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STREP proposal Radiology Assistant Radiology Assistant Proposal full title: Development of a software for recognizing ankle injuries from X-rays Proposal acronym: Radiology Assistant Type of funding scheme: STREP Work programme topics addressed: PHC 30 – 2015 Digital representation of health data to improve disease diagnosis and treatment Name of the coordinating person: Ivana Ribić, Aleksandra Karadžić e-mail: [email protected] , [email protected] Page 1 of 43

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STREP proposal Radiology Assistant

Radiology Assistant

Proposal full title:Development of a software for recognizing ankle injuries from X-rays

Proposal acronym:Radiology Assistant

Type of funding scheme:STREP

Work programme topics addressed:PHC 30 – 2015 Digital representation of health data to improve disease diagnosis and treatment

Name of the coordinating person:Ivana Ribić, Aleksandra Karadžić

e-mail:

[email protected], [email protected]

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STREP proposal Radiology Assistant

List of participants:

Participant no. Participant organisation name Part. short name

Country

1 (Coordinator) Faculty of Mathematics,University of Belgrade,http://www.matf.bg.ac.rs

MATF Serbia

2 Faculty of Electrical Engineering,University of Belgrade,http://www.eft.bg.ac.rs

ETF Serbia

3 Harvard Medical School,http://hms.harvard.edu

HMS United States

4 MediPro, www.medipro.com

MPRO United States

5 National Institute of Medical Statistics,http://nims-icmr.nic.in

NIMS India

Proposal abstract

In a modern day society health is considered the most priceless thing in the world. Broken ankles affect people of all ages. During the past 30 to 40 years, doctors have noted an increase in the number and severity of broken ankles, due in part to an active, older population of "baby boomers".

The key to a successful treatment is a quick and accurate diagnosis. It is well known that the advancement in technology opened a lot of treatments that were simply not possible without the precision of the computers. This project will have a great impact on the field of medicine because it can isolate small details that can not be seen by human eye. It is also possible to notice small anomalies and irregularities on given X-ray or ultrasound image of an ankle that can be cause of painful conditions and instability.

Radiology Assistant is of great help to doctors and it gives chance to choose the best rehabilitation for the ankle to regain strength and flexibility.

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STREP proposal Radiology Assistant

Table of contents

Proposal abstract .................................................................................................................. 2

Section 1. Scientific and/or technical quality, relevant to the topics addressed by the call.... 4

1.1 Concept and objectives .............................................................................................4

1.2 Progress beyond the state-of-the-art .........................................................................7

1.3 S/T methodology and associated work plan ..............................................................8

1.3.1 Describing the overall strategy of the work plan ......................................................8

1.3.2 Work packages - Gantt chart ...................................................................................9

1.3.3.a Work package list ...............................................................................................10

1.3.3.b. List of Deliverables ............................................................................................11

1.3.3.c. Milestones ..........................................................................................................13

1.3.3.d Work package description ..................................................................................15

1.3.3.e Summary of effort ..............................................................................................21

Section 2. Implementation ....................................................................................................22

2.1 Management structure and procedures ..................................................................22

2.2 Individual participants ..............................................................................................23

2.3 Consortium as a whole ............................................................................................26

2.4 Resources to be committed..................................................................................... 27

Section 3. Impact ..................................................................................................................28

3.1 Expected impacts listed in the work programme .....................................................28

3.2 Dissemination and/or exploitation of project results, and management of intellectual property ……………………………………………………………………………………………28

Section 4. Ethical Issues .......................................................................................................29

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STREP proposal Radiology Assistant

Section 1. Scientific and/or technical quality, relevant to the topics addressed by the call

1.1 Concept and objectives

Application Radiology Assistant is a simple software package which with use of graphical algorithms can ease and make better the process of examining state of a human ankle.

X-ray and ultrasound pictures can often be dark and unclear which sometimes leads to problems in diagnose. It can be hard for the doctor who reads them to see some small details. Computers can be much better in that. A software that highlights details on a picture can be helpful, sometimes even essential, in a process of making a correct diagnose.

This major strategy is compatible with major goals expressed in Call H2020-PHC-2014-20 15 .

To stress the compatibility of our approach, we paraphrase here the expected impact of Call (H2020-PHC-2014-20 15 ): The advancement in technology opens a lot of treatments that were simply not possible without the precision of the computers.

The following are the main project objectives:

Objective 0: Project management

The goal of this objective is to make sure that absolutely each and every detail of this proposal, if it is awarded, be properly taken care of, which means: (a) All deliverables delivered in time, (b) All deliverables delivered at quality levels that satisfy the highest FP7 standards, (c) All deliverables delivered in a form which is consistent and helps convey the essence in a way which is easy to comprehend. For all this to happen, an effective set of system of reminders will be set.

Success criteria:

Optimization of the reporting processes involved in the project (deadlines)

Optimization of the control processes involved in the project

Optimizing finances of the project

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STREP proposal Radiology Assistant

Objective 1: Designing an algorithm

All details related to software has to be developed. Firstly, we need to make an accurate algorithm which serves the purpose. This requires consolidation with medical professionals. The process would consist of few stages. Every stage would gradually increase the difficulty of detection of anomalies. Starting with cases of completely healthy or single obvious anomaly ankle and ending with examples of cases in which the doctors had made mistakes in past.

Success criteria:

Finished algorithm implemented and fully functional on a single PC

Each phase is concluded with a positive feedback from the experts

Every diagnosis was equal or more precise with the use of algorithm

Objective 2: To develop a practical input / output system adjusted to standards of every hospital

Once the algorithm is completed and perfected next step is to create a simple method of applying it. Most of the hospitals already have a way to input X-rays to PC. The goal is to prepare the software that is easy for instalment and maintenance on hospital computers.

Success criteria:

Software packet is ready to be installed on any platform used by designated hospitals

Implementation without bugs

Potential speed of processing and communications

Installation and maintenance plan is fully developed

Complete software documentation

Objective 3: Testing

Testing will be set in two universities in Serbia and one university in United States. It will require a team of medical experts and ankle X-rays examples. The result is data about efficiency of our software. The data would consist of the numbers of doctors which detected anomaly without the use of the Radiology Assistant and also the number of doctors who detected while consulting the software.

Success criteria:

15 medical professionals make a testers team

X-rays database is complete

Complete data evaluation with positive feedback (success coefficient is calculated and is bigger than one for every scan which means that the number of doctors giving

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STREP proposal Radiology Assistant

a proper diagnosis without using software divided by the number of successful diagnosis with use is bigger than one)

Objective 4: To do constantly a public dissemination about this project (using media like newspapers, TV, Internet, and public lecturing), to do periodically internal workshops (for consortium members and their students) and scientific symposia (to bring together researchers from outside of this consortium), to help generate spin-off companies interested in making the market product related to this system, and to prepare the market for acquisition of this system

The special sessions, seminars and summers schools will be open events to achieve the maximum dissemination impact and spread knowledge to cognate industries and institutions for maximal regional benefit. Suitable media events will be used to further spread information about the benefits of applications.

Success criteria:

Number of papers presented at internal workshops and the number of papers with potentials to get accepted for publication in SCI journals

Number of participants at workshops, twice a year (min 20 participants per workshop)

Number of participants at scientific symposia, twice a year (minimal 40 per symposium)

Number of public presentations in media, with potential partners

Number of tehnical and scientific meetings

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STREP proposal Radiology Assistant

1.2 Progress beyond the state-of-the-art

Algorithms for image processing are well-known and used all over the world in different areas. One of the fields in which image processing is used extensively is medicine. This field is constantly expanding due to its importance. There are different software packages for processing medical images which improve the image usability in some way.

Relevant references:

Survey: interpolation methods in medical image processing, Lehmann, T.M., Gonner, C., Spitzer, K. Medical Imaging, IEEE Transactions on (Volume:18 , Issue: 11, Pages: 1049-1075), 2002.

Basics of cellular logic with some applications in medical image processing, Preston, K., Jr., Duff, M.J.B., Levialdi, S., Norgren, P.E. Proceedings of the IEEE (Volume:67 , Issue: 5, Pages: 826-856), 2005.

Medical Image Processing, Analysis and Visualization in clinical research, McAuliffe, M.J., Lalonde, F.M., McGarry, D., Gandler, W. Computer-Based Medical Systems, 2001. CBMS 2001. Proceedings. 14th IEEE Symposium on (Pages: 381-386), 2001.

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STREP proposal Radiology Assistant

1.3 S/T methodology and associated work plan

1.3.1 Describing the overall strategy of the work plan

In order to achieve the overall project objectives, the following items are considered as crucial:

Competent researchers well aware of the state of the art in the research field and able to take the research forward;

State of the art research infrastructure;

Ability to work, communicate and collaborate with researchers from various backgrounds, in various circumstances and environments;

Large network of contacts in the research community;

Public awareness of the benefits of the research in a chosen field and promotion of research results and achievements.

The project is organized in 6 work packages as follows:

WP0 Project management

WP1 Designing an algorithm

WP2 Definition of the input / output

WP3 Testing of the Proof of Concept in real-life scenario

WP4 Informing the scientific and technical environment

WP5 Impact on the environment

The main body of work is included in three work packages (WP1, WP2 and WP3). The activities planned in these work packages correspond to the main strands of the project as described above. It is the responsibility of the project management team (WP0) to coordinate these activities to maximize the impact and benefits for everyone involved. Work packages WP4 and WP5 are treated as pillars that support the main body of work.

WP0 or Project management, is, as the name implies, responsible for the overall project management, coordination of all project activities and managing relationship with stakeholders. The project management team will comprise administrative (MATF) and scientific & technical management project manager (ETF).

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STREP proposal Radiology Assistant

1.3.2 Work packages - Gantt chart

Figure 1 – Gantt chart for the workpackages

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STREP proposal Radiology Assistant

1.3.3.a Work package list

Work package

No1

Work package title

Type of activity2

Lead parti

cno.3

Lead partic. short name

Person-months4

Startmonth5

Endmonth5

WP0 Project management

MGT 1 MATF 35 M1 M12

WP1 Designing an algorithm

RTD 2 ETF 50 M1 M6

WP2 Definition of the input / output

RTD 5 NIMS 25 M7 M8

WP3 Testing of the Proof of Concept in real-life scenario

RTD 3 HMS 120 M9 M11

WP4 Informing the scientific and technical environment

DEM 1 MATF 20 M4 M11

WP5 Impact on the environment

DEM 4 MPRO 20 M1 M12

TOTAL 270

1 Workpackage number: WP 1 – WP n.

2 Please indicate one activity per work package:

RTD = Research and technological development; DEM = Demonstration; MGT = Management of the consortium

3 Number of the participant leading the work in the work package.

4 The total number of person-months allocated to each work package.

5 Measured in months from the project start date (month 1).

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STREP proposal Radiology Assistant

1.3.3.b List of Deliverables

Del. no.6

Deliverable name WP no.

Nature7 Dissemi-nation level8

Delivery date9

(proj.month)

D0.1 Progress report for the six months of work WP0 R PU M6

D0.2 Progress report for the six months of work WP0 R PU M12

D0.3 Progress report of whole project WP0 R PU M12

D1.1 Documented code WP1 R CO M3

D1.2 Documented testing procedures and final code documented WP1 R CO M6

D2.1 List containing information about every possible platform and operating system

WP2 R PU M7

D2.2 Report on code optimization for all platforms and operating system WP2 R CO M7

6 Deliverable numbers in order of delivery dates. Please use the numbering convention <WP number>,<number of deliverable within that WP>. For example, deliverable 3.1. would be the first deliverable from work package 3.

7 Please indicate the nature of the deliverable using one of the following codes:

R = Report

P = Prototype

D = Demonstrator

O = Other

8 Please indicate the dissemination level using one of the following codes:

PU = Public

PP = Restricted to other programme participants (including the Commission Services)

RE = Restricted to a group specified by consortium (including the Commission Services)

CO = Confidential, only for members of the consortium (including the Commission Services)

9 Measured in months from the project start date (month 1)

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STREP proposal Radiology Assistant

D2.3 Final version of software implementation WP2 R CO M7

D3.1 Report on testing results in SerbiaWP3 R PU M11

D3.2 Proposal for product development for mass market WP3 R PU M11

D4.1 Set of Rs by partners on planned activities WP4 R PU M1

D4.2 Number of papers (Ps) written for the workshop WP4 R PU M4

D4.3 Number of papers (Ps) written for the first symposium WP4 R PU M11

D5.1 List of public appearances for dissemination purposes and content there-offs

WP5 R PU M12

D5.2 List of investor contact and presentation made WP5 R PU M12

D5.3 List of brainstorming meetings, and contents there-offs WP5 R PU M12

D5.4 List of in-house talks and brainstorming meetings, ad contents there-offs

WP5 R PU M12

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STREP proposal Radiology Assistant

1.3.3.c Milestones

Milestones are control points where decisions are needed with regard to the next stage of the project.

Milestone number

Milestone name Work package(s) involv

ed

Expected date10

Means of verification11

M0.1 Checking on optimization of the reporting processes involved in the project (deadlines)

WP0 M6

M0.2 Checking on optimization of the control processes involved in the project

WP0 M12

M0.3 Checking on optimizing finances of the project

WP0 M12

M1.1 Checking implementation without bugs

WP1 M6

M2.1 Checking on specification of hardware and software throughout the target market

WP2 M7

M2.2 Checking implementation on of algorithm for all possible platforms and operating systems without bugs, whether the installation plan covers all possible troubleshooting regarding the installation

WP2 M8

M2.3 Checking whether the maintenance plan covers all possible troubleshooting regarding the possible hardware and software problems

WP2 M8

10

Measured in months from the project start date (month 1).

11 Show how you will confirm that the milestone has been attained. Refer to indicators if appropriate. For example: a laboratory prototype completed and running flawlessly; software released and validated by a user group; field survey complete and data quality validated.

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STREP proposal Radiology Assistant

M3.1 Checking on test cases developed according to the needs of the beneficiary industry

WP3 M11Web site accessible on Internet

M3.2 Checking on specification of issuesto compare which takes countryspecifics into consideration

WP3 M11Exploitation workshop held with industry participation

M3.3 Checking on details of the requirements for industrial prototype to follow.

WP3 M11

M4.1

Checking on number of papers presented at internal workshopsand the number of papers with potentials to get accepted forpublication in SCI journals

WP4 M11

M4.2 Checking on number of participants at workshops (min 20 participantsper workshop)

WP4 M11

M4.3 Checking on number of participants at scientific symposia (minimal 40 per symposium)

WP4 M11

M4.4 Checking on number of publicpresentations in media (one per months), with potential partners andrepresentatives of future spin-offcompanies

WP4 M11

M5.1 Checking the techno economic impact of the final product in the market environment

WP5 M12

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STREP proposal Radiology Assistant

1.3.3.d Work package description

Work package number WP0 Start date or starting event:

M1

Work package title Project managementActivity type MGTParticipant number 1 2 TotalParticipant short name MATF ETFPerson-months per participant

25 10 35

ObjectivesThe objectives of WP0 are the overall management, progress monitoring and stakeholders management of the project. WP0 aims at: Setting up, operating and maintaining the project administrative and scientific management infrastructure.Ensuring the overall scientific and technical coordination of the project.Ensuring collaboration and coordination with relevant government bodies regarding research programmes.Performing a self-assessment of the project progress.Conducting progress reviews on M6, M12, M12

Description of work WP Leader: MATFThe Project Manager (PM) will be the permanent responsible person for interface towards the Commission and partners of the Consortium for all administrative, contractual and financial matters and handle the overall management of the project. The duties, methodologies, IPR, conflict resolution and management strategies that will be followed in the project are described in detail elsewhere in this proposal. The project manager will submit all deliverables and reports to the Commission, including contractually obligatory reports (periodic management and activity reports, final management and activity report, audit certificates – not referenced as deliverables), an intermediate project report and the Final Project Report. The project manager will maintain the project plan. The exchange of researchers is a crucial issue, both in the initial phases when final set of use cases and related details have to be created, and later on during the implementation and testing. All these exchange visits have to be carefully planned, and their costs carefully minimized. The purchase of each and every detail needed for the success of this project has to be monitored carefully, to avoid errors from some other past projects in which resources were wasted on non-adequate purchases. Also, all purchases have to be selected so that they are usable and after the project is over, for educational purposes at universities involved.T0.1 – Final report (TL: MATF)The Scientific and technical co-ordination of the project will be under the responsibility of the Scientific and technical manager and under the guidance of the project’s Operational Steering Group (OSG). The S&T manager will maintain the Project handbook which will contain the schedule and scientific content of all project events (workshops, seminars, summer schools, research exchanges). The duties and S&T management strategies that will be followed in the project are described in detail elsewhere in this proposal.

DeliverablesD0.1 - D0.2 (M1 – M6; M6 – M12) – Progress report for the six month workD0.3 (M12) – Progress report of the whole project

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STREP proposal Radiology Assistant

Work package number WP1 Start date or starting event:

M1

Work package title Designing an algorithmActivity type SUPPParticipant number 1 2 3 5 TotalParticipant short name MATF ETF MPRO NIMSPerson-months per participant

25 15 5 5 50

ObjectivesThe main objective of this WP is making an accurate algorithm which serves the aforementioned purpose. This requires consolidation with medical professionals. The process would consist of few stages. Every stage would gradually increase the difficulty of detection of anomalies. Starting with cases of completely healthy or single obvious anomaly lungs and ending with examples of cases in which the doctors had made mistakes in past.Description of work WP Leader: ETFThe work in this work package is focused on providing system prototype with reduced functionality set. However, the resulting system prototype should cover the specified and selected business scenarios and use-cases outlined in WP3. Furthermore, the work package will include the system testing and evaluation in order to produce next generation of the system.T5.1 Programming of the applications – The main goal of this task is to conduct exact programming of the PoC applications taking into account the design of conventional components, security aspects and the overall system requirements such as DB and intelligent system behaviour. This task is focused on development of all of the software modules to be used within the prototype system, version 1.Testing strategy will be proposed, and test validation metrics installed. The emphasis will be on testing for real-time systems. Testing patterns will be generated and approved. Testing for application, field application devices and security will be added and performed. Define the test cases for the unit and system tests in order to verify whether the system meets the performance and feature requirements.

DeliverablesD1.1 (M3) – Documented codeD1.2 (M6) – Documented testing procedures and final code documented

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STREP proposal Radiology Assistant

Work package number WP2 Start date or starting event: M7Work package title Definition of the input / outputActivity type SUPPParticipant number 1 2 5 TotalParticipant short name MATF ETF NIMSPerson-months per participant

5 5 15 25

ObjectivesThe objective of WP2 is to prepare the software for easy instalment and maintenance on hospital computers.Description of work WP Leader: NIMST2.1 Checking the target market (TL: NIMS) – Team of experts from NIMS will analyse the specification of hardware and software throughout the target market. Analysis should provide information of the current situation on the market by giving answers to following questions: Which is the most popular software/hardware used? Which software/hardware has the lowest, and which one has the highest specifications?T2.2 Checking the implementation of algorithm (TL: MATF) - Checking the implementation of algorithm for all platforms and operating systems that are in use (information provided in T2.1). In this task application will be tested for bugs on variety of platforms. This task also deals with installation plan, more accurately whether or not it covers all possible troubleshooting regarding the installation.T2.3 Checking for troubleshooting (TL: ETF) – Purpose of this task is to check whether the maintenance plan covers all possible troubleshooting regarding the possible hardware and software problems.

DeliverablesD2.1 (M7) – List containing information about every possible platform and operating system D2.2 (M7) – Report on code optimization for all platforms and operating system D2.3 (M7) – Final version of software implementation

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STREP proposal Radiology Assistant

Work package number WP3 Start date or starting event:

M9

Work package title Testing of the Proof of Concept in real-life scenarioActivity type SUPPParticipant number 1 2 3 4 TotalParticipant short name MATF ETF HMS MPROPerson-months per participant

50 30 20 20 120

ObjectivesThe goal and the final result of this WP is to compile data about the software efficiency.Description of work WP Leader: HMST3.1 Testing (TL: HMS) – Selection of the appropriate hospital for testing purposes. Installation of the PoC at the site. Organizing and performing PoC testing procedures. Testing of exceptions, obstructions, and entropy. Report on testing according to metrics for testing and metrics for maintenance. The findings in the report will be used further and will have impact on the content of the future PfM requirement issues. The report will also serve to widen the cooperation of the pool of researchers who are in the areas listed above. This WP also includes tests definition and planning. Based on the selected scenarios and requirements, the trial applications and execution plan will be specified for each of the organization taking into account its location, business model, targeted application, structure of end users etc. If the proposed field trial raises ethical issues, for example privacy concerns, an ethical review will be undertaken. Furthermore, a comparison metric will be defined in order to compare the test results originating from different test sites. The aim of the metric is to specify the parameters that will be measured during the tests such as end user experience, system price, system performance, final product cost-reduction when using the system etc.T3.2 Testing in Serbia (TL: MATF) – Selection of the appropriate farm for testing purposes in Serbia. Organizing and performing PoC testing procedures. Testing of exceptions, obstructions and entropy. Report on testing according to metrics for testing and metrics for maintenance. T3.3 Comparison and suggestions of product for market (TL: MATF) – During the testing phase on both locations a number of remarks and hints will be generated. These, together with concrete testing results will be the basis for comparison evaluation of the both PoC installation behavior in real-life conditions. Based on these and PoC features, its reduction factor from the system platform and on general system requirements the set of suggestions for PfM will be generated as the basis for spin-off activities of SMS’s both in WB countries and in EU countries. The new framework may also include new geographic regions and potential collaboration with research groups in these regions. Once all the tests have been executed according to the specification produced in T6.1, the results will be compared using the metric defined in the same task. The aim is to quantify the comparison results and deduce which type of the system (or which system’s features) are better suited for the market.

DeliverablesD3.1 (M11) – Report on testing results in SerbiaD3.2 (M11) – Proposal for product development for mass market

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STREP proposal Radiology Assistant

Work package number WP4 Start date or starting event:

M4

Work package title Informing the scientific and technical environmentActivity type SUPPParticipant number 1 2 TotalParticipant short name MATF ETFPerson-months per participant

15 5 20

ObjectivesTo do constantly a public dissemination about this projectTo do periodically internal workshops and scientific symposiaTo help generate spin-off companies interested in making the market product related to this systemTo prepare market for acquisition of this systemTo define strategic research areas of common interest to project participants for the future research

Description of work WP Leader: MATFT4.1 The first annual workshop (partners only) (TL: MATF) – During the project a number of short and long term collaborative activities will take place on bilateral and multilateral basis (research visits, joint PhD studies, joint H2020 proposals). Taking into account the ongoing actions and the output from T7.1 identifying common research interests of different partners, bilateral or multilateral agreements will be put in place. Procedures, policies and ways of working between different parties in the agreement will be formalized to ensure smooth continuation of partnership established in the project. The new framework may also include new geographic regions and potential collaboration with research groups in other Balkan countries.T4.2 The annual symposium (partners and beyond) (TL: MATF) – During the project a number of short and long term collaborative activities will take place on bilateral and multilateral basis (research visits, joint PhD studies, joint H2020 proposals). Taking into account the ongoing actions and the output from T7.1 identifying common research interests of different partners, bilateral or multilateral agreements will be put in place. Procedures, policies and ways of working between different parties in the agreement will be formalized to ensure smooth continuation of partnership established in the project. Each agreement will leverage any existing national, regional or international initiatives, such as ‘Networking with Southeast Europe’ (www.see-era.net) to enhance the new collaboration framework and facilitate better and more efficient collaboration. The new framework may also include new geographic regions and potential collaboration with research groups in other Balkan countries.T4.3 The symposium with closing discussion (TL: ETF) –Final bringing together the elite of the field.

DeliverablesD4.1 (M1) – Set of Rs by partners on planned activitiesD4.2 (M4) – Number of papers (Ps) written for the first workshop D4.3 (M9) – Number of papers (Ps) written for the symposium D4.4 (M7) – Number of papers (Ps) written for the second workshop

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STREP proposal Radiology Assistant

Work package number WP5 Start date or starting event: M1Work package title Impact on the environmentActivity type SUPPParticipant number 1 4 5 TotalParticipant short name MATF MPRO NIMSPerson-months per participant

5 10 5 20

ObjectivesAlthough not typical, this project likes to have different work packages to organize and monitor effects of technical and scientific meetings, on one hand, and public dissemination with search for investors, on the other hand. Conducting progress reviews on M6, M12, M12

Description of work WP Leader: MPROT8.1 Informing the environment via media (TL: MPRO) – It is anticipated that diagnostic automation solutions will be widely applied in the coming years. Based on the project results and experience and taking into account the state of the art in agro automation research and general research interest of each partner, a set of research challenges of public interest will be identified. These challenges will be summarized in a report.Important: To develop two kinds of event series: Open Research Days and Open Innovation Days. They will be focused on the cross-fertilization between scientific results of the project and the potential business interest of entrepreneurs, investors to achieve a wide dissemination through in-house talks, brainstorming meetings, seminars, summer schools and special sessions in EU.T8.2 Search for investors to turn PoC into a market product (TL: MPRO) – Promotional activities - Diverse selected technology focused media events, trade fairs, TV and radio shows and newspaper supplements will be used to promote the project and draw attention to its benefits and potential applications of its relevant technology.T8.3 Organization and monitoring of talks and business plans for PfM investors (TL: MATF) - Organization and monitoring of impact on scientific and technical environment. Organizing meetings with SMS’s, producing business plans and animating deployment of main project results and ideas.T8.4 Supervision of impact on the social environment (TL: NIMS) - Supervision of impact of project result on the social environment.

DeliverablesD5.1 (M12) – List of public appearances for dissemination purposes and content there-offsD5.2 (M12) - List of investor contact and presentation madeD5.3 (M12) - List of brainstorming meetings, and contents there-offsD5.4 (M12) – List of in-house talks and brainstorming meetings, ad contents there-offs

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STREP proposal Radiology Assistant

1.3.3.e Summary of effort

A summary of the effort is useful for the evaluators. Please indicate in the table number of person months over the whole duration of the planned work, for each work package by each participant. Identify the work-package leader for each WP by showing the relevant person-month figure in bold.

Partic. no.

Partic. short name

WP0 WP1 WP2

WP3 WP4 WP5

Total person months

1 MATF 25 25 5 50 15 5 1252 ETF 10 15 5 30 5 0 653 HMS 0 0 20 0 0 0 204 MPRO 0 5 0 20 0 10 355 NIMS 0 5 15 0 0 5 25

Total 35 50 45 100 20 20 270

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STREP proposal Radiology Assistant

Section 2. Implementation

2.1 Management structure and procedures

The project involves several partners from different countries and intends to provide support for multiple activities involving a number of researchers and students from different organizations. Therefore, coordination and management of the project are of paramount importance. The basic project management approach for the project is to have a scientific coordinator focus on the technology and to have an administrative coordinator handle the overall operational and day-to-day business. A clearly defined project management structure will be set up, including precise management processes and decision rules. This will ensure that the project meets its objectives and delivers the results in time and with high quality, using the following project management structure (Figure 2):

Figure 2: Management Structure

Precise milestones and delivery dates as well as the content of the deliverables are defined in a detailed project plan. Project control will be established, supported by communications tools and a central communications platform. A self-check mechanism for the work package leaders and the researchers/developers will provide an early warning system to identify deviations from the work plan and make it possible to establish contingency or recovery plans.

A project management team comprising a senior project manager and a senior researcher as the scientific coordinator will lead the project, making use of state-of-the-art project management techniques. The objective of the day-to-day management is to keep the project always closely aligned with the project plan, reduce the risks associated with project activities and provide support to all partners. Individual effort for administration of the project should stay at a minimum, including the number of meetings necessary to control the project.

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OSG

Project management team

Admin and S&T project coordinator

Work package leader

Team leadersPartner

Partner

Work package leader

Team leadersPartner

Partner

Work package leader

Team leadersPartner

Partner

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STREP proposal Radiology Assistant

The project operational steering board will be established to monitor the progress and direction of the project. Each partner will have one board member.

2.2 Individual participants

Faculty of Mathematics, University of Belgrade, Serbia

Faculty of Mathematics, University of Belgrade, officially exists as independent science and education institution since 1995. but it's roots are much older. Up to present day, it has more than 6000 graduate mathematicians, 400 doctors of mathematics and computer sciences, 700 Masters of Science and many specialists. Numerous graduates occupy various positions in research institutions, government offices, companies and schools in the country and abroad. It is a quality indicator of the studies at the Faculty of Mathematics. It is one of the leading faculties in the country.

Faculty of Electrical Engineering, University of Belgrade, Serbia

The University of Belgrade School of Electrical Engineering also known as Faculty of Electrical Engineering is a constituent body of the University of Belgrade. The word Faculty in Europe stands for an academic institution, the sub-unit inside the University. The first university level lecture in the field of electrical engineering in Serbia was held in 1894. Professor Stevan Marković was the first lecturer and founder of Electrical Engineering Chair

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STREP proposal Radiology Assistant

within the Engineering department of the Belgrade Higher School. In 1898, Marković also founded the first electrical engineering laboratory in Serbia.

Harvard Medical School, United States

Harvard Medical School (HMS) is the graduate medical school of Harvard University. It is located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts. It has been ranked the #1 research medical school in the United States by U.S. News & World Report every year since the magazine began publishing medical school rankings.

The school has a large and distinguished faculty to support its missions of education, research, and clinical care. These faculty hold appointments in the basic science departments on the HMS Quadrangle, and in the clinical departments located in multiple Harvard-affiliated hospitals and institutions in Boston. There are approximately 2,900 full- and part-time voting faculty members consisting of assistant, associate, and full professors, and over 5,000 full or part-time, non-voting instructors.

MediPro, United States

Since 1995, MediPro has been helping healthcare professionals excel by automating patient workflow and implementing award-winning, progressive Practice Management and certified Electronic Health Record solutions. MediPro currently services hundreds of practices in just about every specialty across the country and has received numerous national awards and honors for our unrelenting dedication to user satisfaction.

MediPro’s mission is to provide a complete solution to the healthcare community by recognizing the need for a comprehensive, interactive and cost-effective suite of applications.

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STREP proposal Radiology Assistant

National Institute of Medical Statistics, Indian Council of Medical Research, India

(DEPARTMENT OF HEALTH AND RESEARCH)

The NIMS supports excellence in the development, application, and dissemination of statistical science through technical consultation and statistical service, research, education, publications, dissemination and advocacy. Our members serve in government and academia, advancing research and promoting sound statistical practice to inform public policy and improve human welfare.

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STREP proposal Radiology Assistant

2.3 Consortium as a whole

An excellent mix of competencies, research interests and approaches is present in the consortium. This versatility and mix of complementary skills combined with the mutual understanding gained in previous collaborations will be utilized to the greatest possible extent to cross fertilize the best practices and increase research potential of everyone involved. The resources needed for research support and management activities are integrated from a variety of academic organizations and a large multinational company.

Research focus and expertise covered by the involved organizations spans the complete problem area covered by this proposal. In addition to that, both academic and industry oriented views of the research problems and challenges and consequently approaches are present in the project which ensures a holistic view of the research domain and is an additional added value of the consortium.

Also, where and when necessary, sub-contracting and engagement of experts will be done. Budget for this comes from the S&T coordinator’s budget.

Sub-contracting: For the amount of money up to 4% of the value of the project, coordinator institution can sub-contract (from its share) external organization, for implementing any activity for which the whole consortium determines that is mission critical. All subcontracting activities must be approved by the project leader and the entire consortium.

Expert-engagement: Three external experts from the US will be engaged in the project. These experts are experienced and well-known researchers. They will present the state-of-the-art research in the US, as well as future research directions and will significantly contribute to the overall project objectives.

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2.4 Resources to be committed

Mobilization of resources

The resources needed for the project activities are integrated from two academic organizations, two software development companies and a medical laboratory partners. The resources profile and the participating partners are complementary in many respects. The project targets both shorter term and longer term activities that will set the basis for sustainable collaboration between the partner organizations and takes great care of particular regional strategic needs. External experts that agreed to take active part in project activities will bring additional expertise into the project and will improve the impact of the project both in terms of the project and its partners’ promotion as well as in more extensive people networking opportunities.

Development team resources

Development team consists of highly skilled programmers acquired from two software development companies and their payment is estimated to E250k in accordance to their planned work hours and payment per hour in their respective companies.

Testing equipment resources

The resources needed for testing hardware is in the widest sense are difficult to estimate precisely at this point, and the suggestion is that they be allocated on the level of E350K (and extra money returned, if not used).

Medical team resources

Development team consists of doctors and researchers acquired by university partners, medical partner and other means (individual experts, external applicants) and their payment is estimated to E150k in accordance to their planned work hours and payment per hour.

Work places

Supplied by the medical laboratory partner an estimate is made to E500k to pay for the work place for developing the algorithm, medical testing, presentations, algorithm testing and analysis.

Medical equipment

Supplied by the medical laboratory partner an estimate is made to E800k to pay for the equipment needed for testing and manufacturing proper means for applying the software via simulating hospital environment.

The total estimated budget for the project is about 2.000.000,00 Euro.

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Section 3. Impact

3.1 Expected impacts listed in the work programme

The work of this project has a perfect match with the requirements of the Objective for which it was targeted to. Better coherent use of health data available for a subject in conjunction with the existing medical knowledge in clinical decision making. The main steps to achieve the goal are careful development of use cases, precise implementation of the support technology, testing of the entire system in versatile environments, and dissemination, both on the commercial and scientific domains. This effort is cross-cultural and can be implemented in any medical facility throughout the world and requires international efforts. For the final success, a statistically large enough awareness to become successful. This type of technology is of interest to the experts in the fields of the medical, rehabilitation, medical research and treatment sciences. Due to the fact that concrete use cases will be fully elaborated, and due to the fact that all the feasible aspects of the underlying theory will be implemented, the re-usability of this technology will be easy. This means that beneficiaries of this technology will be able quickly to develop new methods and algorithms and further expand the use of this projects thus helping the society even more.

3.2 Dissemination and/or exploitation of project results, and management of intellectual property

Dissemination is grouped into two major groups of activities: internal and external.

The internal activities are targeting researchers from the organizations participating in the project, in particular those coming from the WBC and the EU’s convergence region. A series of project workshops, lectures and exchanges of researchers are planned to address this need. The external activities are what is usually referred to when dissemination is discussed. These activities are targeting research community, general public and industry in order to promote results and achievements of the project.

The following external dissemination channels and activities are planned:

Website and Presentation

Demonstration of new research infrastructure

Summer schools, conferences and publications

Seminars and workshops

Access through media (local TV and radio stations, newspapers)

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STREP proposal Radiology Assistant

Section 4. Ethical Issues

The proposed project does not directly involve any ethical, legal, social or safety issues. The only possible issues that may arise are those involving training data for developing the software for computer vision and detecting image features regarding human faces, as the volunteers’ images of their faces will have to be taken and used in trials and prototyping. However, their consent will be asked beforehand, in a legal fashion.

YES/NO PAGE

Informed Consent

Does the proposal involve children? NO

Does the proposal involve patients or persons not able to give consent?

NO

Does the proposal involve adult healthy volunteers?

YES 18

Does the proposal involve Human Genetic Material?

NO

Does the proposal involve Human biological samples?

NO

Does the proposal involve Human data collection?

YES 16

Research on Human embryo/foetus

Does the proposal involve Human Embryos? NO

Does the proposal involve Human Foetal Tissue / Cells?

NO

Does the proposal involve Human Embryonic Stem Cells?

NO

Privacy

Does the proposal involve processing of genetic information or personal data (eg. health, sexual lifestyle, ethnicity, political opinion, religious or philosophical conviction)

NO

Does the proposal involve tracking the location or observation of people?

NO

Research on Animals

Does the proposal involve research on animals?

NO

Are those animals transgenic small laboratory animals?

NO

Are those animals transgenic farm animals? NO

Are those animals cloned farm animals? NO

Are those animals non-human primates? NO

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Research Involving Developing Countries

Use of local resources (genetic, animal, plant etc)

NO

Impact on local community NO

Dual Use

Research having direct military application NO

Research having the potential for terrorist abuse

NO

ICT Implants

Does the proposal involve clinical trials of ICT implants?

NO

I CONFIRM THAT NONE OF THE ABOVE ISSUES APPLY TO MY PROPOSAL

YES

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