ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

www.indianactsi.org

Anantha Shekhar MD, PhD

Indiana University School of Medicine

Indiana Clinical and Indiana Clinical and Translational Sciences Translational Sciences

Institute Institute

A Statewide Laboratory for Accelerating Clinical and Translational Research

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

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National Consortium of 60 Academic Health Centers

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

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Indiana CTSI is a multi-partner Institute

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

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1. Creating a Home for Translational Research

2. Building Resources to Accelerate Research

3. Training a New Cadre of Research Workforce

Mission

To Improve Health and Economy of Indiana by:

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

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Summary of the Indiana CTSI Structure

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Progress: Building Research Support Infrastructure

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

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Progress: Engaging Researchers statewide

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Progress: ROIs on Grant Mechanisms

Figure 6. PDT projects outcomes from May 2008 to February 2012. Projects are followed for several years, and the cumulative award dollars received, intellectual property licenses, disclosures, patents and startups for PDT funded projects are tracked for each year’s cohort against the funding (Pilot grant $s), and assistance, mentoring and project management (FTE)

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Progress: Increased Statewide collaborations

Indiana CTSI Intercampus Services Use Year 2 thru 4

Notre Dame 62

IUPUI 1164

This graphic indicates the number of individuals from one Indiana CTSI campus who have utilized at least one service from another Indiana CTSI member campus during Years 2 through 4 of the Indiana CTSI CTSA award. The circles representing each campus are sized to the number of individuals from that campus.

IUB 78

Purdue 221

Collaboration Map in 2012

Collaboration Map in 2009

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Next 5 years of focus: Programs that help move academic innovations out

into real world impact in three major areas

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• CIIS will develop Research and Discovery Units (RDUs) in our health care partners

• Also develop training programs

• Provide ‘laboratories’ for a different type of scientists

• It is expected to roll out in Q4 of 2013

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CHIISInnovations in Clinical Practice

Next 5 years: Health Care PartnersCenter for Health Implementation and Innovation Sciences (CHIIS)

Improved Patient OutcomesImproved Reimbursement

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• Will create a single point of entry for all Clinical Trials• Focused on efficient service to sponsors• Key metrics will be

a) first contact to first patient enrolled in trial; b) full accrual of trials

• Completing a lean six-sigma process to reorganize all clinical trials across IU and IUH under the new IU CRO (timeline below)

Next 5 years: Industry PartnersCreating efficient IU Clinical Research Office (CRO)

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o The MTP is a distributed network of therapeutics development infrastructure within the CTSI

o It will provide project mapping and assistance to investigators

o It will create therapeutic target teams by identifying expertise necessary to facilitate therapeutic development.

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Molecular Therapeutics

Next 5 years: University Partners Develop an Indiana Molecular Therapeutics Program (MTP)

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o Ready to open A commercial grade Phase-I CTSI clinical research unit with Covance

o We are in the final steps of business agreements and a press release will be coming out very soon

o Several potential studies are already being planned for Q1 of 2014

IU – Covance Phase I unit

Next 5 years: Private Sector Partnerships Partnership with Covance on Phase I unit at IUH

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• Strategic Pharma and Academic Research Consortium (SPARC)

• A Midwest based discovery consortium conceived by Lilly and Indiana CTSI

• Now includes Takeda as the second industry partner and five other Midwest CTSAs

• It is expected to roll out the call for proposals in Q4 of 2013

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SPARCMidwest CTSA Consortium

Next 5 years: Private Sector Partnerships SPARC – Midwest consortium

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Over the next 3 years, the CTSI will focus on comprehensive health improvements in two communities:

a) rural - Clinton county

b) urban - Indianapolis

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Community Outreach

Next Steps: Public Sector and Philanthropy Partnerships Expand Community Engagement in Health Outcomes

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For more information

https://www.indianactsi.org

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