Anti-Oxidative and Anti-Inflammatory Effects of Ginger in ... and... · spice and condiment to add flavor to food.[1] ... well which can help in treating infectious diseases.[2,4–6]

Int J Prev Med. 2013 Apr; 4(Suppl 1): S36–S42. PMCID: PMC3665023

Anti-Oxidative and Anti-Inflammatory Effects of Ginger in Health and Physical Activity: Review

of Current Evidence

Nafiseh Shokri Mashhadi, Reza Ghiasvand, Gholamreza Askari, Mitra Hariri, Leila Darvishi, and Mohammad Reza Mofid

Child Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran

Department of Biochemistry, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran

Correspondence to: Mrs. Leila Darvishi, Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of medical

Sciences, Isfahan, Iran. E-mail: [email protected]

Received 2012 Sep 6; Accepted 2012 Nov 29.

Copyright : © International Journal of Preventive Medicine

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and

reproduction in any medium, provided the original work is properly cited.

Abstract

Background:

Ginger (Zingiber officinale Rosc.) belongs to the family Zingiberaceae. The health-promoting perspective of ginger is attributed to its rich

phytochemistry. This study aimed to review the current evidence on ginger effects as an anti-inflammatory and anti-oxidative.

Methods:

We searched MEDLINE for related publications using “ginger” and “anti-oxidative” and “ginger” and “anti-inflammatory” as keywords. This

search had considered Papers that had been published between 2000 and 2010 without any filter.

1,2 1,2 1,2 1,2 3

1

2

3

Anti-Oxidative and Anti-Inflammatory Effects of Ginger in Health and Physical Activity: Review of ... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665023/?report=printable

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Conclusions:

The anticancer potential of ginger is well documented and its functional ingredients like gingerols, shogaol, and paradols are the valuable

ingredients which can prevent various cancers. This review concludes to favor ginger but some ambiguities necessitate further research before

claiming its efficacy.

Keywords: Anti-inflammatory, anti-oxidative, ginger, reactive oxygen species.

INTRODUCTION

Ginger (Zingiber officinale Rosc.) belongs to the family Zingiberaceae. It originated in South-East Asia and then used in many countries as a

spice and condiment to add flavor to food.[1] Besides this, the rhizome of ginger has also been used in traditional herbal medicine. The health-

promoting perspective of ginger is attributed to its rich phytochemistry.[2] Jolad et al. grouped fresh ginger into two wide range categories, i.e.

volatiles and non-volatiles. Volatiles include sesquiterpene and monoterpenoid hydrocarbons providing the distinct aroma and taste of ginger.

On the contrary, non-volatile pungent compounds include gingerols, shogaols, paradols, and zingerone.[3]

Ginger has staring potential for treating a number of ailments including degenerative disorders (arthritis and rheumatism), digestive health

(indigestion, constipation and ulcer), cardiovascular disorders (atherosclerosis and hypertension), vomiting, diabetes mellitus, and cancer. It

also has anti-inflammatory and anti-oxidative properties for controlling the process of aging. Furthermore, it has antimicrobial potential as

well which can help in treating infectious diseases.[2,4–6] Generation of free radicals or reactive oxygen species (ROS) during metabolism

beyond the antioxidant capacity of a biological system results in oxidative stress,[7] which plays an essential role in heart diseases,

neurodegenerative diseases, cancer, and in the aging process.[7,8] The bioactive molecules of ginger like gingerols have shown antioxidant

activity in various modules.[9]

Inflammatory disorders such as gastritis, esophagitis, and hepatitis, which are caused not only by infectious agents such as viruses, bacteria,

and parasites but also by physical and chemical agents like heat, acid, cigarette smoke, and foreign bodies, are recognized as risk factors for

human cancer. Ginger consumption before exercise might reduce naturally occurring quadriceps muscle pain during moderate-intensity

cycling exercise. This effect may be due to anti-inflammatory effect of ginger and further investigation need to prove it in human.[10]

This study aimed to review the current evidence on ginger effects as an anti-inflammatory and anti-oxidative.

METHODS

We conducted a comprehensive search in the following databases: MEDLINE, EMBASE, in order to identify relevant studies. The electronic

search was conducted in July 2012, and developed in collaboration with an experienced librarian. Time restriction were applied to year of


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publication from 2000-2012 and we used literatures only from English language and studied both human and animal models. All titles and

abstracts were examined that met our search terms and full publications were reviewed, when necessary. Medline search with the terms:

[Ginger] AND [anti-oxidative] and [Ginger] AND [anti-inflammatory], then we had 211 articles. Review articles were only included in this

review if they offered new insights or opinions. We could achieve only to 59 articles from these articles and summarized 12 full text studies in

the table.

DISCUSSION

Anti-oxidative stress effects

The rich phytochemistry of ginger includes components that scavenge free radicals produced in biological systems. For the purpose of energy

production, some free radicals which generated during the process of oxidation are essential.[11] Increased production of free radicals results

in oxidative stress that can lead to DNA damage.[12] In such circumstances of imbalance, extra antioxidant supplementation through dietary

modules is essential for organism vitality.[13] The anti-oxidative properties of ginger and its components have been explored in various in

vitro and in vivo tests. Strengthening the body's defenses by improving the antioxidant status will undoubtedly protect human against many

chronic diseases.[2] 6-Shogaol has exhibited the most potent antioxidant and anti-inflammatory properties in ginger, which can be attributed

to the presence of alpha, beta-unsaturated ketone moiety.[9] Animal modeling showed that ginger significantly lowered induced lipid

peroxidation and raised the levels of antioxidant enzymes, together with serum glutathione.[14] Furthermore, feeding ginger to rats at 1% w/w

during administration of malathion (20 ppm) for 4 weeks significantly attenuated malathion-induced lipid peroxidation.[15] Concomitant

dietary feeding of ginger (1%w/w) significantly attenuated lindane-induced lipid peroxidation, reduced glutathione (GSH), and the GSH-

dependent enzymes glutathione peroxidase, glutathione reductase, and glutathione S-transferase.[16] In vitro, zingerone scavenged O and

OH and suppressed lipid peroxidation, so it can possibly value in treatment of Parkinson's disease.[17]

Ethanol significantly decreased the superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione content in

the hepatic tissue. This effect was improved by a treatment with 1% dietary ginger 1 month in rats which suggest that ginger may have

protective role against the ethanol induced hepatotoxicity.[18] Ginger and Arabic Gum showed renoprotective effects in renal failure. These

protective effects may be attributed to their anti-inflammatory properties by attenuating serum C-reactive protein levels and antioxidant effects

by reducing lipid peroxidation marker, malondialdehyde levels, and increasing renal superoxide dismutase activity. They could be beneficial

adjuvant therapy in patients with acute and chronic renal failure to prevent disease progression and delay the need for renal replacement

therapy.[19]

In one study, ethanol extract of Z. officinale alone and in combination with vitamin E partially ameliorated cisplatin-induced nephrotoxicity.

This protection is mediated by renal antioxidant defense system.[20]

2-


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In the other study, the protective effect of the ginger extract was examined on CCl (4) and acetaminophen-induced liver damage and indicated

that Z. officinale could be useful in preventing acute liver injury.[21]

The overall evaluation of one study concludes that both spices ginger and cumin have good antioxidant potential, particularly fresh ginger.

Methanol extracts of all the samples were found to have better antioxidant action than the n-hexane extracts. There was also a good correlation

between the total phenolic content and antioxidant activities of the non-volatile extracts.[22]

Rat studies showed that ginger has an equal antioxidant effect to that of ascorbic acid.[15]

Ghasemzadeh et al. validated the medicinal potential of the leaves and young rhizome of Z. officinale (Halia Bara) and the positive

relationship between total phenolics content and antioxidant activities in Z. officinale.[23]

Anti-inflammatory effects

In ancient cultures, medical practitioners focused on herbs for promoting the immune systems of body. In many countries ginger and its

products raise the immune system.[13]

Gingerol, shogaol, and other structurally-related substances in ginger inhibit prostaglandin and leukotriene biosynthesis through suppression

of 5-lipoxygenase or prostaglandin synthetase. Additionally, they can also inhibit synthesis of pro-inflammatory cytokines such as IL-1, TNF-

α, and IL-8.[24,25] In another investigation, Pan et al. showed that in macrophages,[6] shogaol can down-regulate inflammatory iNOS and

COX-2 gene expression.[26] Jung et al. indicated that rhizome hexane fraction extract of Z. officinale inhibited the excessive production of

NO, PGE (2), TNF-alpha, and IL-1beta.[27] Because of potent compounds in ginger rhizome for inhibiting allergic reactions, it may be useful

for the treatment and prevention of allergic diseases.[28]

Habib et al. showed that ginger extract can reduce the elevated expression of NFκB and TNF-α in rats with liver cancer.[29] The activation of

NF-κB is linked to a variety of inflammatory diseases, including cancer, atherosclerosis, myocardial infarction, diabetes, allergy, asthma,

arthritis, Crohn's disease, multiple sclerosis, Alzheimer's disease, osteoporosis, psoriasis, septic shock, and AIDS.[30]

Lantz et al. showed that gingerols can inhibit LPS-induced COX-2 expression while shogaol containing extracts has no effect on COX-2

expression. These data demonstrate that important compounds in ginger are capable of inhibiting PGE (2) production.[31]

Studies evaluating the effectiveness of ginger in patients with osteoarthritis have controversial results. One study showed ginger extract to

have a statistically significant effect on reducing symptoms of osteoarthritis of the knee.[32] In another study, the effect of ginger in

osteoarthritis was significant only in the first period of treatment.[33] In gout as a rheumatic disease of joints, [6]-shogaol has strong anti-

inflammatory and antioxidant effects and can be used as a curative agent.[34]


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Black et al. showed that treatment of patients with has hypo-algesic effects. They used 2 g of ginger supplementation for 11 days of on 36

participants to cure muscle pain. They proved that daily consumption of raw and heat-treated ginger resulted in moderate-to-large reductions

in muscle pain.[35]

However, cohort studies and controlled trails in sort of in vivo and in vitro need to be to warrant the pharmacological applications of ginger.

Anti-cancer effects

The mechanism of ginger for acting as chemopreventive spice remains a matter of conflict among researchers. Ingredients like [6]-gingerol,

[6]-shogaol, [6]-paradol, and zerumbone in ginger exhibits anti-inflammatory and antitumorigenic activities.[36,37] Ginger and its bioactive

molecules are effective in controlling the extent of colorectal, gastric, ovarian, liver, skin, breast, and prostate cancers.[36,38–43]

Colorectal cancer is more prevalent in vegetarians and ginger could be effective in reducing the extent of this disease. Manju and Nalini

studied the efficacy of ginger against 1, 2 dimethylhydrazine (DMH)-induced colon cancer. They observed that ginger supplementation can

activate various enzymes such as glutathione peroxidase, glutathione-S-transferase, and glutathione reductase and suppress colon

carcinogenesis.[44] Kim et al. administered Zerumbone orally in mouse models and observed inhibition in multiplicity of colonic

adenocarcinomas through suppression of colonic inflammation in a dose-dependent manner. The mechanism of that includes inhibition of

proliferation, induction of apoptosis, and suppression of NF-κB and heme oxygenase (HO)-1 expression.[41]

In gastric cancer, the tumor necrosis factor-related inducing apoptosis ligand (TRIALS) plays a major role by promoting apoptosis. Cascades

of caspase proteins activate by ginger and its functional components.[45] Ishiguro et al. explained a model for [6]-gingerol and[6]-shogaol

action against gastric cancer cells. They observed that [6]-gingerol inhibits TRAIL-induced NF-κB activation by impairing the nuclear

translocation of NF-κB, suppresses cIAP1 expression, and increases TRAIL-induced caspase-3/7 activation.[38]

Yagihashi et al. reported that [6]-gingerol can inhibit both proliferation and invasion of hepatoma cells. Cell cycle arrest and apoptosis

induction are the main causes of [6]-gingerol in these cancerous cells.[46] Habib et al. suggested that ginger extract can reduce the elevated

expression of NF-κB and TNF-alpha in rats with liver cancer.[29]

Inhibition of angiogenesis in the mouse skin is the mechanism of ginger for treating of skin cancer.[47 [6]-Gingerol exhibited considerable

cytotoxicity by growth inhibition of human epidermoid carcinoma cells mediated via reactive oxygen species (ROS) induced apoptosis.[48]

The effectiveness of ginger and its biomolecules has been demonstrated for controlling of ovarian cancer. Ginger inhibited NF-κB activation

and diminished the secretion of VEGF and IL-8 helping to treat ovarian cancer.[49]

Zhang et al. showed that zerumbone induced apoptosis in pancreatic carcinoma cells through p53 signal pathway, formation of apoptotic


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bodies, condensed nuclei, and the increased activity of caspase-3. So, zerumbone is a new therapeutic candidate for controlling of pancreatic

cancer.[50] Lee et al. indicated that ginger can cure breast cancer via inhibiting cell adhesion invasion motility.[42 [6]-gingerol can affect

prostate cancer models by modulation of proteins involved in apoptosis pathway.[51]

Anti-diabetic effects

Some research studies have proved the effectiveness of ginger against diabetes and its complications. Weidner and Sigwart conducted an

experimental study and indicated that ginger extract with a high content of gingerols and shogaols did not induce significant changes in blood

glucose, blood coagulation, blood pressure, and heart rate in rat models.[52] However, ginger significantly lowered blood glucose, serum total

cholesterol, LDL, VLDL, and triglycerides, and raised HDL in hyperglycemic rats, in models that are diabetic, deficient in the apolipoprotein

E gene or those that have been fed a high lipid diet.[53] Bhandari et al. showed that ethanolic extract of Zingiber officinale fed orally for 20

days produced a significant antihyperglycaemic effect (P < 0.01) in diabetic rats.[54] Additionally, Nammi et al. indicated that the ethanolic

extract of ginger reduced body weights and levels of glucose, insulin, total cholesterol, LDL cholesterol, triglycerides, free fatty acids, and

phospholipids in high-fat diets.[55] Heimes et al. supported from this hypoglycemic potential, too.[56] Insulinoptropic properties of ginger

and glucose-lowering potential were explained by Islam and Choi.[56–61]

We summarized 12 studies from these articles in Table 1.

CONCLUSIONS

The health-promoting perspectives of ginger are well known. It can treat a wide range of diseases via immunonutrition and anti-inflammatory

responses. As a result of anti-inflammatory effect of ginger, it can reduce muscle pain after intense physical activity. Likewise, the anticancer

potential of ginger is well documented and its functional ingredients like gingerols, shogaol, and paradols are the valuable ingredients which

can prevent various cancers, angiogenesis and metastasis, induction of apoptosis, and inhibition of cell-cycle progression. Besides these, it

improves cardiovascular disorders, diabetes mellitus, and gastrointestinal health.

This review concludes to favor ginger but some ambiguities necessitate further research before claiming its efficacy.

Footnotes

Source of Support: Nil

Conflict of Interest: None declared

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Figures and Tables


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Table 1


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Twelve selected studies with full text article

Articles from International Journal of Preventive Medicine are provided here courtesy of Wolters Kluwer -- Medknow Publications


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Documents

Anti-Oxidative and Anti-Inflammatory Effects of Ginger in ... and... · spice and condiment to add flavor to food.[1] ... well which can help in treating infectious diseases.[2,4–6]