Addendum

The following abstract [Nolan MS, Podoll AS, Yan C, Finkel K, Murray KO, West Nile Virus and ChronicKidney Disease: A Case-Control Evaluation] is an addendum to [Am J Kidney Dis. 2013;61(4):A1-A100]. Thisabstract belongs to the category “CKD/ESRD - Prevalence, Progression, Preparation for Dialysis”.

WEST NILE VIRUS AND CHRONIC KIDNEY DISEASE: A CASE-CONTROL EVALUATION Nolan MS, Podoll AS, Yan C, Finkel K, Murray KO UTHealth Science Center at Houston and Baylor College ofMedicine, Houston, TX, USA Persistent infection of the kidney with West Nile virus (WNV)is well described in animals, but the potential long termconsequences in humans is poorly understood. Previously, we reported the presence of viral particles in the urine of individualswith remote WNV infection and the association between WNVinfection and chronic kidney disease (CKD). Traditional riskfactors such as diabetes, age, and hypertension were not found tobe associated with CKD in this cohort. This study aims to further distinguish clinical characteristicsbetween CKD patients with and without a history of WNVinfection. WNV negative controls (n=83) were matched to WNVpositive cases (n=40) in a 2:1 ratio by age, race, gender, andCKD stage. We performed a retrospective chart review on WNVnegative controls and used previously collected data on WNVpositive individuals. The two groups were compared for longitudinal progression of kidney disease, presence of riskfactors, and clinical characteristics of CKD. We found theprevalence of diabetes and hypertension were significantly lowerin the WNV positive case group, and the incidence of proteinuriaand hematuria were significantly higher compared to the WNVnegative controls. GFR decline in WNV positive casesproceeded at a rate of -10.77 ml/min/1.73 m2/year versus -5.04ml/min/1.73 m2/year for WNV negative controls (p<0.03 ).These findings suggest that previous WNV infection contributes to declining kidney function. Practitioners should monitor thekidney health of patients with a history of WNV infection.

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