ADVANCED NON-INVASIVE TECHNIQUES IN EARLY DETECTION OF ORAL CANCER

PRESENTED BY: Abhishek Ghosh

3rd prof. B.D.S.Dr.R.Ahmed Dental

college &HospitalGUIDED BY:

Dr. Jay Gopal RayH.O.D.

Dept. Of Oral & Maxillofacial

Pathology

ORAL CANCER : SOME DEADLY STATISTICS• Every hour 1 American dies of oral cancer

• Death rate is higher than cervical cancer

• 25%cases have no risk factor

IMPORTANCE OF EARLY DETECTION

70% cases are diagnosed in late stagesIt leads to 5 year survival rate of 57% patientsOral cancer is 90% curable when detected early

Why non-invasive techniques?• Painless and bloodless technique

• Biopsy is not possible in screening examination

• Helpful for follow-up cases

• Easy and simple for operator

• Patient’s medical status is fragile for biopsy• Patient refuses for biopsy

EXFOLIATIVE CYTOLOGYIt is the histo-

pathological examination of

cells obtained by their physical

removal,followed by placement on glass-slide and

then appropriately stained.

Preparation of ‘Pap-smear’

VIZILITESimple painless non-invasive technology to visualize suspicious areas at earlier stages what we may not see by naked eyes .It’s based on the principle of CHEMILUMINESCENCE

ACTION OF VIZILITEUnder vizilite

normal healthy tissue will

absorb light & appear dark.

Abnormal tissue will

appear white.

HOW VIZILITE WORKS?Mouth

rinse

• Removes mucosal glycoprotei-n

• Increase N-C ratio

Light

stick

• Differentia-te between normal & abnormal tissue

STEPSEncourage the

patient after routine exam

Rinse with 1%acetic acid for 30-60 sec

Bend outer light stick breaking

inner vial

Shake vigorously to mix content of

light stick

Insert it into open end of retractor &

assemble

Make the room dark & re-examine the oral cavity with vizilite

Intra-oral vital

stainingWith Toluidine blue helps to identify dysplastic and malignant mucous membrane in the oral cavity.

STEPSDrying of mucosa with gauge

Mouth rinse with 1% T-blue for 1-2 min

1 min rinse with 1% acetic acid for decolourisation

Maligna-nt cells have more metaboli-c rate

They retain the stain

Normal mucosa decolou-rises

VIZILITE &TOLUIDINE BLUEVIZI-LITE

T-BLUE

SITE

FOR BIOPSY

IR THERMOGRAPHYIt uses the heat of

our body to aid in making diagnosis.It is completely safe and uses no radiation.

2 parts-1.IR CAMERA

2.HIGH RESOLUTION COMPUTER

MECHANISMDetection of breast cancer

Use in oral cancer –on way

Malignant tissue has more vascularity

Raised surface temperature

Detected by thermograph

ADJUNCT TO SURGICAL BIOPSY

Confirm diagnosis

Biopsy

Visual examinati-on

Screening

CONCLUSIONThese screening

techniques help in early detection of malignancy with an accuracy of 90 % and thus

%

THANK YOU