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AGING & CANCER. Gene loss. DNA Repair. Proteasome. telomare. STOP CYCLE/AGING. ENVIRONMENTAL STRESS. mutation silencing and expressing gene. CANCER. Aging as a catabolic malfunction and “Garbage Catastrophe”. Young and clean. Old and Dirty. Oxidative damage. Oxidative damage. - PowerPoint PPT Presentation
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AGING AGING & & CANCERCANCER
telomareSTOP CYCLE/AGINGSTOP CYCLE/AGING
CANCERCANCER
Proteasome
DNA Repair
Gene loss
ENVIRONMENTAL ENVIRONMENTAL
STRESSSTRESS
mutation
silencing and expressing gene
Oxidative damage
Proteosomal
degradation
Oxidative damage
Proteosomal
degradation
Oxidized and
cross-linked
proteins
Oxidized and
cross-linked
proteins
(Lipofuscin)
Young and clean Old and Dirty
“Garbage
catastrophe”
Anti-aging Reversing the catastrophe
Aging as a catabolic malfunction
and
“Garbage Catastrophe”
telomareSTOP CYCLE/AGINGSTOP CYCLE/AGING
CANCERCANCER
Proteasome
DNA Repair
Gene loss
ENVIRONMENTAL ENVIRONMENTAL
STRESSSTRESS
mutation
silencing and expressing gene
ENVIRONMENTAL FACTORENVIRONMENTAL FACTOR
Nutrition excess calories cancers of colon, rectum, stomach,
breast, ovaries excess fat consumtion obesity
cigaretes 1/3 of cancer deaths Cancers of lung, pancreas, mouth,
larynx, liver, alchohol esophagus and bladder
occupation 5% of cancerdeaths cancers of lung, bladder, stomach, blood, liver, bones, skin
Radiation 3% /xray, uv, isotop blood and skin
Other drug, virus, bacteri various
Cancer cells
Normal and Cancer cells contrast in their proliferation capacity
Normal cells
Limited number of divisions
Permanent growth arrest/senescence
Unlimited number of divisions
Tumor
Vs
CANCER NEED MORE ENERGYCANCER NEED MORE ENERGY
environmental stressenvironmental stress
p53, HSF
ApoptosisApoptosisrepair mechanism,
protecting cell
necroticnecrotic
CancerCancer
healty nutrient/suplement
HSF, HO-1, NOS,
P45OR (GENE
PROTECTOR)
interaction of genes between stressor and food cause cancer