A Powerful Natural Anti-Inflammatory

The Role of the Ratio of Omega 6s to

Omega 3s in Optimal Health

The superior Marine Lipid Complex

Required by the human body to manufacture and repair cell membranes

Protect cells from inflammationCannot be made in sufficient

quantities therefore must be obtained from food

Two types:Alpha-linolenic acid (Omega-3)Linoleic acid (Omega-6)

Essential Fatty Acids

Omega 6 and 3

Fish /Marine Oils

Walnuts

Omega 3/Omega 6 Imbalance

Changes in food manufacturing processes have resulted in high amounts of Omega 6 Hydrogenated oilsHigh-fructose corn

syrupGenetically

engineered corn and soy products

Omega 3/Omega 6 Ratio

1

20

Western Diet

Omega 3

Omega 611

Recommended Diet

Omega3 FoodsWalnutsFlaxseed Green Vegetables

Alpha- Linolenic- Acid (ALA)

EPA/DHA Fish/ Animal Sources

Omega6 FoodsCorn OilSoy OilSafflower Oil

Linoleic Acid (LA)

Arachidonic Acid (AA)

COX1 COX2 5LOX

PGG2

PGH2

Prostaglandins (PG2)

Thromboxane (TXA)

5-HPETE

Leucotriene A4

Leucotriene B4

Cysteinyl Leucotrienes

Pro-Inflammatory

Prostaglandins (PG3)Thromboxane (LTB5)

Leucotriene (B5)

Anti-Inflammatory

Inflammatory Pathways

Bodies natural biological protective response of tissue to harmful stimuliPathogensCell damage Irritants

Chronic inflammation characterized by simultaneous tissue healing and destruction

Omega 3/6 Imbalance Leads to Inflammation

AsthmaAlzheimer’sCardiovascular DiseaseMetabolic SyndromeOsteoarthritisRheumatoid ArthritisInflammatory Bowel DiseaseDysmenorrheaDelayed Muscle SorenessAnd many more….

Inflammation is the Basis of Most Degenerative Disease

In secondary prevention of cardiovascular disease, a ratio of 4:1 Omega-6 to Omega-3 fatty acids associated with 70% decrease in total mortality

DeLongeril M, er al. Mediterranean alpha-linoleic acid-rich diet in secondary prevention of coronary heart disease. Lancet 1994; 343: 1454-9.

Effects of Reducing Omega-6:Omega-3 Ratio

Lowering the ratio to 5:1, resulted in alterations in 5-series leukotriene excretion in an asthmatics in ameliorating methacholine-induced respiratory distress

Broughton KS, et al. Reduced asthma symptoms with omega-3 fatty acid ingestion are related to 5-series leukotriene production. Am J Clin Nutr 1997; 65: 1011-17.

Effects of Reducing Omega-6:Omega-3 Ratio

Lowering the Omega-6: Omega-3 ratio by 4:1 by using 4gm of omega-3 fatty acids produced inhibition of production of IL-1β and TNFα associated with rheumatoid arthritis

James MJ, Cleland LG. Dietary omega-3 fatty acids and therapy for rheumatoid arthritis. Semin Arthritis Rheum 1997; 27: 85-97.

Effects of Reducing Omega-6:Omega-3 Ratio

With 30 years of Clinical Studies, OMAPREM is proven to be a Powerful, Effective Cox-2 and 5Lox inhibitor.

In addition to EPA and DHA, OMAPREM contains over 30 fatty acids that contribute to its anti inflammatory benefits. As well as 4 novel compounds*

*Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel ( Perna canaliculus)(PCSO-524™)S. McPhee a , L .D. Hodges a , P.F.A. Wright b , P.M. Wynne c , N. Kalafatis a , D.W. Harney a, T.A. Macrides a,⁎

*Novel anti-inflammatory ω-3 PUFAs from the New Zealandgreen-lipped mussel, Perna canaliculusA.P. Treschow a, L.D. Hodges a, P.F.A. Wright b, P.M. Wynne c, N. Kalafatis a, T.A. Macrides a,⁎

COX2Inflammation

5LOXInflammation

/ Swelling

OMAPREM

The OMAPREM Difference

A structurally related family of ω-3 PUFAs was identified in the most bioactive fractions, which included: C18:4 C19:4 C20:4 C21:5

The novel compounds may be biologically significant as AI agents, as a result of their in vitro inhibition of lipoxygenase products of the AA pathway.

*Novel anti-inflammatory ω-3 PUFAs from the New Zealandgreen-lipped mussel, Perna canaliculusA.P. Treschow a, L.D. Hodges a, P.F.A. Wright b, P.M. Wynne c, N. Kalafatis a, T.A. Macrides a,⁎

OMAPREM Novel Compounds

PurityPotencyEfficacySciencePartner Program

OMAPREM The Superior Choice

Purity

May contain man made pollutants if taken from natural sourcesHeavy MetalsPCB’sPesticidesRadiation

Farm raised fish have lower amounts of Omega 3s and higher amounts of Omega 6s due to corn/grain diet

Bio-magnification

http://www.hsph.harvard.edu/nutritionsource/fish/

Fish Oil Source

Fish, like salmon, consume smaller fish or krill that consume the plankton.

Fish also can absorb industrial contaminates (like mercury) by eating smaller fish.

The farther up the food chain the higher the level of contaminates

http://www.hsph.harvard.edu/nutritionsource/fish/

Fish Oil Source

National Geographic Magazine has warned about the 80 percent drop in krill populations over the last few decades

This drop could potentially harming already depleted whale and other marine mammal populations

Without krill, most of the life forms in the Antarctic would disappear.

http://animals.nationalgeographic.com/animals/invertebrates/krill.html

Krill- Sustainability

Green lipped musselsSustainably farmed in the

pristine waters of New Zealand’s Marlborough Sound.

Evolved to have extraordinary antioxidant content due to ozone deficiency

Blue Ocean Institute, ranked New Zealand Green-lipped mussels as one of the top two ‘eco-friendly seafoods’ in the world.*

*http://www.purenzgreenshell.com/aquaculture/quality-assurance/sustainability.cfm

OMAPREM Purity

Cold press

Distillation

Supercritical fluid extraction

Marine Oil Extraction Process

Cold press and distillation processes result in bound forms of essential fatty acidsTriglycerideEthyl esters

More metabolic processing required by the body in order for absorption

Marine Oil Extraction Process

Extraction Processes

Free Fatty Acids

Triglyceride

Ethyl Easter

Bioavailability

• Free Fatty Acids - easily absorbed and have been shown to have superior bioavailability*

• Triglyceride form- have a triglyceride “backbone” to the grouping of Fatty Acids

• Ethyl Easter- The Fatty acids are grouped together. The body must add the triglyceride backbone for absorption

HUMAN ABSORBTION OF FISHOIL FATIY ACIDS AS TRIACYLGLYCERLS, FREE ACIDS, OR ETHYLESTERSTarry D. Lawson andBronwynG. Hughes

Marine Oil Extraction Process

Free Fatty Acid FormPCSO-524

TriglycerideForm

Ethyl EasterForm

• Enzymes convert Ethyl Easter back into Triglyceride FormGlycerolysis

• Lipases free the fatty acids from Triglycerides forming Micelles that contain Free Fatty Acids

Lipolysis • Intestinal BarrierDiffusion

Across Plasma

Membrane

•Particles called lipoproteins or chylomicrons

Fatty Acids Reformed into Triglycerides • Bioavailabl

eReleased into capillaries then blood stream

Fatty Acid Absorption

SFE (CO2) Patented Supercritical Fluid Extraction

Dissolves nonpolar lipids from freeze dried mussel powder using combination of pressure and low temperature

Process process high quantity of Free Fatty Acids

OMAPREM Extraction Process

Removes marine proteins no allergy

Remove heavy metals no toxins

Provides free fatty acid form for easy absorption into the bloodstream

OMAPREM Extraction Process

OMAPREM: Potency

BioavailabilityThe PCSO-524 oil used in OMAPREM has been shown to have 17 to 22 times more free fatty acid form DHA and EPA, in addition there are 4 novel fatty acids with greater bioactivity then standard fish oils. *Convance –Certificate of Analysis 594817-0 10-jul-2012, 594835-0,594836-0

OMAPREM Potency

Lauric acid

Caprylic acid

ALA

Stearic acid

Docosapentaenoic acid (DPA) 

Eicosatetraenoic acid (ETA)

Linolenic acid

Nervonic acid

DHA

EPA

• PCSO-524tm contains novel fatty acids in addition to 30+ fatty acids that can reduce inflammation many times better than other anti-inflammatory supplements.

• The array of fatty acids offers many unique properties not found in any other marine source

Fish Oils contain little more than these Fatty Acids

Multiple Fatty Acids Multiple Benefits

One tiny capsule of OMAPREM is as powerful as 20 fish oil.

Smaller & Superior

Bioavailability of free fatty acid 5-10 times more in a much smaller quanitity

Kataoka et al. Future Cardiol 2013; 9(2): 177-186.

OMAPREM: Science

30 Years Over 25 Studies

ArthritisAsthmaDOMSDysmenorrhea

Allergies

Inflammatory Bowel Disease*Studies Available Upon Request

Efficacy

50 patients older than 50 yearsPatients treated with PCSO-524™ showed a

statistically significant improvement of both their pain symptoms related to osteoarthritis and improved quality of their daily lives (p = 0.05)

Conclusion: Reduction of pain was statistically evident at four weeks among the subjects who took capsules that contained PCSO-524™.

Practitioners can expect quicker long-term results with less risk of side effects for their osteoarthritis patients when they recommend products that contain PCSO-524™, compared with fish oil.

Szechinski J et al. Measurement of pain relief resulting from the administration of Perna canaliculus lipid complex PCSO-524™ as compared to fish oil for treating patients who suffer from osteoarthritis of hip and/or knee joints. Reumatologia 2011; 49: 244-252.

Arthritis

Week 0 Week 4 Week 8 Week 120.00

10.00

20.00

30.00

40.00

50.00

60.00

70.00

PCSO-524Fish Oil

89%

Visual Analog Scale (Arthritis)

Mea

n

Fish oil

Week

-91%

p < 0,05

Quality of Life – Health Assessment Questionnaire

12 week drug monitoring study evaluated the effects of PCSO-524™ on 50 adult men and women suffering from inflammatory rheumatoid arthritis

21 of the 34 subjects (64%) reduced or terminated current drug therapy

13 patients did not require further therapy38 % of all subjects were regarded as being free

from disorders Number of subjects suffering from severe pain was

significantly decreased from 60% (at baseline) to 25 % (at 3 months)

A significant positive effect was observed for all investigated parameters

Gruenwald J et al. Efficacy and tolerability of mussel-Lyprinol omega-3-complex on inflammatory rheumatoid disorders. PhytoPharm Research.

Rheumatoid Arthritis

The effect of pretreatment with PCSO-524™ on experimentally induced inflammatory bowel disease (IBD) in mice

Body weight and disease activity index (DAI) scores were recorded daily

Treatment significantly reduced body weight loss, DAI scores, crypt area losses, and cecum and colon weights, compared with control

Tenikoff D et al. Stabilized lipid extract of New Zealand green-lipped mussel: a potential preventative treatment modality for inflammatory bowel disease. J Gastroenterol 2005; 40: 361-365.

Inflammatory Bowel Disease

Forty-six patients with atopic asthma received two capsules of lipid extract (PCSO-524™) or placebo b.i.d. for 8 weeks

Significant decrease in daytime wheeze concentration of exhaled H2O2

Increase in morning PEF in the lipid extract group compared to the placebo group

No reported significant side effects

Emelyanov A, et al. Treatment of asthma with lipid extract of New Zealand green-lipped mussel: a randomized clinical trial. Eur Respir J 2002: 20: 596-600.

Asthma

PCSO-524®, derived from the New Zealand green-lipped mussel on DOMS after a 30 km training run.

One group was supplemented with 400 mg per day of PCSO-524® for 11 weeks, the other group with an olive oil placebo.

Conclusion: Pain sensations experienced by distance runners following a 30 km run were reduced by supplementation with the marine oil complex PCSO-524®, an effect which was greater in lesser trained runners

Athletic Performance DOMS

Pharmaceutical Options likeCodeine Based Pain RelieversCortisoneImmune ModulatorsNSAIDs (COX1, COX2)

Create Side Effects LikeCartilage deterioration, osteonecrosis, nerve damage,

adrenal suppression, hyperglycemiaImmune suppressionAddictionGI bleed, stroke, MI, renal failure

No Known Side Effects Just Side Benefits

30+

100

0

• OMAPREM has been shown to be up to 100 times more effective than other fish oils

• OMAPREM contains complex of 30+ different fatty (Including EPA and DHA) acids. This array of fatty acids are unique to the green lipped mussel.

• The fatty acids in OMAPREM are up to 22 times more free form than fish oil therefore easier for the body to absorb.

• 0 known side effects• 0 Drug to Drug interaction• 0 Contaminants• 0 to Lose!

The OMAPREM Advantage

OMAPREM: Partner Program

First Quarter Second Quarter Third Quarter Fourth

Quarter First Year Total

$3,150 $8,625 $13,800 $18,975 $44,550

Fifth Quarter Sixth Quarter Seventh Quarter

Eighth Quarter Second Year Total

$24,150 $29,325 $34,500 $39,675

Ongoing Additional Quarterly Incentive  150-225 Bottles sold per quarter $1 extra per bottle226-300 Bottles sold per quarter $2 extra per bottle301-up Bottles sold per quarter $3 extra per bottle

Profit Per Bottle

$20 per 60 ct. bottle ($64.95 retail)$10 per 30 ct. bottle ($39.95 retail)

Chart based on 1 patient a day, a total of 25 patients each month.

$ 127,650

Benefit Your Patients and Your Practice

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OMAPREM’s Key Points for Patients

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