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Aconcagua:
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Oxygen Research OverviewLeveraging Biology to Enhance Performance
Genetics and Oxygen Efficiency
Oxygen Deprivation Training
Cognition in Low Oxygen Environments
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Early Research
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Human Gene for Physical Performance
VO2 max = 65 ml / kg / minute
Montgomery, Marshall, Hemingway, Myerson, Clarkson, …, Humphries, Nature, 1998
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VO2 max
VO2 max = 65 ml / kg / minute
VO2max trainability is 47% heritableBouchard et al., 1999 (HERITAGE Study)
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Air Force Applications
Warfighter Optimization
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Training Performance Analysis V
O2 M
ax (m
l/kg/
min
) Del
ta P
RE
V P
OS
T
Different Participants Sorted Lowest to Highest Response
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Genetic Model for Trainability
% Increasein
Oxygen Efficiency
10
20
30
40
Low Total Genotype Score
Medium Total Genotype Score
High Total Genotype Score
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Air Force Applications
Warfighter Optimization
Place Proper DISTRIBUTION STATEMENT Here
Oxygen Research OverviewLeveraging Biology to Enhance Performance
Genetics and Oxygen Efficiency
Oxygen Deprivation Training
Cognition in Low Oxygen Environments
Place Proper DISTRIBUTION STATEMENT Here
Oxygen Research OverviewLeveraging Biology to Enhance Performance
Genetics and Oxygen Efficiency
Oxygen Deprivation Training
Cognition in Low Oxygen Environments
Place Proper DISTRIBUTION STATEMENT Here
Personalized Training
➢ MUSCLE TYPE: Sprinter/Power
➢ VARIANT: ACTN3
➢ Your fast-twitch muscle fibers have the alpha-actinin-3 protein
➢ RECOMMENDATION:
High-Intensity Interval Training
✓ Functionalized Circuits✓ Heart-Rate Biofeedback
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Air Force Applications
Warfighter Optimization
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Integrity ★ Service ★ Excellence
Enhancing Human Systems ThroughTranslational Neuroscience
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