Agenda:

- Validation Harmonized Protocol: update - Validation vs pathology- Hippocampal Label Expansion project: update- News- Congress presentations- Papers

XVIII PMT meeting – June 5, 2013

Validation versus pathology

1 tracer (Greg)

Segmentation based on Harmonized Protocol:

Analysis based on the information available for each dataset and vs Bobinsky’s paper

Mayo ClinicAD + CTRL + MCI dataset

with pathologically confirmed diagnosis (Braak’s stages),

but not postmortem hippocampal measurement

Mony DeLeon15 AD + 5 CTRL at 1.5T

postmortem MRI and quantitative histology

(possible additional AD cases)

(Bobinsky paper on 9 AD+4 NL sbj scanned with Philips)

15 Philips + 18 GE13 post-mortem 10 post-m

T1 PD

50antem

de Leon

GE PD

Partial volume??

de Leon

Philips T1

Hippocampal Label Expansion project: update

Subjects = 135 Hippocampi = 270

MRI tracer tracing QC/correction Certification

68/68 1.5 T Masami Complete I-II Complete

(67 3T)30/30 Dominik Complete I-II Complete12/12 Rossana Complete I-II Complete10/10 Martina Complete I-II Complete15/15 Michel Complete I-II Complete

SD received all of the certified labels

Tracers are Masters or platform-Qualified. Anyway, exact ICCs across the 5 can be computed using the volumes of the Qualification round.

PLATFORM

- SD has tech support from PAVI, at Université de Sherbrooke

-They are looking into file formats for the contours

- SD has scheduled a meeting with the Technical Advisory group

Hippocampal Label Expansion project: SD update

News: Subfields

Group composed by Paul Yushkevich, Susan Mueller and Lei Wang aims to converge hippo-subfields imagers for protocol harmonization.

They asked for our participation, to tune the protocols and import harmonizaton methods.

We are invited to present the Hippo Harmonization project a-remoto to their HS3 meeting, June 21-2

http://hippos3.wordpress.com/

News: Duvernoy

Duvernoy explained some unclear anatomy issues and approved:

AC-PC standard orientation

Inclusion of “vestigial” tissue

Choices of the Delphi panel

Participation as a coauthor

NEXT HARMONIZATION MEETING: JULY 17 H 12-14

- AIC-AAIC (Boston, July 13-18, 2013) Training of Naïve Tracers; Statistics for Certification Platform POSTERS

- AIC-AAIC developing topicsValidation phase 1: preliminary data; Expansion project: preliminary data on 1.5T images

SUBMITTED

-CTAD (San Diego, Nov 3-5, 2011)Validation phase 1: preliminary data; Expansion project: preliminary data on 1.5T images

SUBMITTED

Congress Presentations

Papers

1) Survey of protocols (preliminary phase; JAD 2011)2) Operationalization (preliminary phase; Alzheimer’s &

Dementia, published online)3) Axes check short report (Brescia Team, ADJ-D-13-00030,

I revision)4) Master tracers’ practice and reliability (Brescia Team,

Sent to coauthors)

5) Development of certification platform (Duchesne and coll)6) Consensual Protocol definition (Brescia Team –

companion paper 1)

7) Validation data (Brescia Team – companion paper 2)8) Validation vs pathology (TBD)

DO

NE

ON

GO

ING

PL

AN

NE

D

VALIDATION VS CURRENT PROTOCOLSASSESSMENT OF SOURCES OF

VARIANCE TRAINING SET DEVELOPMENT

VALIDATION VS PATHOLOGY

GOLD STANDARD

Harmonized ProtocolADNI scans: 2 x 5 Scheltens’s

atrophy score x 2 sides x 2 magnet strengths (1.5-3T)

Total per rater: 40 hippos

Harmonized ProtocolADNI scans: 2 sides x 5 Scheltens’s atrophy scores

x 3 time points (bl-1y-2y) x 3 scanners (+ retracing @ bl)

x 2 magnet strengths (1.5-3T)Total per rater: 240 hippos

Assessment of variance due to rater and center

Local ProtocolADNI scans: 2 x 5 Scheltens’s atrophy scores

x 2 sides x 2 magnet strengths (1.5-3T)

Harmonized ProtocolADNI scans: 2 x 5 Scheltens’s atrophy score x

2 sides x 2 magnet strength (1.5-3T)Total per rater: 40 hippos Harmonized Protocol:

Pathological datasets: Mayo Clinic and NYU

Total: about 40 hippos

TrainingADNI scans: 10 at 1.5T x 2 sides x 7

SUs x 2 tracing roundsTotal per rater: 40 hippos

20 naïve tracers 5 master tracers 1 tracer

REFERENCE PROBABILISTIC MASKS

with 95% C.I.

QUALIFICATION QUALIFICATION

Best 5 naïve tracers

Assessment of variance due to side, trace-retrace, atrophy, time, scanner, rater

TRAINING SET

Assessment of agreement with volume on pathology or ex vivo

MRI and correlation with neuronal density

GANTT