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What is the Biology of Stress?
EQUATION TO REMEMBER:Strong, Frequent, Prolonged Exposure to an
Adverse Experience
+ No Adult Support
= Toxic Stress
Let’s watch the movie
Resilience: the “Science of Hope”
Resilience is the ability to thrive, adapt
and cope despite tough and stressful
times.
It is a skill that can be taught, learned
and practiced.
Resilience does not mean “get over
it”. It means caring adults have power
to buffer rather than cement the
effect of toxic stress.
Guided Discussion
1. What touched you the most? What had real meaning for you
from what you saw in the film?
2. What is a health or social issue in the film that you were
surprised tied back to ACEs?
3. What are your thoughts about the ACE scores of those in this room?
4. How does a person with an ACE score of 0 or 1 relate
differently than a person with an ACE score of 4+ ?
5. Who is at risk for toxic stress due to trauma in our community?
6. How can we get this information into the hands of the general population?
ACE StudyStrong, Frequent, Prolonged
Exposure to an Adverse
Experience + No Adult Support =
TOXIC STRESS
Toxic Stress can actually change
brain architecture to predispose
maladaptive behaviors. In turn, this
can lead to early onset of chronic
disease and premature death.
The Resilience movement is to
create trauma-informed systems
and self-healing communities
where the perspective is not
“What’s wrong with you?” but
instead “What happened to you?”
Review: Biology of Stress & Science of Hope
“We need to put to bed forever the sense that
children who are born under disadvantaged
conditions circumstances are doomed to poor
life outcomes. Science is saying that is not
true,” Dr. Jack Shonkoff, Harvard University
“Why are we waiting for them to fall apart?” Dr.
David Johnson, Clinical Psychologist
Science of Hope: PEOPLE ARE RESILIENT!
Lakota “Three Sisters Story” told by Dr. Donald Warne, American Indian
Public Health Resource Center, on Prairie Doc
https://www.youtube.com/watch?v=4qad2yfPdR0&feature=youtu.be
Go to minute 39:36
How do we get upstream? “Science of Hope”
Resilience isn’t just for children Adults can learn skills, too.
“We need a two generation approach recognizing that the child is
experiencing ACEs now and the parent likely experienced ACEs
during their own early years.” Angela Giardino, M.D., Ph.D., Texas
Children’s Hospital
If we want to produce dramatic impacts on the outcomes for kids
experiencing toxic stress, we have to transform the lives of the adults
who are taking care of them.” Dr. Jack Shonkoff, Harvard University
“If we can get the science into the hands of the general
population, they will invent very wise actions.”
What would you like to invent?
“Will you stay?”
Historical Trauma
Toxic Stress
Adverse Childhood
Experiences (ACEs)
Biology of Stress: The ACEs model helps to
understand how trauma is transmitted intergenerationally
Types of Trauma
• Affects approximately 90% U.S. adult population.
• Potentially traumatic events include
• Acute events
• Interpersonal trauma
• Community violence or military combat
• Insidious trauma
• Cultural and historical trauma
• Intergenerational trauma
• Institutional trauma
(Kilpatrick, Resnick, Milanak, Miller, Keyes, & Friedman, 2013)
Slide adopted from SAMHSA Trauma-Informed Interviewing Training, March 2016
Stress without the buffering response of a strong adult relationship causes prolonged, brain-controlled secretion of stress hormones
Cortisol, norepinephrine, epinephrine, etc.
Stress responses are beneficial in the short term with adult support, but can be damaging to health if they occur over long periods of time
Constant wear and tear
Potentially permanent changes in gene regulation (epigenetic effect)
Biology of Stress: Physiologic Response
Biology of Stress: The grim toll of
ACEsPremature Death:
In 2015, the median age at death was 80 for all South Dakotans
For white residents the median age at death was 81 years
For American Indians median age at death was 56 years
SD Department of Health Website http://doh.sd.gov/statistics/2015Vital/Mortality.pdf
An American Indian (AI) infant has less of a chance of
surviving to celebrate a first birthday than white infants.
South Dakota Department of Health Website,
http://doh.sd.gov/statistics/2015Vital/InfantMortalit
y.pdf
Compiled for SWO by Northern Plains Tribal
Epidemiology Center from Division of Vital Records,
North Dakota Dept. of Health; Office of Health
Statistics, South Dakota Dept. of Health.
The 5-year incremental infant
mortality rate (2011-2015) is
5.35 for white infants and
12.34 for AI infants.
Pregnancy Health Survey for Parents of Newborns
on the Lake Traverse ReservationSara DeCoteau, Bonny Specker, Ph.D.,
Sherry Johnson, Ed.D., Teresa Binkley, Ph.D., Tianna Beare, Audrey German, Peggy Peters, & Maggie Minett
Sisseton-Wahpeton Oyate & South Dakota State University
Funded through the Sanford Collaborative
Research Center for American Indian
Health Pilot Grant 2015 from the National
Institutes of Health, Minority Health &
Health Disparities Research, Federal Award
No. 5U54MD008164-04
Pregnancy Health Survey for Parents of Newborns on
the Lake Traverse Reservation ACE Score Results 2015
44.6
22.0
14.1
5.9
13.4
18.5
23.7
15.5
8.8
33.4
12.2
21.1
12.2
16.7
37.8
14.3
23.8
19.0
11.1
31.7
0
10
20
30
40
50
0 1 2 3 4+
Pe
rce
nt
ACE Score Categories
SD White
SD Amer Indian
SWO Mother
SWO Father
ACE Score Comparison Discussion44.6
22.0
14.1
5.9
13.4
18.5
23.7
15.5
8.8
33.4
12.2
21.1
12.2
16.7
37.8
14.3
23.8
19.0
11.1
31.7
0
10
20
30
40
50
0 1 2 3 4+
Per
cen
t
ACE Score Categories
SD White
SD Amer Indian
SWO Mother
SWO Father
• Fewer SWO mothers and fathers had ACE scores of 0 than SD White Mothers. In the ACE Study
36% had a score of 0, compared to 14% of SWO fathers and 12% of SWO mothers.
• ACE scores for the 1 and 2 categories were comparable between populations and the ACE
Study.
• Beginning with scores of 3 or higher, contrasts begin to emerge:
• 16.7% of SWO mothers had a score of 3, compared to 9.5% in the ACE Study, 11.1% for SWO
fathers, 8.8% of SD American Indian mothers, and 5.9% of SD White mothers.
• In the ACE Study, 12.4% had a score of 4%. This was similar to the SD White mothers rate at
13.4%. The rate for SWO mothers was three times higher at 37.8%. SD American Indian
mothers and SWO fathers were similarly high at 33.4% and 31.7%.
ACEs and Population Attributable Risks
© 2013www.ACEInterface.com
What are the
implications for
“Science of
Hope”? Where
we can establish
a baseline
measure, we can
monitor change
over time as
interventions are
implemented.
Science of Hope:
1. Safety – creating an environment of
physical and psychological safety
2. Trustworthiness and
Transparency – operating with
transparency to build and maintain
trust
3. Peer Support – providing an
opportunity for support and mutual
self-help from fellow trauma survivors
4. Collaboration and
Mutuality – placing importance
upon the healing power of
relationships (everyone has a role)
5. Empowerment, Voice, and
Choice – understanding the unifying
power of shared experiences of trauma
and cultivating self-advocacy
6. Cultural, Historical, and
Gender Issues – moving past
cultural stereotypes and leveraging the
healing value of traditional cultural
connections by addressing historical
trauma
Six Key Principles of a Trauma-Informed Approach
S
A
M
H
S
A
2
0
1
4
Science of Hope: Practical To-do’s
• Don’t talk bad about others
• Engage with respect and compassion
Share what you know
• Spend more time, less money
• Choose to empower and elevate others
• Set achievable goals; grow them with
time
• Celebrate accomplishments (yours too!)
• Be kind to you so you can be kind to
others
Science of Hope: Change the First Five Years and You Change Everything
https://youtu.be/GbSp88PBe9E
Guided Discussion (Continued)
7. Identify the programs and policies our community is already using to build resilience?
8. What strategies or methods to build resilience might
work here?
9. What are the barriers to implementing these strategies?
How can we get around them?
10.What can the First 1,000 Days Initiative Interagency Forum do?
a) Short term (NOW)
b) Medium term (2018)
c) Long term (next five years)
LINKS TO VIDEOS ABOUT ACES
Prairie Doc, American Indian Health Care, January 2017
https://www.youtube.com/watch?v=4qad2yfPdR0&feature=youtu.be or you can view
TED Talks Motivational Film
http://www.ted.com/talks/nadine_burke_harris_how_childhood_trauma_affects_health_across_a_lifetime?share=19391661a0#t-676574
“Can Family Secrets Make You Sick?”
http://www.npr.org/blogs/health/2015/03/02/377569413/can-family-secrets-make-you-sick
Change the First Five Years and You Change Everything
http://www.youtube.com/watch?v=GbSp88PBe9E
Children’s Hospital of Wisconsin, Pediatric Grand Rounds – August 4, 2017, featuring Dr. Nadine Burke-Harris, Presentation with Slides
http://chw-external.mediasite.com/Mediasite/Play/266cc8440022486ba288884d696110f21d
Children’s Hospital of Wisconsin, Pediatric Grand Rounds, August 4, 2017, featuring Dr. Nadine Burke-Harris, Questions & Answers (Too Small to Fail: The Power of Parents)
http://chw-external.mediasite.com/Mediasite/Play/e117ec800c7b45789429be5253fd99ff1d