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Amlodipine
-Calcium Channel Blocker-
15.06.05
목희연
화학명 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
분류 고혈압 치료제 (dihydropyridine 계열 )
약리 Calcium Channel Blocker
적응증 고혈압
상품명 Norvasc
개발회사 Pfizer
Amlodipine
∙Three Classes of CCBDs
Chemical Type Chemical Names Brand Names
Phenylalkylamines Verapamil Calan,Isoptin
Benzothiazepines Diltiazem Cardizem
1,4-Dihydropyridines Nifedipine
NicardipineIsradipineFelodipineAmlodipine
Adalat,Procardia
CardeneDynaCircPlendilNorvasac
Calcium Channel Blocking Drugs
Verapamil
∙Three Classes of CCBDs
Chemical Type Chemical Names Brand Names
Phenylalkylamines Verapamil Calan,Isoptin
Benzothiazepines Diltiazem Cardizem
1,4-Dihydropyridines Nifedipine
NicardipineIsradipineFelodipineAmlodipine
Adalat,Procardia
CardeneDynaCircPlendilNorvasac
Calcium Channel Blocking Drugs
Diltiazem
∙Three Classes of CCBDs
Chemical Type Chemical Names Brand Names
Phenylalkylamines Verapamil Calan,Isoptin
Benzothiazepines Diltiazem Cardizem
1,4-Dihydropyridines Nifedipine
NicardipineIsradipineFelodipineAmlodipine
Adalat,Procardia
CardeneDynaCircPlendilNorvasac
Calcium Channel Blocking Drugs
Amlodipine
Calcium channel
Type Most often found in
L-type calcium channel ("Long-Lasting" AKA "DHP Receptor") 골격근 , 평활근 , 심장근육
P-type calcium channel ("Purkinje") /Q-type calcium channel 푸르키니에 섬유
N-type calcium channel ("Neural"/"Non-L") 뇌 신경
R-type calcium channel ("Residual") 소뇌 과립세포
T-type calcium channel ("Transient") 신경세포 , 심장근육
Voltage-gated Calcium channel
Calcium binding mechanism
혈관확장 , 동방결절 전기 신호 억제
Calcium channel Blocking
혈관확장 심장수축저해 동방결절억제 방실결절억제
Effects of CCBDs
Benzothiazepines
1,4-Dihydropyridines
Phenylalkylamines
혈관 선택성 Ca2+ 길항작용 : 1,4-Dihydropyridines심장 선택성 Ca2+ 길항작용 : Phenylalkylamines, Benzothiazepines
Thank You