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Acquired Cardiovascular Disease
(Bacterial (Infective)Endocarditis
Dr. Omayah Nassar
https://www.google.jo/search?hl=en&biw=1366&bih=662&tbm=isch&sa=1&ei=-kEgWrCtD4LFwQLH6aGACw&q=child+with+Bacterial+endocarditis&oq=child+with+Bacterial+endocarditis&gs_l=psy-ab.3...37029.41567.0.42063.11.11.0.0.0.0.150.1438.0j11.11.0....0...1c.1.64.psy-ab..0.2.286...0i13k1.0.hZc8lEL-maE#imgrc=BdoTv-yQUAqr_M:
Objectives
By the end of this lecture, the student will be able to:
• Define Infective Endocarditis (IE)
• Explain the pathophysiology of IE
• Analyze the Diagnostic evaluation of IE
• Evaluate the therapeutic management of IE
• Discuss the nursing care management of IE
• Bacterial endocarditis(BE), infective endocarditis(IE), and sub acute bacterial endocarditis (SBE)
• Its an infection of the valves and inner lining of the heart
• It can occur without underlying heart diseases
• Most often complication of bacteremia in the children with:
- Acquired or congenital anomalies of the heart
(Valvular abnormalities)
- Prosthetic valves
- Rheumatic heart disease with valve involvement
The most common causative agent are Staphylococcus aureus and Streptococcus viridans
• Gram-negative bacteria, and fungi such as Candida albicans
Pathophysiology
The organisms may enter the bloodstream from any site of localized infection.
The most common portals of entry are:
• Oral (from dental work) (S. viridans)
• The microorganisms grow on the endocardium, forming vegetation , deposits of fibrin, and platelet thrombi.
Pathophysiology
The lesion may invade neighboring tissues, such as aortic and mitral valves,
• May break off and embolizeelsewhere, especially in the spleen, kidney, and central nervous system
https://www.google.jo/search?hl=en&biw=1366&bih=662&tbm=isch&sa=1&ei=-kEgWrCtD4LFwQLH6aGACw&q=child+with+Bacterial+endocarditis&oq=child+with+Bacterial+endocarditis&gs_l=psy-ab.3...37029.41567.0.42063.11.11.0.0.0.0.150.1438.0j11.11.0....0...1c.1.64.psy-ab..0.2.286...0i13k1.0.hZc8lEL-maE#imgrc=BdoTv-yQUAqr_M:
Clinical Manifestations (BOX 25-8)
• Onset usually insidious
• Unexplained fever (low grade and intermittent)
• Anorexia
• Splenomegaly
• Malaise, headache
• Myalgia, arthralgia
• New murmur
• Weight loss, diaphorisi
Clinical Manifestations (BOX 25-8)
• Characteristic findings caused by extra cardiac emboli formation:
• Osler nodes (red, painful intradermal nodes found on pads of phalanges)
https://www.google.jo/search?hl=en&biw=1366&bih=662&tbm=isch&sa=1&ei=-kEgWrCtD4LFwQLH6aGACw&q=child+with+Bacterial+endocarditis&oq=child+with+Bacterial+endocarditis&gs_l=psy-ab.3...37029.41567.0.42063.11.11.0.0.0.0.150.1438.0j11.11.0....0...1c.1.64.psy-ab..0.2.286...0i13k1.0.hZc8lEL-maE#imgrc=BdoTv-yQUAqr_M:
Clinical Manifestations (BOX 25-8)
• Splinter hemorrhages (thin black lines) under the nails
https://www.healthline.com/health/splinter-hemorrhages
Clinical Manifestations (BOX 25-8)
https://www.slideshare.net/rahulkshirsagar85/endocarditis-41686750
Janeway lesions (painless hemorrhagic areas on palms and soles)
Clinical Manifestations (BOX 25-8)
http://nationaldoc11.blogspot.com/2014/12/mangement-of-infective-endocarditis.html
Clinical Manifestations (BOX 25-8)
• Petechiae on oral mucous membranes
• Neonates may have:
• Feeding difficulties
• Respiratory distress
• Hf
• Tachycardia
• Symptoms of septicemia
https://www.google.jo/search?hl=en&biw=1366&bih=662&tbm=isch&sa=1&ei=TkggWr-HLsr5wQL_jIqgDg&q=child+with+Petechiae+on+oral+mucous+membranes++&oq=child+with+Petechiae+on+oral+mucous+membranes++&gs_l=psy-ab.3...59506.73844.0.74847.26.26.0.0.0.0.222.3570.0j24j2.26.0....0...1c.1.64.psy-ab..0.0.0....0.gj4mnyBlUBs#imgrc=LVc8hiF8COw5QM:
Diagnostic Evaluation
• Clinical manifestations (Box 23-8)
• Duke criteria (major and minor clinical criteria)
• Major criteria:
- Positive blood culture results for IE
- Evidence of endocardial involvement from echocardiography
Diagnostic Evaluation
• Minor criteria: (Fever, predisposing cardiac condition,…)
• Definitive diagnosis rests on growth and identification of the causative agent in the blood
• Vegetation on the valve and abnormal valve function can often be visualized by echocardiography.
Diagnostic Evaluation
• Radiographic evidence of cardiomegaly
• Anemia
• Elevated erythrocyte sedimentation rate, leukocytosis, microscopic hematuria).
Therapeutic Management
• It requires long-term parenteral drug therapy.
• Administration of high doses of antibiotics intravenously between 2 to 8 weeks.
• Blood cultures are taken periodically to evaluate response to antibiotic therapy.
Prevention of Infective Endocarditis• Administration of prophylactic antibiotic therapy 1 hour before
procedures (dental) for high risk children
• Early treatment is important in preventing further cardiac damage, embolic complications, and growth of resistant organisms.
Nursing Considerations
The objective of nursing care is:
• to counsel parents of high-risk children concerning the need for prophylactic antibiotic therapy before procedures such as dental work.
• These children should maintain the highest level of oral health
Nursing Considerations
The nurse educate parents about the signs that need practitioner's attention that include:
• Unexplained fever
• Weight loss
• Change in behavior (lethargy, malaise, anorexia)
• Such symptoms should not be self-diagnosed as a cold or flu.
Nursing Considerations
(1) preparation of the child for IV infusion, usually with an intermittent-infusion device, and several venipunctures for blood cultures
2) Use sterile technique when administering IV antibiotic
(3) Observation for side effects of antibiotics, especially inflammation along venipuncture sites
• IV antibiotics may be administered at home with nursing supervision
Nursing Considerations
(3) Observation for complications, including embolism and CHF
(4) Education regarding the importance of follow-up visits for cardiac evaluation, echocardiographic monitoring, and blood cultures
References
• Hockenberry, M. J., & Wilson, D. (2018). Wong's nursing care of
infants and children. (11th ed.)Elsevier Health Sciences.