Advance Programme & Call for Abstracts...Causes and Consequences of microRNA Dysregulation in Cancer Speaker: C. Croce (USA) The Susan G Komen® for the Cure Supported Symposium: Susceptibility

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Advance Programme & Call for Abstracts

22nd Biennial Congress of theEUROPEAN ASSOCIATION FOR CANCER RESEARCH

From Basic Research to Personalised Cancer Treatment

www.eacr.org

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Congress CommitteesOrganising & Scientific Programme CommitteeJulio Celis (DK), Congress Chair

Anne-Lise Børresen-Dale (NO) Richard Marais (UK)

Ivan Dikic (DE) Moshe Oren (IL)

Raffaella Giavazzi (IT) Joerg Schlehofer (DE)

Clare Isacke (UK) Joan Seoane (ES)

Verena Jendrossek (DE) Marc van de Vijver (NL)

Robert Kenney (UK) Moshe Yaniv (FR)

National & Local Organising Committee Joan Seoane, National Chair

Salvador Aznar-Benitah Manel Esteller

Mariano Barbacid Federico Mayor-Zaragoza

José Baselga José Navas

Miguel Beato Carlos López Otín

María Blasco Eugenio Santos

Ana Carrera Luis Serrano

EACR-22: Save the DatesAbstract Submission Opens 1 December 2011

Abstract Submission Closes 1 March 2012

Bursary Application Closes 22 February 2012

Early Rate Registration Closes 30 March 2012

Regular Rate Registration Closes 30 May 2012

Housing Reservation Closes 30 May 2012

Accreditation for Continuous Medical Education (CME)At the time of printing, an application for accreditation has been submitted to the Accreditation Council of Oncology in Europe (ACOE).

Venue & SecretariatCongress Secretariat

c/o ECCO – the European CanCer OrganisationAvenue E. Mounier 83B-1200 BrusselsBelgium

Tel: +32 (0)2 775 02 01

Fax: +32 (0)2 775 02 00

Email: [email protected]

www.ecco-org.eu

Congress Venue

Centre Convencions Internacional Barcelona (CCIB) – FORUMRambla Prim 1-17ES-08019 Barcelona Spain

Tel : +34 (0)93 230 10 00

Fax : +34 (0)93 230 10 01

Email : [email protected]

www.ccib.es

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Letter of WelcomeEACR - 22 From Basic Research to Personalised Cancer Treatment

It is a great pleasure to announce that the 22nd Biennial EACR Congress will be held in Barcelona 7 -10 July 2012.

I am delighted that the Congress is actively supported by the Spanish Association for Cancer Research (ASEICA) and to be holding the Congress in one of Europe’s most vibrant cities, a city with a remarkable reputation for cancer research and cancer care.

EACR-22 will provide a forum for discussion between scientists working in all fields of cancer research. It will focus on the latest developments in basic and discovery driven translational research, through to personalised cancer treatment.

EACR congresses are well known for providing an exciting programme that is highly valued by participants. EACR-22 in Barcelona will be no exception. The Congress will offer outstanding plenary lectures complemented by focussed symposia

across eighteen topics. There will be opportunities for participants to attend ‘Educational Sessions’ as well as invitations to ‘Meet the Expert’. Posters will be displayed for review and ‘defence’ throughout the Congress in the Exhibition Hall and all participants will be invited to assist in their evaluation.

I hope that you will return from the Congress inspired by colleagues from around the world and that you will have made new friends and scientific contacts that will support you in your essential work. I also hope that the Congress will live long in the memory, combined with the experience of Barcelona and its unique atmosphere.

Julio E. CelisCongress Chair

EACR also wishes to thank the sponsors of the prestigious Award and Keynote lectures at EACR-22 for their partnership and commitment to the congress.

AcknowledgementEACR wishes to acknowledge the support of its Sustaining Members and their valued contribution to the development of the Association and the success of its congress.

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Scientific ProgrammeAdvance Programme at a GlancePlease note that the Advance Programme is provisional and therefore subject to change. For all programme updates kindly visit the EACR-22 Congress website: www.ecco-org.eu

Saturday, 07 July 2012

Room 111+112 Room 113+114 Room 115 Room 116

Opening Address 13:00 - 13:15

Mühlbock Lecture13:15 - 14:15

ASEICA Lecture: Deconstructing Metastasis

14:15 - 15:00

Coffee Break 15:00 - 15:30

Symposium 15:30 - 17:15

Cancer Genomics

Symposium 15:30 - 17:15

Cancer Immunology

Symposium 15:30 - 17:15

DNA Damage & Genome Instability

Pezcoller Foundation – EACR Cancer Researcher

Award Lecture 17:15 - 18:00

Opening Lecture followed by Reception 19:30

Sunday, 08 July 2012


Educational Lecture08:00 - 08:50Sequencing

Educational Lecture08:00 - 08:50

How to Make Drugs


To Be Announced

Meet the Expert09:00 - 09:45

Meet the Editor

Meet the Expert09:00 - 09:45Meet the ERC


EC Personalised Medicine

Coffee Break / Poster Viewing / Exhibition 09:45 - 10:15

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Symposium 10:15 - 12:00 Epigenetics

Symposium 10:15 - 12:00

Viruses and Cancer

Symposium 10:15 - 12:00

Ageing and Cancer

EMBO Lecture: Cancer Genomics

12:15 - 13:00

Lunch - Poster Viewing - Exhibition

Young Cancer Researcher’s WS

13:00 - 14:00

Satellite Symposium13.00 - 14.30


Plenary Lecture: Non Coding RNA

14:30 - 15:15

Anthony Dipple Carcinogenesis Award

15:15 - 16:00

Coffee Break / Poster Defence and Exhibition 16:00 - 17:30

Symposium17:30 - 19:15

Susceptibility Genes


Inflammation and Microenvironment


Cell Death/Autophagy

EACR General Assembly, Awards Ceremony and Reception 19:30

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Monday, 09 July 2012



Bioinformatics

Educational Lecture08:00 - 08:50Biomarkers


Metabolomics


How to Organise Cancer Research


Imaging


Nutrition and Cancer Prevention - World Cancer

Research Fund (WCRF)


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Symposium 10:15 - 12:00

Mouse Models

Symposium 10:15 - 12:00Stem Cells

Symposium 10:15 - 12:00

Molecular Insights into Invasion and Drug

Resistance

FEBS LectureDrug Development

12:15 - 13:00

Lunch - Poster Viewing - Exhibition

Young Cancer Researcher’s WS

13:00 - 14:00



OECI Lecture:Cancer Systems Biology

14:30 - 15:15

Carcinogenesis Young Investigator’s Award

15:15- 16:00

Coffee Break / Poster Defence and Exhibition 16:00 - 17:30


Targeted Therapies


Angiogenesis


Tumour Metabolism

Congress Dinner 20:30

Tuesday, 10 July 2012

Room 113+114 Room 115 Room 116


Proteomics Technology


A-Z of Clinical Trials


Immunotherapy


Molecular Diagnostic

Meet the Expert09:00 - 09:45Biobanking


Systems Biology in Cancer


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FEBS Molecular Oncology Supported Symposium

10:15 - 12:00 Personalised Medicine

Symposium 10:15 - 12:00

Metastases and EMT

Symposium 10:15 - 12:00

Melanoma, an Example of Translational Research

Closing Remarks and EACR-22 Highlights

12:00 Mike Price Gold Medal Award Lecture

12:15 - 13:15

Saturday 7 July 2012

Mühlbock Lecture13:15 - 14:15

Lgr5 Stem Cells in Self-renewal and CancerSpeaker: H. Clevers (NL)

ASEICA Lecture 14:15 - 15:00

Micrometastasis Niches, Signals and PathwaysSpeaker: J. Massagué (USA)

Symposium: Cancer Genomics15:30 - 17:15

Chair: E.R. Mardis (USA)

Genomic Analysis of Human Tumours for Guiding Therapeutic SelectionSpeaker: C.M. Perou (USA)

The Genomic Landscapes of Breast Cancer and Their Clinical RelevanceSpeaker: C. Caldas (United Kingdom)

Presenter to be selected from best abstract

Using Whole Genome Sequencing for Digital Analysis of Tumour EvolutionSpeaker: E.R. Mardis (USA)

Symposium: Immunotherapy of Cancer as the Most Personalised Cancer Treatment15:30 - 17:15

Chair: L. Zitvogel (France)

Immunotherapy of High Risk HPV infectionsSpeaker: C.J.M. Melief (The Netherlands)

Immunogenicity of Cell Death During Chemotherapy: Novel Tools Towards the Personalization of Breast Cancer TreatmentSpeaker: G. Kroemer (France)

Presenter to be selected by best abstract

Novel Predictors of Response to Tyrosine Kinase Inhibitors: The Paradigm of KIT+ Malignancies and NK Cell AttackSpeaker: L. Zitvogel (France)

EACR-22 Advance Programme

Symposium: DNA Damage and Genome Instability 15:30 - 17:15

Chair: J. Bartek (Denmark)

Unexpected New Insights Into ATM and p53Speaker: M. Kastan (USA)

The Molecular Basis for Replication-Induced DNA Damage in Early Stages of Cancer DevelopmentSpeaker: B. Kerem (Israel)


DNA Damage and Genomic Instability in Cancer Development: Mechanisms and Opportunities for Targeted TreatmentSpeaker: J. Bartek (Denmark)

The Pezcoller Foundation – EACR Cancer Researcher Award Lecture17:15 - 18:00

From Normal Cells to Cancer Stem Cells, from Transformation Mechanism to Targeted Therapy: a Leukemia ProspectiveSpeaker: C.W. So (UK)

Opening Ceremony: Opening Lecture and Reception 19:30 - 21:00

Personalised Cancer TreatmentSpeaker: J. Mendelsohn (USA)

Sunday 8 July 2012

Educational Lecture: Sequencing08:00 - 08:50

Speaker: H. Yang (China) Educational Lecture: How to Make Drugs08:00 - 08:50

Speaker: J. Yingling (USA) Educational Lecture08:00 - 08:50

How Do We Study Network Pertubations in Clinical Specimens? How do we Select “Drivers” of Malignancies?Speaker: S. Friend (USA) Meet the Editor: Inside Nature09:00 - 09:45

Speaker: B. Marte (United Kingdom)

The 22nd Biennial Congress of the EACR will take place in Barcelona, Spain, 7th-10th July 2012. The following pages show the most up-to-date scientific programme available at 21st March.

Meet the Expert: Meet the ERC09:00 - 09:45

Speaker: C.H. Heldin (Sweden)

Meet the Expert: Meet the Pharma Industry09:00 - 09:45

Speaker: R. Bergström

Symposium: Epigenetics10:15 - 12:00

Chair: M. Esteller (Spain)

Current Views of the Cancer Epigenome and the Translational ImplicationsSpeaker: S.B. Baylin (USA)

Defining the Functional Cancer EpigenomeSpeaker: J.G. Herman (USA)


Human Cancer EpigeneticsSpeaker: M. Esteller (Spain)

Symposium: Viruses and Cancer10:15 - 12:00

Chair: D. Lowy (USA)

Hepatitis C Virus: Pathogenesis, Immunology and InterventionSpeaker: C. Rice (USA)

Epstein-Barr Virus: Pathogenesis and ImmunobiologySpeaker: A.B. Rickinson (UK)


Current and Future Vaccines to Prevent HPV-associated CancersSpeaker: D. Lowy (USA)

Symposium: Ageing and Cancer 10:15 - 12:00

Chair: M. Serrano (Spain)

Telomeres and Telomerase as Therapeutic Targets for Cancer and AgingSpeaker: M.A. Blasco (Spain)

Mechanisms of Aging and LongevitySpeaker: A. Brunet (USA)


Ageing and Cancer: the Somatotropic LinkSpeaker: M. Holzenberger (France)

EMBO Lecture12:15 - 13:00

Cancer GenomicsSpeaker: M. Stratton (United Kingdom)

Young Cancer Researcher’s Workshop13:00 - 14:00

How to be Effective in Applying for FellowshipsCoordinator: To be announced

OECI Lecture: Cancer Systems Biology14:30 - 15:15

Systems Approaches to Cancer and Other DiseasesSpeaker: L. Hood (USA)

Anthony Dipple Carcinogenesis Award Lecture15:15 - 16:00

Causes and Consequences of microRNA Dysregulation in CancerSpeaker: C. Croce (USA)

The Susan G Komen® for the Cure Supported Symposium: Susceptibility Genes17:30 - 19:15

Chair: B. Ponder (United Kingdom)

The COGS (Collaborative Oncological Gene-environment Study): Progress and Results Speaker: D. Easton (United Kingdom)

The Search for Rare Variants That Contribute to Cancer SusceptibilitySpeaker: F. Lesueur (France)


Clinical Applications of GWAS Data: Lessons from Breast and Prostate Cancer Speaker: B. Ponder (United Kingdom)

Symposium: Inflammation and Microenvironment17:30 - 19:15

Chair: M. Karin (USA)

Targeting Cytokine Networks in MalignancySpeaker: F. Balkwill (United Kingdom)

Tumour Promoting Macrophages and Immune Cells Speaker: A. Mantovani (Italy)


Control of Tumour Progression and Metastasis by Lymphocyte-Produced CytokinesSpeaker: M. Karin (USA)

Symposium: Cell Death / Autophagy17:30 - 19:15

Chair: S. Cory (Australia)

Autophagy and CancerSpeaker: E.P. White (USA)

Regulation of Inflammation and Cell-Death Trough Interactions of RHIM-domain Protein Kinases With Caspase-8Speaker: D. Wallach (Israel)


Regulation of Apoptosis by the Bcl-2 FamilySpeaker: S. Cory (Australia)

Monday 9 July 2012

Educational Lecture: Bioinformatics08:00 - 08:50

Speaker: P. Bork (Germany)

Educational Lecture: Statistical Challenges in the Development of Reliable and Clinically Meaningful Biomarkers 08:00 - 08:50

Speaker: L. McShane (USA)

FEBS Lecture: Targeted Cancer Therapy Development12:15 - 13:00

Targeted Cancer Therapy DevelopmentSpeaker: A. Ullrich (Germany)

Young Cancer Researcher’s Workshop13:00 - 14:00

Women in ScienceSpeaker: M. Blasco (Spain)

Ramon Areces Foundation Lecture14:30 - 15:15

The ceRNA Hypothesis and the Non-coding Revolution in Cancer Research and TherapySpeaker: P.P. Pandolfi (USA)

Carcinogenesis Young Investigator’s Award Lecture15:15 - 16:00

Immune Surveillance of Senescent Cells-biological Significance in Cancer- and Non-cancer PathologiesSpeaker: L. Zender (Germany) Symposium: Targeted therapies / Signalling Pathways17:30 - 19:15

Chair: A. Levitzki (Israel)

Title: To be confirmedSpeaker: D. Arndt-Jovin (Germany)

Targeting JAK-STAT Signalling for Cancer TherapySpeaker: R. Jove (USA)


Targeting the Immune System to CancerSpeaker: A. Levitzki (Israel)

Symposium: Angiogenesis17:30 - 19:15

Chair: K. Alitalo (Finland)

Mechanisms of Resistance to Anti-VEGF Treatment - New Therapeutic StrategiesSpeaker: A.L. Harris (United Kingdom)

Anti-angiogenesis: Novel StrategiesSpeaker: P. Carmeliet (Belgium)


Targeting Multiple Endothelial Growth Factor PathwaysSpeaker: K. Alitalo (Finland)

Symposium: Tumour Metabolism17:30 - 19:15

Chair: T.W. Mak (Canada)

Roles of p53 in the Control of Metabolic PathwaysSpeaker: K. Vousden (United Kingdom)

Profiling Metabolism for Cancer Biomarker DiscoverySpeaker: H. Keun (United Kingdom)


Exploiting Cancer Cell Metabolism: Can it be Done?Speaker: T.W. Mak (Canada)

Educational Lecture: The use of Metabolomics to Discover Novel Metabolic Networks and new Targets for Cancer Treatment08:00 - 08:50 Speaker: E. Gottlieb (United Kingdom)

Meet the Expert: How to Organise Cancer Research09:00 - 09:45

Speaker: N. Jones (United Kingdom)

Meet the Expert: Functional Imaging09:00 - 09:45

Speaker: M. Schwaiger (Germany)

Meet the Expert: Nutrition and Cancer Prevention - World Cancer Research Fund (WCRF)09:00 - 09:45

Speaker: M. Wiseman (United Kingdom) Symposium: Mouse Models10:15 - 12:00

Chair: M. Barbacid (Spain)

Using switchable mouse genetics to find optimal cancer drug targetSpeaker: G.I. Evan (United Kingdom)

Studying Therapy Response and Resistance in Mouse Models of Human Breast CancerSpeaker: J. Jonkers (The Netherlands)


Identification and Validation of Therapeutic Targets in K-Ras Driven TumoursSpeaker: M. Barbacid (Spain) Symposium: Stem Cells10:15 - 12:00

Chair: A. Trumpp (Switzerland)

Cancer-initiating cells in glioblastomaSpeaker: J. Seoane (ES)

To be announcedSpeaker: to be announced


Dormant Blood Stem Cells and Circulating Cancer Stem CellsSpeaker: A. Trumpp (Switzerland)

Symposium: Molecular Insights into Invasion and Drug Resistance10:15 - 12:00

Chair: D.A. Haber (USA)

Acquired Resistance to Targeted TherapiesSpeaker: J.A. Engelman (USA)

Pancreatic Cancer TherapiesSpeaker: D. Tuveson (United Kingdom)


Molecular Characterisation of Circulating Tumour CellsSpeaker: D.A. Haber (USA)

Tuesday 10 July 2012

Educational Lecture: Proteomics Technology08:00 - 08:50

Mass Spectrometric Strategies for Protein Biomarker Discovery and ValidationSpeaker: R. Aebersold (Switzerland)

Educational Lecture: The A-Z of Clinical Trials08:00 - 08:50

The A-Z of Clinical Trials - Clinical Trial Design Incorporating Efficacy, Translational and Biomarker EndpointsSpeaker: E.A. Eisenhauer (Canada)

Educational Lecture: Immunotherapy08:00 - 08:50

Cancer Immunotherapy: Strategies for Enhancing its Activity in Cancer PatientsSpeaker: F. Belardelli (Italy)

Meet the Expert: Molecular Diagnostic09:00 - 09:45

Molecular Diagnostics in Breast Cancer: Getting Beyond ER, PR, HER2 and ProliferationSpeaker: J. Reis-Filho (United Kingdom)

Meet the Expert: Biobanking09:00 - 09:45

Speaker: P.H.J. Riegman (the Netherlands)

Meet the Expert: Systems Biology in Cancer09:00 - 09:45

Speaker: Y. Yarden (Israel)

FEBS Molecular Oncology Supported Symposium: Personalised Medicine10:15 - 12:00

Chair: T. Tursz (France)

Interrogating the Genome to Find Mechanisms of Drug Resistance in CancerSpeaker: R. Bernards (The Netherlands)

New Targeted Agents in Development for Cancer TreatmentSpeaker: J.C. Soria (France)


Personalised Oncology: a Worldwide Challenge for Drug Development, Epidemiology and Public Health Speaker: T. Tursz (France)

Symposium: Metastases and EMT10:15 - 12:00

Chair: J. Thiery (Singapore)

MicroRNAs, EMT and Cancer Stem CellsSpeaker: T. Brabletz (Germany)

Regulation of Epithelial Plasticity and Metastasis of Breast Carcinoma by Lysyl Oxidase-like 2 (LOXL2)Speaker: A. Cano (Spain)


Identification of EMTed Carcinoma and Potential Therapeutic StrategiesSpeaker: J. Thiery (Singapore)

Symposium: Melanoma, an Example of Translational Research10:15 - 12:00

Chair: R. Marais (United Kingdom)

The Basics of Melanoma Cell SignallingSpeaker: R. Marais (United Kingdom)

Treating metastatic melanoma with the BRAF inhibitor vemurafenib and mechanisms of resistance Speaker: P. Chapman (USA)


The Immuno Side of MelanomaSpeaker: A. Ribas (USA)

Closing Session12:00 - 12:15

Closing RemarksPoster AwardsEACR-22 Highlights

Mike Price Gold Medal Award Lecture12:15 - 13:15

The Future of Personalised MedicineSpeaker: J. Baselga (USA)

Pre-Congress Symposia

Prior to the start of the EACR Congress on Saturday afternoon, there will be a choice of two pre-congress symposia for interested participants.

Translational Research in Early Clinical Drug Development

Seve Ballesteros Foundation Symposium on Brain Cancer

There is no additional registration fee to attend a symposium and we hope that you will find that the choice of special conferences will add extra interest and value to your EACR congress experience.

Please register for the symposium you wish to attend on the special EACR-22 congress website:

http://eacr22.eacr.org

More information

For more information on the programme, an A-Z list of all speakers and Pubmed/research links, visit the special congress website: http://eacr22.eacr.org

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Call for Abstracts Abstract submission opens: Thursday 01 December 2011Deadline Abstract submission: Thursday 01 March 2012Abstracts can only be submitted online at: www.ecco-org.eu

For more information on abstract topics, format, submission and selection process please visit the Conference website: www.ecco-org.eu (Select Congresses and Conferences > EACR-22 > Call for Abstracts).

Award Lectures The EACR Mike Price Gold Medal AwardThe EACR Mike Price Gold Medal Award is presented at the biennial EACR Congress to a scientist who has made an outstanding contribution to cancer research.

We are pleased to announce that EACR’s first Gold Medal will be presented to José Baselga at EACR-22 and that Professor Baselga will give the Mike Price Gold Medal Lecture on the final day of the Congress.

The Pezcoller Foundation – EACR Cancer Researcher Award (lecture)Celebrating academic excellence and achievements in the field of cancer research

Call for Nominations for ‘A researcher of excellence’

Nominees will be Cancer Researchers from European countries* with no more than 15 years post doctoral experience and a record of employment in Europe of at least five years.

The winner will give the prestigious Pezcoller Foundation – EACR Award Lecture at EACR-22 and receive a prize of 10,000EUR.

The winner will also be invited by the Pezcoller Foundation to attend a ceremony in Trento where a plaque will be presented in recognition of the achievement.

The award will be presented for the first time at EACR-22 and at future EACR biennial congresses.

Nominations are invited from scientists who are involved in cancer research or have been affiliated with any institution, cancer medicine or cancer-related biomedical science. Self nominations cannot be accepted.

� Further information and nomination forms are available at www.eacr.org

*Country of present employment

Carcinogenesis Award LecturesSenior Award: The Anthony Dipple Carcinogenesis AwardAwarded for major contributions to research in the field of carcinogenesis.

Young Investigator AwardAwarded for a recent, significant contribution to carcinogenesis research.

The call for nominations for the Carcinogenesis Award Lectures is now closed. The award winners will be announced early in 2012.

BursariesMeeting Bursaries (EACR Members Only)Meeting Bursaries will be awarded to assist EACR members to attend the Congress and make a poster presentation.

The scheme is designed to support postgraduate students and members with less than 10 years post-graduate experience who have difficulties in securing alternative funding to participate in the Congress.

The value of each award will be up to 1,000 EUR. This bursary will be used to assist with the cost of the registration fee, travel and accommodation.

� Further information and application forms are available at www.eacr.org

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General InformationCommercially Sponsored Satellite SymposiaEACR-22 Satellite Symposia will take place as follows: Sunday 8 July 2012 13:00 – 14:30 Room 115 Room 116Monday 9 July 2012 13:00 – 14:30 Room 115 Room 116

ExhibitionThe EACR-22 Exhibition represents an essential part and integral element of the Congress, providing participants with an excellent platform for networking as well as perfect opportunity to gain critical insight into cutting edge technology and the latest healthcare solutions and services within the oncology field.

To view the EACR-22 list of exhibitors and a detailed floor plan please visit www.ecco-org.eu (select ‘Congresses and conferences’). Entrance to the exhibition is free for all registered participants.

The EACR-22 Exhibition will be open as follows: Sunday 8 July 09:45 – 17:30Monday 9 July 09:45 – 17:30Tuesday 10 July 09:45 – 12:00

Companies and organisations that would like to participate in the exhibition can download the Invitation to Industry brochure from the Congress website www.ecco-org.eu or contact Bruno De Man, Email: [email protected], Tel: +32(0)2 775 02 04.

Hotel AccommodationHotel accommodation at reduced rates for both individuals and groups can only be booked online at www.ecco-org.eu (select ‘Congresses and conferences’, ‘EACR-22’).

All rooms are booked on a first come first served basis. The deadline for hotel reservation is 30 May 2012. Bookings received after this date will be subject to availability. In order to benefit from reduced rates, please clearly mention ‘EACR-22’ when making your booking.

InsuranceThe organisers do not accept liability for individual medical, travel or personal insurance and participants are strongly advised to make their own arrangements regarding health and travel insurance.

Italian Participants – Prerichiesta AIFAEACR-22 has appointed a sole agency in Italy to manage all administrative details regarding the legal documentation required by Italian Legislative Order n.541 of December 30, 1992, art 12, para 3.

For Italian ‘Prerichiesta AIFA’ we ask you to contact the IPCAA-Italia Association directly:IPCAA-Italia AssociationVia Dario Niccodemi 1420052 Monza (MI), ItalyFax: +39 0389 2121693E-mail: [email protected]

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Language and TranslationThe official language of the Congress is English. No simultaneous translation will be provided.

Lunch and RefreshmentsA light lunch box is included as part of the registration fee and will be provided on Sunday and Monday. Coffee and teas are freely available during the programme breaks.

Official Carrier The Star AllianceTM Network Members are pleased to be appointed as the Official Airline Network for EACR-22. To obtain the Star Alliance Conventions Plus discounts, please quote the event code SK06A23 when calling the

reservation office of a participating Star Alliance member airline. For booking office information please visit: www.staralliance.com/conventionsplus.

Registered participants plus one accompanying person travelling to the event can be granted a discount of up to 20%, depending on the fare and class of travel.

The participating airlines for this event will be announced on www.ecco-org.eu. Discounts are offered on most published business and economy class fares, excluding website/internet fares, senior and youth fares, group fares and Round the World fares.

Please note: for travel from Japan and New Zealand, special fares or discounts are offered by the participating airlines on their own network.

Passport and VisaA valid passport is required for entry into Spain. A visa may be required for some countries. For information about visa and passports please contact your local Spanish Embassy at least 3 months prior to your departure to join us in Barcelona.

Social EventsSaturday 7 July 2012 - Opening Ceremony

All registered delegates are invited to join us for an inspiring Opening Lecture followed by a Welcome Reception. Come and network with friends and colleagues over canapés and local delicacies in a relaxed setting.

� Price per person: 25 EUR.

Tickets can be purchased upon completing the Registration Form or alternatively onsite in Barcelona from the EACR-22 Registration Desk.

Monday 9 July 2012 - Congress Dinner

A Congress Dinner is organised.

� Registered delegates can buy tickets at the price of 80 EUR (student rate: 60 EUR).

TransportationParticipants registered for the entire duration of EACR-22 will be able to buy a public transport ticket at the Congress Centre valid for the days of the Congress at half price.

RegistrationRegistration is now open online – please visit: www.ecco-org.eu (select ‘Congresses and conferences’).

Participants are encouraged to register early in order to benefit from significant savings on fees and to avoid disappointment should the congress become oversubscribed.

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22nd Biennial Congress of theEUROPEAN ASSOCIATIONFOR CANCER RESEARCHwww.eacr.org

Registration FormTitle & contact details Last Name: First Name:

Institute/Company: Department:

Address:

City: Postcode: Country:

Int. Tel. Number: E-mail:

Billing address Indicate ‘As above’ or complete below Institute/Company:

Address:

City: Postcode: Country:

VAT number: Int. Tel. Number:

E-mail:

EACR MembersEnter your Membership number here if registering at the EACR Members’ rate:

Non members wishing to join the Association and benefit from the Members’ registration rate should apply online at www.eacr.org. Annual membership is available at 40 EUR per annum or 120 EUR for the four year membership. Student membership is free of charge for up to four years.

Profession

❑ Basic Scientist❑ Clinical Trial Coordinator❑ General Physician❑ General Surgeon❑ Gynaecologist❑ Haematologist

❑ Medical Affairs❑ Medical Oncologist❑ Neurologist ❑ Neuro-surgeon❑ Nurse❑ Oncology Pharmacist

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❑ Student❑ Neuro-oncologist❑ Translational Scientist❑ Urologist❑ Other

Registration fees (please tick as appropriate)

Early Rate Regular Rate Late Rate On Site Rate

Deadline: 30 March 2012

Deadline:30 May 2012

Deadline:2 July 2012

As of3 July 2012

EACR Members 445 EUR 585 EUR 635 EUR 730 EUR

EACR Non-Members 495 EUR 635 EUR 685 EUR 730 EUR

Students* 250 EUR 270 EUR 290 EUR 350 EUR

Day Rate (On Site only) 240 EUR

Spouse Ticket** 25 EUR 25 EUR 25 EUR 25 EUR

Social Event: Opening Ceremony 25 EUR 25 EUR 25 EUR 25 EUR

Conference Dinner LLLM person(s) at regular rate 80 EURLLLM person(s) at regular rate 60 EUR

All registration fees include local VAT (18%).

* Please send a letter from your Head of Department to confirm your student/’in training’ status.** This ticket allows access to the Opening Ceremony on 07 July 2012. Please note: Access to Scientific Sessions or the Exhibition is NOT permitted.

❑ Prof. ❑ Dr. ❑ Mr. ❑ Mrs. ❑ Ms.

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22nd Biennial Congress of theEUROPEAN ASSOCIATIONFOR CANCER RESEARCHwww.eacr.org

Method of payment❑ Paid by credit card (preferred) ❑ Eurocard/Mastercard ❑ Visa ❑ American Express Card Number: Expiry Date:

Cardholder’s name as shown on the card: Control/CVC-Code:

Please charge the above mentioned credit card to cover my registration fee to attend EACR-22.

Cardholder’s signature:

❑ Remitted by bank transfer (accepted until 2 July 2012 in EUR)

IBAN: BE15 4254 0400 8130Swift/BIC code: KREDBEBBKBC Bank, Chaussée de Wavre 1662, B-1160 Brussels

To facilitate easy processing, please indicate clearly the name of the participant(s) and add the reference ‘Registration Fee EACR-22’ on the transfer document.

Replacements and cancellationsReplacements (= delegate name change) are subject to a charge of 35 EUR per participant. Cancellations of confirmed registrations are subject to a charge of 75 EUR per participant provided the cancellation is received by 30 May 2012. For cancellations received after this date no refunds will be made.

By completing this form I accept the terms and conditions of registration mentioned above.If posting or faxing please sign and date below.

Date: Signature:

The EACR-22 Congress Secretariat can be reached at: ECCO – the European CanCer OrganisationAvenue E. Mounier 83B 1200 BrusselsBelgiumTel.: +32 2 775 02 00 Fax: +32 2 775 02 01 E-mail: [email protected]

For additional information please contact:

ECCO – the European CanCer Organisation

Avenue E. Mounier 83

B-1200 Brussels

Belgium

Tel: +32 2 775 02 01

Fax: +32 2 775 02 00

Email: [email protected]

www.ecco-org.eu

See you in Barcelona

22nd Biennial Congress of theEUROPEAN ASSOCIATION FOR CANCER RESEARCHFrom Basic Research to Personalised Cancer Treatment

7-10 July 2012

Documents

Advance Programme & Call for Abstracts...Causes and Consequences of microRNA Dysregulation in Cancer Speaker: C. Croce (USA) The Susan G Komen® for the Cure Supported Symposium: Susceptibility