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Modern medical imaging and radiation therapy technologies are so complex and computer driventhat it is difficult for physicians and technologists to know exactly what is happening at the point-of-care. Medical physicists responsible for filling this gap in knowledge must stay abreast of the latestadvances at the intersection of medical imaging and radiation therapy. This book provides medicalphysicists and radiation oncologists current and relevant information on Adaptive RadiationTherapy (ART), a state-of-the-art approach that uses a feedback process to account for patient-specific anatomic and/or biological changes, thus delivering highly individualized radiation therapyfor cancer patients. The book should also benefit medical dosimetrists and radiation therapists.Adaptive Radiation Therapy describes technological and methodological advances in the field ofART, as well as initial clinical experiences using ART for selected anatomic sites. Divided into threesections (radiobiological basis, current technologies, and clinical applications), the book covers:Morphological and biological biomarkers for patient-specific planning Design and optimization oftreatment plans Delivery of IMRT and IGRT intervention methodologies of ART Management ofintrafraction variations, particularly with respiratory motion Quality assurance needed to ensurethe safe delivery of ART ART applications in several common cancer types / anatomic sites Thetechnology and methodology for ART have advanced significantly in the last few years andaccumulated clinical data have demonstrated the need for ART in clinical settings, assisted by thewide application of intensity modulated radiation therapy (IMRT) and image-guided radiationtherapy (IGRT). This book shows the real potential for supplying every patient with individualizedradiation therapy that is maximally accurate and precise.

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