Advances in therapy of solid tumors by using different radioisotopes

Prof. Nossrat Firusian,

Recklinghausen, Germany

Different radiations and potential activity of penetration

Energy - Radiation - Radiation

1 Mev 0,0005 mm 4,3 mm

5 Mev 0,014 mm 25 mm

10 Mev 0,105 mm 55 mm

50 Mev 17 mm 190 mm

Penetration of - and - radiation in water

Most important radioisotopes for therapy of malignant diseases

P32 (Natriumphosphat) pure -Emission 14 d

P32 Colloid pure -Emission 14 d

(Chromphosphat)

90 Colloid pure -Emission 60 h

Sr89 (Chlorid) pure -Emission 51 d

Jod 131 + -Emission 8 d

Systemic therapy of bone metastases (Sr89)

Systemic 89-Sr-therapy of bone metastasis (str89)

Intracavitary treatment of tumor-associatedpericard-tamponade

Intracavitary treatment of pericardial-tamponade associated with malignancies (p32-colloid)

Intracavitary therapy of pericardial-tamponade associated with breast-cancer (p32-colloid)

Infiltration therapy bypP32-colloid in patients with thoracic wall metastases

Infiltration therapy by p32-colloid in thoracic wall metastases

Infiltration therapy by p32-colloid in thoracic wall metastases

Important conditions for intralesional therapy by colloidal radioisotopes

1. Appropriate kinetic

2. Lack of absorption

3. Targeting by sonography or CT

4. Lack of toxicity

5. Lack of hemostasiologic disorders

Kinetic investigations by scanning ofBremsstrahlung

after local administration of p32-colloid

Quantitative assay of blood after intralesional administration of 32p-chromphosphat

CT-Documentation before and after

intratumoral application of 32p-colloid in

bronchogenic carcinom

Morphologic behaviour of large

colorectal-metastases under local therapy

with 32p-colloid

CT-Features of a huge metastatic retroperitoneal

formation under 32p-colloid therapy

Characteristics of 22 patients with hepatic metastases and HCC

Toxicities under 22 patients with hepatic metastases, HCC and CCC under 32p-colloid

Sonographic changes of metastatic lesions under 32p-colloid therapy

vor Therapie nach 1. fraktionierter Therapie nach 3. fraktionierter Therapie .

Sonographische Verlaufsuntersuchungen einer großen solitären Lebermetastase

vor Therapie

Sonographische Verlaufsuntersuchungen eines solitären metastatischen Prozesses des re. Leberlappens

3 Wochen nach fraktionierterTherapie

Sonographic changes of hepatic secondary tumors under 32p-colloid therapy

Pathologic anatomical changes after 3x 32p-colloid therapy in an advanced large solitary

metastases of liver

Results of 32p-colloid therapyin different hepatic tumors

Dose Calculation

Conclusions

1. Locoregional 32p-colloid therapy is to be considered after systemic modalities

2. As a microinvasive therapy even possible in any problematic topographic locations

3. Within central part of solid tumors, effective dosis within a range of 1000 gray

4. Unifocal tumor formations are most adequate targets of this treatment