers, Henry J., 63Rosenblum, Eugene D., 424Ruebush, Trenton K., II, 289Ruth, Jerry, 957
Sakamoto, Hiroshi, 377Sande, Merle A., 933Sanders, William J., 531Sapienza, V. J., 276Saral, R., 158Saravolatz, Louis D., 353Sasahara, Kunihiro, 386Sato, K., 837Saunders, Jean, 493Sawada, Yasuo, 980Sawada, Yosuke, 465Sawaki, Masaru, 386Scattergood, Edgar M., 929Schabel, Frank M., Jr., 598Schachter, Julius, 696Schentag, Jerome J., 604Schiller, John, 814Schimpff, Stephen C., 299Schleim, Klaus-Dieter, 397Schoeller, Jean P., 656Schoenherr, Christine K., 20Schuessler, D., 780Schurig, Randolf, 81Scovill, John P., 27, 317Sealey, Lynn B., 922Sebald, Madeleine, 504Seddon, M., 240Shannon, Kevin, 292Shannon, William M., 598Sheld, W. Michael, 933Shelton, Sharon, 476Shiau, George T., 433Shibata, Sharon A., 355Shimamura, Masayoshi, 386Shin, S., 480Shiota, Faith M., 471Shono, Fumiaki, 45Sibilla, Denise J., 651Simon, Gary L., 167Simons, Ruth, 538Singh, Pushpa D., 465Slots, J0rgen, 9Smilack, Jerry D., 559Smit, Hendrik, 249Smith, Arnold L., 610Smith, Thomas F., 738Smyth, Robert D., 746Snydman, David R., 167Soike, Kenneth F., 142Solomon, Nadine A., 465Somerville, Margaret M., 353
Sommers, Herbert M., 88Sora, Silvio, 50Speedie, Marilyn K., 171Spyker, Daniel A., 933Stamm, John M., 766Standiford, Harold C., 448St. Clair, Marty H., 741Steck, Edgar A., 289Steigbigel, Neal H., 722Steigbigel, Roy T., 699Stewart, George C., 424Stocklein, Walter, 863Stouthamer, Adrian H., 249Strausbaugh, Larry J., 882Streips, Uldis N., 926Stroshane, Ronald M., 454Sugata, Toshiaki, 386Sugg, Nancy, 696Sugimoto, Yoshikazu, 527Sugiyama, Masatoshi, 372Summersgill, James, 926Sutherland, R., 182Suthisomboon, Kalaya, 360Suzuki, Kunio, 58Svaan, John, 206Svedhem, Ake, 349Sweet, Richard L., 696Swenson, Christina D., 610Swenson, Jana M., 13Symchowicz, S., 780Synge, Charlotte, 63Szwed, James J., 212
Tabuki, Toshiko, 226Tadanier, Jack, 761Tainturier, Daniel J., 841Takaoka, Masayoshi, 195TaUy, Francis P., 167, 642Tamulevich, Ruth, 622Tanaka, Haruo, 691Tanaka, Yoshitake, 691Tanayama, Shigeharu, 513Tarpay, Martha M., 579Tatem, Beverly A., 448Taylor, Diane E., 480Taylor, Jerry L., 20Then, Rudolf L., 913Thomas, Monica C., 454Thompson, Philip J., 829Thompson, Stephan G., 264Thornsberry, C., 338, 716Thornsberry, Clyde, 13, 88, 487,616,773
Tight, Robert R., 307Timoney, J. F., 480Toda, M., 837Tomasz, Alexander, 629, 730Toyoshima, Shigeshi, 527Trager, Gary M., 877Tramont, Edmund C., 27Tripathy, S. P., 661Tsuchiya, Kanji, 257, 551Tucker, Bruce C., 709Tytell, Alfred A., 929
* *
iv AUTHOR INDEX
Umeda, Isao, 45
van der Goot, Henderikus, 249van Embden, J. D. A., 789Van Harken, Donald R., 746Vanhoof, R., 118van Klingeren, B., 789van Wijngaarden, L. J., 789Vasiljev, Michael, 746Verheul, Henk, 249Vibulyasekha, Somnuk, 360Vidal, Ronald A., 604Vis, Ronald D., 249Vischer, Wolfgang, 656Vogels, Godfried D., 521
Wade, James C., 299Waisbren, Burton A., 969
Waisbren, Steven J., 969Warren, Christine, 292Washington, John A., II, 944Watanabe, Yasuo, 980Weaver, Susanne S., 939Weihermiiller, Klaus, 81Welch, David F., 579Werner, Rolf G., 858Werringloer, Jurgen, 559Whelchel, John D., 709White, A. R., 182White, Richard J., 454Whitley, Richard J., 709Wiernik, Peter H., 299Williamson, Russell, 629Wilson, Walter R., 944Winston, Drew J., 645Wise, R., 240, 369
ANTIMICROB. AGENTS CHEMOTHER.
Wise, Richard, 844Witiak, Donald T., 269Wolinsky, Emanuel, 531Woods, Vivienne E., 63Woolcock, John B., 976Wright, Alan J., 944
Yasuda, K., 105Yocum, Paula, 164Yogev, Ram, 122Yoshida, Kiyoshi, 513Yoshikawa, Thomas T., 355Yoshitake, Akira, 41, 45Yotsuji, Akira, 382Young, Lowell S., 645Young, Viola Mae, 299Yum, Moo N., 983
Zimmermann, Willy, 94
SUBJECT INDEX
VOLUME 18
Acycloguanosineherpesviruses, 622
Acyclovirgranulocyte progenitor cells, 471varicella-zoster virus, 443
Acyclovir triphosphateinhibition of DNA polymerases, 741
Adenosine triphosphataseinhibition by neomycin, 532
Aeromonas hydrophilacefoperazone, 483
Alafosfalinrelated phosphonopeptide antibacterial agents, 897
D-Alanyl-D-alanineanalogs inhibiting E. coli murein synthesis, 887
Amikacindisk susceptibility test interpretation, 616nephrotoxicity in rat model, 983
8-(L-a-Aminoadipyl)-L-cysteinyl-D-valinecyclization to isopenicillin N, 465
5'-Amino-5'-deoxythymidinediphosphate derivative, 433herpes simplex virus inhibitor, 433synthesis, 433
Aminoglycosidescarbenicillin interactions, in vitro and in vivo, 604combination with newer cephalosporins, 651gram-negative bacilli, 645O-demethylfortimicin A, compared, 773uptake and ribosomal resistance mutations, 798
Amphotericin Bantifungal, K+, Na+, and Mg2" influence, 593ion influence on antifungal activity, 593
Ampicillinresistant H. influenzae surveillance, 474S. aureus susceptibility by Autobac I, 922
Animal modelcarbenicillin-aminoglycoside interactions, 604
Antagonismerythromycin, 872
Antifungal agents15-azasterol, produced by G. flavo-brunneum, 822
Antimicrobial susceptibilitythree Providencia species compared, 868
Antiviral agentsenhanced activity in combination, 536influenza viruses, 536
9-fi-D-Arabinofuranosyladenineenhancement by erythro-9-(2-hydroxy-3-nonyl)-
adenine, 598systemic herpesvirus infections in mice, 598
Autobac IS. aureus susceptibility to penicillin and ampicillin,
92215-Azasterolproduction in G. flavo-brunneum, 822
Bactericidal efficacy
in vitro kinetic model, 377Bacteroides fragilis
tetracycline transport, 502Bile
cefoperazone concentrations, 980
Campylobacter fetus subsp. fetus (intestinalis)cephalosporins susceptibility, 948susceptibility different from C. jejuni, 948
Campylobacterjejunicephalosporins susceptibility, 948susceptibility different from C. fetus subsp. fetus,
948Cantharides-induced blisters
pharmacokineticscefotaxime, 369moxalactam, 369
Carbenicillincefazolin-mecillinam combination, 437interactions with aminoglycosides, in vitro and in
vivo, 604septicemia caused by gram-negative organisms, 437
CefazolinK. pneumoniae DT-S in mice, 549plus mecillinam-carbenicillin, 437S. aureus endocarditis in rabbits, 562
Cefmetazoleimpaired renal function, 386pharmacokinetics in normal humans, 386
CefoperazoneA. hydrophila, 483concentrations in bile and gall bladder wall, 980gram-negative bacilli, 645inoculum effect on P. aeruginosa susceptibility, 893nonfermenters, 483
CeforanideS. aureus endocarditis in rabbits, 562
Cefotaximegram-negative bacilli, 645gram-negative bacilli, pediatrics, 476inoculum effect on P. aeruginosa susceptibility, 893vs. moxalactam
pharmacokinetics, 369tissue levels, 369
CefotiamK pneumoniae DT-S in mice, 549
Cefroxadin (CGP 9000)pharmacokinetics, human, 656
Cephalexinpharmacokinetics, human, 656
Cephalosporin ,-lactamase (cephalosporinase)from E. cloacae, 853
CephalosporinsC. fetus subsp. fetus versus C. jejuni susceptibility,948
newer, S. marcescens susceptibility, 651Cephamycin C
enterotoxigenic colibacillosis, 397
ii SUBJECT INDEX
Cerebrospinal fluidvancomycin penetration in rabbits, 882
Cerumenbactericidal activity, 638
Chlamydia trachomatiserythromycin, relative resistance, 696rosaramicin activity in vitro, 978rosoxacin, 738susceptibility in tissue culture system, 696
Chloramphenicolresistant H. influenzae, characterization, 610
CI-867new semisynthetic penicillin, 939
Clavulanic acidsynergy with piperacillin, 582
Na-Cocoyl-L-arginine ethyl esterhepatitis B surface antigen inactivation, 525
Compound A49759O-demethylfortimicin A, 766, 773
Contagious equine metritisH. equigenitalis susceptibility, 841
Corynebacterium diphtheriaeerythromycin resistance plasmids, 814
Corynebacterium equisusceptibility, 976
Cycloheximideribosomal binding in S. cerevisiae, 863
Daunorubicin glycosidesbiosynthesis, 454e-rhodomycinone, 454
O-Demethylfortimicin Acomparative antimicrobial activity, 766compared with aminoglycosides, 773
3-O-Demethylfortimicinssynthesis, 761
Deoxyribonucleic acid polymerasesinhibition by acyclovir triphosphate, 741
Dibekacinnephrotoxicity in rat model, 983pharmacokinetics, human, 372
Diffusion susceptibility testinterpretive criteria, 487netilmicin, 30-lig disks, 487
Disk susceptibility testsamikacin, interpretive standards, 616moxalactam, interpretive standards, 716Sch 21420, interpretive standards, 616
Eikenella corrodenssusceptibility to newer,8-lactams, 832
Endocarditis, enterococcalprophylaxis, 448
Enterobacter cloacaecephalosporinase, 853,8-Lactamase induction by antibiotics, 382
Enterococcipenicillin/aminoglycoside synergy, 944thymine-thymidine requiring, 365
Enterotoxigenic colibacillosiscephamycin C
calves, 397piglets, 397
Erythro-9-(2-hydroxy-3-nonyl)adenine
ANTIMICROB. AGENTS CHEMOTHER.
combination with araA, 598systemic herpesvirus infections in mice, 598
Erythromycinantagonism to other drugs, 872C. trachomatis resistance, 696resistance plasmids
C. diphtheriae, 814diphtheroids, 814
Erythromycin ethyl succinateeffect of food on absorption, 829
Escherichia colimurein synthesis inhibition, 887
Fatty acidsinactivation of enveloped viruses, 962
Foodeffect on erythromycin ethyl succinate absorption,
829N-Formimidoyl thienamycin
activity vs. fB-lactamase producers, 837crystalline derivative of thienamycin, 557effect of /1-lactamases, 837inoculum effect on P. aeruginosa susceptibility, 893in vitro activity, 557, :642
Fortimicin AO-demethylfortimicin A, comparative activity, 766
Fortimicin Bsynthesis of 3-O-demethylfortimicins, 761
Gall bladdercefoperazone concentrations in wall, 980
Gentamicinnephrotoxicity in rat model, 983prophylaxis against enterococcal enterocarditis, 448synergy with penicillin against enterococci, 944uptake by S. aureus mutants, 722
Geotrichum flavo-brunneumantifungal homoazasterol production, 822growth, 822
Gram-negative bacillicefotaxime, 476cephalosporins, 476moxalactam, 476moxalactam, cefotaxime, cefoperazone, piperacillin,
aminoglycosides, 645pediatric isolates, drug susceptibility, 476Ro 13-9904, 476
Gram-positive bacteriaindolmycin uptake, 858
Granulocyte progenitor cellsacyclovir nontoxicity, 471
Group B streptococcitetracycline-resistant R plasmids, 753
Haemophilus equigenitalissusceptibility, 841
Haemophilus influenzaeampicillin resistance surveillance, 474chloramphenicol resistant, 610plasmid characterization of resistant strains, 610
Hepatitis B surface antigeneffect of NV-cocoyl-L-arginine ethyl ester, 525
Herpes simplex virus
VOL. 18, 1980
E-5-propenyl-2'-deoxyuridine activity, 957Herpesvirus
adenine nucleoside analogs in combination, 598comparative study, interferon and 3 agents, 622
High-pressure liquid chromatographyrosaramicin determination in human serum, 780
Homoazasterolproduction in G. flavo-brunneum, 822
Human albuminmedium for interferon-producing Namalva cells, 929
Human erythrocytespolyene antibiotics, large and small, effects, 586
Human polymorphonuclear leukocyteskilling of oxacillin-exposed S. aureus, 807
Indolmycinuptake in gram-positive bacteria, 858
Influenza virusesdrug combinations, enhanced activity, 536
InterferonNamalva cells in medium with human albumin, 929
Interferon, human lymphoblasticherpesviruses, 622
Isoniazideffect of rifampin and prednisolone on metabolism,
661Isopenicillin Nfrom 8-(L-a-aminoadipyl)-L-cysteinyl-D-valine, 465
Klebsiella pneumoniaebroadening aminoglycoside resistance 542cefazolin, 549cefotiam, 549kanamycin resistance, 542mouse experimental pneumonia, 549R-factor determining multiple resistance, 926
Klebsiella spp.bactericidal kinetics, 877inactivation of,8-lactam drugs, 877susceptibility, 877
fl-Lactam antibioticsbinding to penicillin-binding proteins, 834enzymatic method for quantitation, 506N-formimidoyl thienamycin in vitro, 557, 642inactivtion by Klebsiella spp., 877f,-lactamase induction in E. cloacae, 382mecillinam alone and in combination, 906newer, E. corrodens susceptibility, 832S. pneumoniae penicillin-binding proteins, 629
,f-Lactamasedeficient Rl and RP1 plasmid mutants, 667N-formimidoyl thienamycin
activity against producer, 837effect, 837
from P. rettgeri, purification and properties, 687induction in E. cloacae, 382mecillinam susceptibility of enterobacteria, 680R plasmid mutants, pencillin resistance, 675
Bl-Lactamase inhibitorssynergy with piperacillin, 582
Legionella pneumophilasusceptibility to 20 drugs, 403
SUBJECT INDEX iii
Leucomycineffect of magnesium phosphate on production, 691S. kitasatoensis, 691
Magnesium ionsinfluence on antifungal amphotericin B, 593
Magnesium phosphateleucomycin production by S. kitasatoensis, 691
Mechanism of actionpyocin vs. N. gonorrhoeae, 416
Mecillinamactivity alone and in combination, 906added to carbenicillin-cefazolin, 437enterobacterial susceptibility, 680,f-lactamase and salt effects, 680pharmacokinetics in healthy volunteers, 952
Methicillinresistance transduction to S. aureus, 424S. aureus endocarditis in rabbits, 562
Metronidazolemetabolism and bactericidal activity, 566
Micro-broth dilutionS. pneumoniae susceptibility testing, 579
Minimal bactericidal antibiotic concentrationsS. aureus, reliable determination, 699
Minimal lethal antibiotic concentrationsS. aureus, reliable determination, 699
Minimum inhibitory concentration testingsensititre microtitration trays, 844
Moxalactamdisk susceptibility test interpretive standards, 716gram-negative bacilli, 645gram-negative bacilli, pediatrics, 476inoculum effect on P. aeruginosa susceptibility, 893in patients with renal dysfunction, 933pharmacokinetics, 369tissue levels, 369
Mueller-Hinton agarthymidine-dependent enterococci, 365
Murein synthesisinhibited in E. coli by D-alanyl-D-alanine analogs,
887Mycobacterium marinum
in vitro susceptibility, 529
NafcillinS. aureus endocarditis in rabbits, 562
Namalva cellsgrowth in human albumin medium, 929interferon production in human albumin medium,929
Neisseria gonorrhoeaepenicillinase producing, The Netherlands
epidemiology, 789plasmid characterization, :789
penicillin-binding proteins, 730pyocin inhibition, 416rosoxacin, 738
Neomycininhibition of adenosine triphosphatase, 532
Neonatal infectionsK. pneumoniae, aminoglycoside resistant, 42
Nephrotoxicity
ANTIMICROB. AGENTS CHEMOTHER.
dibekacin compared with gentamicin and amikacin,983
Netilmicindiffusion susceptibility test criteria, 487
Oxacillinkilling of exposed S. aureus by polymorphonuclear
leukocytes, 807
PenicillinBi-lactamase-altered plasmids, resistance, 675S. aureus susceptibility by Autobac I, 922S. pneumoniae, binding components, 390synergy with streptomycin and gentamicin, 944
Penicillin-binding componentsS. pneuhoniae, 390
Penicillin-binding proteinsin susceptible and resistant N. gonorrhoeae, 730,B-lactam antibiotics, interaction in vivo, 629S. aureus, binding of,-lactams, 834S. faecalis, binding of f,-lactams, 834S. pneumoniae, 629
Pharmacokinetics, animalpotassium phosphanilate, 746
Pharmacokinetics, humancefmetazole
impaired renal function, 386normal subjects, 386
cefotaxime, 369cefroxadin (CGP 9000) and cephalexin, 656dibekacin, 372impaired renal function: cefmetazole, 386mecillinam, in healthy volunteers, 952moxalactam, 369potassium phosphanilate, 746vidarabine 5'-monophosphate vs. herpes, 709
Phosphonoacetateherpesviruses, 622
Phosphonoformateherpesviruses, 622
Phosphonopeptide antibacterial agentsrelated to alafosfalin, 897
Pichia kluyverieffect of potassium and sodium ions on toxin, 519killing action in S. cerevisiae, 519
Piperacillincomparative in vitro appraisal, 493gram-negative bacilli, 645inoculum effect on P. aeruginosa susceptibility, 893S. typhi, 493synergy with ,B-lactamase inhibitors, 582
pJT2 plasmiddrug resistance, 480S. typhimurium, 480
Pneumococcal meningitis, experimentaleffect on vancomycin in rabbit cerebrospinal fluid,
882Polyene inhibitors
effect on human erythrocytes, 586large, 586small, 586
Polymorphonuclear leukocyteskilling of oxacillin-exposed S. aureus, 807
Polyriboinosinic-polyribocytidylic acid complex
toxicity modulated by component alterations, 409Potassium ions
influence on antifungal amphotericin B, 593influence on antifungal filipin, 593P. kluyveri toxin, 519
Potassium phosphanilatebioavailability, metabolism in humans and animals,
746Prednisolone
isoniazid metabolism, 661Probenecid
effect on vancomycin in rabbit cerebrospinal fluid,882
E-5-Propenyl-2'-deoxyuridineanti-herpes simplex virus, 957anti-human cell growth, 957
Proteus rettgeri,B-lactamase, purification and properties, 687
Providencia alcalifacienssusceptibility compared with other species, 868
Providencia rettgerisusceptibility compared with other species, 868
Providencia stuartiisusceptibility compared with other species, 868
Pseudomonas aeruginosainoculum effect on susceptibility testing, 893morphology changes under drug synergism, 969
PyocinN. gonorrhoeae inhibition, 416
Renal dysfunctionmoxalactam pharmacokinetics, 933
Resistance plasmidserythromycin
C. diphtheriae, 814diphtheroids, 814
R-factorK. pneumoniae, multiply resistant outbreak, 926
e-Rhodomycinoneconversion to daunorubicin glycosides, 454
Ribosomal resistance mutationsrelated to aminoglycoside uptake, 798
Rifampinisoniazid metabolism, 661
Ro 13-9904gram-negative bacilli, pediatrics, 476in vitro and in vivo studies, 913in vitro evaluation, 574
RosaramicinC. trachomatis activity in vitro, 978detefnination in humans, 780high'pressure liquid chromatography, 780
RosoxacinN. gonorrhoeae, C. trachomatis, U. urealyticum,
738Rl plasmid
fB-ladtamase-deficient mutants, 667penicillin resistance, 675
R plasmidsaltered-fi-lactamase mutants, penicillin resistance,
675,f-lactamase-deficient mutants in E. coli, 667
Saccharomyces cerevisiae
iv SUBJECT INDEX
VOL. 18, 1980
cycloheximide binding to ribosomes, 863P. kluyveri toxin killing action, 519ribosomal binding affinity for cycloheximide, 863
Salmonella typhipiperacillin, 493
Salmonella typhimuriumresistance plasmid pJT2, 480virulent, in calves, 480
Salteffect on enterobacterial mecillinam susceptibility,
680SCE-1365
disposition in rats and dogs, 511Sch 21420
disk susceptibility test interpretation, 616Scourscephamycin C
calves, 397piglets, 397
Selective protection conceptantivirus chemotherapy, 957
Sensititre dried microtitration traysMIC accuracy tested, 844
Septicemiaearly therapy with carbenicillin-cefazolin-mecilli-nam, 437
Serratia marcescenssusceptibility to newer cephalosporins, 651
Sodium ionsinfluence on antifungal amphotericin B, 593P. kluyveri toxin, 519
Staphylococcus aureusampicillin susceptibility by Autobac I, 922Autobac I susceptibility testing, 922drug concentration, effect on tolerance, 784endocarditis
ceforanide, cefazolin, methicillin, nafcillin, 562gentamicin uptake, 722growth phase, effect on drug tolerance, 784killing by polymorphonuclear leukocytes, 807methicillin resistance, transduction, 424penicillin-binding protein binding of fB-lactams, 834penicillin susceptibility by Autobac I, 922
SUBJECT INDEX V
small-colony, aminoglycoside-resistant mutants, 722storage, effect on drug tolerance, 784
Streptococcus faecalispenicillin-binding protein binding of 8l-lactams, 834
Streptococcus pneumoniaemicro-broth dilution susceptibility testing, 579penicillin-binding components, 390penicillin-binding proteins vs. f?-lactams, 629
Streptomyces kitasatoensisleucomycin production, 691
Streptomycinsynergy with penicillin against enterococci, 944
SynergismP. aeruginosa morphology changes, 969
Synergypenicillin/aminoglycosides against enterococci, 944piperacillin plus fi-lactamase inhibitors, 582
Tetracyclineresistance plasmids in group B streptococci, 753transport in B. fragilis, 502
Thymidinedependent enterococci, 365
Toxicitymodified poly(I)-poly(C) complex, 409
Ureaplasma urealyticumrosoxacin, 738
Vancomycinpenetration into rabbit cerebrospinal fluid, 882
Varicella-zoster virusacyclovir, 443
Vidarabine 5'-monophosphatepharmacology, tolerance, antiviral activity in hu-mans, 709
Viruses, envelopedinactivation by essential unsaturated fatty acids, 962
Yeastcycloheximide binding to S. cerevisiae ribosomes,
863
ANTIMICROBIAL AGENTS
AND
CHEMOTHERAPY
VOLUME 18
WASHINGTON, DC 20006
1980
ANTIMICROBIAL AGENTS ANDCHEMOTHERAPY
VOLUME 18 0 1980
EDITORIALLEON H. SCHMIDT, Editor-in-Chief (1985)
University ofAlabama in Birmingham,Birmingham, Alabama
HERBERT L. ENNIS, Editor (1982)Roche Institute ofMolecular Biology,
Nutley, New JerseyJOEL G. FLAKS, Editor (1981)
University of Pennsylvania, Philadelphia
BOARDROBERT L. HAMILL, Editor (1985)
Eli Lilly & Company, Inc.Indianapolis, Indiana
EDWARD W. HOOK, Editor (1981)University of Virginia, Charlottesville
GEORGE A. JACOBY, JR., Editor (1985)Massachusetts General Hospital
Boston, Massachusetts
Vincent T. Andriole (1981)John P. Anhalt (1981)Donald Armstrong (1980)Robert Austrian (1980)Arthur L. Barry (1980)John E. Bennett (1981)Lawrence E. Bryan (1982)Robert E. Brummitt (1982)D. Buyske (1980)Yves Chabbert (1980)Royston C. Clowes (1980)C. Glenn Cobbs (1980)Paul S. Cohen (1980)Naomi Datta (1981)Julian Davies (1980)Lawrence E. Day (1980)R. Gordon Douglas, Jr. (1980)Theodore Eickhoff (1982)Arthur English (1980)David S. Felngold (1981)Robert Fekety (1981)Sydney Finegold (1982)Robert J. Fitzgerald (1980)Anthony J. Glazko (1981)Irving H. Goldberg (1982)Harry Gooder (1982)Jack Gwaltney (1980)Maurice W. Harmon (1981)Michael Higgins (1980)Ronald D. Hinsdill (1982)Richard Hornick (1980)L. H. Huang (1982)Milton Huppert (1980)
George Gee Jackson (1980)Thomas Jones (1980)William J. Jusko (1980)Donald Kaye (1982),Jerome 0. Klein (1982)Vernon Knight (1980)George S. Kobayashi (1982)Jordan Konisky (1980)Matthew E. Levison (1981)Friedrich C. Luft (1981)Joan Lusk (1980)R. Luthy (1980)Gerald L. Mandell (1980)Gerald Medoff (1980)Barbara Minshew (1982)S. Mitsuhashi (1980)Robert C. Moellering, Jr. (1982)R. B. Morin (1982)Bernard Moss (1981)John D. Nelson (1980)Harold C. Neu (1980)J. F. Niblack (1980)T. J. Perun (1980)Charles A. Plate (1982)Burton M. Pogeli (1981)K. E. Price (1982)Paul Quie (1980)W. H. G. Richards (1980)Mark H. Richmond (1982)R. W. Rickards (1980)Richard Roberts (1982)Ian M. Rollo (1982)Richard Root (1980)
Jon E. Rosenblatt (1982)Milton R. J. Salton (1981)Merle Sande (1982)Jay Sanford (1980)Arthur K. Saz (1982)F. C. Sciavolino (1982)Oldrich K. Sebek (1980)William M. Shannon (1980)Jerome J. Schentag (1982)John C. Sherris (1980)Charles Shipman, Jr. (1982)Robert W. Sidwell (1981)Walter Siegenthaler (1980)Sigmund S. Socransky (1980)P. Frederick Sparling (1981)R. Sutherland (1982)Vera L Sutter (1981)Morton N. Swartz (1982)Richard B. Sykes (1982)Alexander Tomasz (1982)Ralph Tompsett (1982)Hamao Umezawa (1981)Donald Van Harken (1982)D. Vazquez (1980)Michael Waring (1981)John Washington I (1981)Pamela Waterworth (1982)Jerry A. Weisbach (1982)B. Weisblum (1982)Peter G. Welling (1982)Richard Wenzel (1980)
Gisella Poliock, Acting Managing EditorEleanor Tupper, Production Editor1913 I St., NW, Washington, DC 20006
EX OFFICIOAlbert Balows, President (1980-1981)
J. Mehsen Joseph, Secretary
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Volume 18 Contents for July Number 1
Biosynthesis; Chemistry; Mechanisms of Action and Resistance
High-Yield Interferon Induction by 10-Carboxymethyl-9-Acridanonein Mice and Hamsters. JERRY L. TAYLOR, CHRISTINE K.SCHOENHERR, AND SIDNEY E. GROSSBERG* .. .... 20-26
Effect and Mechanism of Action of Aphidicolin on Yeast Deoxyri-bonucleic Acid Polymerases. PAOLO PLEVANI,* GIANFRANCOBADARACCO, ENRICO GINELLI, AND SILVIO SORA ............ 50-57
Streptococcus faecium-Derived Antibacterial Substance Antagonis-tic to Bifidobacteria. RYO HARASAWA,* KUNIO SUZUKI, ANDTOMOTARI MITSUOKA ..................................... 58-62
Antibacterial Effect of Scandium and Indium Complexes of Entero-chelin on Klebsiella pneumoniae. HENRY J. ROGERS,* CHAR-LOTTE SYNGE, AND VIVIENNE E. WOODS..................... 63-68
Purification and Properties of Cephalosporinase in Escherichiacoli. SHINZABURO MINAMI, MATSUHISA INOUE, AND SUSUMUMITSUHASHI * ............................................ 77-80
Penetration of fB-Lactam Antibiotics into Their Target Enzymes inPseudomonas aeruginosa: Comparison of a Highly SensitiveMutant with Its Parent Strain. WILLY ZIMMERMANN ....... 94-100
Cefroxadine (CGP-9000), an Orally Active Cephalosporin. K. YA-SUDA, S. KURASHIGE, AND S. MITSUHASHI* ....... ..... 105-110
Regulatory Properties of O-Acetyl-L-Serine Sulfhydrylase of Ceph-alosporium acremonium: Evidence of an Isoenzyme and ItsImportance in Cephalosporin C Biosynthesis. H. DOBELI ANDJ. NUESCH* .............................................. 111-117
Examination of Parameters Affecting Human Interferon Productionwith Microcarrier-Grown Fibroblast Cells. DONALD J. GIARD*AND ROBERT J. FLEISCHAKER..... .. .. 130-136
Penicillin-Binding Proteins in Bacteria. NAFSIKA H. GEORGOPA-PADAKOU * AND FUNG Y. LIu ............ 148-157
Affinity ofCefoperazone for Penicillin-Binding Proteins. NOBUYUKIMATSUBARA,* SHINZABURO MINAMI, MICHIO MATSUHASHI,MASAYOSHI TAKAOKA, AND SUSUMU MITSUHASHI .... ....... 195-199
New Translocation Sequence Mediating Tetracycline ResistanceFound in Escherichia coli Pathogenic for Piglets. SIGRID TUEJ0RGENSEN,* BRUNELLO OLIVA, JOHN GRINSTED, AND PETERM. BENNETT......... .. .... 200-205
Physiological Effects and Microbial Susceptibility
In Vitro Antimicrobial Activity of Cefotaxime, a New Cephalospo-rin. SHINJI MASUYOSHI,* SusuMu ARAI, MASAKI MIYAMOTO,AND SUSUMU MITSUHASHI...... 1-8
In Vitro Antimicrobial Susceptibility of Actinobacillus actinomyce-temcomitans. J0RGEN SLOTS,* RICHARD T. EVANS, PHYLLISM. LOBBINS, AND ROBERT J. GENCO... 9-12
Susceptibility of Clostridium botulinum to Thirteen AntimicrobialAgents. JANA M. SWENSON,* CLYDE THORNSBERRY, LORETTAM. MCCROSKEY, CHARLES L. HATHEWAY, AND V. R. DOWELL,JR... 13-19
Asterisk refers to person to whom inquiries regarding the paper should be addressed.
Inhibition of Clinically Significant Bacterial Organisms In Vitro by2-Acetylpyridme Thiosemicarbazones. ARTHUR S. DOBEK,*DANIEL L. KLAYMAN, EDWARD T. DICKSON, JR., JOHN P.SCOVILL, AND EDMUND C. TRAMONT ................ ..... 27-36
Cefotaxime: In Vitro Activity and Tentative Interpretive Standardsfor Disk Susceptibility Testing. PETER C. FUCHS,* ARTHUR L.BARRY, CLYDE THORNSBERRY, RONALD N. JONES, THOMAS L.GAVAN, E. HUGH GERLACH, AND HERBERT M. SOMMERS . 88-93
Metronidazole in Treatment Against Haemophilus vaginalis (Cory-nebacterium vaginale). EDWARD D. RALPH* AND YURI E.AMATNIEKS .......................................... 101-104
Bacteriostatic and Bactericidal Activities of 24 Antimicrobial AgentsAgainst Campylobacter fetus subsp. jejuni. R. VANHOOF,* B.GORDTS, R. DIERICKx, H. COIGNAU, AND J. P. BUTZLER ...... 118-121
Inhibition of Dengue Virus Replication by Amantadine Hydrochlo-ride. WAYNE C. KOFF, * JOE L. ELM, JR., AND ScoTT B.HALSTEAD.......... 125-129
Incidence of Polyene-Resistant Yeasts Recovered from Clinical Spec-imens. J. D. DICK,* W. G. MERZ, AND R. SARAL ..... 158-163
Beta-Lactamase-Producing Isolates of Bacteroides Species fromChildren. ITZHAK BROOK,* LESLIE CALHOUN, AND PAULAYOCUM .......................... 164-166
Radiometric Prescreen for Antitumor Activity with a Saccharomycescerevisiae Mutant Strain. MARILYN K. SPEEDIE,* DOROTHYV. FIQUE, AND RALPH N. BLOMSTER. 171-175
Comparative Bactericidal Effects of Azlocillin and Ticarcillin AgainstPseudomonas aeruginosa. A. R. WHITE, K. R. COMBER, ANDR. SUTHERLAND*.............. 182-189
In Vitro Susceptibility Testing of Paracoccidioides brasiliensis toSulfonamides. ANGELA RESTREPO M.* AND MARIA D.ARANGO ................................................. 190-194
Microdilution Aminoglycoside Susceptibility Testing of Pseudomo-nas aeruginosa and Escherichia coli with a Cation-Supple-mented Inoculum. JOHN E. CHERNE AND LANCE R.PETERSON * .............................................. 210-211
Pharmacology and Therapeutics
Antibacterial Activity of Miloxacin. AKIO IZAWA, YOKo KISAKI,KENJI IRIE, YASUKO EDA, TAKENARI NAKAGOME, AND To-SHIAKI KOMATSU* ............................... 37-40
Absorption and Excretion of Miloxacin in Mice, Rats, andDogs. AKIO IZAWA, AKIRA YOSHITAKE, AND TOSHIAKIKOMATSU* ............................................... 41-44
Determination of Miloxacin and Metabolites in Human Serum andUrine by High-Pressure Liquid Chromatography. AKIRAYOSHITAKE,* KAZUO KAWAHARA, FUMIAKI SHONO, ISAOUMEDA, AKIO IZAWA, AND TOSHIAKI KOMATSU .............. 4549
Biliary Elimination of Mezlocillin: an Experimental and ClinicalStudy. J. M. BROGARD, J. KOPFERSCHMITT, J. P. ARNAUD, M.DORNER, AND J. LAVILLAUREIX* ........................... 69-76
Effects of Impaired Renal Function, Hemodialysis, and PeritonealDialysis on the Pharmacokinetics of Mezlocillin. DIETERKAMPF,* RANDOLF SCHURIG, KLAUS WEIHERMULLER, AND DIE-TER FORSTER ........... .. ....... ...... 81-87
Synergistic Action of Nafcillin and Ampicillin Against Ampicillin-Resistant Haemophilus influenzae Type b Bacteremia andMeningitis in Infant Rats. RAM YOGEV* AND WILLIAM J.KABAT ................................. 122-124
Direct-Current Bactericidal Effect on Intact Skin. L. BOLTON,* B.FOLENO, B. MEANS, AND S. PETRUCELLI.137-141
Ineffectiveness of Adenine Arabinoside and Adenine Arabinoside 5'-Monophosphate in Simian Varicella Infection. KENNETH F.SOIKE,* AMBHAN D. FELSENFELD, SUSAN GIBSON, AND PETERJ. GERONE.142-147
Clinical Trial of Piperacillin with Acquisition of Resistance by Pseu-domonas and Clinical Relapse. GARY L. SIMON, DAVID R.SNYDMAN, FRANCIS P. TALLY, AND SHERWOOD L. GORBACH* 167-170
Comparative Low-Dose Nephrotoxicities of Gentamicin, Tobramy-cin, and Amikacin. G. H. HOTTENDORF* AND LEON L.GORDON.176-181
In Vitro Effect of Rifampin on Serum Bilirubin Determinations.STEVEN MEISEL,* ROBERT PUPKOFF, AND JOHN SVAAN 206-207
Protection of Staphylococci Ingested by Macrophages from Bacteri-cidal Action of Rifampin. EDWARD L. PESANTI.208-209
Hypoxanthine-Arabinoside Pharmacokinetics After Adenine Arabi-noside Administration to a Patient with Renal Failure. GEORGER. ARONOFF,* JAMES J. SZWED, ROBERT L. NELSON, EDWIN L.MARCUS, AND STUART A. KLEIT ........................... 212-214
Volume 18 Contents for August Number2Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Plasmid-Determined Resistance to Fosfomycin in Serratia marces-cens. CARMEN MENDOZA, JUAN M. GARCIA, JUAN LLANEZA,FRANCISCO J. MENDEZ, CARLOS HARDISSON, AND JOSE M.ORTIZ* ..... 215-219
Mode of Action of Copper Complexes of Some 2,2'-Bipyridyl Analogson Paracoccus denitrificans. HENDRIK SMIT, HENDERIKUSVAN DER GOOT,* WIJBE T. NAUTA, PIETER J. PIJPER, SIJBEBALT, MARTINUS W. G. DE BOLSTER, ADRIAN H. STOUTHAMER,HENK VERHEUL, AND RONALD D. VIS ............. .. 249-256
Antiviral Activity of Antilipidemic Compounds on Herpes SimplexVirus Type 1. J. KURT MEHL, DONALD T. WITIAK, VINCENTV. HAMPARIAN, AND JOHN H. HUGHES* .................... 269-275
How Partially Inhibitory Concentrations of Chloramphenicol Affectthe Growth of Escherichia coli. ROBERT J. HARVEY* ANDARTHUR L. KOCH.................... 323-337
Physiological Effects and Microbial SusceptibilityCharacterization of Three Different f8-Lactamases from the Bacte-
roides fragilis Group. BARBRO OLSSON-LILJEQUIST, KATH-RINE DORNBUSCH, AND CARL ERIK NORD* .. ...... 220-225
Classification of Polyene Antibiotics According to Their SynergisticEffect inCombination with BleomycinA2 or Fusidic Acid. SHIN-ICHI AKIYAMA,* TOSHIKO TABUKI, MASAE KANEKO, SOHTAROKOMIYAMA, AND MICHIHIKO KUWANO ............ ...... 226-230
Antifungal and Antibacterial Activities of Diarylamidine Deriva-tives. JOSEF ANNE,* ERIK DE CLERCQ, HENDRIK EYSSEN, ANDOTTo DANN.............. 231-239
Antimycoplasmal Activity of Dimethylphenols in a Tracheal ExplantCulture System. C. COE AGEE,* J. A. ENGELHARDT, AND M.G. GABRIDGE.. 243-248
Substrate-Labeled Fluorescent Immunoassay for Amikacin in Hu-man Serum. STEPHAN G. THOMPSON* AND JOHN F. BURD 264-268
Antiviral Activity of Arildone on Deoxyribonucleic Acid and Ribo-nucleic Acid Viruses. K. S. KIM,* V. J. SAPIENZA, AND R. I.CARP.... 276-280
Effects of Steroid Hormones on Neisseria gonorrhoeae. PAUL G.LYSKO AND STEPHEN A. MORSE*.. 281-288
In Vitro Antibacterial Activity and Susceptibility of the Cephalospo-rin Ro 13-9904 to Beta-Lactamases. KEVIN SHANNON, ANNAKING, CHRISTINE WARREN, AND IAN PHILLIPS*.292-298
In Vitro Activity of Chloramphenicol and Thiamphenicol Analogs.HAROLD C. NEU* AND KWUNG P.Fu................... ..... 311-316
Activity of 2-Acetylpyridine Thiosemicarbazones Against Trypano-soma rhodesiense In Vitro. ROBERT A. CASERO, JR., DANIELL. KLAYMAN,* GEORGE E. CHILDS, JOHN P. SCOVILL, AND ROB-ERT E. DESJARDINS..... 317-322
Comparison of In Vitro Activity of Sch 21420, a Gentamicin BDerivative, with Those of Amikacin, Gentamicin, Netilmicin,Sisomicin, and Tobramycin. C. THORNSBERRY,* A. L. BARRY,R. N. JONES, C. N. BAKER, R. E. BADAL, AND R. R. PACKER.. 338-345
Effect of Clavulanic Acid on Minimal Inhibitory Concentrations of16 Antimicrobial Agents Tested Against Legionella pneumo-phila. DONALD J. POHLOD,* LOUIS D. SARAVOLATZ, EDWARDL. QUINN, AND MARGARET M. SOMERVILLE ........ ... 353-354
In Vitro Activity ofRo 13-9904, Cefuroxime, Cefoxitin, and AmpicillinAgainst Neisseria gonorrhoeae. THOMAS T. YOSHIKAWA, *SHARON A. SHIBATA, PAMELA HERBERT, AND PHYLLIS A. OILL 355-356
Effects of Antituberculosis and Antileprosy Drugs on Mycobacter-iophage D29 Growth. HUGO L. DAVID,* SABINE CLAVEL,FRANSOISE CLEMENT, AND JOSE MONIZ-PEREIRA.... 357-359
Pharmacology and TherapeuticsPharmacokinetics of Ro 13-9904, a Broad-Spectrum Cephalosporin.
M. SEDDON, R. WISE,* A. P. GILLETT, AND R. LIVINGSTON ... 240-242Comparative Activities of Cefotiam and Cefazolin Against Urinary
Tract Infections with Proteus mirabilis in Mice. TOMOYUKIIWAHI AND KANJI TSUCHIYA* ......................... 257-263
Chemotherapy of Babesia microti Infections in MongolianJirds. TRENTON K. RUEBUSH II,* PETER G. CONTACOS, ANDEDGAR A. STECK.289-291
Potential of Mezlocillin as Empiric Single-Agent Therapy in FebrileGranulocytopenic Cancer Patients. JAMES C. WADE,* STE-PHEN C. SCHIMPFF, KATHRYN A. NEWMAN, CLARENCE L. FORT-NER, MARCIA R. MOODY, VIOLA MAE YOUNG, AND PETER H.WIERNIK.. 299-306
Ampicillin Therapy of Experimental Enterococcal Endocarditis.ROBERT R. TIGHT.307-310
Comparative Nephrotoxicities of High-Dose Netilmicin and Tobra-mycin in Rats. RICHARD A. PARKER,* DAVID N. GILBERT,DONALD C. HOUGHTON, GEORGE A. PORTER, AND WILLIAM M.BENNETT... .......... 346-348
Phlebitis Induced by Parenteral Treatment with Flucloxacillin andCloxacillin: a Double-Blind Study. AKE SVEDHEM,* KJELLALESTIG, AND MARIANNE JERTBORN... 349-352
Resistance to Penicillin and Identification of Penicillinase-ProducingNeisseria gonorrhoeae Among Clinical Isolates in Thailand.JOHN W. CRUM,* CHIRAPHUN DUANGMANI, SOMNUK VIBULY-ASEKHA, AND KALAYA SUTHISOMBOON ....................... 360-361
ErrataPurification and Properties of a New f,-Lactamase from Pseudomo-
nas cepacia. K. HIRAI, S. IYOBE, M. INOUE, AND S.MITSUHASHI ................................... 362
Bacteriostatic and Bactericidal Activities of,-Lactam AntibioticsEnhanced by the Addition of Low Concentrations of Gentami-cin. GOHTA MASUDA, KISHIo NAKAMURA, TARO YAJIMA, ANDKAZUE SAKU ............................................. 363
Effect of Orally Administered Probenecid on the Pharmacokineticsof Cefoxitin. PETER H. VLASSES, ANNE M. HOLBROOK, JOHNJ. SCHROGIE, J. DOUGLAS ROGERS, ROGER K. FERGUSON, ANDWILLIAM B. ABRAMS.................... 363
Volume 18 Contents for September Number 3
Biosynthesis; Chemistry; Mechanisms of Action and ResistancePenicillin-Binding Components of Penicillin-Susceptible and -Resist-
ant Strains of Streptococcus pneumoniae. P. B. PERCHESONAND L. E. BRYAN* ............... ........ 390-396
Pyocin Inhibition of Neisseria gonorrhoeae: Mechanism of Action.STEPHEN A. MORSE,* BENJAMIN V. JONES, AND PAUL G.LYSKO ............................. 416-423
Transduction of Methicillin Resistance in Staphylococcus aureus:Recipient Effectiveness and Beta-Lactamase Production.GEORGE C. STEWART AND EUGENE D. ROSENBLUM* .. 424-432
5'-Amino-5'-Deoxythymidine: Synthesis, Specific Phosphorylationby Herpesvirus Thymidine Kinase, and Stability to pH of theEnzymically Formed Diphosphate Derivative. MING S. CHEN,GEORGE T. SHIAU, AND WILLIAM H. PRUSOFF* ... 433-436
Biosynthesis of Daunorubicin Glycosides: Role of E-Rhodomycinone.JEFFREY C. McGUIRE,* MONICA C. THOMAS, RONALD M. STRO-SHANE, BRUCE K. HAMILTON, AND RICHARD J. WHITE ... 454-464
Cell-Free Cyclizatin of 8-(L-a-Aminodipyl)-L-Cysteinyl-D-Valine toIsopenicillin N. YOSUKE SAWADA, JACK E. BALDWIN, PUSHPAD. SINGH, NADINE A. SOLOMON, AND ARNOLD L. DEMAIN* 465470
pJT2: Unusual Hi Plasmid in a Highly Virulent Lactose-Positiveand Chloramphenicol-Resistant Salmonella typhimuriumStrain from Calves. J. F. TIMONEY,* DIANE E. TAYLOR, S.SHIN, AND P. MCDONOUGH ................................ 480-482
Physiological Effects and Microbial SusceptibilityIncidence of Thymidine-Dependent Enterococci Detected on Muel-
ler-Hinton Agar with Low Thymidine Content. RITA C. HAL-TINER, PAULA C. MIGNEAULT, AND RICHARD G. ROBERTSON* 365-368
Induction of f-Lactamase by Various ,B-Lactam Antibiotics in Enter-obacter cloacae. SHINZABURO MINAMI,* AKIRA YOTSUJI,MATSUHISA INOUE, AND SUSUMU MITSUHASHI .. 382-385
Susceptibility of Legionella pneumophila to Twenty AntimicrobialAgents. PAUL H. EDELSTEIN* AND RICHARD D. MEYER ..... 403-408
In Vitro Susceptibility of Varicella-Zoster Virus to Acyclovir. KARENK. BIRON* AND GERTRUDE B. ELION.... 443-447
Lack of Toxicity of Acyclovir to Granulocyte Progenitor Cells inVitro. ROBERT W. MCGUFFIN, FAITH M. SHIOTA, AND JOEL D.MEYERS* ............. 471-473
Prevalence of Ampicillin-Resistant Strains of Haemophilus influ-enzae Causing Systemic Infection. STEPHEN J. LERMAN,* JANM. BRUNKEN, AND MITzI BOLLINGER ...... ... 474-475
In Vitro Susceptibility of Gram-Negative Bacilli from Pediatric Pa-tients to Moxalactam, Cefotaxime, Ro 13-9904, and Other Ceph-alosporins. SHARON SHELTON, JOHN D. NELSON,* ANDGEORGE H. MCCRACKEN, JR............................... 476-479
In Vitro Activity of Cefoperazone Against Nonfermenters and Aero-monas hydrophila. ROBERT J. FASS .... .... 483-486
Tentative Interpretive Criteria for the Diffusion Susceptibility TestUsing 30-,ug Netilmicin Disks. RONALD N. JONES,* ARTHUR L.BARRY, AND CLYDE THORNSBERRY ...... ................... 487-490
Pharmacology and TherapeuticsComparison of Cefotaxime and Moxalactam Pharmacokinetics and
Tissue Levels. R. WISE,* S. BAKER, AND R. LIVINGSTON .... 369-371Pharmacokinetic Studies with Dibekacin, a New Aminoglycoside,
After Intravenous and Intramuscular Administration to HumanVolunteers. MITSUYOSHI GOTO,* MASATOSHI SUGIYAMA, ANDTAKASHI ISHIZAKI ............... ...... ........ 372-376
New In Vitro Kinetic Model for Evaluating Bactericidal Efficacy ofAntibiotics. TAKEO MURAKAWA, HIROSHI SAKAMOTO, TOSHI-HARU HIROSE, AND MINORU NISHIDA*.. 377-381
Phannacokinetics of Cefmetazole in Normal Subjects and in Patientswith Impaired Renal Function. MITSUO OHKAWA,* MATSUOORITO, TOSHIAKI SUGATA, MASAYOSHI SHIMAMURA, MASARUSAWAKI, EINOSUKE NAKASHITA, KYOICHI KURODA, AND KUNI-HIRO SASAHARA .......................................... 386-389
Cephamycin C Treatment of Induced Enterotoxigenic Colibacillosis(Scours) in Calves and Piglets. THOMAS M. JACKS,* KLAUS-DIETER SCHLEIM, FREDERICK R. JUDITH, AND BRINTON M.MILLER ............................................... 397-402
Modified Polyriboinosinic-Polyribocytidylic Acid Complex: Modula-tion of Toxicity for Rabbits by Alterations in Components.BIENVENIDO G. GATMAITAN, HILTON B. LEVY, AND A. MARTINLERNER* .................... 409-415
Carbenicillin plus Cefazolin with or Without Mecillinam as an EarlyTreatment of Bacteremia Caused by Gram-Negative Organsms:Randomized Double-Blind Study. J. KLASTERSKY,* L. Cop-PENS, F. MEUNIER-CARPENTIER, AND A. P. MENDAY .... ..... 437-442
Prophylaxis Against Enterococcal Endocarditis: Comparison of theAminoglycoside Component of Parenteral Antimicrobial Regi-mens. JORGE MURILLO, HAROLD C. STANDIFORD,* H. PRES-TON HOLLEY, BEVERLY A. TATEM, AND ELLIS S. CAPLAN ..... 448-453
ErrataInhibition of Clinically Significant Bacterial Organisms In Vitro by
2-Acetylpyridine Thiosemicarbazones. ARTHUR S. DOBEK,DANIEL L. KLAYMAN, EDWARD T. DICKSON, JR., JOHN P. SCOV-ILL, AND EDMUND C. TRAMONT ......................... 491
Absorption and Disposition Kinetics of Amoxicillin in Nornal Hu-man Subjects. A. ARANCIBIA, J. GUTTMAN, G. GONZALEZ, ANDC. GONZALEZ ............................................. 491
Combined Antibacterial Activity of Amoxicillin with Clavulanic AcidAgainst Ampicillin-Resistant Strains. M. MATSUURA, H. NAKA-ZAWA, T. HASHIMOTO, AND S. MITSUHASHI .............. .... 491
Volume 18 Contents for October 1980 Number 4
Biosynthesis; Chemistry; Mechanism of Action and Resistance
Tetracycline Transport in Bacteroides fragilis. FRANCOISE FAY-OLLE, GAETANO PRIVITERA,* AND MADELEINE SEBALD.502-505
Enzymatic Method for Rapid and Sensitive Determination of f8-Lactam Antibiotics. JEAN-MARIE FRERE, DANIEL KLEIN, ANDJEAN-MARIE GHUYSEN* .................................. 506-510
Effects of Potassium and Sodium Ions on the Killing Action of aPichia kluyveri Toxin in Cells of Saccharomyces cerevisiae.EVERT J. MIDDELBEEK,* ANS Q. H. CRUTZEN, AND GODFRIEDD. VOGELS.519-524
Influence of Chemical Modification of Na-Cocoyl-L-Arginine EthylEster on Its Hepatitis B Surface Antigen-Inactivating Effect.YOSHIKAZU SUGIMOTO* AND SHIGESHI TOYOSHIMA .......... 525-528
Neomycin Inhibition of Adenosine Triphosphatase: Evidence for aNeomycin-Phospholipid Interaction. JAMES J. LIPSKY* ANDPAUL S. LIETMAN .............. .......................... 532-535
Klebsiella Neonatal Infections: Mechanism of Broadening Amino-glycoside Resistance. D. J. HARDY, R. J. LIEGEAI, AND R. J.O0CALLAGHAN* .. ...... ... ........... 542-548
Relationship Between Metronidazole Metabolism and BactericidalActivity. EWAN J. T. CHRYSTAL, RONALD L. KOCH, MARTHAA. MCLAFFERTY, AND PETER GOLDMAN* ................... 566-573
Characterization of Chloramphenicol-Resistant Haemophilus influ-enzae. MARILYN C. ROBERTS,* CHRISTINA D. SWENSON, LYNNM. OWENS, AND ARNOLD L. SMITH ....... .................. 610-615
In Vivo Interaction of ,B-Lactam Antibiotics with the Penicillin-Binding Proteins of Streptococcuspneumoniae. RUSSELL WIL-LIAMSON, REGINE HAKENBECK, AND ALEXANDER TOMASZ* ... 629-637
Physiological Effects and Microbial SusceptibilityComparative In Vitro Appraisal of Piperacillin, Including Its Activity
Against Salmonella typhi. RoY G. ROBINSON, JEAN SAUN-DERS, ROBERT CASSEL, COLIN S. BLOCK, AND HENDRIK J.KOORNHOF* ........ ............... 493-501
In Vitro Susceptibility of Mycobacterium marinum to Eight Anti-microbial Agents. WILLIAM J. SANDERS AND EMANUELWOLINSKY* ... ....... ... .... ....... 529-531
Enhancement of Activity Against Influenza Viruses by Combinationsof Antiviral Agents. FREDERICK G. HAYDEN, R. GORDONDOUGLAS, JR.,* AND RUTH SIMONS ......................... 536-541
In Vitro Activity of N-Formimidoyl Thienamycin (MK0787), a Crys-talline Derivative of Thienamycin. VICTOR W. HORADAM,JERRY D. SMILACK,* CAROL L. MONTGOMERY, AND JURGENWERRINGLOER... 557-561
In Vitro Evaluation of Ro 13-9904. ANNE M. HINKLE AND GERALDP. BODEY*.574-578
Antimicrobial Susceptibility Testing of Streptococcus pneumoniaeby Micro-Broth Dilution. MARTHA M. TARPAY,* DAVID F.WELCH, AND MELVIN I. MARKS ............................ 579-581
Synergistic Activity of Piperacillin in Combination with f?-LactamaseInhibitors. HAROLD C. NEU* AND KWUNG P. Fu... 582-585
Permeabilizing and Hemolytic Action of Large and Small PolyeneAntibiotics on Human Erythrocytes. JANINA BRAJTBURG,*GERALD MEDOFF, GEORGE S. KOBAYASHI, SVETLANA ELBERG,AND CAROLYNN FINEGOLD... .... 586-592
Influence of Extracellular K+ or Mg2e on the Stages of the AntifungalEffects of Amphotericin B and Filipin. JANINA BRAJTBURG,*GERALD MEDOFF, GEORGE S. KOBAYASHI, AND SVETLANAELBERG ................. 593-597
Interpretive Standards for Disk Susceptibility Tests with Sch 21420and Amikacin. ARTHUR L. BARRY,* CLYDE THORNSBERRY,RONALD N. JONES, AND E. HUGH GERLACH........ 616-621
Comparative Studies of Interferon and Three Antiviral Agents onNeurotropic and Oncogenic Herpesviruses. MUTHIAH D. DAN-IEL,* LAWRENCE A. FALK, NORVAL W. KING, RUTH TAMULE-VICH, JAMES S. HOLLAND, AND J. GEORGE BEKESI.622-628
Bactericidal Activity of Cerumen. TUU-JYI CHAI* AND TOBY C.CHAI................................ 638-641
In Vitro Activity of N-Formimidoyl Thienamycin (MK0787). FRAN-CIS P. TALLY,* NILDA V. JACOBUS, AND SHERWOOD L.GORBACH ............................... 642-644
Comparative In Vitro Activity of Moxalactam, Cefotaxime, Cefo-perazone, Piperacillin, and Aminoglycosides Against Gram-Neg-ative Bacilli. TERRANCE 0. KURTZ, DREW J. WINSTON, JANETA. HINDLER, LOWELL S. YOUNG, WILLIAM L. HEWITT, ANDWILLIAM J. MARTIN*... 645-648
Pharmacology and TherapeuticsMetabolic Fate of SCE-1365, a New Broad-Spectrum Cephalosporin,
After Parenteral Administration to Rats and Dogs. SHIGEHARUTANAYAMA,* KIYOSHI YOSHIDA, KIMIKO ADACHI, AND TAKAOKONDO .... ... ... ........... ..... ............. 511-518
Therapeutic Effects of Cefotiam and Cefazolin on ExperimentalPneumonia Caused by Klebsiella pneumoniae DT-S inMice. TAKESHI NISHI AND KANJI TSUCHIYA*............. 549-556
Comparison of Ceforanide, Cefazolin, Methicillin, and Nafcillin inStaphylococcus aureus Endocarditis Therapy in Rabbits. J.CARRIZOSA, W. D. KOBASA, AND D. KAYE*.................. 562-565
Erythro-9-(2-Hydroxy-3-Nonyl)Adenine Alone and in Combinationwith 9-fl-D-Arabinofuranosyladenine in Treatment of SystemicHerpesvirus Infections in Mice. WILLIAM M. SHANNON,* GUS-SIE ARNETT, FRANK M. SCHABEL, JR., THOMAS W. NORTH, ANDSEYMOUR S. COHEN.... 598-603
Animal Model Distinguishing In Vitro from In Vivo Carbenicillin-Aminoglycoside Interactions. JOHN A. PIEPER, RONALD A. VI-DAL, AND JEROME J. SCHENTAG* ........ ... 604-609
Erratum
In Vitro Antimicrobial Susceptibility of Actinobacillus actinomyce-temcomitans. J0RGEN SLOTS, RICHARD T. EVANS, PHYLLIS M.LOBBINS, AND ROBERT J. GENCO ........................... 649
Volume 18 Contents for November Number 5
Biosynthesis; Chemistry; Mechanisms of Action and ResistanceCharacterization of fi-Lactamase-Deficient (bla) Mutants of the R
Plasmid Rl in Escherichia coli K-12 and Comparison withSimilar Mutants of RP1. IAN CROWLESMITH AND T. G. B.HOWE* ................................... 667-674
Quantitative Correlation Between Penicillin Resistance and 8-Lac-tamase Activity Specified by the R Plasmids Rl, Rl bla-45, andRP1 in Escherichia coli K-12. IAN CROWLESMITH AND T. G.B. HOWE* ... ... ................................. 675-679
Purification and Biochemical Properties of fi-Lactamase Producedby Proteus rettgeri. MASAYUKI MATSUURA, HISASHI NAKA-ZAWA, MATSUHISA INOUE,* AND SUSUMU MITSUHASHI ....... 687-690
Gentamicin Uptake in Wild-Type and Aminoglycoside-ResistantSmall-Colony Mutants of Staphylococcus aureus. MICHAEL H.MILLER,* STEPHEN C. EDBERG, LAURA J. MANDEL, CAREN F.BEHAR, AND NEAL H. STEIGBIGEL ......................... 722-729
Penicillin-Binding Proteins of Penicillin-Susceptible and IntrinsicallyResistant Neisseria gonorrhoeae. THOMAS J. DOUGHERTY,*ANTJE E. KOLLER, AND ALEXANDER TOMASZ ................ 730-737
Inhibition of Cellular a and Virally Induced Deoxyribonucleic AcidPolymerases by the Triphosphate of Acyclovir. MARTY H. ST.CLAIR,* PHILLIP A. FURMAN, CAROL M. LUBBERS, AND GER-TRUDE B. ELION .......................................... 741-745
Identification of Tetracycline-Resistant R-Plasmids in Streptococcusagalactiae (Group B). VICKERS BURDETT.753-760
Synthesis of 3-O-Demethylfortimicins. JERRY R. MARTIN,* PAU-LETTE JOHNSON, JACK TADANIER, AND ALMA GOLDSTEIN 761-765
Penicillinase-Producing Neisseria gonorrhoeae in the Netherlands:Epidemiology and Genetic and Molecular Characterization ofTheir Plasmids. J. D. A. VAN EMBDEN,* B. VAN KLINGEREN,M. DESSENS-KROON, AND L. J. VAN WIJNGAARDEN .......... 789-797
Interaction Between Aminoglycoside Uptake and Ribosomal Resist-ance Mutations. M. H. AHMAD, ANGELIKA RECHENMACHER,AND AUGUST BOCK* ......................... ........ 798-806
Plasmids in Corynebacterium diphtheriae and Diphtheroids Me-diating Erythromycin Resistance. JOHN SCHILLER, NEAL GRO-MAN,* AND MARIE COYLE ................................. 814-821
Growth and Antifungal Homoazasterol Production in Geotrichumflavo-brunneum. R. J. RODRIGUEZ AND L. W. PARKS* 822-828
Binding of,-Lactam Antibiotics to Penicillin-Binding Proteins ofStaphylococcus aureus and Streptococcus faecalis: Relation toAntibacterial Activity. NAFSIKA H. GEORGOPAPADAKOU * ANDFUNG Y. LIU... 834-836
Physiological Effects and Microbial SusceptibilityComparative Susceptibilities of Clinical Isolates of Serratia marces-
cens to Newer Cephalosporins, Alone and in Combination withVarious Aminoglycosides. SHELDON M. MARKOWITZ* ANDDENISE J. SIBILLA............... ... ..... ..... 651-655
Effect of Beta-Lactamase and Salt on Mecillinam Susceptibility ofEnterobacterial Strains. GER P. A. BONGAERTS* AND KRIS-TIANE M. BRUGGEMAN-OGLE ............................ 680-686
Stimulation of Leucomycin Production by Magnesium Phosphateand Its Relevance to Nitrogen Catabolite Regulation. SATOSHIOMURA,* YOSHITAKE TANAKA, CHIAKI KITAO, HARUO TANAKA,AND YUZURU IWAI.691-695
Relative Resistance to Erythromycin in Chlamydia trachomatis.ALY MOURAD, RICHARD L. SWEET, NANCY SUGG, AND JULIUSSCHACHTER*... 696-698
Method for Reliable Determination of Minimal Lethal AntibioticConcentrations. RICHARD D. PEARSON, Roy T. STEIGBIGEL,*HENRY T. DAVIS, AND STANLEY W. CHAPMAN.699-708
Tentative Interpretive Standards for Disk Susceptibility Tests withMoxalactam (LY127935). A. L. BARRY,* C. THORNSBERRY, R.N. JONES, AND E. H. GERLACH...... 716-721
In Vitro Antimicrobial Activity of Rosoxacin Against Neisseria gon-orrhoeae, Chlamydia trachomatis, and Ureaplasma urealyti-cum. RICHARD A. DOBSON,* JOHN R. O'CONNOR, SHARON A.POULIN, RUTH B. KUNDSIN, THOMAS F. SMITH, AND PAUL E.CAME .............. ....... 738-740
Comparative Antimicrobial Activity of O-Demethylfortimicin A, aDerivative of Fortimicin A. ROLAND L. GIROLAMI* AND JOHNM. STAMM....... 766-772
Compound A49759, a 3-O-Demethyl Derivative of Fortimicin A: InVitro Comparison with Six Other Aminoglycoside Antibiotics.RONALD N. JONES,* CLYDE THORNSBERRY, ARTHUR L. BARRY,RICHARD R. PACKER, CAROLYN N. BAKER, AND ROBERT E.BADAL......................... 773-779
High-Pressure Liquid Chromatographic Method for Determinationof Rosaramicin in Humans. C. LIN,* H. KIM, D. SCHUESSLER,E. ODEN, AND S. SYMCHOWICZ ............................. 780-783
Effect of Storage and Changes in Bacterial Growth Phase and Anti-biotic Concentrations on Antimicrobial Tolerance in Staphylo-coccus aureus. C. GLEN MAYHALL* AND ELAINE APOLLO 784-788
Killing of Oxacillin-Exposed Staphylococci in Human Polymorpho-nuclear Leukocytes. VICTOR LORIAN* AND BARBARAATKINSON..... 807-813
Susceptibility of Eikenella corrodens to Newer Beta-Lactam Anti-biotics. ELLIE J. C. GOLDSTEIN,* MYLES E. GOMBERT, ANDEMMANUEL 0. AGYARE.8324833
Effect of N-Formimidoyl Thienamycin (MK0787) on f?-Lactamasesand Activity Against ,B-Lactamase-Producing Strains. M.TODA,* K. SATO, H. NAKAZAWA, M. INOUE, AND S.MITSUHASHI.837-838
Pharmacology and TherapeuticsPharmacokinetic Comparison of Cefroxadin (CGP 9000) and Ce-
phalexin by Simultaneous Administration to Humans. JEANB. LECAILLON,* JEAN L. HIRTZ, JEAN P. SCHOELLER, GUYHUMBERT, AND WOLFGANG VISCHER ....................... 656-660
Effect of Prednisolone and Rifampin on Isoniazid Metabolism inSlow and Rapid Inactivators of Isoniazid. G. RAGHUPATISARMA, S. KAILASAM, N. G. K. NAIR, A. S. L. NARAYANA, ANDS. P. TRIPATHY*.661-666
Pharmacology, Tolerance, and Antiviral Activity of VidarabineMonophosphate in Humans. RICHARD J. WHITLEY,* BRUCE C.TUCKER, ARLYN W. KINKEL, NANCY H. BARTON, ROBERT F.
PASS, JOHN D. WHELCHEL, C. GLENN COBBS, ARNOLD G.DIETHELM, AND ROBERT A. BUCHANAN.709-715
Bioavailability and Metabolism of Potassium Phosphanilate in Lab-oratory Animals and Humans. FRANCIS H. LEE,* DONALD R.VAN HARKEN, MICHAEL VASILJEV, ROBERT D. SMYTH, AND G.H. HOTTENDORF.... 746-752
Influence of Food on Absorption of Erythromycin Ethyl Succinate.PHILIP J. THOMPSON, KEITH R. BURGESS, AND GRAHAM E.MARLIN * ... ...... ................ ...... 829-831
ErratumFactors Affecting Gentamicin Assay. LENNART NILSSON .......... 839
Volume 18 Contents for December Number 6Biosynthesis; Chemistry; Mechanisms of Action and Resistance
Purification and Properties of a Cephalosporinase from Enterobac-ter cloacae. SHINZABURO MINAMI,* MATSUHISA INOUE, ANDSUSUMU MITSUHASHI..... 853-857
Uptake of Indolmycin in Gram-Positive Bacteria. ROLF G.WERNER ........................... 858-862
Binding of Cycloheximide to Ribosomes from Wild-Type and MutantStrains of Saccharomyces cerevisiae. WALTER STOCKLEIN*AND WOLFGANG PIEPERSBERG ........ ..................... 863-867
Inhibition of Peptidoglycan Synthesis in Ether-Permeabilized Esch-erichia coli Cells by Structural Analogs of D-Alanyl-D-Alarnie. HELMUT PELZER* AND WOLFGANG REUTER ....... 889-892
R-Factor Responsible for an Outbreak of Multiply Antibiotic-Resist-ant Klebsiella pneumoniae. MARY-ANNE COURTNEY, JAMESR. MILLER, JAMES SUMMERSGILL, JULIO MELO, MARTIN J.RAFF, AND ULDIS N. STREIPS* .. ..... ... 926-929
Replacement of Animal Serum Proteins by Human Albumin forGrowth and Interferon Production by Namalva Cells. A. KIRKFIELD,* EDGAR M. SCATTERGOOD, CHARLES J. HOPKE, ALFREDA. TYTELL, AND MAURICE R. HILLEMAN .................... 930-932
Anti-Herpes Simplex Virus and Anti-Human Cell Growth Activityof E-5-Propenyl-2'-Deoxyuridine and the Concept of SelectiveProtection in Antivirus Chemotherapy. YUNG-CHI CHENG,*SUSAN GRILL, JERRY RUTH, AND DONALD E. BERGSTROM .... 957-961
Interaction of Polyunsaturated Fatty Acids with Animal Cells andEnveloped Viruses. A. KOHN,* J. GITELMAN, AND M. INBAR 962-968
Physiological Effects and Microbial SusceptibilityIn Vitro Susceptibility Haemophilus equigenitalis, the Causative
Organism of Contagious Equine Metritis 1977, to AntimicrobialAgents.-HENRY J. DABERNAT,* CATHERINE F. DELMAS, DAN-IEL J. TAINTURIER, AND MARIE B. LARENG... 841-843
Comparison of Sensititre Dried Microtitration Trays with a StandardAgar Method for Determination of Minimum Inhibitory Con-centrations of Antimicrobial Agents. DAVID S. REEVES, ALANHOLT, MARTIN J. BYWATER, RICHARD WISE, MARGARET N.LOGAN, JENNY M. ANDREWS, AND JOHN M. BROUGHALL* ... 844-852
Differences Among Providencia Species in Their In Vitro Suscepti-bilities to Five Antibiotics. J. L. PENNER* AND M. A.PRESTON.868-871
In Vitro Antagonism by Erythromycin of the Bactericidal Action ofAntimicrobial Agents Against Common Respiratory Patho-gens. JOHN R. COHN, * DONALD L. JUNGKIND, AND JOHN S.BAKER ................................................ 872-876
Klebsiella Species: Antimicrobial Susceptibilities, Bactericidal Ki-netics, and In Vitro Inactivation ofBeta-Lactam Agents. ANANDP. PANWALKER, GARY M. TRAGER,* AND PRISCILLA E.POREMBSKI...... 877-881
Influence of Inoculum Size on Activity of Cefoperazone, Cefotaxime,Moxalactam, Piperacillin, and N-Formimidoyl Thienamycin(MK0787) Against Pseudomonas aeruginosa. MICHAEL L.CORRADO,* SHELDON H. LANDESMAN, AND CHARLES E.CHERUBIN........ ... 893-896
Phosphonopeptide Antibacterial Agents Related to Alafosfalin: De-sign, Synthesis, and Structure-Activity Relationships. FRANKR. ATHERTON, MICHAEL J. HALL, CEDRIC H. HASSALL,* SIMONW. HOLMES, ROBERT W. LAMBERT, WILLIAM J. LLOYD, ANDPETER S. RINGROSE... ... .. 897-905
Activity of Mecillinam Alone and in Combination with Other ,B-Lactam Antibiotics. ROBERT J. FASS .... .. 906-912
Two-Hospital Study of Staphylococcus aureus Susceptibility to Pen-icillin and Ampicillin by Autobac I. PATRICIA C. HARRIS* ANDLYNN B. SEALEY...... .. 922-925
CI-867, a New Semisynthetic Penicillin: In Vitro Studies. SUSANNES. WEAVER AND GERALD P. BODEY* .. .. ........ .. 939-943
Synergy of Penicillin and Decreasing Concentrations of Aminogly-cosides Against Enterococci from Patients with Infective Endo-carditis. JOSEPH Y. MATSUMOTO,* WALTER R. WILSON, ALANJ. WRIGHT, JOSEPH E. GERACI, AND JOHN A. WASHINGTON II 944-947
Antimicrobial Susceptibility of Campylobacterjejuni and Campylo-bacter fetus subsp. fetus to Eight Cephalosporins with SpecialReference to Species Differentiation. M. A. KARMALI, S. DEGRANDIS, AND P. C. FLEMING*. 948-951
Morphological Expressions of Antibiotic Synergism Against Pseu-domonas aeruginosa as Observed by Scanining Electron Micros-COPY. STEVEN J. WAISBREN, DAVID J. HURLEY, AND BURTONA. WAISBREN* ........................................... 969-975
Corynebacterium equi: In Vitro Susceptibility to Twenty-Six Anti-microbial Agents. JOHN B. WOOLCOCK* AND MALCOLM D.MUTIMER........ .... .......... 976-977
In Vitro Activity of Rosaramicin Against Chlamydia tracho-matis. W. R. BOWIE.... ... .. 978-979
Pharmacology and TherapeuticsEffect of Meningitis and Probenecid on the Penetration of Vanco-
mycin into Cerebrospinal Fluid in Rabbits. DANIEL P. KRONTZAND LARRY J. STRAUSBAUGH* ... .... 882-886
Ro 13-9904, a Long-Acting Broad-Spectrum Cephalosporin: In Vitroand In Vivo Studies. PETER ANGEHRN,* PETER J. PROBST,ROLAND REINER, AND RUDOLF L. THEN .. .. ... ... 913-921
Pharmacokinetics of Moxalactam in Subjects with Various Degreesof Renal Dysfunction. W. KLINE BOLTON,* W. MICHAELSHELD, DANIEL A. SPYKER, TERRY L. OVERBY, AND MERLE A.SANDE.. 933-938
Pharmacokinetics of Mecillinam in Healthy Subjects. JOHN G.GAMBERTOGLIO,* STEVEN L. BARRIERE, EMIL T. LIN, AND JOHNE. CONTE, JR. ............................................ 952-956
Cefoperazone Concentrations in Bile and Gall Bladder Wall AfterIntravenous Administration. TAKASHI NAKAMURA, * IKUOHASHIMOTO, YASUO SAWADA, JIROH MIKAMI, EIICHI BEKKI,SADAKO HIRASAWA, HIROMu ABE, AND YASUO WATANABE ... 980-982
Comparative Nephrotoxicities of Dibekacin, Amikacin, and Genta-micin in a Rat Model. LAURA L. RANKIN,* FRIEDRICH C. LUFT,Moo N. YUM, AND LINDA L. ISAACS ...... .................. 983-985
ErratumpJT2: Unusual Hi Plasmid in a Highly Virulent Lactose-Positive
and Chloramphenicol-Resistant Salmonella typhimuriumStrain from Calves. J. F. TIMONEY, DIANE E. TAYLOR, S. SHIN,AND P. MCDONOUGH ..................................... 986
INDEX TO DATE OF ISSUE
Month Date of Issue PagesJuly 30 July 1980 1-214August 4 September 1980 215-363September 22 September 1980 365-491October 13 October 1980 493-649November 13 November 1980 651-839December 26 December 1980 841-987