A476 P1 Laboratory Report Grace

8/6/2019 A476 P1 Laboratory Report Grace

http://slidepdf.com/reader/full/a476-p1-laboratory-report-grace 1/5

Done by: Grace Chong, 942011

L ABORATORY REPORT

A476 Pharmaceutical Compounding

Problem 01: Wrap It Up

1.0 INTRODUCTION:

In this experiment, we have carried out a simple experiment to prepare a prescription for the

patient.

2.0 AIMS/OBJECTIVES:

The objective is to prepare the powder dosage form following a prescription and dispense the

prescribed preparation.

3.0 MATERIALS AND METHODS:

3.1 Materials:

Per class

y Gloves

y Weighing Boat

y Weighing Machine

Per team

y Zip lock bag

y Labelsy Charcoal Powder

y Lactose Powder

y Spatula

y Wrapping paper

y Mortar

y Pestle



Done by: Gr e Chong, 942012

3.2

ethod¡

:

3.20 Part A: Geometric dilution method

1. Wei¢ £ ¤ ¥ ¦ ¦ £

e in¢ §

edien¦ ̈

to be mixed.

2. Select a suitably sized mortar and pestle.

3. © lace all of the in¢ redients with the smallest quantity into the mortar (in this case, the

acti

ated charcoal powder).

4. A dd approximately an equal amount of the in¢

redient with the second smallest quantity

(in this case, the lactose). Triturate li¢

htly until a unif orm mixture is obtained.

5. epeat the process until all in¢ redients have been incorporated.

6.

epeat similarly if there are more than 2 in¢

redients.

3.21 Part B:Wrapping the powders

1. A rran

e the paper so that the lon

edges and parallel to the f ront of the bench.

2. Turn up the long edge to about one-seventh of its width.

3. Weigh out the powder and place the powder towards the f ront of the paper.

4. Fold the paper over and slide below the turn-up edge.

5. Fold the turn-up edge until it covers about two-thirds of the distance to the edge of thepac

et.

6. Turn the edges under the pac

et.

7. Firm the edges using a spatula but avoid excessi ve pressure, which would cause the

powder to cake.

8. The packets are best packed inpairs, flap to flap, restrained with an elastic band.

In a well wrapped product, there should not be any powders within the flaps or f olds. When

opened by the user, the powder should appear in the centre of the paper f or easy administration.




3.22 Par

C: Compounding Work

h

Item Name/ Strength of preparation:

Charcoal (60mg)

Batch No.

151068

Shelf Life

1 month

Raised by

RP Medical Centre

Instructions:-

Rx

Ingredients Quantity Done By Checked By

Activated

Charcoal

0.3 g Grace Shi Yun

Lactose Powder 1.5g Zoa Sya

Calculation:-

Amt of Charcoal needed (together with 20% additional)

= 60mg * 5 = 300mg = 0.3g

Amt of Lactose needed (together with 20% additional)

= 300mg * 5 = 1500mg = 1.5g

Procedure:-

Refer to above




Label:-

Label prepared by:-

Shi Yun 21 st April 2011

Name Date

Label checked by:-

Grace Chong 21st April 2011

Name Date




4.0 RESULTS AND DISCUSSION:

4.1 Results:

4.

Discussi

n:

Precautions:

y Ensure that there are no wind and water close to our preparation

y Ensure that things are placed further apart from our preparation area so that we would not

knock over anything

y Wear gloves at all times when handling the various materials and equipment

Some mistakes that we made:

y Weighing machine wasn·t properly calibrated resulting in wrong measurements

y We thought that we only need to prepare 200mg per packetand had changed the

measurements accordingly.

5.0 CONCLUSION

Through the different parts of the experiment that we have conducted today, we have learnt, as a

team, to titrate the powdered prescription. Through the process of compounding, we also learnt

about how to do geometric dilution.

Documents

A476 P1 Laboratory Report Grace