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Accurate and exact CNV identification from targeted high-throughput sequence data. 出處： BMC Genomics 2011 報告人：嚴孝昇. OUTLINE. Background CNV MicroArray Methods & Results Conclusions. Background. CNV. Background. MicroArray. Background. Background. - PowerPoint PPT Presentation
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Accurate and exact CNV identification from targeted high-throughput sequence data
出處： BMC Genomics 2011
報告人：嚴孝昇
OUTLINE
Background CNV MicroArray
Methods & Results Conclusions
Background
CNV
Background
MicroArray
Background
Background
Green – DNA from reference sample hybridized to target DNA
Red – DNA from test sample hybridized to target DNA
Yellow – DNA from both samples hybridized equally to target DNA
Background
Methods & Results
Methods
Methods & Results
Methods & Results
Results
Methods & Results
Methods & Results
Methods & Results
Methods & Results
Conclusions
Estimate absolute copy Robust, simple to implement
Conclusions
優點： 方法易用，可利用已知資料進行驗證。
缺點： 各家MicroArray晶片設計不同。 對未知基因序列斷點，僅能預測無法驗證。
對本人研究影響： 可多方對 CNV驗證。 可提出準確 CNV位置供實驗驗證。
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