Reactions 1464, p7 - 10 Aug 2013 Antibacterials Facial oedema and exanthematic pustulosis: case report An adolescent girl experienced facial oedema and exanthematic pustulosis after receiving an unspecified antibacterial, which recurred during treatment with amoxicillin/clavulanic acid and cefuroxime. The girl presented for allergy tests at age 17 years. She reported receiving an antibiotic (that she described like a penicillin) for a cold 1 year previously [route and dosage not stated]. She had developed facial oedema and exanthematic pustulosis in the peribuccal region and forehead after 3 days of treatment. The girl’s reaction resolved after 3 days of systemic corticosteroids. The same reaction occurred when she received amoxicillin/clavulanic [indication, route, dosage and duration of therapy before reaction onset not stated] acid 3 months prior to presentation. This also resolved with corticosteroid treatment. Skin prick and intradermal tests were negative for benzylpenicilloyl polylysine, benzylpenicillin, amoxicillin, ampicillin, cefuroxime and minor determinant mixture. Oral challenge to penicillin V, ampicillin and amoxicillin were also negative after 2 hours. She was given amoxicillin/clavulanic acid every 8 hours for 5 days with no reaction. However, when given cefuroxime every 8 hours for 5 days [route and dose not stated] she developed exanthematic pustulosis, similar to her previous reaction, on the fifth day. Author comment: Drug allergy is not always diagnosed with tests performed inside the Allergy Department of a hospital. Sometimes, we have to repeat the conditions under which the reaction occurred. Burgos Montero A, et al. Exanthematic pustulosis by cefuroxime: A case report. Allergy 67: 432, Nov 2012. Available from: URL: http://dx.doi.org/10.1111/ all.12036 [Abstract]. - Spain 803090938 1 Reactions 10 Aug 2013 No. 1464 0114-9954/13/1464-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved

Antibacterials

Download PDF Report

Upload
omran
View
213
Download
0

Embed Size (px)

Citation preview

Reactions 1464, p7 - 10 Aug 2013

Antibacterials

Facial oedema and exanthematic pustulosis: casereport

An adolescent girl experienced facial oedema andexanthematic pustulosis after receiving an unspecifiedantibacterial, which recurred during treatment withamoxicillin/clavulanic acid and cefuroxime.

The girl presented for allergy tests at age 17 years. Shereported receiving an antibiotic (that she described like apenicillin) for a cold 1 year previously [route and dosage notstated]. She had developed facial oedema and exanthematicpustulosis in the peribuccal region and forehead after 3 days oftreatment.

The girl’s reaction resolved after 3 days of systemiccorticosteroids. The same reaction occurred when shereceived amoxicillin/clavulanic [indication, route, dosage andduration of therapy before reaction onset not stated] acid3 months prior to presentation. This also resolved withcorticosteroid treatment. Skin prick and intradermal tests werenegative for benzylpenicilloyl polylysine, benzylpenicillin,amoxicillin, ampicillin, cefuroxime and minor determinantmixture. Oral challenge to penicillin V, ampicillin andamoxicillin were also negative after 2 hours. She was givenamoxicillin/clavulanic acid every 8 hours for 5 days with noreaction. However, when given cefuroxime every 8 hours for5 days [route and dose not stated] she developed exanthematicpustulosis, similar to her previous reaction, on the fifth day.

Author comment: Drug allergy is not always diagnosedwith tests performed inside the Allergy Department of ahospital. Sometimes, we have to repeat the conditions underwhich the reaction occurred.Burgos Montero A, et al. Exanthematic pustulosis by cefuroxime: A case report.Allergy 67: 432, Nov 2012. Available from: URL: http://dx.doi.org/10.1111/all.12036 [Abstract]. - Spain 803090938