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ANESTH ANALG 1

1983;62:1-8

Absolute Bioavailability of Oral and Intramuscular Diazepam:

Effects

of Age and Sex

Marcia Divoll,

BS,

David

J.

Greenblatt, MD, Hermann R. Ochs, MD,

and Richard I. Shader, MD

M .

DIVOLL, D.

J GREENBLATT, H. R. OCHS,

R.

I.

SHADER: Absolute bioavailability

of

oral and

intramuscular diazepa m: effects of age and sex. Anesth

Analg 1983;62:1-8.

Tzuenty -two healthy volun teers aged 20-78 years received

single 5-m g doses of diazepam by intra venou s injection , by

mouth in the fasting state, and by

a

deltoid intramuscular

injection. The kinetic profile of diazep am by each route was

determined from multiple plasma diazepam concentrations

measured

7 14

days after each dose. After intravenous in -

jection, diazepam volume o f distribution (Vd)was larger in

women than in men, but increased with age regardless of

sex. Elimination half-life was longer in elderly than in you ng

men 101 v 32 h, P < 0. 02 5) , partly due to the increased

Vd

as

well

a s

to

a

significant reduction in total metabolic

clearance (0.24

v

0.46 mllminlkg, P