AES Biomedical Capabilities & Case Studies Case Studies on Biomedical Pharmaceutical and healthcare

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  • ADVANCED ENGINEERING SOLUTIONS INC.

    Innovative Steps to Excellence …

    AES Property/Confidential information 1

    AES Biomedical Capabilities

    AES Biomedical Capabilities & Case Studies

  • ADVANCED ENGINEERING SOLUTIONS INC.

    Innovative Steps to Excellence …

    AES Property/Confidential information 2

    AES Biomedical Capabilities 11/14/07

    Advanced Engineering Solutions Inc. (AES), is one of the leading product design and engineering

    consulting company providing product development and engineering solutions to major global companies.

    • Aerospace

    • Automotive

    • Biomedical

    • Chemical Industries

    • Consumer Goods

    • Electronic

    • Environmental

    • Energy

    • Gas Turbine

    • HVAC

    • Industrial

    • Oil & Gas

    • Power Generation

    • Process Industries

    • Pumps

    • Semiconductor

    • Steam Turbine

    • Turbo-machinary

  • ADVANCED ENGINEERING SOLUTIONS INC.

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    AES Biomedical Capabilities

    Flow Modeling Solutions for the Biomedical, Healthcare & Pharmaceutical Industries

    • Visualization and prediction of physical phenomena for crucial information.

    • Understanding the physics into delicate and often inaccessible areas

    • Helping the designer in design and development of bio-medical systems.

    • System studies include: Respiratory, Pharmaceutical, breath-activated device, Drug

    delivery (inhalers, etc.), Blood handling (pumps, separators), In vivo blood and non-

    blood flow etc.

  • ADVANCED ENGINEERING SOLUTIONS INC.

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    AES Biomedical Capabilities

    a. Troubleshooting: Diagnosing the problem and defects will be done faster, safer at less

    cost.

    b. Analyzing: Statically and Graphical data will reveal the cause/effect relationships to

    improve performance and effectiveness.

    c. Optimizing: Project viability and accuracy can be enhanced by doing number of changes

    prior to laboratory testing to save time and money.

    d. Understanding: Evaluate implications of changes in process variables to rapidly gain a

    wider knowledge base at a low cost.

    e. Reducing Development Time (Turn-around Time): Understanding the changes and

    modifications for unsuccessful attempts before conducting time-consuming laboratory tests

    and validations will be come down drastically and results in faster progress.

    e. Reducing Development Cost

    CFD Benefits

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    AES Biomedical Capabilities

    AES CFD Services

    • Steady & Transient Flows

    • Flow Distribution (Laminar & Turbulent ) using Different Turbulent Methods

    • Incompressible and Compressible

    • Swirling & Rotating Flows

    • Conjugate Thermal Analysis

    • Flow Through Porous Media

    • Rotating Frames of Reference

    • Multiple Species Transport,

    • Multi-component & Multi Phase Flow- Mixing, Flashing, Reacting Evaporation

    • Mixing

    • Multiphase

    • Fluid Structure Interaction (Including Deforming Grid),

    • Radiation Modeling

    • Cavitations

    • Lagrangian Particle Tracking

    • Forced & Natural Convection Heat Transfer

    • Free Surfaces by VOF Method

    • Deformable Meshes

    • Design Optimization studies

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    AES Biomedical Capabilities

     Inhaler Performance

    Design/Prototype Testing

     Needles

     Blood Processing Devices

    Micro-Fluidic Diagnostic Devices

    Manufacturing Process Optimization

     Blood Pumps

    Artificial Organs

    CFD Applications -Medical Device Design & Performance

    Inhaler

    Inspiratory flow

    Blood Pump

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    AES Biomedical Capabilities

    Medical Tubing Extrusion

     Blow Molding of Medical Balloons

    Micro-Electro-Mechanical Devices (MEMS)

     3D Injection Molding

     Compression Molding

    Magnetic Drug Targeting

    Blood flow within aneurysms Compression MoldingInjection

    CFD Applications - Device Manufacturing Process

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    AES Biomedical Capabilities

     Diagnostic and Therapeutic Methods

     Drug Delivery Modeling

     Blood and Other Physiological Flows

    Arteriosclerosis

     Pathologies

     Toxicology Research

    Air Flow in Physiological Passages

     Fluid Structure Interaction

     Valve Modeling

     Surgical Analysis

     Complex Rheologies

     Oxygenation

    Multiphase Flow

    Aerosol inhaler

    Heart Throb

    Bronchial tubes

    CFD Applications - Physiological Transport Modeling

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    AES Biomedical Capabilities

    P resen

    ted

    to

    Case Studies

    on

    Biomedical Pharmaceutical and healthcare

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    AES Biomedical Capabilities

    Case Study for real-time visualization of tissue viability and function

    Objective :

    • Real-time visualization of tissue viability and function based on computer simulations that will provide a new tool for

    doctors to help them in planning.

    • Pressure load calculations on the tissue walls and flow paths and directions at different locations of blood vessel (arteries)

    CFD Modeling :

    • Flow is 3D laminar, Steady and Incompressible & Conjugate heat transfer problem.

    Task Executed:

    • The model is created in Unigraphics. Tetrahedral meshing is carried out using ICEM. Analysis is carried out in CFX after

    applying the material properties and different boundary conditions. Different plots are provided in the technical report using

    CFX- Post-processing.

    Conclusion & Reliability :

    • our 3-D simulation models employing computational fluid dynamics (CFD) calculations of flow in blood vessels and

    facilitates by improving our whole organ thermal modeling by developing an improved understanding of tissue perfusion,

    metabolism, and vasculature blood flow under surgical or emergency conditions. .

    CAD Model Mesh Pressure Contours for the blood vessel

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    AES Biomedical Capabilities

    CAD Model Mesh

    Case Study for High Pressure Gas & Low Quantity Fluid Nozzle Study Objective :

    • CFD analysis to predict the flow pattern in the nozzle system.

    • To predict the static pressure & total pressure distribution , velocity and mass flow distribution of liquid in the nozzle

    system.

    • To optimise the design.

    CFD Modeling :

    • Isothermal, Turbulent and steady incompressible flow in 3D Domain is solved in Ansys CFX 11 parallel solver.

    Task Executed:

    • The model is created in Unigraphics. Hexahedral meshing is carried out using ICEM. Analysis is carried out in CFX after

    applying the material properties and different boundary conditions. Different plots are provided in the technical report using

    CFX- Post-processing.

    Conclusion & Reliability :

    •From the Analysis, the static pressure, total pressure, mach number, static temperature, mass fractions of fluids at different

    location and velocity components are plotted. Based on the analysis, the liquid gas ratio and performance are optimized

    for the given design as per the SOW. Customer verified the initial results as well as optimized results obtained by CFD

    analysis with the experimental data.

    Contours : Stream lines, Velocity and mass fraction

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    AES Biomedical Capabilities

    Case Study for MEB mobile charger head coil assembly thermal analysis Objective :

    • Neuro-modulation CFD Analysis describing the transient thermal performance of the MEB mobile charging head coil assembly in

    multiple simulated cases is to simulate test conditions used during design verification testing. .

    • Thermal performance includes the temperature distribution throughout the entire assembly to outer surface temperature.

    • To estimate response times to reach the specified temperature by the sensors

    CFD Modeling :