Anti-Cancer Diets_ What’s the Deal With Dairy_ _ Eat and Beat Cancer

11/20/2015 AntiCancerDiets:WhatstheDealwithDairy?| EatandBeatCancer

http://eatandbeatcancer.com/2014/07/23/anticancerdietswhatsthedealwithdairy/ 1/12

AntiCancerDiets:WhatstheDealwithDairy?PostedonJuly23,2014

Ivebeenreservingjudgmentondairyproductsfor55yearsnowsinceGrade1,whenmymomliedtotheschoolauthoritiesandtoldthemIwasallergictomilk.Truthwas:itmademegag.

ButnowthatDr.WalterWillett,chairmanoftheDepartmentofNutrition,HarvardsSchoolofPublicHealth,andanesteemedpanelofscientistshaveopinedonthesubjectandwevehadtimetoreflect,Icansaythiswithcertaintyaboutwhetherornotdairyproductshaveanyplaceinananticancerdiet:

Gotmilk?Gotprostatecancer?

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TheUSandCanadianguidelinessuggestingatleast3servingsadayofdairyproducts,especiallyloworfatfreeones,areclearlywrong.Atthatlevel,dairyproductsmaybedrivingcancersofthereproductiveorgans,nomatterwhatthefatcontent.Andthisisthenumber1puzzlethatnutritionalscientistsneedtosolvenow!

Yes,somedairyproducts(milk,notcheese)mayprotectagainstcolorectalcancer,saystheWorldCancerResearchFoundationandAmericanInstituteofCancerResearch(WCRF/AICR),whoseinternationalteamofscientistshavebeenevaluatingthestudiesondietandcancersincethe1990s.Butwhatsthepointineatingfoodsthatmaypromotecancerinotherorgans?

DairyandProstateCancer

Formen,thestudiesinhumanpopulationsarequiteclear.Highcalciummorethan1500mgadayisprobablyassociatedwithprostatecancer,saysWCRF/AICR.(Somestudieshavealsofoundanassociationwithtesticularcancer.)

(T)heevidencethatmilkconsumptionisrelatedtoprostatecancerriskisactuallyverystrong,specificallyforaggressiveandfatalprostatecancers,Willettsaidin2006duringasymposiumatMcGillUniversity.

Havescientistslearnedanythingsincethattimethatwouldchangehisview?(W)edonthaveanysubstantialnewdataonthistopic,hesaid.

DairyandFemaleCancers

Forwomen,whilethestudiesinbreastcanceraremixed,whatsparticularlytroublesomearestudieslinkingdairytoovariancancer,specificallythreelargestudiesshowinganassociationwithevensmallamounts.

InSweden,wheredairyproductconsumptionandovariancancerratesarehigh,researchersfollowedmorethan60,000womenoveranaverage131/2yearsandfoundthatcomparedtowomenwhoneverorseldomdrankmilk,womenwhoconsumedmorethan1glassofmilkadayhaddoubletheriskofaverycommonandaggressivetypeofovariancancertypicallynotfounduntillatestage.

Thoseresultswereconsistentwithtwoearlierstudies.

HarvardsNursesHealthStudy,anongoinglookatvariousissuesinwomenshealththatWilletthasbeenspearheading,foundthatwomenwhoconsumedoneglassormoreadayofskimorlowfatmilkhada69percentincreaseinthatsamedeadlyovariancancercomparedtowomenwhoalmostneverdrankmilk.Andcomparedtowomenwhoalmostneverateyogurt,womenwhoconsumedfiveormoreservingsaweekweremorethantwiceaslikelytodevelopthatcancer.

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AndtheIowaWomensHealthStudyofpostmenopausalwomenfoundthatthosewhodrankmorethan1glassofskimmilkadayhada73%greaterriskofovariancancerthanthosewhodranklessornoneofit.

Whiletheevidenceisnotasfirmorasrobustasitisforprostatecancerrisk,Willettsaidatthatsymposium,ithastomakeoneworriedaboutrecommendingthreeservingsofmilkaday,especiallysinceovariancancerissodeadly.

Isitthecalcium?

Scientistsarenttotallysurewhatmechanismsareatplay.

HighcalciumintakecandisturbyourproductionofVitaminD,thesunshinevitamin,which,inanimalandcellstudies,keepscancercellsfromproliferatingandhelpsthemreverttotheirnoncancerousstates.ThecurrentUSrecommendationsfordietarycalciummaybetoohigh,Willettsuggested.

Butcalciummightnotbetheortheonlyculprit.

TheSwedishandHarvardstudiesinwomenbothfoundanassociationwithlactose,ormilksugar.Foreach1011gramsoflactoseaday(equivalenttoaglassofmilk),therewasa20percentgreaterrisk.Onecomponentofthatsugar,moleculesofgalactose,maybeparticularlyharmfultoovaries.

Orisittheproteinssendingsignals?

AGermandermatologistwhohasfoundthatdairyproductsarelinkedtobothacneandprostatecancersaysthattheproblemismilksaminoacids.Milkproteinstriggeracascadeofsignalsthattellallcellstogrow.

Sustainedproliferationisthemostcriticalhallmarkofcancer.Thatiswhatmilkisdoing,aprogramofmammalianevolutionintendedtobeoperativeonlyinthepostnatalnursingperiodandnotforlifelongabuse!saidDr.BodoMelnik.

Everwonderwhybodybuildersflocktowheyproteinsupplementsafterworkouts?

Dairyproductscontaintwotypesofprotein:casein,abundantintheaminoacidmethionine,andwhey,richintheaminoacidleucine.

Leucinetriggersmusclegrowth.Ithelpsbuildmusclebydirectlyactivatingacompoundinmusclecalledthemammaliantargetofrapamycin(mTOR).Inconjunctionwithothercompounds,mTORfunctionsasamolecularswitch,ahubforcoordinatingthecomplexsignalingsysteminvolvedinsendingmessageswithincells.Leucineflipstheswitch,turningonthemachinerythattellsyourcells

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tomanufacturemuscleproteins.

Theproblemis:CancercellsalsotakeadvantageofthiscontinuallyopenswitchconstantmTORsignallinginordertokeepproliferating.

Casein,accordingtoT.ColinCampbellsdecadesofresearch(TheChinaStudy),hasdemonstratedaremarkableabilitytopromotecancergrowthintestanimalswhenconsumedinexcessofproteinneeds,andinanimalandcellstudies,dietaryrestrictionofmethionineinhibitsandreversestumorgrowth.

Bothproteins,Melniksays,stimulatetheproductionofhormonesthatindirectlyactivatemoremTORsignalinginsulinandInsulinGrowthFactor1(IGF1).Thesehormonesalsosendmessagesthatsignalcells,includingcancerousones,togrowandthatleadtoreductionsinyourSexHormoneBindingGlobulin,leavingestrogenandtestosteronetocirculateinyourblood.

HighlevelsofIGF1havebeenassociatedwithmanycancers,includingprostateandestrogenpositivebreastcancer.Cancersdrivenbyandrogens(yes,malehormonesbuttheyvebeenimplicatedinbreastandovariancancer)maybeparticularlysusceptibletodairy,Melniksuggests,becauseIGF1stimulatesaverypotentformoftestosteronethatactivatesmTORsignaling,andinwhatscientistscallcrosstalk,overactivemTORsignalingmaythendriveproductionofevenmoretestosterone.

Thefemalehormonesinmilkfrompregnantcowsmayalsoplayapart,hesays.

Hesparticularlyconcernedaboutdairyproductsduringpuberty.Duringthissensitivetimeperiod,thepituitaryglandisalreadysecretinglargeamountsofgrowthhormone,whichstimulatesthelivertoproduceIGF1.Inonestudy,dailymilkconsumptionduringadolescencemorethantripledtheriskofaggressiveprostatecancerlaterinlife.

(Leucinealsostimulatestheoilproducingglands,anddairyproductsduringpubertyhavealsobeenlinkedtoteenageacne.Anotherstudyfoundanassociationbetweenseverelonglastingacneandincreasedriskofprostatecancerlaterinlife.)

ToreadmoreaboutMelniksworkondairyandprostatecancer,seethisreviewandthisone.Forhisdietandacnework,seethisarticleandthisone.ForadiscussionofinsulinandIGF1,seethis.

Whataboutyourbones?

Dontweneedmilkforstrongbones?

Thatsamyth,Willettsaid.Everylargestudythathaslookedatthisissuehas



foundthatthereisnoreductioninfractureriskwithhigherdairyconsumption,veryconsistentfindings,allthewayuptoover4glassesofmilkaday,hetoldthesymposium.Hesjustpublishedastudyshowingthatmilkconsumptioninadolescencemayactuallyincreasefracturerisk.

Arealldairyproductscreatedequal?

TheUSgovernmenthasbeenurgingconsumerstoswitchfromfulltolowornonfatdairy,butifthecalciumorsugars/lactoseorproteins/aminoacidsaredrivingcancer,thenlowfatproductsarenotanybetterandperhapsevenworse.

Thefatcontentofmilkdoesntalteritslactosecontent.Infact,twopercent,lowandnonfatcowsmilkactuallyhavemoreleucineandmorecalciumthanwhole.Andsheepsmilkhasaroundtwiceasmuchleucineasbovinesecretions.

Sowhatsthedairyproductthatslowestinproteins?Butter.Itsvirtuallyallfat.(Buthighintakesofsaturatedanimalfatsmaybeassociatedwithsomecancers,sotreatitlikeBrylcreemalittledablldoya.)

Howmuchistoomuch?

Thatshardtosay,Willetttoldthesymposium.Withadults,probablyoneservingadayisthelevelwherewedontreallyseemuchevidenceofharm,hesaid.(W)estarttogetconcernedabouttwoorthreeservingsadaybecauseitlookslikethereissomestrongpotentialforharm,particularlyformenandmaybeforwomen.Forchildren,ofcourse,everythingismuchmorecomplicated,andwealsohavemuchlessdata..

Afterdiagnosis?

Talkaboutcomplicated!

Thefewstudiesondairyconsumptionaftercancerdiagnosissuggestthatwholebutnotlowfatproductsmaydriveprogression,althoughitsnotentirelyclear:

breastcancer:Highbutnotlowfatdairyrelatedtohigherriskofdying.breastcancer:Lowerintakeofsaturatedandtransfatslinkedtosurvival.prostatecancer:Wholemilklinkedtolethaldiseasebutlowfatdairyintakemaybeprotectiveintheauthorswords,asurprisingfindingthatshouldbeinterpretedwithcaution.

Itsoundslikethisproblemofwhattodoaboutdairyis(likethecurrentoceantestingpostFukushimaproject)justperfectforcrowdsourcingfunds.Shallwepoolourpennies?

Thebottomline,forusadults,fornow



Thankgoodnessforplantmilks!

WhenitcomestoIGF1,ofallfoodsdairyproductsappeartobethelargestcontributormoresothananimalmuscle.Incontrast,thehormoneissubstantiallylowerinpeopleonplantbaseddiets.PlantscontainlargeamountsofIGF1bindingproteins,andaccordingtoMelnik,manyhavecomponentsthatcannaturallyinhibitmTORsignaling

greenteacrucifersturmericwholesoyresveratrolandgetthiscaffeine.

(Metformin,adrugcommonlyusedtocontrolinsulinlevelsintype2diabetics,alsolowersmTORsignaling,hesays,butIllsavethatsuccessstoryforanotherday.)

Itlookslikemygutwasrightinrejectingcowsmilkwaybackwhen.Untilthesciencebecomesmorecertain,Illbepracticingtheprecautionaryprincipleofanticancerdietsandsippinganalmondmilklatteinthesunshine.Thanks,mom.Iwonttellanyoneelseaboutyourlittlemilkylie.

2014HarrietSugarMiller

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17THOUGHTSONANTICANCERDIETS:WHATSTHEDEALWITHDAIRY?

ThisentrywaspostedinDairyproducts,Drinks,FatsGoodandBadandtaggedanticancer,anticancerdiet,anticancerfoods,anticancerresources,cancer,canceranddiet,cancerandfood,cancerandnutrition,cancerdiet,cancerprevention,dairy,dairyproductsamdcancer,health,milkbyhsugarmill.Bookmarkthepermalink[http://eatandbeatcancer.com/2014/07/23/anticancerdietswhatsthedealwithdairy/].

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coacervateonJuly24,2014at4:01pmsaid:

Brilliant,thanks!

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hsugarmillonJuly25,2014at6:23amsaid:

Melnikresponds:TherearenewconvincingdatafromaGermaneconometricstudy(UniversityofFrankfurt)showingtherelationshipbetweenmilk/dairyconsumptionandmortalityratesofprostateandovariancancerin50countries.

Thearticle,inGerman,isathttp://www.econstor.eu/bitstream/10419/97324/1/786965215.pdf.Theabstract,inEnglish,isathttp://www.econstor.eu/handle/10419/97324.

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alThomasononJuly29,2014at12:38pmsaid:

Veryclearconclusionsforthelast30plusyearsbutwhataboutdairyinthefirstpartofthe20thcenturywithoutall



Pingback:What'stheDealwithDairy?byHarrietSugarMiller,freelancehealthjournalistTheAntiCancerClubBlog|TheAntiCancerClubBlog

thepesticidesetcbeingputintothefoodchain?Noneofmyrelativesthatlivedonthedairyoperationsofthe1920s,30s40or50sdiedduetocancersandeventheonesthatmovedawaytotownastheybecameadultshadthatcausemostlyoldage,asthebodyfinallytiredoutinlate80sand90s.HM.

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AnonymousonNovember21,2014at3:03amsaid:

TheGermanstudylooksinteresting,itsashameitisnotavailableinEnglish.Youdoagoodjobofthissummaryondairythanks.

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hsugarmillonNovember21,2014at7:46amsaid:

TheGermanstudiesareavailableinEnglish.Iidentifiedtheminthisparagraph.Justgototheparagraphinthearticleandclickonthelinks:

ToreadmoreaboutMelniksworkondairyandprostatecancer,seethisreviewandthisone.Forhisdietandacnework,seethisarticleandthisone.ForadiscussionofinsulinandIGF1,seethis.

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AnonymousonJuly26,2014at11:58amsaid:

Shockingcancerwithmilk

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AnonymousonJuly26,2014at1:10pmsaid:

Ifdairyproductscausedcancerorincreasetheriskofcancer,onewouldthinkpowerlifters,bodybuilders,professionalandamateurathleteswoulddisplayahigherincidentrateofcancerthanthegeneralpopulation.ImnottosureImthesciencebehindthisresearch.

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hsugarmillonJuly26,2014at1:17pmsaid:

Youraiseanimportantquestion.Arethosewheysupplementsincreasingcancerrisk?Isthereanygooddataonthat?Andhowdostudiescontrolfortheprotectiveeffectsofexercise?

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rdfeinmanonJuly26,2014at2:06pmsaid:

Myseriousanswertothisissimplyonecannotacceptanyconclusionsofthistypefromtheseresearcherswithoutaverycarefulanalysisoftheprimarydata.(Sometimesscientists)donotdistinguishbetweenstatisticallysignificantandclinicallyimportant,thatis,havingameaningful



effectsize.Frequently,theydonotdistinguishbetweenstatisticallysignificantandsimplecommonsense.IusuallycommentwithsomeironybecauseIfinditgenuinelydistressingtoseethiskindofcorruptionofscience.Areallthesestudieswrong?Nowaytotellwithoutgoingbacktotheoriginalreportandanalyzingcarefully.

commentedited

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hsugarmillonJuly26,2014at2:31pmsaid:

Thisquestionwhattodoaboutdairyneedsanswersnow.Untilthescienceissettled,Illbeadoptingtheprecautionaryprinciple,weighingtherisks(notjustthelikelihood,butthegravitytoo)andproceedingcautiously.Thepotentialconsequencesaregrave.

Thankyou,Dr.RichardFeinman,forcontributingtothediscussionandforyourenlighteningblog.http://feinmantheother.com/

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rdfeinmanonJuly27,2014at10:53amsaid:

Ididnotmeantobeoverlynegative.Itisveryimportantthatweexaminetheeffectofdietoncancerbutifwedoitinanonrigorousway,takingeverythingofftheshelf(ratherthanstartingfromfundamentalprinciples)andtestitandbesatisfiedwithanyrisknomatterhowsmall,wewillwindupwithmoreblindalleys



thanresults.Whatweknowisthatreducingcaloriesand/orreducingcarbohydrateisthemostreasonableapproachtocancertherapyrightnow.

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AnonymousonAugust3,2014at11:03pmsaid:

ThisisaloadofbullIhavedrankmilkfor53yearsanddonthaveanycancer.Itrytogownallmyownfood.Milkfromafarmisalotbetterthenfromthestores.Havetheyeverdidtestbetweenmilkfromafarmandstoremilk?

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AndyFarrellonJune11,2015at6:39pmsaid:

Ifthesestudiesofscoresofpeoplearebull,howisityourstudyof1personismorereliable?

IfyoumetsomeonewhosurvivedaplanecrashandarguedplanecrashesareperfectlysurvivablethereforesafebecauseIsurvived,youwouldlaugh.

Ourpersonalexperiencesarecertainlyinterestingbuttheyarenotverygoodindicatorsastowhatriskswemayhavedodgedorwhatbadbehaviourswevesimplybeenluckytonotexperiencetheconsequencesof.

Thewholepointofastudyistotryandeliminatesubjectivenessandfocusonwhathappenstomostofthepeoplemostofthetime.

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AdrienonAugust24,2014at4:01amsaid:

Hi,Couldyouprovidethesources(citations)forthelistoffoodsthatreduceIGF1byalteringmTorsignaling?Thanks.

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hsugarmillonAugust24,2014at7:17amsaid:

ThesourceisDr.Melniksarticlepublishedin2012inNutritionandMetabolism:http://www.nutritionandmetabolism.com/content/9/1/74%20

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Anti-Cancer Diets_ What’s the Deal With Dairy_ _ Eat and Beat Cancer