To review the role of Radiation Neurotoxins in triggering, developing of radiation induced central nervous system injury. Radiation Neurotoxins – rapidly acting blood toxic lethal agent, which activated after irradiation and concentrated, circulated in interstitial fluid, lymph, blood with interactions with cell membranes, receptors and cell compartments.
Acute Radiation Cerebrovascular Syndrome
Advanced Medical Technology & Systems Inc.Dmitri Popov, PhD
Radiobiology.Acute Radiation CerebroVascular Syndrome. Part 1.Acute
Radiation Cerebrovascular Syndrome.Key words: Cerebrovascular Acute
Radiation Syndrome (Cv ARS), Radiation Neurotoxins (RNT),
Neurotransmitters, Radiation Countermeasures, Antiradiation Vaccine
(ArV), Antiradiation Blocking Antibodies, Antiradiation Antidote.
Psychoneuroimmunology, Neurotoxicity, Autoimmunity.Acute Radiation
Cerebrovascular Syndrome. Functional areas of human brain.
Acute Radiation Cerebrovascular Syndrome.Cerebrovascular
circulation
Acute Radiation Cerebrovascular Syndrome.To review the role of
Radiation Neurotoxins in triggering, developing of radiation
induced central nervous system injury. Radiation Neurotoxins
rapidly acting blood toxic lethal agent, which activated after
irradiation and concentrated, circulated in interstitial fluid,
lymph, blood with interactions with cell membranes, receptors and
cell compartments. Acute Radiation Cerebrovascular
Syndrome.Radiation Neurotoxins biological moleculesproteins with
high enzymatic activity and specific lipids, activated after
irradiation. The Radiation Neurotoxins induce increased
permeability of blood vessels, disruption of the blood-brain
barrier, blood-cerebrospinal fluid (CSF) barrier and developing
severe disorder of blood macro- and micro-circulation. Acute
Radiation Cerebrovascular SyndromePrinciples of Radiation
Psychoneuro-immunology and Psychoneuro-allergology were applied for
determination of pathological processes developed after irradiation
or selective administration of Radiation Neurotoxins to radiation
nave mammals. Effects of radiation and exposure to radiation can
develop severe irreversible abnormalities of Central Nervous
System, brain structures and functionsAcute Radiation
Cerebrovascular Syndrome. Antiradiation Vaccine.Antiradiation
Vaccine most effective, advanced methods of protection, prevention,
mitigation and treatment and was used for of Acute Radiation
Syndromes and elaboration of new technology for immune-prophylaxis
and immune-protection against , Heavy Ion, Neutron irradiation and
UV Radiation. Acute Radiation Cerebrovascular Syndrome.
Antiradiation Vaccine.Results of experiments suggested that
blocking, antitoxic,specific antiradiation antibodies can
significantly reduce toxicity of Radiation Toxins. New, advanced
technology include active immune-prophylaxis with Antiradiation
Vaccine and effective specific Antiradiation therapy that included
specific blocking antibodies to Radiation Neurotoxins.Acute
Radiation Cerebrovascular Syndrome.Antiradiation Vaccine and
Antiradiation IgG preparations prospective effective
antidote/countermeasure for -irradiation, heavy ions irradiation,
neutron irradiation and UV Radiation. Recommendations for treatment
and immune-prophylaxis of CNS injury, induced by radiation, were
proposed. Specific immune therapy and specific immune prophylaxis
reduce symptoms of ARCvS.Acute Radiation Cerebrovascular
Syndrome.CerebrovascularAcuteRadiationSyndrome (ARCv S) is an
extremely severe, specific, dynamic injury of Central Nervous
System (CNS) and Peripheral Nervous System (PNS).Toxic stimulation
and inhibition of Autonomic Nervous System Parasympathetic and
Sympathetic Nervous System occur after irradiation. Even small
doses of radiation could induce injury or disturbance of CNS, PNS
and gastrointestinal nervous system.Acute Cerebrovascular Radiation
Syndrome.Grading System for Acute Cerebro-vascular Radiation
Syndrome based on general clinical signs.Degree 1 Mild form of
ACvRS. Radiation Neurotoxins SRD 4.1; Nausea, Vomiting - Occasional
(once per day).Anorexia - Able to eat , appetite decreased. Fatigue
syndrome Able to work. Hypotension - Blood pressure>100/170 mm
Hg.
Acute Cerebrovascular Radiation Syndrome.Neurologic deficit
Detectable. Cognitive deficit Detectable,
minor.--------------------------------------------------------
Degree 2 - Moderate Form. Radiation Neurotoxins : SRD
4.2.Nausea, Vomiting - Intermitted (2-5 times per day).Anorexia -
Intake decreased. Fatigue syndrome - Impaired work ability.
Acute Cerebrovascular Radiation Syndrome.Hypotension - Blood
pressure
