A N N U A L R E P O R T2 0 1 7 - 2 0 1 8

Dépôt légal : 1er trimestre 2019Bibliothèque nationale du Canada Bibliothèque nationale du Québec ISBN : 2-920803-48-4

A WORD FROM THE DIRECTOR 4

OVERVIEW OF BALSAC 5

NEWS 6

DEVELOPMENT ACTIVITIES 8

VALORIZATION AND OPERATING ACTIVITIES 10

ACCESS TO DATA AND PROTECTION OF PRIVACY 14

APPENDIX AONGOING RESEARCH PROJECTS 16

GENETIC EPIDEMIOLOGY 16

EVOLUTIONARY BIOLOGY AND BIODEMOGRAPHY 18

SOCIAL SCIENCES 19

METHODOLOGICAL DEVELOPMENTS 21

APPENDIX BLIST OF DISSEMINATION ACTIVITIES 24

ARTICLES AND COMMUNICATION PAPERS 24

COMMUNICATIONS 24

THESES, DISSERTATIONS AND WORKING PAPERS 27

Table of contents

4

retirement, which we hope will be long, peaceful and pro-

ductive. Two employees left to join the staff at UQAC. This

includes Ève-Marie Lavoie, who spent almost 20 years with

BALSAC, first as a graduate student, then as a research pro-

fessional. We wish them success in their new endeavours.

In the midst of these changes, we welcomed new team

members: James McGrath in IT and Gabrielle Rouleau in

data management. We are now ready to begin our next

stage of development!

I will conclude by thanking Simon Girard, professor in

Bioinformatics at UQAC, who took over leadership of BAL-

SAC during my sabbatical. He notably organized a panel

on BALSAC during the ACFAS conference at UQAC last

May. This conference, which got nice visibility in the me-

dia, was a chance to reflect on the past, present and future

of BALSAC. This was a timely exercise as the database will

celebrate its 50th anniversary in a few years.

It is with great pleasure that I present the 2017-18 BAL-

SAC Report. It was a year marked by transition. First and

foremost, we completed the integrated infrastructure for

historical microdata of the Quebec population (IMPQ), a

project launched in 2013. The portal is now in operation,

and the number of requests so far exceeds all our expec-

tations.

We also received approval from the Canada Foundation

for Innovation last spring for our project titled i-BALSAC:

A Multisectoral Infrastructure for High-Resolution Mapping

of the French-Canadian Population. This project was sub-

mitted in fall 2018 under the Cyberinfrastructure Initiative

and, as its title infers, will allow us to explore the Quebec

population under multiple angles simultaneously. Our

multidisciplinary team of demographers, historians, gene-

ticists and geographers will develop, build and populate

this research infrastructure that will regroup genealogical,

genetic and geographic data over three centuries. I am

very enthusiastic to tackle this structuring project with a

dynamic new team.

Transition was also manifest in team turnover. With the

completion of the IMPQ, two linkage technicians ended

their mandate. Jacinthe Sabourin, who had been with

BALSAC for 25 years, took the opportunity to begin her

A Word from the Director

4 5

The BALSAC database has been in development since

1971 at Université du Québec à Chicoutimi, in partnership

with Université Laval, McGill University and Université de

Montréal. The database is comprised of digitized Qué-

bec vital event records, interconnected using a linkage

method based on nominative information allowing for

the automatic recreation of genealogies and kinship

structures in the Quebec population over four centuries.

BALSAC covers the entire Quebec territory from the be-

ginning of European settlement in the 17th century to the

contemporary period.

To this day, 2.9 million records have been digitized, inclu-

ding all Catholic marriage records (and partial records for

other denominations) from 1621 to 1965. For the Sague-

nay-Lac-St-Jean region, the database also includes birth

and death records from 1838 to 1971. It is now possible

to include virtual records, or data from sources other than

vital events records. Since late 2014, over 45,000 virtual

records have been entered, a third of them for events that

occurred after 1965.

BALSAC is a remarkable piece of Quebec’s scientific heri-

tage. The data is used by researchers in Quebec, Canada

and abroad who are interested in population genetics, ge-

netic epidemiology, demography, geography, sociology

and history.

Overview of BALSAC

To fulfill its mission, the BALSAC team is composed of re-

search professionals, linkage technicians, IT technicians,

support staff and students.

The BALSAC Project can now count on the advice of an In-

terinstitutional Steering Committee to discuss the high-le-

vel direction of the project, guide leadership on deve-

lopment priorities and support activities to exploit and

valorize the database.

Here are the members of the ISC:

• BERNARD BRAIS, Professor of Human Genetics at McGill University and neurogeneticist at the Montreal Neurological Institute.

• DAMIAN LABUDA, Professor in the Department of Pediatrics at the Université de Montréal and researcher at the Research Center of the CHU Ste-Justine.

• MARC ST-HILAIRE, Professor in the Department of Geography at Université Laval and Director of CIEQ Université Laval.

• HÉLÈNE VÉZINA, Professor in the Department of Human Sciences at the Université du Québec à Chicoutimi and Director of BALSAC Project.

6

News

On Track…The BALSAC team is thrilled to announce funding was

approved last March by the Canadian Foundation for In-

novation (CFI) under the Cyberinfrastructure Initiative.

Supported by a multidisciplinary team of ten researchers,

the project titled i-BALSAC: Multisectoral Infrastructure for

High-Resolution Mapping of the French-Canadian Popula-

tion has for objective to develop and implement a multi-

sectoral platform for cutting edge research in biological

and social sciences.

The project centers on the integration of genealogical,

genetic and geographic data, as well as the development

of analytical, statistical and mapping tools to optimize its

exploration. Building i-BALSAC will make it possible to

achieve high-resolution mapping of the French-Canadian

population in an approach that is at once genomic, genea-

logical and geographic to provide a historical overview

over four centuries. The idea is particularly well suited to

the French-Canadian population, due to the particularities

of its formation, the resulting genetic structure and the ex-

ceptional quality of its genealogical data. Ultimately, i-BAL-

SAC will become a laboratory for population studies and

a space for researchers to tackle complex questions and

conduct innovative multidisciplinary projects. Researchers

in both social and health sciences will benefit from this

new research infrastructure, which is entirely original and

perhaps even unique in the world.

The creation of i-BALSAC will respond to three different

needs: to integrate genealogical and genetic data in a

formal and sustainable structure, to extend the period for

which we can exhaustively reconstruct the Quebec popu-

lation up to the 20th century, and to create a framework to

analyze and interpret the spatial dimensions of genealo-

gical and genetic data. In this optic, i-BALSAC aims to be-

come an international reference by providing a complete

overview of the French-Canadian population. It will enable

Quebec and Canada to consolidate their expertise in the

development and exploitation of population databases

and maintain their leadership in a highly competitive field

where large-scale projects are already ongoing in the aca-

demic and private spheres.

The BALSAC population database, which received funding

from the CFI three times in the last 15 years, will be the

core of this infrastructure that is the continuation of the

partnerships with the Centre interuniversitaire d’études

québécoises (CIEQ), Programme de recherche en démo-

graphie historique (PRDH) and the CARTaGENE project.

The project relies on the participation of researchers who,

by their education, expertise and achievements, will be

able to best respond to the needs of the scientific com-

munity. They will be supported by the professional staff

of the stakeholder organizations already associated in the

project. The project has five objectives, which include the

integration of genealogical, genetic and geographic data,

the creation of analytical tools and a historical geogra-

phic information system, and finally the development of

the database and access portal. The management plan for

i-BALSAC depends on the experience acquired by project

partners managing and exploiting research infrastructures.

To increase usage, access to the data will be free through a

Web portal, and only limited by the confidential nature of

some of the data.

6 7

The creation of i-BALSAC will have many concrete bene-

fits. First, the preservation, valorisation and development

of a wealth of exceptional scientific, historical and biologi-

cal data in a structure unique in the world. It will also open

new perspectives to understand the evolution of structural

social factors in Quebec and Canada and the relationships

between their cultural and social groups. In the health sec-

tor, i-BALSAC will provide Canadians with data and tools

to study genetic determinants of health and contribute to

projects aimed at identifying genetic variations associated

with complex diseases along with strategies to treat, dia-

gnose and prevent them.

The project is scheduled to launch in January 2019 and

will occupy a big part of our time in the next three years.

We will report on the next steps in our future reports and

on our website.

8

Development Activities

Official Launch of the IMPQ We are also proud to present the final version of the inte-

grated infrastructure for historical microdata of the Que-

bec population (IMPQ), which began in 2013. Recall that

this ambitious project, also funded by the CFI, combined

the expertise of the Centre interuniversitaire d’études qué-

bécoises (CIEQ), the Research Programme in Historical

Demography (PRDH) and BALSAC to create an integrated

database of all serial microdata from the Quebec civil re-

cords between 1621 and 1917 and the Canadian census

from 1852 to 1911.

Data from the IMPQ are now accessible to researchers via

an online portal here: www.impq.cieq.ca. Development

and implementation are the responsibility of the Universi-

té du Québec à Trois-Rivières. The portal enables the free,

but also secure, exchange of data and linkages. A private

and secure network between partners (www.risq.qc.ca) al-

lows for the regular synchronization of data as well as qui-

ck and secure transfers of data. Researchers can therefore

access genealogical information on the Quebec popula-

tion over three and a half centuries and the demographic

history of individuals and families over almost 250 years

(1621-1849).

Quebec Allele Frequency Database Simon Girard, Professor in the UQAC Department of Basic

Sciences, received funding last March from the Network of

Applied Medical Genetics (RMGA) to develop the second

phase of the allele frequency database for the French-Ca-

nadian population (BDFAQ). We plan to build an interface

to connect the BDFAQ and BALSAC. It is an essential up-

date given the research potential that lies in the combi-

nation of genealogical and genomic data. It is even more

pertinent given the CFI funding for i-BALSAC, making the

BDFAQ a very interesting research resource that will bene-

fit from an ever-growing genomic database. This tool will

be made available soon to researchers in genetics to en-

able them to better parameter studies on the French-Cana-

dian population and maximize discoveries and outcomes.

8 9

Technological Developments Though our activities are mainly focused on specific pro-

jects, a significant part of our time and efforts are directed

to maintaining and upgrading BALSAC. Behind the sce-

nes, there are still some technological artifacts from pre-

vious stages of development. While they are still functional

and useful, we have prioritized this upgrade considering

the progressive implementation of i-BALSAC and in anti-

cipation of more important user volume. We try to follow

the pace of technology by optimizing the tools at our dis-

posal, and by developing a more modular infrastructure to

include new tools and diversify our activities in the future.

We cannot fail to mention the support provided by the

UQAC IT department (STI), who are responsible for most

of the maintenance of the physical BALSAC infrastructure.

The collaboration between STI and BALSAC will make it

possible to adapt some of the progress accomplished for

BALSAC to fill needs in other areas and benefit the whole

academic community.

10

Valorization and Operating Activities

Research ProjectsThe 45 projects active in 2017-2018 were in three broad

fields of research (see table below) that each account for

about a third of projects. The fourth field includes five me-

thodological projects, including the construction of the

IMPQ. The complete list of research projects can be found

in Appendix A, at page 16.

A third of the researchers are affiliated with partner uni-

versities, namely McGill, Laval and UdeM. The number of

requests from foreign researchers has been steady in the

past few years and revolves around 19-20%, which shows a

real interest for BALSAC data abroad. Foreign researchers

are mainly in human and social sciences, while projects in

Quebec tend to be in genetics. The size of research teams

is evident in the second figure, where we can see a strong

concentration in partner universities. The list of publica-

tions and communications by researchers who use BAL-

SAC data can be found in Appendix B, at page 24.

Networking and CollaborationsQuebec Network of Applied Medical Genetics

As part of the Strategic Grouping for Population Gene-

tics of the Quebec Network of Applied Medical Genetics

(RMGA) and to support researchers in theoretical and

applied genetics, BALSAC offers researchers access to

genealogical data that can be analyzed alongside gene-

tic data. These anonymized records cover eight regional

populations in Quebec and are available on the Quebec

Reference Sample: Population Genetics and Genetic Epi-

demiology in Quebec website: www.quebecgenpop.ca

Remember that Hélène Vézina and Simon Girard are,

along with Simon Gravel from McGill University, jointly res-

ponsible for the Population Genetics Strategic Group. The

direction of this group was reviewed in 2018 and the name

THIS SECTION COVERS USAGE OF THE BAL-

SAC DATABASE IN THE LAST YEAR, AS WELL

AS AN OVERVIEW OF THE ACTIVITIES TO PRO-

MOTE THE FILE TO CURRENT AND POTENTIAL

USERS AND BUILD CONNECTIONS WITH THE

NATIONAL AND INTERNATIONAL SCIENTIFIC

COMMUNITY. WHETHER THROUGH COMMU-

NICATIONS, PUBLICATIONS, COLLABORATIONS

OR INFORMAL MEETINGS, BALSAC MANAGE-

MENT IS COMMITTED TO NETWORKING AND

PROMOTING THE DATABASE. THE VISIBILITY

AND IMPORTANCE OF BALSAC HAVE A DIRECT

IMPACT ON THE PROFILE OF THE IMPQ AND

OTHER ONGOING PARTNERSHIPS.

10 11

was changed to Genomic Resources Sharing and Valorisa-

tion to better reflect the new orientation.

Nouveaux regards… Project

From 2016 to 2018, BALSAC partnered in the project Nou-

veaux regards sur l’occupation du continent nord-améri-

cain par la population canadienne-française, 1760-1914

led by Yves Frenette from Université de Saint-Boniface and

funded by the Social Sciences and Humanities Research

Council as part of its Partnership Development Grants.

The project made use of the program that connected cen-

sus and civil records in BALSAC to link French-Canadians

found in American census data. The project ended with a

working session in Winnipeg in June, in which Hélène Vé-

zina and Jean-Sébastien Bournival participated.

BALSAC pursues this collaboration for the project Trois

siècles de migrations francophones en Amérique du Nord,

1640-1940, which has been submitted to SSHRC for fun-

ding. The letter submitted in February 2018 received a fa-

vorable response in June, and the full application was sub-

USERSAFFILIATION

mitted in October. This partnership is an opportunity for

BALSAC to consolidate its relationship with Université de

Saint-Boniface through the Canada Research Chair held by

Yves Frenette (Migrations, transferts et communautés fran-

cophones) as well as the Centre interuniversitaire d’études

québécoises where many BALSAC users works.

Other Collaborations

As part of the research services we offer, we sometimes get

requests that are not directly related to research projects

but are still pertinent and offer interesting opportunities

for collaboration. In the last two years, we have responded

positively to the following requests:

• Linked data set containing Quebec City censuses and

vital events up to 1917 to Marc St-Hilaire from the CIEQ

at the Laval University.

Outreach

Knowledge and skill sharing outside of academia is very

important to the BALSAC team. Interventions in the media

12

Finally, during Heritage Week in February, the Société his-

torique du Saguenay and the city of Saguenay invited ci-

tizens and the academic community to the launch of the

first 2018 issue of Saguenayensia magazine. Members

of the BALSAC team contributed to the issue: Eve-Marie

Lavoie and Gabrielle Rouleau presented some studies

conducted using BALSAC data on the geographic origin

of founding ancestors and the genetic heritage of regional

Quebec populations.

on trending news or scientific topics help increase the visi-

bility of BALSAC and the various studies conducted using

the data.

The most important media event this year was undoub-

tedly our conference Le fichier BALSAC, d’hier à demain,

presented during the ACFAS last May. The main objective

of the conference was to gauge the interest in population

data in various areas of research and promote a forward-

looking vision of the science based on current and future

data. Researchers from many disciplines, some from as far

as Europe, participated and exchanged on the needs of

the scientific community in terms of data, methods and

accessibility. The program of the conference is available

on the ACFAS website. The meeting also provided an op-

portunity to celebrate the contribution of Damian Labuda,

pioneer researcher in multidisciplinary genetic and genea-

logical science.

Another conference was also organised to honor the work

of Gérard Bouchard and his considerable contribution

to social science. Seven broad themes emerged: social

population history; the origin of New World cultures and

nations; structures of social thought; collective myths and

imagination; human genetic, genetic demographics, and

population history; interculturalism and the Bouchard-Tay-

lor Commission; and novels as an extension of academic

work. Over a dozen panelists presented over the two days

of the conference last September. See the website for de-

tails.

12 13

LIST OF THE COMMUNICATIONS THAT HAVE HELPED PROMOTE BALSAC

TO VARIOUS AUDIENCES AND PLATFORMS

ACFAS :

• Interview with Gérard Bouchard, Hélène Vézina and Simon Girard about the BALSAC database on the show Style Libre

on Ici Première - Radio-Canada.

• Interviews with Sophie Desportes on the important contribution of Filles du roi to the genetic heritage of the Quebec

population on Radio-Canada, in print in Le Devoir and Journal de Québec, and on the show L’œuf ou la Poule.

Le Temps :

• Coverage in the Swiss journal Le Temps for a study by Laurent Excoffier published in Genetics explaining the higher

frequency of genetic diseases in Quebec, notably in Saguenay—Lac-Saint-Jean.

14

Access to Data and Protection of Privacy

Université du Québec à Chicoutimi is responsible for ma-

naging access to the BALSAC database and preserving the

confidentiality of the personal information it contains. The

Committee for the Protection of Privacy and Access to Data

(CPAD) was established by the UQAC Board of Directors to

apply the Policy on Access to BALSAC Data for Research Pur-

poses. The Steering Committee was also mandated by the

UQAC Board of Directors to evaluate requests for access to

non-confidential data.

Report from the BALSAC Steering Committee

During the last year, the Steering Committee was conve-

ned about thirty times to discuss issues related to data

access and protection of personal information. Three (3)

requests for access to non-confidential data and ten (11)

requests for extensions were submitted to the Committee.

Report from the Committee for the Protection of Privacy and

Access to Data

This section of the BALSAC Annual Report serves as the offi-

cial summary of the CPAD’s activities to the UQAC Board of

Directors.

For 2017-2018, the Committee has been asked to evaluate

the admissibility of two (2) requests for access to confidential

data.

COMMITTEE MEMBERSCOMMITTEE MEMBERSHIP HAS CHANGED SINCE

THE DEPARTURE OF MS. CHRISTINE DROLET, WHO

WAS A MEMBER OF THE COMMUNITY SERVED BY

THE UNIVERSITY BUT NOT DIRECTLY AFFILIATED

WITH IT. MS. CHRISTINE GAGNON NOW HOLDS THIS

POSITION. HERE IS THE NEW COMPOSITION OF THE

COMMITTEE:

• MARC TREMBLAY,

PROFESSOR, HUMAN SCIENCES, UQAC;

• CLAUDE THIBEAULT,

RESEARCH ETHICS BOARD COORDINATOR,

UQAC;

• CATHERINE LAPRISE,

PROFESSOR, BASIC SCIENCES, UQAC;

• CHRISTINE GAGNON,

HEAD OF INSTITUTIONAL SUITABILITY,

INTEGRATED HEALTH AND SOCIAL SERVICES

CENTER (CISSS) SAGUENAY—LAC-SAINT-JEAN;

• JEAN-SÉBASTIEN BOURNIVAL,

RESEARCH PROFESSIONAL, BALSAC PROJECT.

14

Appendix AOngoing

Research Projects

16

Appendix A Ongoing Research Projects

Genetic Epidemiology Study on Genetic Predisposition to Multiple Sclerosis in Quebec BRAIS Bernard Montreal Neurological Institute & Hospital / McGill UniversityST-HILAIRE Marc Université LavalDUBÉ Marie-Pierre Université de Montréal

Demographic and Genealogical Study of Leber’s Hereditary Optic Neuropathy BRAIS Bernard Montreal Neurological Institute & Hospital / McGill UniversityDESJARDINS Bertrand Université de MontréalTREMBLAY Marc Université du Québec à ChicoutimiST-HILAIRE Marc Université LavalVÉZINA Hélène Université du Québec à Chicoutimi Genetic Characterization of Hereditary Spinocerebellar Ataxias: Genealogical Component BRAIS Bernard Montreal Neurological Institute & Hospital / McGill UniversityST-HILAIRE Marc Université LavalDESJARDINS Bertrand Université de MontréalTREMBLAY Marc Université du Québec à ChicoutimiVÉZINA Hélène Université du Québec à Chicoutimi Genealogical Study of Oculopharyngeal Muscular Dystrophy BRAIS Bernard Montreal Neurological Institute & Hospital / McGill UniversityDESJARDINS Bertrand Université de MontréalVÉZINA Hélène Université du Québec à ChicoutimiST-HILAIRE Marc Université LavalTREMBLAY Marc Université du Québec à Chicoutimi Study of the Introduction of Hereditary Sensory and Autonomic Neuropathy Type 2 (HSAN 2) Mutations in Quebec and Sensitive Modifications in Heterozygous CarriersBRAIS Bernard Montreal Neurological Institute & Hospital / McGill UniversityST-HILAIRE Marc Université LavalVÉZINA Hélène Université du Québec à ChicoutimiTREMBLAY Marc Université du Québec à Chicoutimi Research on Genetic and Other Factors Associated with Hypertension HAMET Pavel CHUM Hôtel-Dieu

16 17

Study on the Genetic Determinants of Asthma in Saguenay—Lac-Saint-JeanLAPRISE Catherine Université du Québec à ChicoutimiVÉZINA Hélène Université du Québec à ChicoutimiLABUDA Damian Université de MontréalROY-GAGNON Marie-Hélène CHU-Ste Justine The Polygenic Nature of Open-Angle GlaucomaRAYMOND Vincent Université Laval Analysis of the Effects Associated with Parental Transmission of Familial Hypercholesterolemia and the Demo-Genetic Determinants of the Distribution of Various Mutations and Intolerance to Statins COUTURE Patrick Université LavalGAUDET Daniel CSSS-ChicoutimiBRISSON Diane CSSS-ChicoutimiTREMBLAY Marc Université du Québec à Chicoutimi Congenital Heart Defects: Towards a Full Genomic AnalysisANDELFINGER Gregor U. Cardiologist, CHU-Ste JustineDUBÉ Marie-Pierre Université de Montréal Retrospective Study of the Clinical and Paraclinical Parameters of Patients Presenting Catecholamine-Secreting Tumours at CHUM (Adrenal Paraganglioma Pheochromocytoma and Ganglioneuroma)BOURDEAU Isabelle CRCHUM-Hôtel-DieuGRUNENWALD Solange CRCHUM-Hôtel-DieuVÉZINA Hélène Université du Québec à ChicoutimiBINET Marie-Claire Médecine génique CHUM

Towards Optimal Use of Genealogical Resources for the Quebec Population in Genetic Epidemiology ROY-GAGNON Marie-Hélène Ottawa UniversityLABUDA Damian Université de MontréalVÉZINA Hélène Université du Québec à Chicoutimi

Biobank on Cancer Risk Factors: Genealogical DataSIMARD Jacques CHUL

Personalized Medicine for Epilepsy: Genealogical ComponentGIRARD Simon McGill UniversityCOSSETTE Patrick CHUM - Hôpital Notre-Dame

18

Evolutionary Biology and BiodemographyDemo-Genetic Characterization of Regional Quebec PopulationsTREMBLAY Marc Université du Québec à ChicoutimiVÉZINA Hélène Université du Québec à ChicoutimiDESJARDINS Bertrand Université de MontréalROY-GAGNON Marie-Hélène CHU - Ste-Justine Genetic and Demographic Ramifications of the Founder Effect in QuebecBHÉRER Claude Université de Montréal Demo-Genetic Portrait of the Quebec PopulationVÉZINA Hélène Université du Québec à ChicoutimiTREMBLAY Marc Université du Québec à Chicoutimi Analysis of the Genealogical Characteristics of CARTaGENE Project ParticipantsTREMBLAY Marc Université du Québec à Chicoutimi

Study of Genetic Surfing in the Populations of Charlevoix and Saguenay—Lac-Saint-JeanLABUDA Damian Université de MontréalVÉZINA Hélène Université du Québec à ChicoutimiEXCOFFIER Laurent Université de Berne, Switzerland Reference Group in Genetic Epidemiology and Human Population Genetics in Quebec VÉZINA Hélène Université du Québec à ChicoutimiLABUDA Damian Université de MontréalTREMBLAY Marc Université du Québec à ChicoutimiROY-GAGNON Marie-Hélène CHU - Ste JustineEXCOFFIER Laurent Université de Berne, Switzerland Fecundity and Human EvolutionGALOR Oded Brown University, United StatesKLEMP Marc Brown University, United States Test of the Accumulation of Deleterious Mutations during Spatial Expansion by Exome Sequencing EXCOFFIER Laurent Université de Berne, SwitzerlandDUPERRET Isabelle Université de Berne, SwitzerlandFOUCAL Adrien Université de Berne, Switzerland

18 19

Demographic and Genetic Contribution of “Filles du Roy” to the Contemporary Quebec PopulationDESPORTES Sophie Université du Québec à Chicoutimi

Founding Mutations in the Quebec PopulationGRAVEL Simon McGill UniversityLABUDA Damian Université de Montréal

Intergenerational Dynamics in the Population of Quebec and its RegionsTREMBLAY Marc Université du Québec à Chicoutimi

Dynamics of Sex-Linked Genes in the Quebec PopulationDOYON Alexandra Université du Québec à Trois-Rivières

Genealogical Study of Genetic Diseases in the Quebec PopulationGRAVEL Simon McGill University

Demo-Genetic Study of Urban and Regional Populations in Quebec from 1851 to 1911 Census DataVÉZINA Hélène Université du Québec à ChicoutimiTREMBLAY Marc Université du Québec à Chicoutimi

Social SciencesSpatial Occupation in QuebecST-HILAIRE Marc Université Laval Sociohistorical Study of the Kinship of Doctors in Quebec from the French Regime to World War IIBRAIS Bernard Montreal Neurological Institute & Hospital / McGill UniversityGOULET Denis Université du Québec à Trois-Rivières Historical International Social Mobility Analysis (HISMA): International Comparison of Mobility Patterns During the 19th and 20th CenturiesMAAS Ineke Utrecht University, NetherlandsVAN LEEUWEN Marco Utrecht University, NetherlandsVÉZINA Hélène Université du Québec à Chicoutimi

20

EurAmerica: Comparative Research on the Micro Demography of 20th Century Europe and AmericaVÉZINA Hélène Université du Québec à ChicoutimiGAGNON Alain Université de MontréalGAUVREAU Danielle Concordia University Influence of Sibling on Access to Marriage: Comparative Study of Quebec and BelgiumCARON Marianne Université de MontréalDILLON Lisa Université de MontréalGAGNON Alain Université de MontréalMATTHIS Koenraad Center for Sociological Research, Family and Population, BelgiumNEYRINCK Ward Center for Sociological Research, Family and Population, BelgiumDESJARDINS Bertrand Université de Montréal Diversity and DevelopmentKLEMP Marc Brown University, United StatesGALOR Oded Brown University, United States

Montréal l’avenir du passé (MAP)OLSON Sherry McGill University

Economic Maturity and Family Dynamics: Evolution of Household Models in the Context of Industrialization and Urbanization in Haut-SaguenayBOURNIVAL Jean-Sébastien Université Laval

Kinship and Capital in Quebec, 1901ST-HILAIRE Marc Université Laval

French-Canadian Trajectories, 1830-1940ST-HILAIRE Marc Université Laval

Status Transmission Within Extended Family LineagesCLARK Gregory University of California, United States

Searching for French-Canadian Builders who Worked on the Saint Paul Capitol (Minnesota) 1895-1905FRENETTE Yves Université de Saint-BonifaceHARTON Marie-Eve Université de Saint-BonifaceWILLIS John Canadian Museum of History

20 21

Methodological DevelopmentsIntegrated Infrastructure for Historical Microdata of the Quebec Population (1621-1965) (IMPQ)VÉZINA Hélène Université du Québec à ChicoutimiTREMBLAY Marc Université du Québec à ChicoutimiLABUDA Damian Université de MontréalDILLON Lisa Université de MontréalGAGNON Alain Université de MontréalDESJARDINS Bertrand Université de MontréalGAUVREAU Danielle Concordia UniversityST-HILAIRE Marc Université LavalMARCOUX Richard Université LavalBELLAVANCE Claude Université du Québec à Trois-RivièresNORMAND France Université du Québec à Trois-Rivières Spatio-Temporal Genealogical ModelsBOUCHARD-CÔTÉ Alexandre University of British ColumbiaKIRKPATRICK Bonnie University of British Columbia Preliminary Operations to Link BALSAC with the Registre de population du Québec ancien (RPQA) to Create an Integrated DatabaseDESJARDINS Bertrand Université de Montréal

Pairing of a Sample from the 1871 Canadian Census to the 1881 CensusDILLON Lisa Université de Montréal

BALSAC, a Tool to Track Francophones Outside Quebec in Quebec GenealogiesVÉZINA Hélène Université du Québec à Chicoutimi

Appendix BList of

Dissemination Activities

24

Articles and Communication PapersDillon L, Dribe M, Engelhardt S, Gagnon A, Hanson HA, Quaranta L, Smith KR, and Vézina H. “Helpful Grandmothers and High Fertility: Testing Evolutionary Theories on Historical Demographic Data in Scandinavia and North America”, in Oskar Burger, Rebecca Sear and Ronald Lee (Eds.), Human Evolutionary Demography, Open Book Publishers, (accepted).

Peischl S, Dupanloup I, Foucal A, Jomphe, M, Bruat V, Grenier JC, Gouy A, Gilbert KJ, Gbeha E, Bosshard L, Hip-Ki E, Agbessi M, Hodgkinson A, Vézina H, Awadalla P, Excoffier L (2018). Relaxed Selection During a Recent Human Expansion. Genetics, vol. 208, 763-777. https://doi.org/10.1534/genetics.117.300551

Rouleau G, Tremblay M (2017). Les origines des ancêtres fondateurs de la RMR de Saguenay. Saguenayensia, 58-3:11-15.

Tremblay M (2017). The Measurement of Ancestral Roots with Genealogical Data. Historical Methods: A Journal of Quantitative and Interdisciplinary History, 50-4:210-217.

Vézina H, Jomphe M, Lavoie EM, Bournival JS (2018). Le fichier BALSAC et la démogénétique : des outils pour comprendre le patrimoine génétique des populations régionales du Québec. Saguenayensia. La revue d’histoire du Saguenay—Lac-Saint-Jean 58-3 : 16-21

CommunicationsBhérer C (2018). Généalogie et génomique de l’effet fondateur québécois. Conference “Explorer le social. Au passé et au présent, du biologique au symbolique” organized to honor the work of Gérard Bouchard, Chicoutimi, September 28-29.

Bournival J-S, Harton M-E, Vézina H (2018). Identification des parcours transfrontaliers: le jumelage des recensements américains (1880 et 1910) au fichier BALSAC. Sessions from the Partenariat sur les déploiements canadiens-français en Amérique du Nord (1760-1914). Saint-Boniface, June 20-21.

Desportes S (2018). La contribution démographique et génétique des Filles du roi à la population québécoise contemporaine. 86th ACFAS Conference, Chicoutimi, May 7-11.

Dillon L, Dribe M, Engelhardt S, Gagnon A, Hanson H A, Quaranta L, Smith KR, Vézina H (2017). Helpful Grandmothers and High Fertility: Testing Evolutionary Theories on Historical Demographic Data in Scandinavia and North America. IUSSP Conference, Cape Town, November.

Appendix BList of Dissemination Activities

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Frenette Y, Willis J (2018). Les ouvriers canadiens-français du Capitole du Minnesota (1895-1905), http://deploiements-francophones.ustboniface.ca/resultats/

Frenette Y, Harton M-E, Gauvreau D (2018). Les migrants canadiens-français en Nouvelle-Angleterre: la première décennie du 20e siècle, Session “Déploiements canadiens-français en Amérique du Nord (1760-1914): Bilan, synthèse et prospectives”, Université de Saint-Boniface, June 20-21.

Frenette Y, Roberts E, Harton M-E (2018). À la recherche des ouvriers canadiens-français de la construction du Capitole de Saint Paul (Minnesota), 1895-1905, Session “Déploiements canadiens-français en Amérique du Nord (1760-1914): Bilan, synthèse et prospectives”, Université de Saint-Boniface, June 20-21.

Gauvreau D (2018). BALSAC, le Saguenay et l’histoire de la population québécoise. Conference “Explorer le social. Au passé et au présent, du biologique au symbolique” organized to honor the work of Gérard Bouchard, Chicoutimi, September 28-29.

Harding T, Lefebvre J-F, Moreau C, Bournival J-S, Lalueza-Fox C, Loewen B, Vézina H, Casals F, Ribot I, Milot E and Labuda D (2018). Identification de restes humains du Québec ancien à l’aide de données génétiques et généalogiques. 86th ACFAS Conference, Chicoutimi, May 7-11.

Harding T, Lefebvre J-F, Moreau C, Bournival J-S, Lalueza-Fox C, Loewen B, Vézina H, Casals F, Ribot I, Milot E and Labuda D (2018). Human Remains Identification Using Extensive Quebec Genealogical Archives and DNA Typing Through an Automatic Bioinformatics Pipeline. 63rd Annual Conference of the Canadian Society of Forensic Science, Gatineau, Canada, May.

Harton M-E, Bournival J-S, Vézina H (2018). Partir pour les «États» : une affaire de famille et de parenté. L’apport du jumelage des données de recensements américains au fichier BALSAC. Conference “Le fichier BALSAC, d’hier à demain”, 86th ACFAS Conference, Chicoutimi, May 7-11.

Labuda D, Lefebvre J-F, Moreau C, Milot E, Vézina H (2018). BALSAC – histoire des lignages maternels et paternels de la population du Québec. Conference “Le fichier BALSAC, d’hier à demain”, 86th ACFAS Conference, Chicoutimi, May 7-11.

Labuda D, Lefebvre J-F, Moreau C, Harding T, Milot E, Vézina H (2018). Lignages maternels et paternels de la population du Québec. Genetics Days of the Network of Applied Medical Genetics (RMGA), Montreal, May 1-2.

Saint-Hilaire M (2018). Du Saguenay à l’Amérique : BALSAC et l’histoire sociale nord-américaine. Conference “Explorer le social. Au passé et au présent, du biologique au symbolique” organized to honor the work of Gérard Bouchard, Chicoutimi, September 28-29.

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Tremblay M (2018). Analyse des descendances des ancêtres franco-américains dans les régions du Québec. Session “Déploiements canadiens-français en Amérique du Nord (1760-1914): Bilan, synthèse et prospectives”, Université de Saint-Boniface, Winnipeg, June 20-21.

Tremblay M (2018). Apparentement intrarégional et interrégional dans les RMR du Québec. Conference of the Association des démographes du Québec, Centre Urbanisation-Culture-Société-INRS, Montreal, May 14-15.

Tremblay M, Rouleau G, Lavoie E-M (2018). Patrimoine et matrimoine: une partie de l’héritage «culturo-génétique» québécois révélé à l’aide de données généalogiques. Conference “Le fichier BALSAC, d’hier à demain”, 86th ACFAS Conference, Chicoutimi, May 7-11.

Vézina H (2018). BALSAC, un outil pour l’étude des migrations canadiennes-françaises en Amérique du Nord. Session “Déploiements canadiens-français en Amérique du Nord (1760-1914): Bilan, synthèse et prospectives”, Université de Saint-Boniface, Winnipeg, June 20-21.

Vézina H (2018). BALSAC au carrefour des études généalogiques et génétiques sur la population québécoise. Presented at the conference “Sur la piste de nos gènes” organised by the Société généalogique canadienne-française on its 75th anniversary. Montreal, June 1-3.

Vézina H (2018). BALSAC, un outil pour l’étude des migrations canadiennes-françaises en Amérique du Nord. Meeting of the Association des démographes du Québec. Montreal, May 14-15.

Vézina H (2018). L’Infrastructure intégrée des microdonnées historiques de la population québécoise : une ressource pour le jumelage et l’analyse des données d’état civil et de recensement. Conference “Sciences des données et sciences sociales : regards croisés”, 86th ACFAS Conference, Chicoutimi, May 7-11.

Vézina H (2017). BALSAC: An Infrastructure at the Crossroads of Biological and Social Research. Paper presented in the session The Development of Major Databases and their Results from the Beginning Till Now at the 42th Annual meeting of the Social Science History Association, November 3.

Vézina H (2017). BALSAC: une interface entre les sciences biologiques et sociales. Genealogy and Genetics Days. Trois-Rivières, October 23.

Vézina H (2017). BALSAC et la démogénétique : une interface entre les sciences biologiques et sociales. Conference “Explorer le social. Au passé et au présent, du biologique au symbolique” organized to honor the work of Gérard Bouchard, Chicoutimi, September 28-29.

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Theses, dissertations and working papersDesportes S (2018). La contribution démographique et génétique des Filles du roi à la population québécoise contemporaine (Masters Thesis). Université Laval. https://corpus.ulaval.ca/jspui/handle/20.500.11794/31767

Lavoie EM, Tremblay M (2017). Mise en production finale fusion PRDH-BALSAC. Document BALSAC 278, 14 pages, Chicoutimi (Quebec).

Lavoie EM (2017). Dérivation des individus non mariés. Document BALSAC 279, 2 pages, Chicoutimi (Quebec).