Agenda01 About Pollogen – Expect more

02 geneO+ Revolutionary skin care platform

03 OxyGeneo™ & TriPollar® – Technologies Overview

04 Clinical results and B&A

01 About PollogenExpect more

As technology leaders, we continuously challenge ourselvesto deliver innovation withgenuine added value foraesthetic professionals.

Pollogen develops & markets advanced solutions for the aesthetics market

Pollogen - Expect more

We believe that every customer deserves to benefit from the best of all worlds: safe, pleasant and non-invasive treatment, as well as long-lasting results that can be seen and felt immediately

To contend with this challenge, we develop innovative technologies, manufacture smart & user-friendly systemsand offer a broad variety of treatments with proven results.Above all, we redefine the standards in the world of aesthetics and are committed at all times to give you more…

More Global presence

Over 60 distributors worldwide

More ResultsClinically provenPeer reviewed papers in leading medical journals confirming the safety and effectiveness of Pollogen’s technologies.

More PartnershipWith Pollogen, you have a true partnerPollogen will accompany you the whole way and provide you with a comprehensive range of services of exceptional standard:

•Updates on new technological developments

•Product training

•Clinical support

•Technical support

•Supply of marketing materials

•Direct communication with the sales manager

•Comprehensive marketing consulting and support

From small niche to a $4.4B market

In the past decade, the global aesthetics market has grown at a double-digit pace, developing from a small niche to a $3.3B market in 2010.

Despite the global recession, consumers continue to invest in beauty treatments, & the market is expected to reach $4.4B in 2015.

More Opportunities

Source: BCC Research

More InnovationsPollogen® is a world leader in innovative, clinically proven, aesthetic solutions for facial treatments and body sculpting.

Revolutionary skin care platform02

Introducing…

Where superior aesthetic treatments meet RF technology to create a breakthrough skin-care platform

Designed with the aesthetic professional in mind, geneO+ integrates Pollogen’s new patented OxyGeneo technology with renowned TriPollar technology.

geneO+ delivers superior skin nourishment and oxygenation together with clinically proven anti-aging results.

Product Overview

The combination of TriPollar RF and OxyGeneo improves skin quality both at the epidermis and dermis layers delivering long lasting results

• New treatment options and increased customer flow• Position your clinic as a leader and gain an advantage over your

competitors with cutting-edge technology and design• Increased income & quick ROI• Affordable product entry price• Charge premium price for treatments • Increase repeat customers and customer loyalty• geneO+ treatments are an ideal opportunity to upsell home use

cosmetics/treatments

Join the success! Be one of the thousands of clinics worldwide that offer patented TriPollar & OxyGeneo Technologies!

OxyGeneo™ and TriPollar® combination protocol

Advantages of OxyGeneo & TriPollar

OxyGeneo - A 3 in 1 skin care treatment to actively nourish, vitalize and hydrate the skin:• Exfoliation of the outer skin layer• Infusion of revitalizing nutrients • Oxygenation of skin generated from within

TriPollar RF – The 3rd generation RF anti-aging technology•Wrinkle reduction•Skin tightening•Safe, effective and pleasant•Immediate and long term results

Protocol according to indicationTreatment focused on fine lines and wrinkles - •6 weekly sessions, followed by monthly touch up session.•First OxyGeneo (NeoRevive or NeoBright ~8 min) and then TriPollar (full face ~30 min)•The OxyGeneo treatment exfoliates the stratum corneum and enables better impact of the RF

Treatment focused on improving skin texture and nourishment •6 weekly sessions, followed by monthly touch up session•First TriPollar (full face ~20 min) and then OxyGeneo (NeoRevive or NeoBright ~8 min)•The RF treatment increases blood circulation and improves penetration of the active ingredients of the gel.Note: both protocols can be finalized with NeoMassage session (~5 min)

OxyGeneo & TriPollarTechnologies Overview03

OxyGeneo Technology

Similar to the natural hot springs effect, OxyGeneo™ is the world’s first technology that significantly accelerates the absorption and optimal utilization of nutrients by the skin using our exclusive Capsugen and specialized Gels.

Natural hot springs have been known through the ages for their therapeutic benefits, allowing minerals to be effectively absorbed through the skin to revitalize body cells.

• Harnesses the body's natural mechanisms to deliver 3 effective treatments simultaneously:• Exfoliation of the outer skin layer• Infusion of revitalizing nutrients with Pollogen’s unique skin care

formulas• Natural skin Oxygenation from within• OxyGeneo’s “3 in 1” approach creates an optimal environment for the

skin to absorb essential nutrients both during and after treatment.• OxyGeneo uses disposable and easy to sterilize components that

ensures maximum hygiene during every treatment.

OxyGeneo Technology

Each treatment includes a unique

combination of Capsugen™

and gels developed by Pollogen from natural ingredients

OxyGeneo - How it works• Pollogen’s unique Capsugen™ is

composed of sodium bi-carbonate and citric acid. Our exclusive gel contains natural active ingredients.

• When the effervescent Capsugen™ comes in contact with the exclusive treatment gel on the skin surface an immediate reaction is triggered.

• This reaction induces the OxyGeneo effect that simultaneously:

• Exfoliates the skin’s outer layer • Prepares it for infusion of active

ingredients• Infuses the natural active ingredients

deep into the epidermis• Enriches the area with O2 rich blood

OxyGeneo - How it works

OxyGeneo produces countless minute CO2 bubbles which gently burst on the skin surface.

•The OxyGeneo applicator is designed to degas the CO2 bubbles from the gel and infuse them into the epidermis. •The applicator’s frequency and amplitudes are specifically designed to:

• Produce a kinetic force that optimizes the chemical reaction generating CO2 bubbles and:

• Enable optimal penetration of CO2 bubbles into the epidermis.

OxyGeneo - How it worksThe outcome is a CO2 rich environment on the skin's surface*.

The body responds by:•Sending O2 rich blood to the area•Increasing capillary blood flow•Increasing metabolism of the skin cells

The desired result: Optimal absorption of the active ingredients by the skin

* The chemical reaction between the Capsugen and the gel that generates CO2:

OxyGeneo and The Bohr Effect

C02 rich environment & infusion of active ingredients

Oxygenation of skin cells & skin rejuvenation

This C02 rich environment induces a physiological response called the BOHR EFFECT leading to increased tissue oxygen.

• TriPollar 3rd generation RF technology: • TriPollar utilizes RF energy to induce collagen & elastin regeneration

in the dermis layer. Leading to:

• Smoother and tighter skin• Fine lines and wrinkles reduction

• Improved skin texture

TriPollar® Technology

• 3rd generation TriPollar RF - applies conductive RF to the skin via 3 or more electrodes

• Energy is focused in the target area for optimal effect – not requires cooling

• Volumetric heating generates clinical effect• The most pleasant RF treatment due to focused energy field

allowing low power consumption

Pollogen’s Breakthrough TriPollar Technology

TriPollar® Preparation Gel• The matching fluid for the TriPollar

treatment is the TriPollar Preparation Gel.

• The TriPollar preparation gel should be applied on the treatment area before starting the TriPollar RF treatment.

• The gel lubricates the area and allows smooth movement of the applicator on the skin.

• Has a high electrical resistance forcing the electrical current to enter deep into the skin, avoiding the current from flowing on the surface and creating sparks

Clinical Results and B&A04

Clinical studies and B&A

EVALUATION OF SAFETY AND EFFICACY OF THE TRIPOLLAR® TECHNOLOGY FOR TREATMENT OF WRINKLESSteven D. Shapiro MD & Amos Leviav MD

Study Objective: • To evaluate the safety of the apollo™ system for treatment of wrinkles and rhytides. • To evaluate the efficacy of the apollo™ system for treatment of wrinkles and rhytides.

Methods: Subjects: 37 Female subjects were recruited - 37 completed all treatments, 3 lost to

follow-up due to travel or change of residence.

Visits: 8 Weekly treatments, Follow-Up at 1 month and 3 months after treatment 8.

Two sites:―Steven Shapiro MD (Dermatologisit) – Gardens Dermatology and Cosmetic Surgery Center, Florida US―Amos Leviav MD (Plastic Surgeon) - Kaplan Hospital, Israel

STUDY # 1

Results

Safety ― No unexpected adverse side effects were detected or reported. ― All subjects reported no pain or mild pain during the treatments.

Efficacy ― A downgrade of at least 1 score in Fitzpatrick scale was found in 94% (1st

reviewer) and 97% (2nd reviewer) of study subjects. ― Subjects satisfaction questionnaires revealed high level of satisfaction.― PI’s scoring of subjects’ facial skin appearance at baseline and 3 at month FU

demonstrated average reduction of 1.55 (Dr. Leviav) and 2.4 (Dr. Shapiro) .

ConclusionsThe results of this study clearly indicate that the TriPollar technology offers a non-invasive, effective, safe and virtually painless wrinkle and rhytides reduction treatment.

STUDY # 1

Sample photos: A 51 years old femaleBefore - Baseline After - 3M following 8 Tx

STUDY # 1

Sample photos: A 42 years old femaleBefore- Baseline After - 3M following 8 Tx

STUDY # 1

Sample photos: A 59 years old female

Before- Baseline After - 3M following 8 Tx

STUDY # 1

Sample results: A 61 years old female

Before- Baseline After - 3M following 8 Tx

STUDY # 1

CLINICAL EXPIRIENCE WITH A TRIPOLLAR® RADIOFREQUENCY SYSTEM FOR FACIAL AND BODY AESTHETIC TREATMENTSDr. Alex Levenberg

Study Objective: To evaluate the safety and efficacy of the TriPollar® for non-invasive treatment of localized excess fat and facial tightening

Materials and Methods: •37 female patients •Average of 7 treatments for wrinkles, laxity and circumference reduction on different facial and body areas. •Evaluation methods:

o Facial results objectively analyzed with Primos 3D imaging system o Photographs – evaluate facial results

STUDY # 2

Results:•Average circumference reduction, in main body areas (abdomen, buttocks, thighs): 3.6 ± 2.4 cm (P < 0.0001)

• Abdomen: 4.5 ± 2.7 cm, max 10.5 cm• Buttocks: 3.1 ± 1.7 cm, max 5 cm• Thighs: 2.4 ± 2.0 cm, max 6.4 cm

•Improvement of perioral and periorbital wrinkles was achieved

Before After 8 Tx

STUDY # 2

Clinical studies and B&A

OxyGeneo™ TECHNOLOGY CLINICAL STUDY

Study Objective• To understand the OxyGeneo™ mechanism by evaluating its effects on blood perfusion, tissue CO2 and O2 levels and the thermal effect of the treatment.

Study method• Blood perfusion, tissue CO2 and O2 levels and thermal imaging profiles were measured on different body areas of 11 subjects. • Base line control measurements were taken before treatment.• Treatment was performed for ~10 minutes.

Study was performed by an independent 3rd party: Physiological Models

STUDY # 1

OxyGeneo™ TECHNOLOGY CLINICAL EFFECT

CO2 and O2 levels as measured before and after treatment:

CO2 levels (in blue) returned to baseline values while the O2 (in green) levels rose above the baseline levels 15 min after treatment.

STUDY # 1

• Increase in blood perfusion immediately after the treatment and a gradual return to base line levels.

• 15 min after treatment the values were higher than the baseline. • These parameters demonstrate an increase in flow and intensity

OxyGeneo™ TECHNOLOGY CLINICAL EFFECT

STUDY # 1

Study method•20 female volunteers, ages 32 - 58 were included in the study. •6 weekly facial treatments were conducted.•Treatment was performed for ~10 minutes. •The procedure was performed by a beautician and supervised by a dermatologist.•The following assessments were included:

o Auto evaluation (questionnaires to volunteers) Evaluation Scale:1.Repulsive2.Not satisfactory3.Acceptable4.Good5.Excellent

o Evaluation by professional expert (dermatologist)o B&A photographs

OxyGeneo™ TECHNOLOGY– NEOREVIVE CLINICAL STUDY

STUDY # 2

NeoRevive® Results

STUDY # 2

before after

• Enhancement of skin's pebbled appearance (elastosis). • The diffuse netted pigmentation of the encircled area has almost cleared. • The region looks more uniform and shiny.

NeoRevive® Results

STUDY # 2

More B&A

Courtesy of Dr. Stavros Eleftheriou, Surgical Art Clinic, Larnaca, Cyprus

Treated sideNon-treated side

Facial Skin Tightening after 1 treatment

TriPollar Technology - Immediate Results

50

Facial Skin Tightening after 5 treatments

Pollogen in house collection – Tel Aviv, Israel

TriPollar Technology - Long Term Results

51

before after

OxyGeneo treatment resultsFine lines improvementImmediately after 1 NeoRevive treatment

afterbeforeGFM PRIMOS portable 3D measuring system version 5.6Same client as on previous slide

OxyGeneo treatment resultsSkin smoothness demonstrated by (x500 ) MicroscopeImmediately after 1 NeoRevive treatment

before after

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