Volume 17 Number 2, Part 1 August 1987

Express ion o f neural-t issue markers 191

l i f e r a t i o n s tha t d isp lay such a react ivi ty . Hence , a n t i b o d i e s to S-100 pro te in and to Leu -7 antigen c a n s e r v e as a use fu l ad junct in the differential d i a g n o s i s b e t w e e n g landular and nonglandular a d n e x a l s k i n tumors , ju s t like ant ibodies to car- c i n o e m b r y o n i c ant igen. The i r usefu lness is also e n h a n c e d b y the fac t that bo th can be used on f o r m a l i n - f i x e d , p a r a f f i n - e m b e d d e d t issues.

T h e a n t i g e n r ecogn ized by Leu-7 ant ibody on n a t u r a l k i l l e r cells has o n l y par t ly been character-

i z e d . 6 T h e na ture o f the L e u - 7 - r e a c t i v e molecu le e x p r e s s e d b y swea t g lands r ema ins to be eluci- d a t e d . M o s t l ikely it will p r o v e to be different f rom t h e m o l e c u l e s r ecogn ized on na tura l kil ler and S c h w a n n cel l s , this fact be ing ano ther example o f t h e c r o s s - r e a c t i v i t y that a m o n o c l o n a l ant ibody m a y e x h i b i t t oward dif ferent ant igens sharing com- m o n e p i t o p e s . ~7

Authors' note added in proof. Since submission of the manuscr ipt , the following paper was presented at the 3rd Immunodermatology Symposium, Milan, Italy (Oct . 16-18, 1986): S. Schuller-Petrovic et al. Reac- t ivify o f anti-HNK1 (Leu-7) antibody with sweat gland tumors .

REFERENCES

1. Penneys NS, Nadji M, McKinney EC. Carcinoembryonic antigen present in human eccrine sweat. J AM ACAD DERMATOL 1981;4:401-3.

2. Penneys NS, Nadji M, Morales A. Carcino-embryonic antigen in benign sweat gland tumors. Arch Dermatol 1982;118:225-7.

3. Kanitakis J, Zambruno G, Viac J, Thivolet J. Involucrin expression in adnexal skin tumours. An immanohisto- logical study. Virchows Arch [A] 1986;408:527-40.

4. Abo T, Balch CM. A differentiation antigen of human

NK and K cells identified by a monoclonal antibody (HNK-1). J Immunol 1981;127:1024-9.

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6. Lipinski M, Braham K, Cailloud JM, Carlu C, Tursz T. HNK-1 antibody detects an antigen expressed on neu- roectodermal cells. J Exp Med 1983;158:1775-80.

7. McGarry RC, Helfand SL, Quarles RH, Roder JC. Rec- ognition of myelin-associated glycoprotein by the mono- clonal antibody HNK-1. Nature 1983;306:376-8.

8. Ando I, Tamaki K. HNK-1 antibody reacts with periph- eral nerves and sweat glands in the skin. Br J Dermatol 1985;113:175-8.

9. Moore BW. A soluble protein characteristic of the ner- vous system. Biophys Biochem Res Commun 1965;19: 739-44.

10. Nakajima T, Kameya T, Watanabe S, Hirota T, Sato Y, Shimosato Y. An immunoperoxidase study of S-100 pro- tein distribution in normal and neoplastic tissues. Am J Surg Pathol 1982;6:715-27.

11. Kahn HJ, Baumal R, Marks A. The value of immuno- histochemical studies using antibody to S-100 protein in dermatopathology. Int J Dermatol 1984;23:38-44.

12. Penneys NS. Immunohistochemistry of adnexal neo- plasms. J Cutan Pathol 1984;11:357-64.

13. Smolle J, Walter GF, Kerl H. Myelin-associated glyco- protein in neurogenic tumors of the skin: an immuno- histological study using Leu-7 monoclonal antibody. Arch Dermatol Res 1985;277; 141-2.

14. TokuraY, IwatsukiK, YamadaM. S-100 protein-positive cells in sweat apparatus tumors. Jpn J Dermatol 1985; 95:447-54.

15. Tokura Y, Takigawa M, Inoue K, Matsumoto K, Ya- mada M. S-100 protein-positive cells in hidroeystomas. J Cutan Pathol 1986;13;102-10.

16. Lever W, Schaurnburg-Lever G. Histopathology of the skin. 6th ed. Philadelphia: Lippineott, 1983.

17. Thivolet J, Schmitt D, Vise J, Brochier J. Les antigrnes reeonnus par les anticorps monoelonaux anti-lympho- cytes peuvent avoir une localisation tissulaire inattendue. Comp Rend Aead Sei (Paris), 1983 series 11I;203-6.

ABSTRACTS

Kaposi's sarcoma associated with mycosis fungoides

Fagundes L, Miranda M, Suguimoto S, Ishida CE, Pereira Junior AC, de Souza Marques A. AnaJs Bras Dermatol 1986;61:331-5 (Portuguese)

A 65-year-old man presenting with typical parapsoriasis en plaque early mycosis fungoides later developed purple nodules that were shown O n histopathologic examination to be Kaposi's sarcoma. The authors relate this event to the well-known propensity of Kaposi's sarcoma to appear in immunosuppressed patients.

Yehudi M. Fehnan, M.D.

Fluocinolone acetonide in psoriasis: continuous or alternate therapy?

Wozel G, Barth J. Dermatol Monatssehr 1986;172:620-3 (German)

There was no difference in therapeutic results in 20 patients with psoriasis with application of fluoeinolone acetonide cream 0.025% under occlusion once daily, once every other day, or once every three days.

Yehudi M. Felman, M.D.