Anti Hyperlipidemics

8/11/2019 Anti Hyperlipidemics

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ANTI-HYPERLIPIDEMIC

AGENTSIN PRACTICE

4FPH GROUP 2AVEDILLO

BULANLO

MAPALOMENDOZA

SANTOS


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SIMVASTATIN

IUPAC Name(1S ,3R ,7S ,8S ,8a R )-8-{2-[(2R ,4R )-4-hydroxy-6-oxotetrahydro-2 H -pyran-2-yl]ethyl}-3,7-dimethyl-

1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoateTrade Names

and

Manufacturer

Selling Price(per tab)

DosageForm and

Strength

Clinical IndicationsPregnancyCategory

Zocor(Merck Sharp &Dohme)

PHP 28.56 10 mg tab Reduction of the risk ofCHD death, majorvascular & coronaryevents, stroke,hospitalization forangina pectoris &developing peripheralmacrovascularcomplications inpatients w/ diabetes.

X

PHP 28.56 20 mg tabPHP 36.00 40 mg tabPHP 36.00 80 mg tab

Vidastat(Therapharma) PHP 27.58 10 mg tab Reduce increased totalplasma & LDL-cholesterol in patientsw/hypercholesterolemia(type IIa) or combinedhyperlipidemia (typeIIb) in combination w/dietary measures whenno adequate effect isobtained w/ dietary &nonpharmacologicalmeasures alone (e.g.fitness training & wt.loss). For secondaryprevention of CHD.

X


Cholestad(Littman)

PHP 20.00 20 mg tab Prevention of CHD &treatment ofhyperlipidemia.

XPHP 34.00 40 mg tab
http://www.mims.com/PHILIPPINES/Company/Info/merck%20sharp%20and%20dohmehttp://www.mims.com/PHILIPPINES/Company/Info/merck%20sharp%20and%20dohmehttp://www.mims.com/PHILIPPINES/Company/Info/Therapharmahttp://www.mims.com/PHILIPPINES/Company/Info/Therapharmahttp://www.mims.com/PHILIPPINES/Company/Info/merck%20sharp%20and%20dohmehttp://www.mims.com/PHILIPPINES/Company/Info/merck%20sharp%20and%20dohme


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Wilsim(Hizon)

PHP 14.75 20 mg tab Reduction of LDL-cholesterol,apolipoprotein B &triglycerides, toincrease HDL-cholesterol in thetreatment ofhyperlipidemiasincludinghypercholesterolemia &mixed hyperlipidemia(type IIa or IIbhyperlipoproteinemias).

X

PHP 19.00 40 mg tab

Zivas(Pascual)

PHP 13.27 10 mg tab Treatment ofhypercholesterolemia,particularly in type IIa &IIbhyperlipoproteinemias,hyperlipidemia,ischemic heart disease,CHD & severe renalimpairment.

X

ROSUVASTATIN

IUPAC Name(3R ,5S ,6E )-7-[4-(4-fluorophenyl)-2-( N -methylmethanesulfonamido)-6-(propan-2-yl)pyrimidin-

5-yl]-3,5-dihydroxyhept-6-enoic acid

Trade NamesandManufacturer


DosageForm

Clinical Indications PregnancyCategory

Crestor(Astra Zeneca)

PHP 26.33 5 mg tab Prevention of CVevents.

XPHP 57.67 10 mg tabPHP 70.17 20 mg tabPHP 91.37 40 mg tab
http://www.mims.com/PHILIPPINES/Company/Info/Pascualhttp://www.mims.com/PHILIPPINES/Company/Info/Pascual


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Rosucol(Ajanta)

PHP 16.47 10 mg tab Adjunct to diet for thetreatment of patientsw/ elevated serumtriglyceride (TG) levels.

XPHP 26.33 20 mg tab

ATORVASTATIN

IUPAC Name(3R ,5R )-7-[2-(4-Fluorophenyl)-3-phenyl-4-(phenylcarbamoyl)-5-propan-2-ylpyrrol-1-yl]-3,5-dihydroxyheptanoic acid

Trade Namesand

Manufacturer


DosageForm


Lipitor(Pfizer)

PHP 32.73 10 mg tab Reduction of elevatedtotal & LDL cholesterol,Apolipoprotein B &triglycerides & increaseHDL cholesterol in

patients w/ primaryhypercholesterolemia.

XPHP 37.1720 mg tab

PHP 47.98 40 mg tabPHP 48.10 80 mg tab

Atorwin(sanofi-aventis)

PHP 19.24 10 mg film-coated tab

Treatment ofhypercholesterolemia& prevention of CVdisorders. X




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GEMFIBROZIL

IUPAC Name5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid

Trade Namesand

Manufacturer


DosageForm


Lipigem(Littman)

PHP 11.00 300 mg tab Treatment ofhypertriglyceridemiasMixed dyslipidemia:Fredickson types IIA,IIB, III, IV, V.Hyperlipidemiasassociated withdiabetesPrimary prevention ofCHD & MI in patientswithhypercholesterolemia

X

Lopid OD(Pfizer)


Lipizile(IntegratedPharma)

PHP 10.35 300 mg tab

Reducel(GXI)



FENOFIBRATE

IUPAC NamePropan-2-yl 2-{4-[(4-chlorophenyl)carbonyl]phenoxy}-2-methylpropanoate

Trade Namesand

Manufacturer


DosageForm


Lipanthyl Supra(Abbott)

PHP 62.67 160 mgmodified-release tab

Hypercholesterolemia andhypertriglyceridemiaalone, or combined (typesIIa, IIb, III, IV, and V

C


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dyslipidemias) in patientsunresponsive to dietaryand other non-drugtherapeutic measures(e.g., weight reduction orincreased physicalactivity), particularly whenthere is evidence ofassociated risk e.g.,hypertension andsmoking.

Fenoflex(LR Imperial)

PHP 34.35 160mg cap Treatment of types IIa, IIb,III, IV, & Vhyperlipoproteinemias. C

Fenogal(SMB)

PHP 29.50 160mg cap Treatment of appropriatecases of hyperlipidemia,hypercholesterolemia(type IIa), endogenoushypertriglyceridemia (typeIVa) & mixedhyperlipidemia (type IIb).

C

Lipway SR(Cathay Drug)

PHP 34.69 250 mgmodified-release cap

Treatment ofhyperlipidemias of typeIIa, IIb, III, IV, & V inpatients who have not

responded adequately todiet & other appropriatemeasures.

C

Nubrex(Sandoz)

PHP 17.87 100 mg cap Treatment of types IIa, IIb,III, IV, & Vhyperlipoproteinemias inconjunction w/ dietarymodification.

CPHP 31.50 300 mg cap


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EZETIMIBE

IUPAC Name(3R ,4S)-1-(4-fluorophenyl)-3-[(3 S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-

hydroxyphenyl)azetidin-2-one Trade Names

andManufacturer


DosageForm


Ezedoc

(Lupin) IndiaINR 6.78

(PHP 4.88)

10 mg tab Used as adjunctive

therapy to diet for thereduction of elevated totalcholesterol, LDL, andApolipoprotein B inpatients with primary(heterozygous familial andnon-familial)hypercholesterolemia.

C

Ezetib(Unisearch) India

INR 6.07(PHP 4.37)

10 mg tab

Ezetrol(Merck Sharp &Dohme)

PHP 39.76 10 mg tab

Ezzicad(GlenmarkPharmaceuticals) -India

INR 6.66(PHP 4.80)

10 mg tab

Zetia

(Merck Sharpe &Dohme/Schering-Plough) - US

USD 5.16

(PHP 224.95)

10 mg tab

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Anti Hyperlipidemics