The risk of an unfavorable outcome was calculated using ‘patients without both’ as the reference, adjusting for female sex, age ≥72 years, onset to admission time ≤12 hours, dyslipidemia, facial palsy, and sensory items of the National Institutes of Health Stroke Scale (NIHSS) in patients with baseline NIHSS score of 0 to 4 (A) and 0 to 5 (B) in the SUMO (Stroke Unit Multicenter Observational) Study cohort.

(A) Patients with baseline NIHSS of 0 to 4

(B) Patients with baseline NIHSS of 0 to 5

Ris

k of

an

unfa

vora

ble

outc

ome

Ris

k of

an

unfa

vora

ble

outc

ome

Intra- or extracranial vascular lesion

Leg weakness or extinction/inattention --

-+

+-

++

n=1031 n=436 n=345 n=129

Intra- or extracranial vascular lesion

Leg weakness or extinction/inattention --

-+

+-

++

n=1105 n=582 n=373 n=173

p<0.001

p=0.001

p<0.001

p<0.001

p<0.001

p<0.001

Figure e-1. Combined effects of intra/extracranial vascular occlusive lesion and leg weakness or extinction/inattention on unfavorable outcome