Addison Disease

Brenda SengsavathCHEM 4700

Protein Structure & Function3.18.15

What is Addison Disease?Addison Disease is when your body produces insufficient amount of certain hormones

produced by your adrenal glands.

Symptoms:

•Muscle weakness and fatigue•Weight loss and decreased appetite•Darkening of Skin•Salt Craving•Depression•Body Hair Loss and Sexual Dysfunction in women•Low Blood Pressure

Term of Sickness?

Although the disease is a lifelong condition, but there are no long-term implications that medication cannot take care of.

Affects of Addison Disease

We know that Addison Disease is caused by the insufficient steroid hormones, which can also damage the body’s immune system.

In order for the adrenal gland to function, it requires cholesterol, which is converted biochemically into steroid hormones.

In biological terms, Addison disease is a rare endocrine disease that results from underproduction of aldosterone and cortisol hormones by the adrenal glands.

TreatmentAddison disease is treated by taking medication in replacement of needed cortisol depending on

different individuals.

Treatment usually involves replacing the hormones that the adrenal cortex is no longer manufacturing.

If medications are properly taken, there should not be any side effects.

Addison Disease

Secondary Motifs and Domains

There are stable, independently folding formed by the segments of the chain with function distinguishable from other regions and stabilized through the same kind of linkages.

Sometimes it may contain motifs, sometimes don’t.

It does contain some domains referring back to the image.

There are small ligand and surface to bind to other proteins.

In some cases, each domain in a protein is encoded by a separate exon.

References

Addison T. On the Constitutional and Local Effects of Disease of the Supra-renal Capsules. London, UK: Samuel Highley; 1855.

Alder R. Addison's disease. Magill’S Medical Guide (Online Edition) [serial online]. January 2013;Available from: Research Starters, Ipswich, MA. Accessed April 29, 2014.

Blackie, Rosmary. Chemist & Druggist. 10/13/2012, Vol. 278 Issue 6842, p14-18. 3p.

Huseby ES. Replacement therapy for Addison's disease: recent developments. Expert Opin Investig Drugs. 2008 Apr;17(4):497-509. doi:

Micheals, A. Michels, N. Addison disease: early detection adn treatment principles. April 2014; Avaliable from: http://www.ncbi.nlm.nih.gov/pubmed/24695602. Accessed March 18, 2015.

Lovas, K. Husebye, ES. Replacement therapy in Addison’s Disease. Feb. 2004. http://www.ncbi.nlm.nih.gov/pubmed/14640913. Accessed Marc 18, 2015.

Napier C. Pearce SH. Current and Emerging Therapies for Addison’s Diease. June 2014. http://www.ncbi.nlm.nih.gov/pubmed/24755997. Accessed March 18, 2015.