I am 60 years old, but I want to be always young in heart and healthy. Physiclly, mentally, social living inthe meaningful condition for waiting the hopeful something for tomorrow

SCIENCE :SCIENCE : 1. THEORITICAL SCIENCE1. THEORITICAL SCIENCE a. Nomothetic theoritical sciencea. Nomothetic theoritical science b. Descriptive theoritical scienceb. Descriptive theoritical science 2. APPLIED SCIENCE2. APPLIED SCIENCE a. Normative applied sciencea. Normative applied science b. Teleologic applied scienceb. Teleologic applied science c. Comprehensive applied sciencec. Comprehensive applied science d. Finalistic applied scienced. Finalistic applied science e. Complementary sciencee. Complementary science 3. PROFESSIONALISM3. PROFESSIONALISM a. Subjective cummulative value baseda. Subjective cummulative value based b. market oriented basedb. market oriented based c. divergensive mechanismc. divergensive mechanism d. competition and survivald. competition and survival

Clinical Interventional Clinical Interventional Radiology and the Aging Radiology and the Aging

ProcessProcessSoetjiptoSoetjiptoMei 1996Mei 1996

( Department of Radiology, School of ( Department of Radiology, School of Medicine, UNS University / dr Muwardi Medicine, UNS University / dr Muwardi

Teaching HospitalTeaching HospitalSurakarta )Surakarta )

Presented in national congress of Radiology 1996Presented in national congress of Radiology 1996

The medicine postulation :The medicine postulation :

1. BIO-ORGANIC POSTULATION 1. BIO-ORGANIC POSTULATION Until 1950Until 1950 2. BIOCELLULAR POSTULATION2. BIOCELLULAR POSTULATION Until 2000Until 2000 After all, it was still to be primadona in After all, it was still to be primadona in Indonesia now adaysIndonesia now adays 3, BIOM OLECULAR POSTULATION3, BIOM OLECULAR POSTULATION in the beginning of the third in the beginning of the third mellinneummellinneum

Bio-organic postulateFunctional equilibrium

Interdependency

Feedback mechanism

organon

C-DNA

nucleus

150.000

Endothermicbiochemistry

Mt-DNA

BIOMOLECULARY POSTULATEExothermic biochemistry

1. oxidant2. Energy

No repairy Mt-DNA

Decreasing energy

1. Aging process2. Mets3. Auto-immune disease4. Functional disbalancing5. Apoptosis

The cell

17.p.23

The information The information revolutionrevolution

1. The human development index 1. The human development index 2. Biocellular to biomolecular postulate2. Biocellular to biomolecular postulate3. How to win the competition 3. How to win the competition 4. How to have the safety, the security 4. How to have the safety, the security and the prosperity of the applied and the prosperity of the applied

science and its professionalismscience and its professionalism

The philosophy of existentialism inThe philosophy of existentialism in applied science is one of the manyapplied science is one of the many ways to solve ways to solve

How is about Radiology in the How is about Radiology in the effort to overcome effort to overcome the challenging future ?the challenging future ? depending upon Tdepending upon T 1 modality vs multiple modality 1 modality vs multiple modality

SWOTSWOT One of the many ways is the matters One of the many ways is the matters of meaning given by the Radiologist of meaning given by the Radiologist in the Clinical Interventional in the Clinical Interventional RadiologyRadiology

C-DNA

nucleus

150.000

Endothermicbiochemistry

Mt-DNA

Exothermic biochemistry

1. oxidant2. Energy

No repairy Mt-DNA

Decreasing energy

1. Aging process2. Mets3. Auto-immune disease4. Functionasl disbalancing5. Apoptosis

The cell

17.p.23

LIFE IS INDEED THE BIOCHEMISTRY MECHANISM LIFE IS INDEED THE BIOCHEMISTRY MECHANISM PROCESSPROCESS

Aging process is really a diseaseAging process is really a disease

1. The genetic Mt-DNA vs the c-DNA1. The genetic Mt-DNA vs the c-DNA 2. The target organ :2. The target organ : a. nutrition given cell ( 22.p.72 anda. nutrition given cell ( 22.p.72 and 22.p.92 genes) vs the endothelial22.p.92 genes) vs the endothelial responseresponse b. fibroprotein & collagen vs GAGb. fibroprotein & collagen vs GAG c. Auto-immune Ag formation.c. Auto-immune Ag formation. d. Metabolic syndrome&Organ dysfunctiond. Metabolic syndrome&Organ dysfunction 3. Ecosystem’s influenced variables ( oxydant, 3. Ecosystem’s influenced variables ( oxydant, foetal & inheritance program, nutrition, foetal & inheritance program, nutrition, life style / corpus amygdale )life style / corpus amygdale )

THE CELL

22.P.7222.P.92

1.METALOPROTEINASE I a. Angiopoetin for capillary bed b. vasculopoetin for vascularity 2. METALOPROTEINASE II For nutritional cytocine3. METALOPROTEINASE III For extracellulary matrix (ECM) a. For the frame of ECM ( collagen, elastin, fibroprotein b. For the basic ontent of spaces inter the frame ( mucopolysacharide fluid ) c. For the substances supporting the living cell ( GAG, laminin, nutrition, mineral, aminoglican, hyalin, etc ) 4. METALOPROTEINASE IV For protocollagenase and proto stromelysin (active after contact with the proteinase enzym

THE CELL

RECEPTOR c-AMP

RECEPTOR c-GMP

GAP-JUNCTION 200 ANGSTROM

THE ACTIN MECHNISM

THE INTEGRIN MECHANISM

THE ECM

THE INTERDEPENDENCY

THE COMPONENT

ENDOTHELIAL DYSFUNCTION

Endothelin NO Adhesion mol

Prostacyclin

C-DNA

At-1R Ar-2R

C-Amp A-GmpCa+ Ca+Oligopeptide OligopeptideOligosachaeride Oligosacharide

Nutrition receptor

Endothelium

component

The fourth fundamental physical law of nature : interdependency

cytokineNutrition for the cell

The vascular with its general nutritional substance

Endothel ia

The cell

22.p.72

At

t

At-1R At-2R

nucleus

mitochondria

Extracellulary matrix

Atheroscclerotic plaque

Ig-G anti CMV –

Ig-G anti Mitochondria +

Double contour aortitis

Proteinuri 500 mg %

Creatinin 3,2 mg %

Ig-G antimitochondria +

atheroma

double contour aortitis

HbA1c 10

Ig-G anti mitochondria +

Ig-G anti chlamydea +

granulomatous

wall

atherosclerotic plaque

Cholesterol total 350 mg %LDL 250 mg %HDL 25 mg %uric acid 10 mg %tensi 180/60

atheroma

atherosclerotic plaque dan atheroma

granulomatous wall

Kadar gula darah sewaktu 425mg % HBA1c 17 Chol:HDL=7 LDL:HDL=5Tensi 170/110 trombosit 400.000/cc, fibrinogen 450 mg / dl

cephalgia khronik, badan lemah sekali, Hb 10 gr %, HBA1-c 8 HS-CRP 8 chol:HDL 7 LDL:HDL 4,5 Ig-G anti mitochondria – Endogenic anti-oksidan drop

atheroma dan atherosclerotic plaque

Lemah sekali, sulit jalan, reflex pateler normal,anorexia Head Ct Scan : chronic ischemic brain HS-CRP 15, Ig-G anti mitochondria + HBA1-c 7,5 uric acid 8 mg % creatinin 1,3 mg %

chol : HDL 7, LDL : HDL 4,5

granulomatous wall

kadar gula darah sewaktu 425 mg % Chol:HDL= 7 LDL:HDL 5

Ig-G anti CMV -. Ig-G anti chlamydea -

I am satisfied, ….and Matur Nuwun